JPWO2022081927A5 - - Google Patents
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- Publication number
- JPWO2022081927A5 JPWO2022081927A5 JP2023523013A JP2023523013A JPWO2022081927A5 JP WO2022081927 A5 JPWO2022081927 A5 JP WO2022081927A5 JP 2023523013 A JP2023523013 A JP 2023523013A JP 2023523013 A JP2023523013 A JP 2023523013A JP WO2022081927 A5 JPWO2022081927 A5 JP WO2022081927A5
- Authority
- JP
- Japan
- Prior art keywords
- heteroaryl
- ring
- alkyl
- aryl
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063091894P | 2020-10-14 | 2020-10-14 | |
| US63/091,894 | 2020-10-14 | ||
| PCT/US2021/055104 WO2022081927A1 (en) | 2020-10-14 | 2021-10-14 | Tricyclic compounds to degrade neosubstrates for medical therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023545509A JP2023545509A (ja) | 2023-10-30 |
| JPWO2022081927A5 true JPWO2022081927A5 (https=) | 2024-10-22 |
| JP2023545509A5 JP2023545509A5 (https=) | 2024-10-22 |
Family
ID=81208653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023523013A Pending JP2023545509A (ja) | 2020-10-14 | 2021-10-14 | 医学的療法のための、ネオ基質を分解する三環式化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240018118A1 (https=) |
| EP (1) | EP4228624A4 (https=) |
| JP (1) | JP2023545509A (https=) |
| KR (1) | KR20230107807A (https=) |
| CN (1) | CN116457339A (https=) |
| AU (1) | AU2021360596A1 (https=) |
| CA (1) | CA3194351A1 (https=) |
| IL (1) | IL302036A (https=) |
| MX (1) | MX2023004369A (https=) |
| WO (1) | WO2022081927A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4717317A2 (en) | 2017-06-20 | 2026-04-01 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| IL302038A (en) * | 2020-10-14 | 2023-06-01 | C4 Therapeutics Inc | Tricyclic ligands for degradation of ikzf2 or ikzf4 |
| KR20240052805A (ko) * | 2021-08-27 | 2024-04-23 | 항저우 글루바이오 파마수티컬 코., 엘티디. | 이소인돌리논 화합물 및 이의 용도 |
| WO2023125877A1 (zh) | 2021-12-30 | 2023-07-06 | 上海翰森生物医药科技有限公司 | 三并环类衍生物抑制剂、其制备方法和应用 |
| CN120303264A (zh) * | 2022-09-09 | 2025-07-11 | 医诺康治疗公司 | CK1α和双重CK1α/GSPT1降解化合物 |
| WO2024073507A1 (en) | 2022-09-28 | 2024-04-04 | Theseus Pharmaceuticals, Inc. | Macrocyclic compounds and uses thereof |
| US20260109715A1 (en) | 2022-10-03 | 2026-04-23 | Public University Corporation Yokohama City University | Imidazopyridine derivatives with bicyclic structure |
| WO2024096753A1 (en) | 2022-11-02 | 2024-05-10 | Captor Therapeutics S.A. | Nek7 degraders and methods of use thereof |
| WO2024153246A1 (zh) * | 2023-01-20 | 2024-07-25 | 海南先声再明医药股份有限公司 | 取代的三环化合物及其应用 |
| WO2024157953A1 (ja) | 2023-01-24 | 2024-08-02 | 第一三共株式会社 | 置換ベンゼン化合物 |
| WO2024259303A1 (en) * | 2023-06-16 | 2024-12-19 | Oncopia Therapeutics, Inc. D/B/A Sk Life Science Labs | Compounds and compositions as cereblon ligands and uses thereof |
| CN121925410A (zh) | 2023-09-29 | 2026-04-24 | 第一三共株式会社 | 3-苯基丙胺衍生物 |
| WO2025162410A1 (zh) * | 2024-01-31 | 2025-08-07 | 微境生物医药科技(上海)有限公司 | 新型蛋白降解剂及抗体-蛋白降解剂偶联物 |
| WO2026021557A1 (zh) * | 2024-07-26 | 2026-01-29 | 上海超阳药业有限公司 | 苯并吲哚衍生物的药物组合物、制备方法及用途 |
| WO2026048766A1 (ja) * | 2024-08-27 | 2026-03-05 | 第一三共株式会社 | 多環性化合物 |
| WO2026065268A1 (en) * | 2024-09-29 | 2026-04-02 | Biofront Ltd | Novel conjugates for protein degradation, compositions comprising the same, and methods of using the same |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06003320A (es) * | 2003-09-24 | 2006-06-08 | Combinatorx Inc | Regimenes terapeuticos para administrar combinaciones de farmacos. |
| JP6815318B2 (ja) * | 2014-12-23 | 2021-01-20 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | 二官能性分子によって標的化タンパク質分解を誘導する方法 |
| CN105985282B (zh) * | 2015-01-28 | 2020-12-08 | 中国科学院广州生物医药与健康研究院 | 一种2-氧代-1,2-二氢苯并[cd]吲哚类化合物及其应用 |
| WO2017197056A1 (en) * | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Bromodomain targeting degronimers for target protein degradation |
| BR112019015484A2 (pt) * | 2017-01-31 | 2020-04-28 | Arvinas Operations Inc | ligantes de cereblon e compostos bifuncionais compreendendo os mesmos |
| MX2020002869A (es) * | 2017-09-15 | 2020-07-24 | Aduro Biotech Inc | Compuestos de pirazolopirimidinona y usos de los mismos. |
| US11220515B2 (en) * | 2018-01-26 | 2022-01-11 | Yale University | Imide-based modulators of proteolysis and associated methods of use |
| AU2019284608A1 (en) * | 2018-06-13 | 2020-12-17 | Biotheryx, Inc. | Aminoamide compounds |
| EP3813834B1 (en) * | 2018-06-29 | 2025-03-26 | Dana-Farber Cancer Institute, Inc. | New crbn modulators |
| AR116109A1 (es) * | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| EP3924055B1 (en) * | 2019-02-15 | 2024-04-03 | Novartis AG | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| CN120172958A (zh) * | 2019-04-12 | 2025-06-20 | C4医药公司 | Ikaros和aiolos的三环降解物 |
| US20240383886A1 (en) * | 2019-12-20 | 2024-11-21 | Calico Life Sciences Llc | Protein Tyrosine Phosphatase Degraders and Methods of Use Thereof |
| MX2023001545A (es) * | 2020-08-07 | 2023-05-03 | C4 Therapeutics Inc | Terapias ventajosas para trastornos mediados por ikaros o aiolos. |
| IL302038A (en) * | 2020-10-14 | 2023-06-01 | C4 Therapeutics Inc | Tricyclic ligands for degradation of ikzf2 or ikzf4 |
| EP4228625A4 (en) * | 2020-10-14 | 2026-01-14 | C4 Therapeutics Inc | TRICYCLIC HETEROBFUNCTIONAL COMPOUNDS FOR TARGETED PROTEIN DEGRADATION |
-
2021
- 2021-10-14 CN CN202180079148.7A patent/CN116457339A/zh active Pending
- 2021-10-14 MX MX2023004369A patent/MX2023004369A/es unknown
- 2021-10-14 EP EP21881144.6A patent/EP4228624A4/en active Pending
- 2021-10-14 WO PCT/US2021/055104 patent/WO2022081927A1/en not_active Ceased
- 2021-10-14 JP JP2023523013A patent/JP2023545509A/ja active Pending
- 2021-10-14 IL IL302036A patent/IL302036A/en unknown
- 2021-10-14 KR KR1020237015799A patent/KR20230107807A/ko active Pending
- 2021-10-14 AU AU2021360596A patent/AU2021360596A1/en active Pending
- 2021-10-14 CA CA3194351A patent/CA3194351A1/en active Pending
-
2023
- 2023-04-14 US US18/134,990 patent/US20240018118A1/en active Pending
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