JPWO2020076977A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020076977A5 JPWO2020076977A5 JP2021520217A JP2021520217A JPWO2020076977A5 JP WO2020076977 A5 JPWO2020076977 A5 JP WO2020076977A5 JP 2021520217 A JP2021520217 A JP 2021520217A JP 2021520217 A JP2021520217 A JP 2021520217A JP WO2020076977 A5 JPWO2020076977 A5 JP WO2020076977A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- dll3
- nos
- binds
- set forth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims description 521
- 102100036466 Delta-like protein 3 Human genes 0.000 claims description 518
- 229940127276 delta-like ligand 3 Drugs 0.000 claims description 515
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 287
- 229920001184 polypeptide Polymers 0.000 claims description 280
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 280
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 252
- 230000027455 binding Effects 0.000 claims description 188
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 157
- 150000001413 amino acids Chemical class 0.000 claims description 134
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 56
- 239000012634 fragment Substances 0.000 claims description 46
- 230000001747 exhibiting effect Effects 0.000 claims description 36
- 239000000427 antigen Substances 0.000 claims description 35
- 102000036639 antigens Human genes 0.000 claims description 35
- 108091007433 antigens Proteins 0.000 claims description 35
- 210000002865 immune cell Anatomy 0.000 claims description 20
- 230000004048 modification Effects 0.000 claims description 20
- 238000012986 modification Methods 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 19
- 108091008034 costimulatory receptors Proteins 0.000 claims description 15
- 108091033319 polynucleotide Proteins 0.000 claims description 14
- 102000040430 polynucleotide Human genes 0.000 claims description 14
- 239000002157 polynucleotide Substances 0.000 claims description 14
- 239000013598 vector Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 108091008042 inhibitory receptors Proteins 0.000 claims description 9
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 8
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 8
- 102000005962 receptors Human genes 0.000 claims description 6
- 108020003175 receptors Proteins 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 230000004068 intracellular signaling Effects 0.000 claims description 5
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims description 3
- 108060003951 Immunoglobulin Proteins 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 claims description 3
- 102000003675 cytokine receptors Human genes 0.000 claims description 3
- 108010057085 cytokine receptors Proteins 0.000 claims description 3
- 102000018358 immunoglobulin Human genes 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 3
- 230000035772 mutation Effects 0.000 claims description 3
- 230000004936 stimulating effect Effects 0.000 claims description 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 102000053255 human DLL3 Human genes 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 description 105
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 description 11
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 description 11
- 210000004899 c-terminal region Anatomy 0.000 description 10
- 206010028980 Neoplasm Diseases 0.000 description 8
- 230000004075 alteration Effects 0.000 description 7
- 150000007523 nucleic acids Chemical group 0.000 description 7
- 230000001568 sexual effect Effects 0.000 description 6
- 108091005804 Peptidases Proteins 0.000 description 5
- 239000004365 Protease Substances 0.000 description 5
- 239000012636 effector Substances 0.000 description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 230000011664 signaling Effects 0.000 description 4
- 102000002227 Interferon Type I Human genes 0.000 description 3
- 102000008070 Interferon-gamma Human genes 0.000 description 3
- 108010074328 Interferon-gamma Proteins 0.000 description 3
- 102000014150 Interferons Human genes 0.000 description 3
- 108010050904 Interferons Proteins 0.000 description 3
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 description 3
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 239000012642 immune effector Substances 0.000 description 3
- 229940121354 immunomodulator Drugs 0.000 description 3
- 229940079322 interferon Drugs 0.000 description 3
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 description 2
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000001398 Granzyme Human genes 0.000 description 2
- 108060005986 Granzyme Proteins 0.000 description 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 2
- 108010073807 IgG Receptors Proteins 0.000 description 2
- 102000009490 IgG Receptors Human genes 0.000 description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 2
- 108010014726 Interferon Type I Proteins 0.000 description 2
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 description 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 2
- 102000050862 Transmembrane Activator and CAML Interactor Human genes 0.000 description 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 2
- 101710178302 Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 2
- 102100023990 60S ribosomal protein L17 Human genes 0.000 description 1
- 102100027207 CD27 antigen Human genes 0.000 description 1
- 101150013553 CD40 gene Proteins 0.000 description 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 description 1
- 229940045513 CTLA4 antagonist Drugs 0.000 description 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 description 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 description 1
- 101100166600 Homo sapiens CD28 gene Proteins 0.000 description 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 description 1
- 101001042104 Homo sapiens Inducible T-cell costimulator Proteins 0.000 description 1
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 description 1
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 description 1
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 1
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 description 1
- -1 ICOS Proteins 0.000 description 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 108010091175 Matriptase Proteins 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
- 108010006035 Metalloproteases Proteins 0.000 description 1
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 102220596304 Pre-mRNA-splicing factor CWC22 homolog_L368A_mutation Human genes 0.000 description 1
- 102100037942 Suppressor of tumorigenicity 14 protein Human genes 0.000 description 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 description 1
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 description 1
- 101710178300 Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 description 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000000139 costimulatory effect Effects 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 description 1
- 239000000833 heterodimer Substances 0.000 description 1
- 238000005734 heterodimerization reaction Methods 0.000 description 1
- 102000043396 human ICOS Human genes 0.000 description 1
- 102000050320 human TNFRSF4 Human genes 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 102220058260 rs730881636 Human genes 0.000 description 1
- 102220096762 rs876660260 Human genes 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024226838A JP2025060787A (ja) | 2018-10-11 | 2024-12-24 | Ｄｌｌ３シングルドメイン抗体およびその治療用組成物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862744638P | 2018-10-11 | 2018-10-11 | |
| US62/744,638 | 2018-10-11 | ||
| US201962832265P | 2019-04-10 | 2019-04-10 | |
| US62/832,265 | 2019-04-10 | ||
| US201962877815P | 2019-07-23 | 2019-07-23 | |
| US62/877,815 | 2019-07-23 | ||
| PCT/US2019/055436 WO2020076977A2 (en) | 2018-10-11 | 2019-10-09 | Dll3 single domain antibodies and therapeutic compositions thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024226838A Division JP2025060787A (ja) | 2018-10-11 | 2024-12-24 | Ｄｌｌ３シングルドメイン抗体およびその治療用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022504822A JP2022504822A (ja) | 2022-01-13 |
| JPWO2020076977A5 true JPWO2020076977A5 (enExample) | 2022-10-18 |
| JP7611820B2 JP7611820B2 (ja) | 2025-01-10 |
Family
ID=68343541
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021520217A Active JP7611820B2 (ja) | 2018-10-11 | 2019-10-09 | Ｄｌｌ３シングルドメイン抗体およびその治療用組成物 |
| JP2024226838A Pending JP2025060787A (ja) | 2018-10-11 | 2024-12-24 | Ｄｌｌ３シングルドメイン抗体およびその治療用組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024226838A Pending JP2025060787A (ja) | 2018-10-11 | 2024-12-24 | Ｄｌｌ３シングルドメイン抗体およびその治療用組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US12365728B2 (enExample) |
| EP (1) | EP3864045A2 (enExample) |
| JP (2) | JP7611820B2 (enExample) |
| CN (1) | CN113166263A (enExample) |
| CA (1) | CA3115089A1 (enExample) |
| TW (1) | TW202028245A (enExample) |
| WO (1) | WO2020076977A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202515920A (zh) * | 2017-04-11 | 2025-04-16 | 美商因荷布瑞克斯生物科學公司 | 具有經受限cd3結合的多重特異性多肽構築體及使用其之方法 |
| KR20210006913A (ko) | 2018-04-11 | 2021-01-19 | 인히브릭스, 인크. | 제한된 ｃｄ3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 관련된 방법 및 용도 |
| US12037391B2 (en) | 2018-05-08 | 2024-07-16 | Phanes Therapeutics, Inc. | Anti-DLL3 antibodies and uses thereof |
| TW202035451A (zh) * | 2018-07-24 | 2020-10-01 | 美商英伊布里克斯公司 | 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法 |
| MX2022009306A (es) * | 2020-01-29 | 2022-09-26 | Inhibrx Inc | Loseta de nucleo de espuma densificada (dfc) con linea de anticuerpos de dominio individual de cd28 y constructos multivalentes y multiespecíficas de los mismos. |
| CN115397866B (zh) * | 2020-03-31 | 2025-10-31 | 中外制药株式会社 | 靶向dll3的多特异性抗原结合分子及其用途 |
| EP4294845A1 (en) * | 2021-02-22 | 2023-12-27 | Abdera Therapeutics Inc. | Immunoconjugates for targeted radioisotope therapy |
| KR20240004860A (ko) * | 2021-05-08 | 2024-01-11 | 상하이 치루 파마슈티컬 리서치 앤 디벨롭먼트 센터 리미티드 | 디엘엘3에 대한 결합 분자 및 이의 용도 |
| CN116271079B (zh) * | 2021-07-30 | 2025-11-14 | 上海复旦张江生物医药股份有限公司 | 一种抗dll3抗体及其制备方法、其药物偶联物和应用 |
| TWI847270B (zh) * | 2021-09-17 | 2024-07-01 | 大陸商上海藥明生物技術有限公司 | D3結合分子及其用途 |
| CN118234510A (zh) * | 2021-09-17 | 2024-06-21 | 上海药明生物技术有限公司 | D3结合分子及其用途 |
| WO2023053272A1 (en) * | 2021-09-29 | 2023-04-06 | Chugai Seiyaku Kabushiki Kaisha | Uses of dll3-targeting multispecific antigen-binding molecules |
| WO2023122436A2 (en) * | 2021-12-20 | 2023-06-29 | Amgen Inc. | Dll3 binding peptides and uses thereof |
| CN119213028A (zh) * | 2022-01-05 | 2024-12-27 | 印希比生物科学有限公司 | 结合γδ T细胞的多肽及其用途 |
| WO2024044550A1 (en) * | 2022-08-22 | 2024-02-29 | Abdera Therapeutics Inc. | Dll3 binding molecules and uses thereof |
| CA3265449A1 (en) * | 2022-08-22 | 2024-02-29 | Abdera Therapeutics Inc. | MULTIVALENT IMMUNOCONJUGATES FOR TARGETED RADIOISOTOPIC THERAPY |
| WO2024230793A1 (en) * | 2023-05-10 | 2024-11-14 | Nanjing Legend Biotech Co., Ltd. | Chimeric antigen receptors and methods of use thereof |
| CN118878683B (zh) * | 2023-07-11 | 2025-11-04 | 四川大学 | 靶向人dll3的嵌合抗原受体t细胞及其应用 |
| WO2025036352A1 (zh) * | 2023-08-14 | 2025-02-20 | 海南先声再明医药股份有限公司 | 特异性识别Delta样配体3的纳米抗体及其应用 |
| WO2025067338A1 (en) * | 2023-09-26 | 2025-04-03 | Nanjing Legend Biotech Co., Ltd. | Dll3 binding moieties and uses thereof |
| WO2025179051A1 (en) * | 2024-02-21 | 2025-08-28 | Abdera Therapeutics Inc. | Dll3 binding immunoconjugates and uses thereof |
| WO2025201493A1 (zh) * | 2024-03-29 | 2025-10-02 | 诺纳生物（苏州）有限公司 | Dll3结合分子及其用途 |
Family Cites Families (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DE3414831A1 (de) | 1984-04-19 | 1985-10-31 | Hoechst Ag, 6230 Frankfurt | Herstellung von polypeptiden mit human-gammainterferon-aktivitaet |
| DE3536939A1 (de) | 1985-10-17 | 1987-04-23 | Hoechst Ag | Biologisch aktive derivate des human-(gamma)-interferons, ihre herstellung und arzneimittel, die solche derivate enthalten |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| DE4036856C1 (enExample) | 1990-11-19 | 1992-05-27 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De | |
| US5525491A (en) | 1991-02-27 | 1996-06-11 | Creative Biomolecules, Inc. | Serine-rich peptide linkers |
| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| US7381803B1 (en) | 1992-03-27 | 2008-06-03 | Pdl Biopharma, Inc. | Humanized antibodies against CD3 |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5770191A (en) | 1995-05-24 | 1998-06-23 | University Of Florida | Active C-terminal peptides of interferon--gamma and their use |
| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| AU751659B2 (en) | 1997-05-02 | 2002-08-22 | Genentech Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
| BR9813365A (pt) | 1997-12-05 | 2004-06-15 | Scripps Research Inst | Método para produção e humanização de um anticorpo monoclonal de rato |
| GB9815909D0 (en) | 1998-07-21 | 1998-09-16 | Btg Int Ltd | Antibody preparation |
| EP1002861A1 (en) | 1998-10-26 | 2000-05-24 | Unilever Plc | Antigen-binding proteins comprising a linker which confers restricted conformational flexibility |
| US20020142000A1 (en) | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
| FR2822845B1 (fr) | 2001-03-30 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques |
| FR2823763A1 (fr) | 2001-04-18 | 2002-10-25 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'interferon alpha 6 |
| FR2823764B1 (fr) | 2001-04-24 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides et polypeptides du gene ifn alpha-17 |
| FR2824333B1 (fr) | 2001-05-03 | 2003-08-08 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'ifn alpha 5 |
| FR2825102B1 (fr) | 2001-05-23 | 2003-08-29 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'interferon alpha 14 |
| FR2825716B1 (fr) | 2001-06-11 | 2004-09-24 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'ifn alpha 7 |
| US7647184B2 (en) | 2001-08-27 | 2010-01-12 | Hanall Pharmaceuticals, Co. Ltd | High throughput directed evolution by rational mutagenesis |
| EP1391213A1 (en) | 2002-08-21 | 2004-02-25 | Boehringer Ingelheim International GmbH | Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents |
| EP1539950A1 (en) | 2002-09-09 | 2005-06-15 | Nautilus Biotech | Rational directed protein evolution using two-dimensional rational mutagenesis scanning |
| US7611700B2 (en) | 2002-09-09 | 2009-11-03 | Hanall Pharmaceuticals, Co., Ltd. | Protease resistant modified interferon alpha polypeptides |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| JP3803790B2 (ja) | 2003-02-17 | 2006-08-02 | 株式会社東北テクノアーチ | 新規なダイアボディ型二重特異性抗体 |
| US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
| KR20120125634A (ko) | 2003-10-16 | 2012-11-16 | 마이크로메트 에이지 | 다중특이적 탈면역화된 ｃｄ3-바인더 |
| WO2005040395A1 (en) | 2003-10-22 | 2005-05-06 | Keck Graduate Institute | Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy |
| CN1922210A (zh) | 2003-12-19 | 2007-02-28 | 健泰科生物技术公司 | 可用作治疗剂的单价抗体片段 |
| MXPA06011199A (es) | 2004-03-31 | 2007-04-16 | Genentech Inc | Anticuerpos anti-tgf-beta humanizados. |
| WO2005100402A1 (en) | 2004-04-13 | 2005-10-27 | F.Hoffmann-La Roche Ag | Anti-p-selectin antibodies |
| EA010350B1 (ru) | 2004-06-03 | 2008-08-29 | Новиммун С.А. | Антитела против cd3 и способы их применения |
| US20060024272A1 (en) | 2004-07-29 | 2006-02-02 | Large Scale Biology Corporation | C-terminally truncated interferon |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| EP1866339B8 (en) | 2005-03-25 | 2021-12-01 | GITR, Inc. | Gitr binding molecules and uses therefor |
| PT2650020T (pt) | 2005-05-06 | 2016-12-12 | Providence Health & Services - Oregon | Proteína de fusão de imunoglobulina ox-40 trimérica e métodos do campo de utilização |
| GB0510790D0 (en) | 2005-05-26 | 2005-06-29 | Syngenta Crop Protection Ag | Anti-CD16 binding molecules |
| AU2006291005A1 (en) | 2005-09-12 | 2007-03-22 | Novimmune S.A. | Anti-CD3 antibody formulations |
| FI2155783T4 (fi) | 2007-04-03 | 2022-12-15 | Lajien välisesti spesifinen cd3-epsilon-sitoutumisdomeeni | |
| CN101952312A (zh) | 2007-07-31 | 2011-01-19 | 米迪缪尼有限公司 | 多特异性表位结合蛋白及其应用 |
| CA3128656A1 (en) | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| WO2009067800A1 (en) | 2007-11-27 | 2009-06-04 | Viventia Biotech Inc. | Antibodies against a cancer-associated epitope of variant nfkbib and uses thereof |
| ES2563027T3 (es) | 2008-01-07 | 2016-03-10 | Amgen Inc. | Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática |
| CA2720763A1 (en) | 2008-04-07 | 2009-10-15 | Ablynx Nv | Amino acid sequences directed against the notch pathways and uses thereof |
| WO2010037836A2 (en) | 2008-10-01 | 2010-04-08 | Micromet Ag | Cross-species-specific psmaxcd3 bispecific single chain antibody |
| EP2352765B1 (en) | 2008-10-01 | 2018-01-03 | Amgen Research (Munich) GmbH | Cross-species-specific single domain bispecific single chain antibody |
| CN102482347B (zh) | 2009-01-12 | 2017-04-26 | 希托马克斯医疗有限责任公司 | 修饰抗体组合物及其制备和使用方法 |
| RU2011138951A (ru) | 2009-02-23 | 2013-03-27 | Сайтомкс Терапьютикс, Инк. | Пропротеины и способы их применения |
| JP5497887B2 (ja) | 2009-04-07 | 2014-05-21 | ロシュ グリクアート アクチェンゲゼルシャフト | 二重特異性抗ＥｒｂＢ−２／抗ｃ−Ｍｅｔ抗体 |
| MX368932B (es) | 2009-06-26 | 2019-10-22 | Regeneron Pharma | Anticuerpos biespecificos facilmente aislados con formato de inmunoglobulina original. |
| CN102574924A (zh) | 2009-09-03 | 2012-07-11 | 先灵公司 | 抗-gitr抗体 |
| BR112012026227A2 (pt) | 2010-04-13 | 2020-08-04 | Celldex Therapeutics, Inc. | anticorpo monoclonal humano ou humanizado, molécula biespecífica, vetor de expressão, célula transformada, composição, e, usos de um anticorpo |
| KR101860963B1 (ko) | 2010-04-23 | 2018-05-24 | 제넨테크, 인크. | 이종다량체 단백질의 생산 |
| WO2011143545A1 (en) | 2010-05-14 | 2011-11-17 | Rinat Neuroscience Corporation | Heterodimeric proteins and methods for producing and purifying them |
| EA031849B1 (ru) | 2010-08-23 | 2019-03-29 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Антитела к ox40 и способы их применения |
| RU2013110876A (ru) | 2010-08-24 | 2014-09-27 | Рош Гликарт Аг | Активируемые биспецифические антитела |
| SG10201912092VA (en) | 2010-09-09 | 2020-02-27 | Pfizer | 4-1bb binding molecules |
| RU2604490C2 (ru) | 2010-11-05 | 2016-12-10 | Займворкс Инк. | ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ |
| WO2013026837A1 (en) | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| WO2014067011A1 (en) | 2012-11-02 | 2014-05-08 | Zymeworks Inc. | Crystal structures of heterodimeric fc domains |
| AU2012362378B2 (en) | 2011-12-27 | 2016-06-23 | Dcb-Usa Llc | Light chain-bridged bispecific antibody |
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| EP2872170A4 (en) | 2012-07-13 | 2016-06-22 | Zymeworks Inc | ASYMMETRIC BISPECIFIC HETERODIMERS WITH ANTI-CD3 CONSTRUCTS |
| WO2014018572A2 (en) | 2012-07-23 | 2014-01-30 | Zymeworks Inc. | Immunoglobulin constructs comprising selective pairing of the light and heavy chains |
| JP2015529236A (ja) | 2012-09-25 | 2015-10-05 | グレンマーク ファーマシューティカルズ， エセ．アー． | ヘテロ二量体免疫グロブリンの精製 |
| US10087250B2 (en) | 2012-10-08 | 2018-10-02 | Roche Glycart Ag | Fc-free antibodies comprising two fab-fragments and methods of use |
| AU2013352812B2 (en) | 2012-11-27 | 2019-06-20 | Ajou University Industry-Academic Cooperation Foundation | CH3 domain variant pair inducing formation of heterodimer of heavy chain constant region of antibody at high efficiency, method for preparing same, and use thereof |
| WO2014089354A1 (en) | 2012-12-07 | 2014-06-12 | The Regents Of The University Of California | Cd138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
| US9703815B2 (en) | 2012-12-17 | 2017-07-11 | Salesforce.Com, Inc. | Third party files in an on-demand database service |
| WO2014099997A1 (en) | 2012-12-18 | 2014-06-26 | Novartis Ag | Compositions and methods that utilize a peptide tag that binds to hyaluronan |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| CA2898100C (en) | 2013-01-14 | 2023-10-10 | Xencor, Inc. | Novel heterodimeric proteins |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| GB201302447D0 (en) | 2013-02-12 | 2013-03-27 | Oxford Biotherapeutics Ltd | Therapeutic and diagnostic target |
| US9562099B2 (en) | 2013-03-14 | 2017-02-07 | Genentech, Inc. | Anti-B7-H4 antibodies and immunoconjugates |
| JP6594855B2 (ja) | 2013-03-15 | 2019-10-23 | ゼンコア インコーポレイテッド | ヘテロ二量体タンパク質 |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| US10093745B2 (en) | 2013-05-29 | 2018-10-09 | The Regents Of The University Of California | Anti-CSPG4 fusions with interferon for the treatment of malignancy |
| ES2776706T3 (es) | 2013-07-05 | 2020-07-31 | Genmab As | Anticuerpos contra CD3 humanizados o quiméricos |
| HRP20220553T1 (hr) | 2013-07-25 | 2022-06-10 | Cytomx Therapeutics Inc. | Polispecifična protutijela, polispecifična protutijela koja se mogu aktivirati i postupci uporabe navedenih protutijela |
| EP2840091A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof |
| TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| US20150087810A1 (en) | 2013-09-25 | 2015-03-26 | Cytomx Therapeutics, Inc. | Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof |
| CN112390883A (zh) | 2013-12-17 | 2021-02-23 | 基因泰克公司 | 抗cd3抗体及使用方法 |
| WO2015095412A1 (en) | 2013-12-19 | 2015-06-25 | Zhong Wang | Bispecific antibody with two single-domain antigen-binding fragments |
| BR112016017649B1 (pt) | 2014-01-31 | 2024-01-30 | Cytomx Therapeutics, Inc | Polipeptídeo isolado compreendendo substratos de matriptase e de ativador do plasminogênio u e outras porções cliváveis, composição farmacêutica compreendendo o dito polipeptídeo, bem como métodos para produzir e fabricar um polipeptídeo isolado compreendendo uma porção clivável e uso da composição farmacêutica e quantidade terapeuticamente eficaz da dita composição no tratamento de um distúrbio ou doença |
| MX2016012779A (es) | 2014-03-31 | 2017-04-27 | Genentech Inc | Terapia de combinacion con agentes antiangiogénesis y agonistas de unión a ox40. |
| JP2017514522A (ja) | 2014-05-02 | 2017-06-08 | エモリー ユニバーシティー | ヒト化可変性リンパ球受容体（ｖｌｒ）および組成物ならびにそれに関連する使用 |
| GB201411420D0 (en) | 2014-06-26 | 2014-08-13 | Ucb Biopharma Sprl | Antibody constructs |
| CA2952532A1 (en) | 2014-06-27 | 2015-12-30 | Innate Pharma | Multispecific antigen binding proteins |
| WO2016014974A2 (en) | 2014-07-25 | 2016-01-28 | Cytomx Therapeutics, Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
| MA40510A (fr) | 2014-08-04 | 2017-06-14 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t |
| EP2982693A1 (en) | 2014-08-07 | 2016-02-10 | Affimed Therapeutics AG | CD3 binding domain |
| JP2017529853A (ja) | 2014-09-25 | 2017-10-12 | アムジエン・インコーポレーテツド | プロテアーゼにより活性化可能な二重特異性タンパク質 |
| CA2963696A1 (en) | 2014-10-09 | 2016-04-14 | Engmab Ag | Bispecific antibodies against cd3epsilon and ror1 for use in the treatment of ovarian cancer |
| HRP20211273T1 (hr) | 2014-11-26 | 2021-11-12 | Xencor, Inc. | Heterodimerna protutijela koja vežu cd3 i cd20 |
| PL3227332T3 (pl) | 2014-12-03 | 2020-06-15 | F. Hoffmann-La Roche Ag | Wielospecyficzne przeciwciała |
| JP6904902B2 (ja) | 2014-12-05 | 2021-07-21 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ドメイン交換抗体 |
| EP3237449A2 (en) | 2014-12-22 | 2017-11-01 | Xencor, Inc. | Trispecific antibodies |
| TWI608015B (zh) | 2015-01-16 | 2017-12-11 | 中央研究院 | 具有組織標的功能的抗發炎分子 |
| MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| JP7001474B2 (ja) | 2015-01-21 | 2022-01-19 | インヒブルクス，インコーポレイティド | 非免疫原性単一ドメイン抗体 |
| AU2016219772A1 (en) | 2015-02-22 | 2017-09-21 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind CD137 |
| MA41613A (fr) | 2015-02-23 | 2018-01-02 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs |
| CN114573680A (zh) | 2015-05-04 | 2022-06-03 | 皮里斯制药有限公司 | Cd137特异性的蛋白 |
| TWI716405B (zh) | 2015-05-07 | 2021-01-21 | 美商艾吉納斯公司 | 抗ox40抗體及其使用方法 |
| CN119219778A (zh) | 2015-05-13 | 2024-12-31 | 埃博灵克斯股份有限公司 | 基于cd3反应性的t细胞募集多肽 |
| WO2016192613A1 (zh) | 2015-06-01 | 2016-12-08 | 中山大学 | 具有融合至常规Fab片段的单域抗原结合片段的二价抗体 |
| WO2016204966A1 (en) | 2015-06-16 | 2016-12-22 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
| RU2753439C2 (ru) | 2015-07-23 | 2021-08-16 | Инхибркс, Инк. | Поливалетные и полиспецифичные gitr-связывающие слитые белки |
| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI793062B (zh) | 2015-07-31 | 2023-02-21 | 德商安美基研究（慕尼黑）公司 | Ｄｌｌ３及ｃｄ３抗體構築體 |
| CN105384825B (zh) * | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| PT3353212T (pt) | 2015-09-23 | 2022-01-05 | Regeneron Pharma | Anticorpos biespecíficos anti-cd3 otimizados e suas utilizações |
| MA43017A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf |
| RU2018116402A (ru) | 2015-10-07 | 2019-11-07 | Ф. Хоффманн-Ля Рош Аг | Биспецифические антитела, четырехвалентные в отношении костимуляторного tnf-рецептора |
| US20170198051A1 (en) | 2016-01-11 | 2017-07-13 | Inhibrx Lp | Multivalent and multispecific ox40-binding fusion proteins |
| BR112018013677A2 (pt) | 2016-01-11 | 2019-01-22 | Inhibrx Inc | proteínas de fusão de ligação de 41bb multivalentes e multiespecíficas |
| GB201602156D0 (en) | 2016-02-05 | 2016-03-23 | Jones Philip C And Boku University Of Natural Resources And Life Sciences | Heterodimers and purification thereof |
| KR20230148844A (ko) | 2016-03-29 | 2023-10-25 | 유니버시티 오브 써던 캘리포니아 | 암을 표적하는 키메라 항원 수용체 |
| EP3231813A1 (en) | 2016-03-29 | 2017-10-18 | F. Hoffmann-La Roche AG | Trimeric costimulatory tnf family ligand-containing antigen binding molecules |
| AU2017249698B2 (en) | 2016-04-13 | 2023-03-09 | Vivia Biotech, S.L | Ex vivo bite-activated T cells |
| EP3493844A4 (en) | 2016-05-20 | 2021-03-24 | Harpoon Therapeutics Inc. | SINGLE DOMAIN SERUM ALBUMIN BINDING PROTEIN |
| WO2018014260A1 (en) * | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| WO2018027025A1 (en) | 2016-08-03 | 2018-02-08 | Oncomed Pharmaceuticals, Inc. | Cd40-binding agents and uses thereof |
| WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| CR20190309A (es) | 2017-01-03 | 2019-08-21 | Hoffmann La Roche | Moleculas de unión de3 antígeno biespecíficas que comprenden el clon 20h4.9 anti-4-1bb |
| PE20200006A1 (es) | 2017-04-04 | 2020-01-06 | Hoffmann La Roche | Nuevas moleculas de union antigeno biespecificas capaces de unirse especificamente cd40 y a fap |
| TW202515920A (zh) | 2017-04-11 | 2025-04-16 | 美商因荷布瑞克斯生物科學公司 | 具有經受限cd3結合的多重特異性多肽構築體及使用其之方法 |
| EP3502140A1 (en) | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules |
| MX2020006715A (es) | 2017-12-27 | 2020-08-20 | Teneobio Inc | Anticuerpos especificos del heterodimero de cd3-delta/epsilon. |
| KR20210006913A (ko) | 2018-04-11 | 2021-01-19 | 인히브릭스, 인크. | 제한된 ｃｄ3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 관련된 방법 및 용도 |
| TW202035451A (zh) | 2018-07-24 | 2020-10-01 | 美商英伊布里克斯公司 | 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法 |
| CN113286817B (zh) * | 2018-09-25 | 2025-01-28 | 哈普恩治疗公司 | Dll3结合蛋白及使用方法 |
| US20210340273A1 (en) | 2018-10-11 | 2021-11-04 | Inhlbrx, inc. | 5t4 single domain antibodies and therapeutic compositions thereof |
| EP3864049A1 (en) | 2018-10-11 | 2021-08-18 | Inhibrx, Inc. | Pd-1 single domain antibodies and therapeutic compositions thereof |
| CA3115082A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | B7h3 single domain antibodies and therapeutic compositions thereof |
| MX2022009306A (es) | 2020-01-29 | 2022-09-26 | Inhibrx Inc | Loseta de nucleo de espuma densificada (dfc) con linea de anticuerpos de dominio individual de cd28 y constructos multivalentes y multiespecíficas de los mismos. |
-
2019
- 2019-10-09 CA CA3115089A patent/CA3115089A1/en active Pending
- 2019-10-09 TW TW108136743A patent/TW202028245A/zh unknown
- 2019-10-09 US US17/283,903 patent/US12365728B2/en active Active
- 2019-10-09 EP EP19794390.5A patent/EP3864045A2/en active Pending
- 2019-10-09 CN CN201980082197.9A patent/CN113166263A/zh active Pending
- 2019-10-09 JP JP2021520217A patent/JP7611820B2/ja active Active
- 2019-10-09 WO PCT/US2019/055436 patent/WO2020076977A2/en not_active Ceased
-
2024
- 2024-12-24 JP JP2024226838A patent/JP2025060787A/ja active Pending
-
2025
- 2025-06-18 US US19/242,642 patent/US20250313623A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2020076977A5 (enExample) | ||
| TWI821202B (zh) | 抗ｃｄ３８抗體及其使用方法 | |
| US20250361326A1 (en) | Method for generating multispecific antibodies from monospecific antibodies | |
| AU2012236603B2 (en) | Dual variable region antibody-like binding proteins having cross-over binding region orientation | |
| CN101495510B (zh) | 单链fc多肽 | |
| JP5755148B2 (ja) | 組換え一価抗体 | |
| CN118852460A (zh) | 具有非FcγR依赖性激动活性的肿瘤坏死因子(TNF)受体超家族(TNFRSF)受体-激活抗体融合蛋白(具有非FcγR依赖性激动活性的TNFRSF受体-激活抗体融合蛋白；TRAAFFIAA) | |
| JPWO2020023553A5 (enExample) | ||
| WO2016166139A1 (en) | Bispecific fusion proteins for enhancing immune responses of lymphocytes against tumor cells | |
| TW201803899A (zh) | 三特異性和／或三價結合蛋白 | |
| JPWO2020076970A5 (enExample) | ||
| JPWO2019200022A5 (enExample) | ||
| GB2638094A (en) | Il-21 Polypeptides And Targeted Constructs | |
| IL307308A (en) | Multispecific antibodies targeting BCMA | |
| WO2022105817A1 (en) | Bi-functional molecules | |
| EP4215547A1 (en) | Single-domain antibody targeting 4-1bb, fusion protein thereof, pharmaceutical composition and use thereof | |
| WO2020192709A1 (en) | Novel bispecific polypeptide complexes | |
| TW202221015A (zh) | 單一及雙靶定配體誘導之t細胞銜接體組合物 | |
| TW202306984A (zh) | 抗ｃｄ１３７抗體及使用方法 | |
| CN119816523A (zh) | 抗Nectin-4抗体和包含其的多特异性抗体 | |
| WO2025092987A1 (zh) | 基于Fc区的异二聚体分子及其用途 | |
| HK40031028A (en) | Method for generating multispecific antibodies from monospecific antibodies | |
| JPWO2021030488A5 (enExample) | ||
| HK1162962A (en) | Il6 immunotherapeutics | |
| HK1163129A (en) | Cd86 antagonist multi-target binding proteins |