JPWO2020006267A5 - - Google Patents

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JPWO2020006267A5
JPWO2020006267A5 JP2020571686A JP2020571686A JPWO2020006267A5 JP WO2020006267 A5 JPWO2020006267 A5 JP WO2020006267A5 JP 2020571686 A JP2020571686 A JP 2020571686A JP 2020571686 A JP2020571686 A JP 2020571686A JP WO2020006267 A5 JPWO2020006267 A5 JP WO2020006267A5
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modified oligonucleotide
pharmaceutical composition
oligomer compound
lrrk2
disease
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JP2020571686A
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JP7315594B2 (ja
JP2021530204A (ja
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Priority claimed from PCT/US2019/039558 external-priority patent/WO2020006267A1/en
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Priority to JP2023114861A priority Critical patent/JP7678033B2/ja
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Publication of JP7315594B2 publication Critical patent/JP7315594B2/ja
Priority to JP2025076009A priority patent/JP2025121956A/ja
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JP2020571686A 2018-06-27 2019-06-27 Lrrk2発現を低減するための化合物及び方法 Active JP7315594B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023114861A JP7678033B2 (ja) 2018-06-27 2023-07-13 Lrrk2発現を低減するための化合物及び方法
JP2025076009A JP2025121956A (ja) 2018-06-27 2025-05-01 Lrrk2発現を低減するための化合物及び方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862690790P 2018-06-27 2018-06-27
US62/690,790 2018-06-27
PCT/US2019/039558 WO2020006267A1 (en) 2018-06-27 2019-06-27 Compounds and methods for reducing lrrk2 expression

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JP2023114861A Division JP7678033B2 (ja) 2018-06-27 2023-07-13 Lrrk2発現を低減するための化合物及び方法

Publications (3)

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JP2021530204A JP2021530204A (ja) 2021-11-11
JPWO2020006267A5 true JPWO2020006267A5 (enExample) 2022-07-01
JP7315594B2 JP7315594B2 (ja) 2023-07-26

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JP2020571686A Active JP7315594B2 (ja) 2018-06-27 2019-06-27 Lrrk2発現を低減するための化合物及び方法
JP2023114861A Active JP7678033B2 (ja) 2018-06-27 2023-07-13 Lrrk2発現を低減するための化合物及び方法
JP2025076009A Pending JP2025121956A (ja) 2018-06-27 2025-05-01 Lrrk2発現を低減するための化合物及び方法

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JP2023114861A Active JP7678033B2 (ja) 2018-06-27 2023-07-13 Lrrk2発現を低減するための化合物及び方法
JP2025076009A Pending JP2025121956A (ja) 2018-06-27 2025-05-01 Lrrk2発現を低減するための化合物及び方法

Country Status (25)

Country Link
US (4) US11332746B1 (enExample)
EP (1) EP3814503A4 (enExample)
JP (3) JP7315594B2 (enExample)
KR (1) KR102768381B1 (enExample)
CN (1) CN112400019B (enExample)
AR (1) AR116102A1 (enExample)
AU (1) AU2019294838B2 (enExample)
BR (1) BR112020024564A2 (enExample)
CA (1) CA3104676A1 (enExample)
CL (1) CL2020003309A1 (enExample)
CO (1) CO2020015256A2 (enExample)
CR (1) CR20210044A (enExample)
EA (1) EA202190140A1 (enExample)
IL (1) IL279632A (enExample)
JO (1) JOP20200334A1 (enExample)
MX (1) MX2020013653A (enExample)
MY (1) MY205775A (enExample)
PE (1) PE20210518A1 (enExample)
PH (1) PH12021500003A1 (enExample)
SG (1) SG11202011864XA (enExample)
TW (1) TWI833770B (enExample)
UA (1) UA128406C2 (enExample)
UY (1) UY38282A (enExample)
WO (1) WO2020006267A1 (enExample)
ZA (1) ZA202007444B (enExample)

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CN120310791A (zh) 2018-01-12 2025-07-15 百时美施贵宝公司 靶向α-突触核蛋白的反义寡核苷酸及其用途
US11732260B2 (en) 2018-03-02 2023-08-22 Ionis Pharmaceuticals, Inc. Compounds and methods for the modulation of amyloid-β precursor protein
WO2020006018A1 (en) 2018-06-27 2020-01-02 Bristol-Myers Squibb Company Substituted naphthyridinone compounds useful as t cell activators
TWI833770B (zh) 2018-06-27 2024-03-01 美商Ionis製藥公司 用於減少 lrrk2 表現之化合物及方法
WO2021150969A1 (en) * 2020-01-24 2021-07-29 Alnylam Pharmaceuticals, Inc. LEUCINE-RICH REPEAT KINASE 2 (LRRK2) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
KR20230006560A (ko) 2020-05-06 2023-01-10 르 라보레또레 쎄르비에르 새로운 거대고리 lrrk2 키나제 억제제
BR112023001624A2 (pt) 2020-07-28 2023-02-23 Ionis Pharmaceuticals Inc Compostos e métodos para reduzir a expressão de app
BR112023017834A2 (pt) 2021-03-18 2023-10-03 Servier Lab Inibidores de lrrk2 cinase macrocíclicos
CN115137744A (zh) * 2021-03-30 2022-10-04 南京大学 一种用于治疗帕金森的rna质粒递送系统
JP7536187B2 (ja) 2021-04-19 2024-08-19 ノヴォ ノルディスク アー/エス 核内受容体サブファミリー1グループhメンバー3(nr1h3)発現を阻害するための組成物および方法
US20240191304A1 (en) * 2021-04-20 2024-06-13 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Malignant Mesothelioma Susceptibility As A Result Of Germline Leucine-Rich Repeat Kinase 2 (LRRK2) Alterations
MX2024000065A (es) * 2021-06-29 2024-02-23 Alnylam Pharmaceuticals Inc Composiciones del agente de arni de la cinasa de repeticion 2 rica en leucina (lrrk2) y metodos de uso de estas.
EP4469572A1 (en) * 2022-01-26 2024-12-04 Syddansk Universitet Allele specific splice switching oligonucleotides targeting pseudoexons
WO2024090499A1 (ja) 2022-10-28 2024-05-02 日本精工株式会社 回転支持装置、及び軸支持装置の支持機構位置調整機構
WO2024263694A1 (en) * 2023-06-20 2024-12-26 Adarx Pharmaceuticals, Inc. Lrrk2-modulating compositions and methods of use thereof
WO2025067351A2 (en) * 2023-09-27 2025-04-03 Neuro3 Therapeutics, Inc. Novel sirna constructs, therapeutics, and modifications

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