JPS61200991A - スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤 - Google Patents

スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤

Info

Publication number
JPS61200991A
JPS61200991A JP60041234A JP4123485A JPS61200991A JP S61200991 A JPS61200991 A JP S61200991A JP 60041234 A JP60041234 A JP 60041234A JP 4123485 A JP4123485 A JP 4123485A JP S61200991 A JPS61200991 A JP S61200991A
Authority
JP
Japan
Prior art keywords
group
hydrogen
formula
spiro
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60041234A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0372226B2 (enExample
Inventor
Masatsune Kurono
昌庸 黒野
Takuji Yamaguchi
山口　卓治
Toshinao Usui
臼井　敏直
Masahito Fukushima
将人 福嶋
Kuniharu Mizuno
邦治 水野
Akira Matsubara
旭 松原
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanwa Kagaku Kenkyusho Co Ltd
Original Assignee
Sanwa Kagaku Kenkyusho Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanwa Kagaku Kenkyusho Co Ltd filed Critical Sanwa Kagaku Kenkyusho Co Ltd
Priority to JP60041234A priority Critical patent/JPS61200991A/ja
Priority to US06/835,823 priority patent/US4740517A/en
Priority to DE8686301530T priority patent/DE3679920D1/de
Priority to EP86301530A priority patent/EP0193415B1/en
Publication of JPS61200991A publication Critical patent/JPS61200991A/ja
Publication of JPH0372226B2 publication Critical patent/JPH0372226B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP60041234A 1985-03-04 1985-03-04 スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤 Granted JPS61200991A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP60041234A JPS61200991A (ja) 1985-03-04 1985-03-04 スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
US06/835,823 US4740517A (en) 1985-03-04 1986-03-03 Antidiabetic spiro-3-heteroazolidines
DE8686301530T DE3679920D1 (de) 1985-03-04 1986-03-04 Spiro-3-heteroazolidinverbindungen und ihre salze, ihre herstellung und diese enthaltende pharmazeutische mittel.
EP86301530A EP0193415B1 (en) 1985-03-04 1986-03-04 Spiro-3-heteroazolidine compounds and salts thereof, their preparation and pharmaceutical agents thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60041234A JPS61200991A (ja) 1985-03-04 1985-03-04 スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤

Publications (2)

Publication Number Publication Date
JPS61200991A true JPS61200991A (ja) 1986-09-05
JPH0372226B2 JPH0372226B2 (enExample) 1991-11-18

Family

ID=12602722

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60041234A Granted JPS61200991A (ja) 1985-03-04 1985-03-04 スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤

Country Status (4)

Country Link
US (1) US4740517A (enExample)
EP (1) EP0193415B1 (enExample)
JP (1) JPS61200991A (enExample)
DE (1) DE3679920D1 (enExample)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6357588A (ja) * 1986-08-28 1988-03-12 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
JPS63126881A (ja) * 1986-11-14 1988-05-30 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩、これらの製法並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
JPS63250373A (ja) * 1987-04-08 1988-10-18 Sanwa Kagaku Kenkyusho Co Ltd （＋）―３，４―ジヒドロ―４―オキソ―２ｈ―１―ベンゾピラン―２―カルボン酸誘導体及びその製法
JPH0193588A (ja) * 1987-08-27 1989-04-12 Sanwa Kagaku Kenkyusho Co Ltd 光学活性を有するヒダントイン誘導体の製法
JPH037225A (ja) * 1989-02-22 1991-01-14 Sanwa Kagaku Kenkyusho Co Ltd アルドース還元酵素阻害作用を有し且つ吸収性の良好な薬剤組成物
JPH049384A (ja) * 1990-04-27 1992-01-14 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体を有効成分とする循環器系疾患の予防及び治療剤並びに循環器系疾患と糖尿病合併症の同時的予防及び治療剤
WO2005079792A1 (ja) * 2004-02-20 2005-09-01 Sanwa Kagaku Kenkyusho Co., Ltd. 重症糖尿病網膜症の予防又は治療剤
WO2005072066A3 (ja) * 2004-01-30 2005-10-06 Sanwa Kagaku Kenkyusho Co 糖尿病黄斑症の予防又は治療剤
JPWO2004043491A1 (ja) * 2002-11-14 2006-03-09 小野薬品工業株式会社 脊柱管狭窄症治療剤
WO2007069727A1 (ja) 2005-12-16 2007-06-21 Sanwa Kagaku Kenkyusho Co., Ltd. 急性腎不全の予防または治療剤
WO2008093691A1 (ja) 2007-01-31 2008-08-07 Sanwa Kagaku Kenkyusho Co., Ltd. 網膜神経又は視神経の保護剤
WO2011087066A1 (ja) 2010-01-14 2011-07-21 株式会社三和化学研究所 眼内血管新生及び／又は眼内血管透過性亢進を伴う疾患の予防又は治療のための医薬
WO2011136161A1 (ja) 2010-04-28 2011-11-03 株式会社 三和化学研究所 内耳障害の予防又は治療薬

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0264586B1 (en) * 1986-08-28 1991-04-03 Sanwa Kagaku Kenkyusho Co., Ltd. Hydantoin derivatives for treating complications of diabetes
US4985573A (en) * 1986-08-28 1991-01-15 Sanwa Kagaku Kenkyusho Co., Ltd. Hydantoin derivatives for treating complications of diabetes
JP2708507B2 (ja) * 1988-04-07 1998-02-04 株式会社三和化学研究所 （ｄ）‐６‐フルオロ‐２，３‐ジヒドロ‐２’，５’‐ジオキソ‐スピロ［４Ｈ‐１‐ベンゾピラン‐４，４’‐イミダゾリジン］‐２‐カルボキサミド誘導体、これらの製法及び用途
ES2062125T3 (es) * 1989-02-22 1994-12-16 Sanwa Kagaku Kenkyusho Co Una composicion farmaceutica que contiene derivados de hidantoina.
US5164391A (en) * 1989-09-20 1992-11-17 Sanwa Kagaku Kenkyusho Co., Ltd. Hydantoin derivatives for treating complications of diabetes and circulatory diseases
JP3049284B2 (ja) * 1990-11-07 2000-06-05 株式会社三和化学研究所 ヒダントイン誘導体並びにそれを有効成分とする糖尿病合併症及び循環器系疾患の予防及び治療剤
JP2997894B2 (ja) * 1990-11-07 2000-01-11 株式会社三和化学研究所 循環器系疾患の予防及び治療剤
AU655666B2 (en) * 1991-08-28 1995-01-05 Pharmacia & Upjohn Company Spirocyclic benzopyran imidazolines
JP4273406B2 (ja) * 2001-06-01 2009-06-03 小野薬品工業株式会社 アルドース還元酵素阻害剤を有効成分とする脱髄性疾患または脱髄を伴う疾患治療剤
RU2243227C1 (ru) * 2003-07-25 2004-12-27 Институт проблем химической физики РАН (dl)-1-гидрокси-3,7,7,9,9-пентаметил-1,4,8-триазаспиро [4,5] декан-2-он и способ его получения
US20080096923A1 (en) * 2004-07-23 2008-04-24 Aniz Girach Methods For Diagnosing And Treating Diabetic Microvascular Complications
WO2007097301A1 (ja) * 2006-02-20 2007-08-30 Sanwa Kagaku Kenkyusho Co., Ltd. 脳卒中における脳虚血又は脳虚血再灌流障害の予防又は治療剤
WO2011072064A1 (en) * 2009-12-08 2011-06-16 Array Biopharma Inc. S piro [chroman - 4, 4 ' - imidazol] ones as beta - secretase inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5353653A (en) * 1976-10-18 1978-05-16 Pfizer Hydantoin derivatives medicines
JPS53144575A (en) * 1977-05-23 1978-12-15 Pfizer Spiroohydantoin
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
JPS58213717A (ja) * 1982-01-20 1983-12-12 Eisai Co Ltd ヒダントイン誘導体を含有する治療用薬剤
JPS6013774A (ja) * 1983-06-23 1985-01-24 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト チアゾリジン誘導体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB807678A (en) * 1956-01-16 1959-01-21 Harold Crowther Brimelow New substituted hydantoins and thiohydantoins
DE1940709A1 (de) * 1969-04-11 1970-11-05 Bitterfeld Chemie Fungizide Mittel
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4283409A (en) * 1979-10-29 1981-08-11 Pfizer Inc. Imidazolone derivatives
US4464385A (en) * 1982-04-15 1984-08-07 Alcon Laboratories, Inc. Treatment of diabetic complications with hydantoins
DK277484A (da) * 1983-06-23 1984-12-24 Hoffmann La Roche Thiazolidinderivater

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5353653A (en) * 1976-10-18 1978-05-16 Pfizer Hydantoin derivatives medicines
JPS53144575A (en) * 1977-05-23 1978-12-15 Pfizer Spiroohydantoin
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
JPS58213717A (ja) * 1982-01-20 1983-12-12 Eisai Co Ltd ヒダントイン誘導体を含有する治療用薬剤
JPS6013774A (ja) * 1983-06-23 1985-01-24 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト チアゾリジン誘導体

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6357588A (ja) * 1986-08-28 1988-03-12 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
JPS63126881A (ja) * 1986-11-14 1988-05-30 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩、これらの製法並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
JPS63250373A (ja) * 1987-04-08 1988-10-18 Sanwa Kagaku Kenkyusho Co Ltd （＋）―３，４―ジヒドロ―４―オキソ―２ｈ―１―ベンゾピラン―２―カルボン酸誘導体及びその製法
JPH0193588A (ja) * 1987-08-27 1989-04-12 Sanwa Kagaku Kenkyusho Co Ltd 光学活性を有するヒダントイン誘導体の製法
JPH037225A (ja) * 1989-02-22 1991-01-14 Sanwa Kagaku Kenkyusho Co Ltd アルドース還元酵素阻害作用を有し且つ吸収性の良好な薬剤組成物
JPH049384A (ja) * 1990-04-27 1992-01-14 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体を有効成分とする循環器系疾患の予防及び治療剤並びに循環器系疾患と糖尿病合併症の同時的予防及び治療剤
JPWO2004043491A1 (ja) * 2002-11-14 2006-03-09 小野薬品工業株式会社 脊柱管狭窄症治療剤
JP4552189B2 (ja) * 2002-11-14 2010-09-29 小野薬品工業株式会社 脊柱管狭窄症治療剤
WO2005072066A3 (ja) * 2004-01-30 2005-10-06 Sanwa Kagaku Kenkyusho Co 糖尿病黄斑症の予防又は治療剤
US7910615B2 (en) 2004-01-30 2011-03-22 Sanwa Kagaku Kenkyusho Co., Ltd. Prophylactic or therapeutic agent for diabetic maculopathy
US8097640B2 (en) 2004-01-30 2012-01-17 Sanwa Kagaku Kenkyusho Co., Ltd. Prophylactic or therapeutic agent for diabetic maculopathy
WO2005079792A1 (ja) * 2004-02-20 2005-09-01 Sanwa Kagaku Kenkyusho Co., Ltd. 重症糖尿病網膜症の予防又は治療剤
WO2007069727A1 (ja) 2005-12-16 2007-06-21 Sanwa Kagaku Kenkyusho Co., Ltd. 急性腎不全の予防または治療剤
WO2008093691A1 (ja) 2007-01-31 2008-08-07 Sanwa Kagaku Kenkyusho Co., Ltd. 網膜神経又は視神経の保護剤
EP2594267A1 (en) 2007-01-31 2013-05-22 Sanwa Kagaku Kenkyusho Co., Ltd Protective Agent for Retinal Nerve or Optic Nerve
WO2011087066A1 (ja) 2010-01-14 2011-07-21 株式会社三和化学研究所 眼内血管新生及び／又は眼内血管透過性亢進を伴う疾患の予防又は治療のための医薬
WO2011136161A1 (ja) 2010-04-28 2011-11-03 株式会社 三和化学研究所 内耳障害の予防又は治療薬
CN102884067A (zh) * 2010-04-28 2013-01-16 株式会社三和化学研究所 内耳障碍的预防或治疗药
JPWO2011136161A1 (ja) * 2010-04-28 2013-07-18 株式会社三和化学研究所 内耳障害の予防又は治療薬

Also Published As

Publication number Publication date
US4740517A (en) 1988-04-26
EP0193415B1 (en) 1991-06-26
EP0193415A3 (en) 1987-09-02
DE3679920D1 (de) 1991-08-01
JPH0372226B2 (enExample) 1991-11-18
EP0193415A2 (en) 1986-09-03

Similar Documents

Publication Publication Date Title
JPS61200991A (ja) スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
EP0747368B1 (en) Derivatives of monocyclic polyamines, their preparation, and their use as antiviral agents
DE69232336T2 (de) Stickstoff enthaltende hydrocyclische verbindungen
US4430343A (en) Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
IL44061A (en) 4,5,6,7-tetrahydro-furo(or thieno)(3,2-c)pyridines their preparation and pharmaceutical compositions containing the
HU190408B (en) Process for producing pharmaceutical preparations comprising new benzimidazole-derivatives
JPS63107990A (ja) キノリンカルボン酸誘導体
HU191757B (en) Process for producing new tricyclic ethers
DE2740588A1 (de) Imidazo- eckige klammer auf 1,2-a eckige klammer zu -chinolin-2-carbon- saeuren und deren derivate sowie pharmazeutische zubereitungen, die diese verbindungen enthalten
KR900003368B1 (ko) 신규한 인데노티아졸 유도체의 제조방법
JPH0377885A (ja) ２―オキソ―１―オキサ―８―アザスピロ〔４，５〕デカン誘導体、それを含む医薬組成物及びその製造方法
DK156222B (da) Analogifremgangsmaade til fremstilling af substituerede thiazolooe3,2-aaapyrimidiner eller salte eller isomere eller isomerblandinger heraf
WO1986000899A1 (en) Use of 4-(isoxazolyl)-thiazole-2-oxamic acid derivatives
US4267332A (en) 3-(Tetrazol-5-yl)-1-azaxanthones
EP0244352B1 (en) Pyrido[4,3-d]pyrimidine derivatives
DK159924B (da) Pyridooe1,2-aaapyrimidinderivater, fremgangsmaade til deres fremstilling samt farmaceutisk praeparat til behandling af allergiske sygdomme indeholdende derivaterne
SU1042620A3 (ru) Способ получени замещенных N-(5-тетразолил)-1-кето-1- @ -тиазол(3,2- @ )пиримидин-2-карбоксамидов или их солей и его вариант
HU181608B (en) Process for producing imidazo-thieno-pyrimidine derivatives
JPH01319487A (ja) イミダゾ［２，１−ｂ］ベンゾチアゾール誘導体及び該化合物を有効成分とする抗潰瘍剤
NO781053L (no) Kinazolinderivater.
JPS6357588A (ja) ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
US4254121A (en) 3-Oxo-5H-pyrimido[2,1-c][1,4 ]benzoxazines
US2807616A (en) Oxazolopyrimidines and method of preparing same
EP0232399A1 (de) Neue amine, verfahren zu ihrer herstellung, ihre anwendung und sie enthaltende arzneimittel
JPH04502475A (ja) １，２―ジヒドロ―２―オキソキノキサリンの新規誘導体、その製造および治療への該化合物の適用

Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term