JPS6118525B2 - - Google Patents
Info
- Publication number
- JPS6118525B2 JPS6118525B2 JP54055609A JP5560979A JPS6118525B2 JP S6118525 B2 JPS6118525 B2 JP S6118525B2 JP 54055609 A JP54055609 A JP 54055609A JP 5560979 A JP5560979 A JP 5560979A JP S6118525 B2 JPS6118525 B2 JP S6118525B2
- Authority
- JP
- Japan
- Prior art keywords
- drug
- hydrogel
- porous
- water
- sintered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000011148 porous material Substances 0.000 claims description 97
- 239000000017 hydrogel Substances 0.000 claims description 72
- 239000000126 substance Substances 0.000 claims description 67
- 239000007788 liquid Substances 0.000 claims description 52
- -1 polyethylene Polymers 0.000 claims description 50
- 229920002284 Cellulose triacetate Polymers 0.000 claims description 39
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims description 38
- 238000003860 storage Methods 0.000 claims description 33
- 241000282849 Ruminantia Species 0.000 claims description 29
- 239000000463 material Substances 0.000 claims description 27
- 239000004698 Polyethylene Substances 0.000 claims description 20
- 229920000573 polyethylene Polymers 0.000 claims description 20
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 13
- 229910000831 Steel Inorganic materials 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 239000010959 steel Substances 0.000 claims description 12
- 239000004743 Polypropylene Substances 0.000 claims description 7
- 229920001155 polypropylene Polymers 0.000 claims description 7
- 229910052742 iron Inorganic materials 0.000 claims description 6
- 239000013043 chemical agent Substances 0.000 claims description 5
- 239000002657 fibrous material Substances 0.000 claims description 5
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 5
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical group OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- 239000004800 polyvinyl chloride Substances 0.000 claims description 4
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 4
- 229940095064 tartrate Drugs 0.000 claims description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical group [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 3
- 229920002821 Modacrylic Polymers 0.000 claims description 3
- 239000004793 Polystyrene Substances 0.000 claims description 3
- 230000002496 gastric effect Effects 0.000 claims description 3
- 229920002223 polystyrene Polymers 0.000 claims description 3
- 239000000273 veterinary drug Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 description 136
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- 238000000034 method Methods 0.000 description 44
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 38
- 238000013270 controlled release Methods 0.000 description 34
- 239000000243 solution Substances 0.000 description 26
- GGXQONWGCAQGNA-UUSVNAAPSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;1-methyl-2-[(e)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCCN=C1\C=C\C1=C(C)C=CS1 GGXQONWGCAQGNA-UUSVNAAPSA-N 0.000 description 24
- 229960003546 morantel tartrate Drugs 0.000 description 24
- 238000009304 pastoral farming Methods 0.000 description 23
- 244000045947 parasite Species 0.000 description 22
- 239000000546 pharmaceutical excipient Substances 0.000 description 22
- 244000309466 calf Species 0.000 description 20
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 17
- 239000010935 stainless steel Substances 0.000 description 17
- 229910001220 stainless steel Inorganic materials 0.000 description 17
- 238000009792 diffusion process Methods 0.000 description 16
- NVEPPWDVLBMNMB-SNAWJCMRSA-N 1-methyl-2-[(e)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound CN1CCCN=C1\C=C\C1=C(C)C=CS1 NVEPPWDVLBMNMB-SNAWJCMRSA-N 0.000 description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- 229960005121 morantel Drugs 0.000 description 15
- 241000283690 Bos taurus Species 0.000 description 14
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 14
- 238000012360 testing method Methods 0.000 description 14
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 13
- 239000000835 fiber Substances 0.000 description 13
- 239000000203 mixture Substances 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 235000013601 eggs Nutrition 0.000 description 11
- 239000002609 medium Substances 0.000 description 11
- 238000011109 contamination Methods 0.000 description 10
- 238000000338 in vitro Methods 0.000 description 10
- 238000001727 in vivo Methods 0.000 description 10
- 239000012528 membrane Substances 0.000 description 10
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 10
- 244000025254 Cannabis sativa Species 0.000 description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 description 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 9
- 208000015181 infectious disease Diseases 0.000 description 9
- 229960001614 levamisole Drugs 0.000 description 9
- 229910052751 metal Inorganic materials 0.000 description 9
- 239000002184 metal Substances 0.000 description 9
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 9
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 9
- 241001494479 Pecora Species 0.000 description 8
- 230000035699 permeability Effects 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 8
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 7
- 239000004372 Polyvinyl alcohol Substances 0.000 description 7
- 229910052782 aluminium Inorganic materials 0.000 description 7
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 7
- 230000000507 anthelmentic effect Effects 0.000 description 7
- 239000004744 fabric Substances 0.000 description 7
- 235000019253 formic acid Nutrition 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 229920002451 polyvinyl alcohol Polymers 0.000 description 7
- OLOCXIJVDIVAHH-FXRZFVDSSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;1-methyl-2-[(e)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CN1CCCN=C1\C=C\C1=C(C)C=CS1 OLOCXIJVDIVAHH-FXRZFVDSSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 6
- 230000001418 larval effect Effects 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 229960005134 pyrantel Drugs 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 208000030852 Parasitic disease Diseases 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
- 229940124339 anthelmintic agent Drugs 0.000 description 5
- 239000000921 anthelmintic agent Substances 0.000 description 5
- 239000002585 base Substances 0.000 description 5
- 229920002301 cellulose acetate Polymers 0.000 description 5
- 229920001577 copolymer Polymers 0.000 description 5
- 239000003599 detergent Substances 0.000 description 5
- YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 4
- LAZPBGZRMVRFKY-HNCPQSOCSA-N Levamisole hydrochloride Chemical compound Cl.C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 LAZPBGZRMVRFKY-HNCPQSOCSA-N 0.000 description 4
- 244000309464 bull Species 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 238000012377 drug delivery Methods 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 4
- 230000007613 environmental effect Effects 0.000 description 4
- 210000003608 fece Anatomy 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 238000005470 impregnation Methods 0.000 description 4
- 229960003734 levamisole hydrochloride Drugs 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 4
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical group C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 3
- 229910001209 Low-carbon steel Inorganic materials 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
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- 239000012458 free base Substances 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 239000012229 microporous material Substances 0.000 description 3
- 229920001778 nylon Polymers 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 229920002689 polyvinyl acetate Polymers 0.000 description 3
- 239000011118 polyvinyl acetate Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 229920001059 synthetic polymer Polymers 0.000 description 3
- 235000019786 weight gain Nutrition 0.000 description 3
- 230000004584 weight gain Effects 0.000 description 3
- VWRCYAZJKNPEQR-NIEARKAZSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;1-methyl-2-[(e)-2-thiophen-2-ylethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCCN=C1\C=C\C1=CC=CS1 VWRCYAZJKNPEQR-NIEARKAZSA-N 0.000 description 2
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical class C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 2
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 description 2
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- 229920002972 Acrylic fiber Polymers 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 208000005577 Gastroenteritis Diseases 0.000 description 2
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
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- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
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- 208000035415 Reinfection Diseases 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
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- YOCUPQPZWBBYIX-UHFFFAOYSA-N copper nickel Chemical compound [Ni].[Cu] YOCUPQPZWBBYIX-UHFFFAOYSA-N 0.000 description 2
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- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 2
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- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
- 229960000344 thiamine hydrochloride Drugs 0.000 description 2
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- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- POUMFISTNHIPTI-BOMBIWCESA-N hydron;(2s,4r)-n-[(1r,2r)-2-hydroxy-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;chloride Chemical compound Cl.CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 POUMFISTNHIPTI-BOMBIWCESA-N 0.000 description 1
- PJBQYZZKGNOKNJ-UHFFFAOYSA-M hydron;5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine;dichloride Chemical compound Cl.[Cl-].NC1=NC(CCC)=NC=C1C[N+]1=CC=CC=C1C PJBQYZZKGNOKNJ-UHFFFAOYSA-M 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- GRRNUXAQVGOGFE-NZSRVPFOSA-N hygromycin B Chemical class O[C@@H]1[C@@H](NC)C[C@@H](N)[C@H](O)[C@H]1O[C@H]1[C@H]2O[C@@]3([C@@H]([C@@H](O)[C@@H](O)[C@@H](C(N)CO)O3)O)O[C@H]2[C@@H](O)[C@@H](CO)O1 GRRNUXAQVGOGFE-NZSRVPFOSA-N 0.000 description 1
- 229940097277 hygromycin b Drugs 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 1
- 229960005287 lincomycin Drugs 0.000 description 1
- 229960001595 lincomycin hydrochloride Drugs 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 229940041033 macrolides Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229940097364 magnesium acetate tetrahydrate Drugs 0.000 description 1
- XKPKPGCRSHFTKM-UHFFFAOYSA-L magnesium;diacetate;tetrahydrate Chemical compound O.O.O.O.[Mg+2].CC([O-])=O.CC([O-])=O XKPKPGCRSHFTKM-UHFFFAOYSA-L 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 125000005395 methacrylic acid group Chemical class 0.000 description 1
- OCINZYYLBMOJAQ-UHFFFAOYSA-N methyl prop-2-enoate;propane-1,2-diol Chemical compound CC(O)CO.COC(=O)C=C OCINZYYLBMOJAQ-UHFFFAOYSA-N 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003750 molluscacide Substances 0.000 description 1
- 230000002013 molluscicidal effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- BSCJIBOZTKGXQP-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-methylprop-2-enamide Chemical compound CC(=C)C(=O)NCCO BSCJIBOZTKGXQP-UHFFFAOYSA-N 0.000 description 1
- YPHQUSNPXDGUHL-UHFFFAOYSA-N n-methylprop-2-enamide Chemical compound CNC(=O)C=C YPHQUSNPXDGUHL-UHFFFAOYSA-N 0.000 description 1
- WDFKEEALECCKTJ-UHFFFAOYSA-N n-propylprop-2-enamide Chemical compound CCCNC(=O)C=C WDFKEEALECCKTJ-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- RZPAKFUAFGMUPI-KGIGTXTPSA-N oleandomycin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C RZPAKFUAFGMUPI-KGIGTXTPSA-N 0.000 description 1
- 229960002351 oleandomycin Drugs 0.000 description 1
- 235000019367 oleandomycin Nutrition 0.000 description 1
- 229960000535 oxantel Drugs 0.000 description 1
- VRYKTHBAWRESFI-VOTSOKGWSA-N oxantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CC(O)=C1 VRYKTHBAWRESFI-VOTSOKGWSA-N 0.000 description 1
- 125000005702 oxyalkylene group Chemical group 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- 229960004368 oxytetracycline hydrochloride Drugs 0.000 description 1
- 230000036281 parasite infection Effects 0.000 description 1
- 230000024241 parasitism Effects 0.000 description 1
- 230000003108 parasitologic effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 230000036211 photosensitivity Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000007180 physiological regulation Effects 0.000 description 1
- 229960005141 piperazine Drugs 0.000 description 1
- 238000009372 pisciculture Methods 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 238000009790 rate-determining step (RDS) Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000000090 ruminant stomach Anatomy 0.000 description 1
- WVYADZUPLLSGPU-UHFFFAOYSA-N salsalate Chemical class OC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1O WVYADZUPLLSGPU-UHFFFAOYSA-N 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000002336 sorption--desorption measurement Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229960002135 sulfadimidine Drugs 0.000 description 1
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 229920005992 thermoplastic resin Polymers 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical class OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- MWKJTNBSKNUMFN-UHFFFAOYSA-N trifluoromethyltrimethylsilane Chemical compound C[Si](C)(C)C(F)(F)F MWKJTNBSKNUMFN-UHFFFAOYSA-N 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000009489 vacuum treatment Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
Landscapes
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- External Artificial Organs (AREA)
- Paper (AREA)
- Fodder In General (AREA)
- Dairy Products (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90404978A | 1978-05-08 | 1978-05-08 | |
| US90407878A | 1978-05-08 | 1978-05-08 | |
| US06/014,387 US4220152A (en) | 1978-05-08 | 1979-02-22 | Delivery system |
| US06/014,388 US4220153A (en) | 1978-05-08 | 1979-02-22 | Controlled release delivery system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5514080A JPS5514080A (en) | 1980-01-31 |
| JPS6118525B2 true JPS6118525B2 (fr) | 1986-05-13 |
Family
ID=27486383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5560979A Granted JPS5514080A (en) | 1978-05-08 | 1979-05-07 | Improved discharge device |
Country Status (40)
| Country | Link |
|---|---|
| JP (1) | JPS5514080A (fr) |
| AR (1) | AR219795A1 (fr) |
| AT (1) | AT389463B (fr) |
| AU (1) | AU513656B2 (fr) |
| BE (1) | BE876074A (fr) |
| CA (1) | CA1113395A (fr) |
| CH (1) | CH643140A5 (fr) |
| CS (1) | CS236761B2 (fr) |
| DD (2) | DD143504A5 (fr) |
| DE (1) | DE2918522C2 (fr) |
| DK (1) | DK153917C (fr) |
| EG (1) | EG15524A (fr) |
| ES (1) | ES480320A0 (fr) |
| FI (1) | FI75735C (fr) |
| FR (1) | FR2425242A1 (fr) |
| GB (1) | GB2020181B (fr) |
| GR (1) | GR73637B (fr) |
| HK (1) | HK13384A (fr) |
| HU (1) | HU186995B (fr) |
| IE (1) | IE48751B1 (fr) |
| IL (1) | IL57227A (fr) |
| IN (1) | IN152178B (fr) |
| IT (1) | IT1202924B (fr) |
| KE (1) | KE3367A (fr) |
| LU (1) | LU81233A1 (fr) |
| MA (1) | MA18423A1 (fr) |
| MX (1) | MX5953E (fr) |
| NL (1) | NL179703C (fr) |
| NO (1) | NO147902C (fr) |
| NZ (1) | NZ190386A (fr) |
| PH (1) | PH17566A (fr) |
| PL (1) | PL126835B1 (fr) |
| PT (1) | PT69583A (fr) |
| RO (1) | RO81625B (fr) |
| SE (1) | SE440449B (fr) |
| SG (1) | SG65583G (fr) |
| SU (1) | SU1222186A3 (fr) |
| YU (1) | YU44183B (fr) |
| ZA (1) | ZA792129B (fr) |
| ZM (1) | ZM4079A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8305797D0 (en) * | 1983-03-02 | 1983-04-07 | Graham N B | Hydrogel-containing envelopes |
| GB8328916D0 (en) * | 1983-10-28 | 1983-11-30 | Castex Prod | Pharmaceutical pellet |
| GB8403138D0 (en) * | 1984-02-07 | 1984-03-14 | Graham N B | Sustained release of active ingredient |
| GR851195B (fr) * | 1984-06-02 | 1985-11-25 | Castex Prod | |
| US4666704A (en) * | 1985-05-24 | 1987-05-19 | International Minerals & Chemical Corp. | Controlled release delivery system for macromolecules |
| DE3533369A1 (de) * | 1985-09-19 | 1987-03-19 | Alois Prof Dr Med Bloemer | Antibioticahaltiges mittel und seine verwendung als chirurgisches kunststoffmaterial |
| US4717567A (en) * | 1985-11-25 | 1988-01-05 | Eastman Kodak Company | Rumen-stable pellets |
| US5342624A (en) * | 1989-02-16 | 1994-08-30 | British Technology Group Ltd. | Dispensing device |
| DE4100920A1 (de) * | 1991-01-15 | 1992-07-16 | Degussa | Wirkstoffzubereitung zur oralen verabreichung an wiederkaeuer |
| WO1995001138A1 (fr) * | 1993-07-02 | 1995-01-12 | Materials Evolution And Development Usa, Inc. | Systeme implantable s'appliquant a la regulation du developpement cellulaire |
| US6479066B1 (en) | 1999-12-16 | 2002-11-12 | Rst Implanted Cell Technology, Llc | Device having a microporous membrane lined deformable wall for implanting cell cultures |
| CN1305953C (zh) * | 2005-04-06 | 2007-03-21 | 福建师范大学 | 一种具有驱虫功能的塑料农用薄膜母粒的制备方法 |
| MX2023006678A (es) | 2020-12-08 | 2023-08-22 | Ruminant Biotech Corp Ltd | Mejoras en los dispositivos y métodos para suministrar sustancias a los animales. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1693890A (en) * | 1922-09-11 | 1928-12-04 | Duclaux Jacques | Ultrafilter membrane |
| US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
| US3993073A (en) * | 1969-04-01 | 1976-11-23 | Alza Corporation | Novel drug delivery device |
| US3948262A (en) * | 1969-04-01 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
| US3777015A (en) * | 1970-01-19 | 1973-12-04 | Alza Corp | Device for suppressing fertility |
| BE789524A (fr) * | 1971-09-30 | 1973-01-15 | Alza Corp | Dispositif de liberation de medicaments |
| US3948254A (en) * | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
| US3975350A (en) * | 1972-08-02 | 1976-08-17 | Princeton Polymer Laboratories, Incorporated | Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles |
| US3846404A (en) * | 1973-05-23 | 1974-11-05 | Moleculon Res Corp | Process of preparing gelled cellulose triacetate products and the products produced thereby |
| US3961628A (en) * | 1974-04-10 | 1976-06-08 | Alza Corporation | Ocular drug dispensing system |
-
1979
- 1979-03-21 IN IN188/DEL/79A patent/IN152178B/en unknown
- 1979-03-26 DK DK122779A patent/DK153917C/da not_active IP Right Cessation
- 1979-05-03 ZA ZA792129A patent/ZA792129B/xx unknown
- 1979-05-03 MA MA18616A patent/MA18423A1/fr unknown
- 1979-05-04 GB GB7915602A patent/GB2020181B/en not_active Expired
- 1979-05-06 CS CS793159A patent/CS236761B2/cs unknown
- 1979-05-07 RO RO97439A patent/RO81625B/ro unknown
- 1979-05-07 CH CH426279A patent/CH643140A5/de not_active IP Right Cessation
- 1979-05-07 NZ NZ190386A patent/NZ190386A/xx unknown
- 1979-05-07 FR FR7911434A patent/FR2425242A1/fr active Granted
- 1979-05-07 AU AU46742/79A patent/AU513656B2/en not_active Expired
- 1979-05-07 GR GR59048A patent/GR73637B/el unknown
- 1979-05-07 PT PT69583A patent/PT69583A/pt unknown
- 1979-05-07 FI FI791452A patent/FI75735C/fi not_active IP Right Cessation
- 1979-05-07 YU YU1066/79A patent/YU44183B/xx unknown
- 1979-05-07 NL NLAANVRAGE7903549,A patent/NL179703C/xx not_active IP Right Cessation
- 1979-05-07 IT IT22426/79A patent/IT1202924B/it active
- 1979-05-07 IL IL57227A patent/IL57227A/xx unknown
- 1979-05-07 EG EG265/79A patent/EG15524A/xx active
- 1979-05-07 MX MX797956U patent/MX5953E/es unknown
- 1979-05-07 CA CA327,100A patent/CA1113395A/fr not_active Expired
- 1979-05-07 LU LU81233A patent/LU81233A1/fr unknown
- 1979-05-07 BE BE0/195018A patent/BE876074A/fr not_active IP Right Cessation
- 1979-05-07 AT AT0339379A patent/AT389463B/de not_active IP Right Cessation
- 1979-05-07 SU SU792761214A patent/SU1222186A3/ru active
- 1979-05-07 HU HU823729A patent/HU186995B/hu unknown
- 1979-05-07 ES ES480320A patent/ES480320A0/es active Granted
- 1979-05-07 JP JP5560979A patent/JPS5514080A/ja active Granted
- 1979-05-07 SE SE7903973A patent/SE440449B/sv not_active IP Right Cessation
- 1979-05-07 NO NO79791514A patent/NO147902C/no unknown
- 1979-05-08 DE DE2918522A patent/DE2918522C2/de not_active Expired
- 1979-05-08 AR AR276441A patent/AR219795A1/es active
- 1979-05-08 PL PL1979215452A patent/PL126835B1/pl unknown
- 1979-05-08 ZM ZM40/79A patent/ZM4079A1/xx unknown
- 1979-05-08 DD DD79212725A patent/DD143504A5/de unknown
- 1979-08-08 IE IE891/79A patent/IE48751B1/en not_active IP Right Cessation
-
1980
- 1980-01-21 PH PH23528A patent/PH17566A/en unknown
- 1980-05-08 DD DD80223101A patent/DD152482A5/de unknown
-
1983
- 1983-11-02 SG SG65583A patent/SG65583G/en unknown
-
1984
- 1984-01-13 KE KE3367A patent/KE3367A/xx unknown
- 1984-02-16 HK HK133/84A patent/HK13384A/xx not_active IP Right Cessation
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