JPS6018653B2 - 新規な2,6−ジ置換2−フエニルイミノ−イミダゾリジンおよびその酸付加塩の製造方法 - Google Patents
新規な2,6−ジ置換2−フエニルイミノ−イミダゾリジンおよびその酸付加塩の製造方法Info
- Publication number
- JPS6018653B2 JPS6018653B2 JP50118196A JP11819675A JPS6018653B2 JP S6018653 B2 JPS6018653 B2 JP S6018653B2 JP 50118196 A JP50118196 A JP 50118196A JP 11819675 A JP11819675 A JP 11819675A JP S6018653 B2 JPS6018653 B2 JP S6018653B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- group
- chloro
- acid addition
- bromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2446758.1 | 1974-10-01 | ||
DE2446758A DE2446758C3 (de) | 1974-10-01 | 1974-10-01 | 2-(2-Fluor-6-trifluormethylphenylimino)-imidazolidin, dessen Säureadditionssalze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung der Hypertonie |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5159863A JPS5159863A (en) | 1976-05-25 |
JPS6018653B2 true JPS6018653B2 (ja) | 1985-05-11 |
Family
ID=5927202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50118196A Expired JPS6018653B2 (ja) | 1974-10-01 | 1975-09-30 | 新規な2,6−ジ置換2−フエニルイミノ−イミダゾリジンおよびその酸付加塩の製造方法 |
Country Status (27)
Country | Link |
---|---|
JP (1) | JPS6018653B2 (de) |
AT (1) | AT344159B (de) |
BE (1) | BE834051A (de) |
BG (2) | BG25220A3 (de) |
CA (1) | CA1056836A (de) |
CH (5) | CH620682A5 (de) |
CS (1) | CS193524B2 (de) |
DD (1) | DD123602A5 (de) |
DE (1) | DE2446758C3 (de) |
DK (1) | DK441875A (de) |
ES (4) | ES441385A1 (de) |
FI (1) | FI61883C (de) |
FR (1) | FR2286649A1 (de) |
GB (1) | GB1515019A (de) |
HU (1) | HU178469B (de) |
IE (1) | IE42130B1 (de) |
IL (1) | IL48214A (de) |
LU (1) | LU73472A1 (de) |
NL (1) | NL7511490A (de) |
NO (1) | NO143459C (de) |
NZ (1) | NZ178810A (de) |
PH (1) | PH13653A (de) |
PL (2) | PL98984B1 (de) |
SE (1) | SE418497B (de) |
SU (1) | SU575026A3 (de) |
YU (1) | YU230281A (de) |
ZA (1) | ZA756185B (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2630060C2 (de) * | 1976-07-03 | 1984-04-19 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-(2-Brom-6-fluor-phenylimino)-imidazolidin, dessen Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung |
DE2806775A1 (de) * | 1978-02-17 | 1979-08-30 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
DE2806811A1 (de) * | 1978-02-17 | 1979-08-23 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine, deren saeureadditionssalze, diese enthaltene arzneimittel und verfahren zur herstellung derselben |
ZA801680B (en) * | 1979-04-03 | 1981-03-25 | Fujisawa Pharmaceutical Co | 2-imidazoline derivatives,process for the preparation thereof and the pharmaceutical composition of the same |
HU192986B (en) | 1984-05-23 | 1987-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of imidasodiline derivatives |
EP1981498A2 (de) * | 2006-01-27 | 2008-10-22 | F. Hoffmann-la Roche AG | Verwendung von 2-imidazolen zur behandlung von leiden des zentralen nervensystems |
CA2675221C (en) | 2007-02-02 | 2016-02-23 | F. Hoffmann-La Roche Ag | Novel 2-aminooxazolines as taar1 ligands |
WO2008098857A1 (en) | 2007-02-15 | 2008-08-21 | F. Hoffmann-La Roche Ag | 2-aminooxazolines as taar1 ligands |
US8242153B2 (en) | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
EP3757102A1 (de) | 2016-03-17 | 2020-12-30 | F. Hoffmann-La Roche AG | 5-ethyl-4-methyl-pyrazole-3-carboxamid-derivat mit wirkung als taar agonist |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3236857A (en) * | 1961-10-09 | 1966-02-22 | Boehringer Sohn Ingelheim | 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products |
DE1670807A1 (de) * | 1967-02-17 | 1971-03-11 | Bayer Ag | Verfahren zur Herstellung von cyclischen Guanidinen |
DE1670918A1 (de) * | 1967-09-07 | 1971-04-08 | Bayer Ag | Verfahren zur Herstellung von 2-Aryl-amino-substituierten stickstoffhaltigen Heterocyclen |
BE787683A (fr) * | 1971-08-20 | 1973-02-19 | Boehringer Sohn Ingelheim | 2-phenylimino-imidazolidines, leurs sels d'addition avec des acides et procedes pour les fabriquer |
-
1974
- 1974-10-01 DE DE2446758A patent/DE2446758C3/de not_active Expired
-
1975
- 1975-09-22 AT AT722875A patent/AT344159B/de not_active IP Right Cessation
- 1975-09-23 SU SU7502174605A patent/SU575026A3/ru active
- 1975-09-26 PH PH17613A patent/PH13653A/en unknown
- 1975-09-29 BG BG7500031110A patent/BG25220A3/xx unknown
- 1975-09-29 CS CS756573A patent/CS193524B2/cs unknown
- 1975-09-29 LU LU73472A patent/LU73472A1/xx unknown
- 1975-09-29 BG BG7500032014A patent/BG25221A3/xx unknown
- 1975-09-29 DD DD188613A patent/DD123602A5/xx unknown
- 1975-09-30 CH CH1267875A patent/CH620682A5/de not_active IP Right Cessation
- 1975-09-30 GB GB40012/75A patent/GB1515019A/en not_active Expired
- 1975-09-30 NL NL7511490A patent/NL7511490A/xx not_active Application Discontinuation
- 1975-09-30 DK DK441875A patent/DK441875A/da not_active Application Discontinuation
- 1975-09-30 JP JP50118196A patent/JPS6018653B2/ja not_active Expired
- 1975-09-30 CA CA236,670A patent/CA1056836A/en not_active Expired
- 1975-09-30 ES ES441385A patent/ES441385A1/es not_active Expired
- 1975-09-30 BE BE160578A patent/BE834051A/xx not_active IP Right Cessation
- 1975-09-30 NZ NZ178810A patent/NZ178810A/xx unknown
- 1975-09-30 IL IL48214A patent/IL48214A/xx unknown
- 1975-09-30 HU HU75BO1573A patent/HU178469B/hu unknown
- 1975-09-30 FI FI752728A patent/FI61883C/fi not_active IP Right Cessation
- 1975-09-30 PL PL1975197816A patent/PL98984B1/pl unknown
- 1975-09-30 PL PL1975183670A patent/PL97003B1/pl unknown
- 1975-09-30 ZA ZA756185A patent/ZA756185B/xx unknown
- 1975-09-30 NO NO753314A patent/NO143459C/no unknown
- 1975-10-01 SE SE7511028A patent/SE418497B/xx not_active IP Right Cessation
- 1975-10-01 FR FR7530117A patent/FR2286649A1/fr active Granted
- 1975-10-01 IE IE2150/75A patent/IE42130B1/en unknown
-
1976
- 1976-02-04 ES ES444900A patent/ES444900A1/es not_active Expired
- 1976-02-04 ES ES444898A patent/ES444898A1/es not_active Expired
- 1976-02-04 ES ES444901A patent/ES444901A1/es not_active Expired
-
1980
- 1980-07-01 CH CH506380A patent/CH627453A5/de not_active IP Right Cessation
- 1980-07-01 CH CH506280A patent/CH627452A5/de not_active IP Right Cessation
- 1980-07-01 CH CH506580A patent/CH627454A5/de not_active IP Right Cessation
- 1980-07-01 CH CH506480A patent/CH626352A5/de not_active IP Right Cessation
-
1981
- 1981-09-24 YU YU02302/81A patent/YU230281A/xx unknown
Also Published As
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