JPS5738711A - Manufacture of slow-release medicinal composition - Google Patents
Manufacture of slow-release medicinal compositionInfo
- Publication number
- JPS5738711A JPS5738711A JP9846481A JP9846481A JPS5738711A JP S5738711 A JPS5738711 A JP S5738711A JP 9846481 A JP9846481 A JP 9846481A JP 9846481 A JP9846481 A JP 9846481A JP S5738711 A JPS5738711 A JP S5738711A
- Authority
- JP
- Japan
- Prior art keywords
- component
- melting
- finely divided
- slow
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002844 melting Methods 0.000 abstract 9
- 230000008018 melting Effects 0.000 abstract 9
- 239000011149 active material Substances 0.000 abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3024416A DE3024416C2 (de) | 1980-06-28 | 1980-06-28 | Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5738711A true JPS5738711A (en) | 1982-03-03 |
| JPS6140204B2 JPS6140204B2 (cg-RX-API-DMAC7.html) | 1986-09-08 |
Family
ID=6105792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9846481A Granted JPS5738711A (en) | 1980-06-28 | 1981-06-26 | Manufacture of slow-release medicinal composition |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4483847A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0043254B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS5738711A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE7655T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU545279B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1165691A (cg-RX-API-DMAC7.html) |
| DD (1) | DD159966A5 (cg-RX-API-DMAC7.html) |
| DE (2) | DE3024416C2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK155711C (cg-RX-API-DMAC7.html) |
| ES (1) | ES503414A0 (cg-RX-API-DMAC7.html) |
| FI (1) | FI76928C (cg-RX-API-DMAC7.html) |
| HU (1) | HU184862B (cg-RX-API-DMAC7.html) |
| IE (1) | IE51353B1 (cg-RX-API-DMAC7.html) |
| SU (1) | SU1360575A3 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA814094B (cg-RX-API-DMAC7.html) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5959632A (ja) * | 1982-09-28 | 1984-04-05 | Teikoku Chem Ind Corp Ltd | 徐放性組成物 |
| JPH0232012A (ja) * | 1988-07-18 | 1990-02-01 | Shionogi & Co Ltd | 徐放性製剤の製造法 |
| JP2021504487A (ja) * | 2017-11-30 | 2021-02-15 | ベーイーテー ファルマ ゲーエムベーハー | 固体分散体を調製するための方法および装置 |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713245A (en) * | 1984-06-04 | 1987-12-15 | Mitsui Toatsu Chemicals, Incorporated | Granule containing physiologically-active substance, method for preparing same and use thereof |
| JPS6150912A (ja) * | 1984-08-16 | 1986-03-13 | Shionogi & Co Ltd | リポソ−ム製剤の製造法 |
| US4755387A (en) * | 1985-03-21 | 1988-07-05 | The Procter & Gamble Company | Therapeutic particles |
| FR2581541B1 (fr) * | 1985-05-09 | 1988-05-20 | Rhone Poulenc Sante | Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation |
| US4820523A (en) * | 1986-04-15 | 1989-04-11 | Warner-Lambert Company | Pharmaceutical composition |
| US4837381A (en) * | 1986-08-11 | 1989-06-06 | American Cyanamid Company | Compositions for parenteral administration and their use |
| US4822619A (en) * | 1987-02-18 | 1989-04-18 | Ionor, Inc. | Controlled release pharmaceutical preparation containing a gastrointestinal irritant drug |
| JP2668880B2 (ja) * | 1987-06-23 | 1997-10-27 | 日本油脂株式会社 | 被覆アミノ酸類の製造方法 |
| DE3737741A1 (de) * | 1987-11-06 | 1989-05-18 | Goedecke Ag | Oral anzuwendende arzneiform zur einmal taeglichen behandlung der hypertonie mit diltiazemhydrochlorid |
| EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
| US5213810A (en) * | 1990-03-30 | 1993-05-25 | American Cyanamid Company | Stable compositions for parenteral administration and method of making same |
| IE61651B1 (en) * | 1990-07-04 | 1994-11-16 | Zambon Spa | Programmed release oral solid pharmaceutical dosage form |
| US5134016A (en) * | 1990-10-31 | 1992-07-28 | E. I. Du Pont De Nemours And Company | Fiber reinforced porous sheets |
| US5266331A (en) * | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
| US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| DE59302200D1 (de) * | 1992-05-22 | 1996-05-15 | Goedecke Ag | Verfahren zur herstellung retardierter arzneimittelzubereitungen |
| NZ260408A (en) | 1993-05-10 | 1996-05-28 | Euro Celtique Sa | Controlled release preparation comprising tramadol |
| US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
| IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
| US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
| KR100354702B1 (ko) * | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
| US5891471A (en) * | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
| US5843480A (en) * | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
| GB9422154D0 (en) | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
| US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| WO1996031197A1 (en) * | 1995-04-03 | 1996-10-10 | Abbott Laboratories | Homogeneous mixtures of low temperature-melting drugs and additives for controlled release |
| DE19522899C1 (de) * | 1995-06-23 | 1996-12-19 | Hexal Pharmaforschung Gmbh | Verfahren zum kontinuierlichen Ersintern eines Granulats |
| WO1997014407A1 (en) * | 1995-10-17 | 1997-04-24 | Research Triangle Pharmaceuticals | Insoluble drug delivery |
| US7255877B2 (en) | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
| US6465016B2 (en) | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
| DE19705538C1 (de) * | 1997-02-14 | 1998-08-27 | Goedecke Ag | Verfahren zur Trennung von Wirkstoffen in festen pharmazeutischen Zubereitungen |
| US5891476A (en) * | 1997-12-22 | 1999-04-06 | Reo; Joe P. | Tastemasked pharmaceutical system |
| AU762246B2 (en) * | 1998-02-11 | 2003-06-19 | Rtp Pharma Corporation | Method and composition for treatment of inflammatory conditions |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| US8415329B1 (en) | 1998-05-29 | 2013-04-09 | Jagotec Ag | Thermoprotected compositions and process for terminal steam sterilization of microparticle preparations |
| ES2211151T3 (es) | 1998-08-19 | 2004-07-01 | Skyepharma Canada Inc. | Dispersiones acuosas inyectables de propofol. |
| US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
| JP4809533B2 (ja) | 1998-11-20 | 2011-11-09 | オバン・エナジー・リミテッド | 分散し得るリン脂質で安定化されたミクロ粒子 |
| DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
| KR20020011985A (ko) * | 1999-05-07 | 2002-02-09 | 파르마솔 게엠베하 | 액상 및 고체상 지질 혼합물에 기초한 지질입자들 및 그의제조방법 |
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
| EP2305218A1 (en) * | 1999-10-29 | 2011-04-06 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
| WO2001080828A2 (en) | 2000-04-20 | 2001-11-01 | Rtp Pharma Inc. | Improved water-insoluble drug particle process |
| AU2001288471B2 (en) | 2000-08-31 | 2006-03-02 | Rtp Pharma Inc. | Milled particles |
| US8586094B2 (en) | 2000-09-20 | 2013-11-19 | Jagotec Ag | Coated tablets |
| CN103690540A (zh) | 2000-10-30 | 2014-04-02 | 欧罗赛铁克股份有限公司 | 控释氢可酮制剂 |
| ES2290095T3 (es) * | 2000-12-27 | 2008-02-16 | Ares Trading S.A. | Microparticulas lipidicas por micronizacion criogenica. |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| DE10300325A1 (de) | 2003-01-09 | 2004-07-22 | Hexal Ag | Granulat mit öliger Substanz, Herstellungsverfahren und Tablette |
| US8486447B2 (en) | 2003-02-03 | 2013-07-16 | Novartis Ag | Pharmaceutical formulation |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| RU2267318C1 (ru) * | 2004-05-25 | 2006-01-10 | Закрытое акционерное общество "ФАРМАПЭК" | Пролонгированный антиангинальный препарат изосорбида динитрата и способ его получения |
| EP1765292B1 (en) | 2004-06-12 | 2017-10-04 | Collegium Pharmaceutical, Inc. | Abuse-deterrent drug formulations |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US20080075768A1 (en) * | 2006-07-21 | 2008-03-27 | Vaughn Jason M | Hydrophobic opioid abuse deterrent delivery system using opioid antagonists |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| WO2009080275A1 (en) * | 2007-12-21 | 2009-07-02 | Ludwig-Maximilians-Universität | Extruded rod-shaped devices for controlled release of biological substances to humans and animals |
| NZ586792A (en) | 2008-01-25 | 2012-09-28 | Gruenenthal Chemie | Tamper resistant controlled release pharmaceutical tablets form having convex and concave surfaces |
| TWI524904B (zh) | 2008-05-09 | 2016-03-11 | 歌林達股份有限公司 | 製備醫藥用固體劑型,尤指錠劑之方法,及製備固體劑型,尤指錠劑之前驅物之方法 |
| EP2456427B1 (en) | 2009-07-22 | 2015-03-04 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
| RU2555531C2 (ru) | 2009-07-22 | 2015-07-10 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма для чувствительных к окислению опиоидов |
| US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| EP2531176B1 (en) | 2010-02-03 | 2016-09-07 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of an extruder |
| PE20131102A1 (es) | 2010-09-02 | 2013-10-12 | Gruenenthal Chemie | Forma de dosificacion resistente a manipulacion que comprende una sal inorganica |
| NZ608865A (en) | 2010-09-02 | 2015-03-27 | Gruenenthal Chemie | Tamper resistant dosage form comprising an anionic polymer |
| CN103857386A (zh) | 2011-07-29 | 2014-06-11 | 格吕伦塔尔有限公司 | 提供药物立即释放的抗破碎片剂 |
| NO2736495T3 (cg-RX-API-DMAC7.html) | 2011-07-29 | 2018-01-20 | ||
| BR112014019988A8 (pt) | 2012-02-28 | 2017-07-11 | Gruenenthal Gmbh | Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico |
| AR090695A1 (es) | 2012-04-18 | 2014-12-03 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| WO2014191397A1 (en) | 2013-05-29 | 2014-12-04 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
| AR096439A1 (es) | 2013-05-29 | 2015-12-30 | Gruenenthal Gmbh | Forma de dosificación resistente al uso indebido que contiene una o más partículas |
| CA2917136C (en) | 2013-07-12 | 2022-05-31 | Grunenthal Gmbh | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| JP6480936B2 (ja) | 2013-11-26 | 2019-03-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | クライオミリングによる粉末状医薬組成物の調製 |
| JP2017518980A (ja) | 2014-05-12 | 2017-07-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールを含む、改変防止即時放出カプセル製剤 |
| US9872835B2 (en) | 2014-05-26 | 2018-01-23 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
| PL3188713T5 (pl) * | 2014-08-11 | 2024-07-29 | Perora Gmbh | Sposób wywoływania uczucia sytości |
| BR112017021475A2 (pt) | 2015-04-24 | 2018-07-10 | Gruenenthal Gmbh | forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente |
| US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
| US9737530B1 (en) | 2016-06-23 | 2017-08-22 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
| EP4549008A1 (en) | 2016-11-10 | 2025-05-07 | Medisca Pharmaceutique Inc. | Pharmaceutical compounding methods and systems |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2875130A (en) * | 1956-11-20 | 1959-02-24 | Smith Kline French Lab | Method of preparing sustained release particles and the product of the method |
| GB906422A (en) * | 1958-05-02 | 1962-09-19 | Wellcome Found | Improvements in and relating to prolonged acting pharmaceutical preparations |
| US3108046A (en) * | 1960-11-25 | 1963-10-22 | Smith Kline French Lab | Method of preparing high dosage sustained release tablet and product of this method |
| US3146167A (en) * | 1961-10-05 | 1964-08-25 | Smith Kline French Lab | Method of preparing sustained release pellets and products thereof |
| US3279998A (en) * | 1962-06-22 | 1966-10-18 | Smith Kline French Lab | Method of preparing sustained release tablets |
| GB1021924A (en) * | 1962-06-22 | 1966-03-09 | Smith Kline French Lab | Improvements in or relating to method of preparing sustained release tablets |
| US3308217A (en) * | 1965-02-09 | 1967-03-07 | Lowy Lawrence | Method of granulating materials for subsequent forming into tablets |
| US4132753A (en) * | 1965-02-12 | 1979-01-02 | American Cyanamid Company | Process for preparing oral sustained release granules |
| US3374146A (en) * | 1966-04-18 | 1968-03-19 | American Cyanamid Co | Sustained release encapsulation |
| US3487138A (en) * | 1966-11-23 | 1969-12-30 | Merck & Co Inc | Process for preparing a delayed release medicinal tablet |
| DE1617418C3 (de) * | 1967-12-16 | 1980-01-24 | Hoechst Ag, 6000 Frankfurt | Herstellung von festen Arzneimittelformen mit verzögerter Wirkstoffabgabe |
| SE335202B (cg-RX-API-DMAC7.html) * | 1968-06-19 | 1971-05-17 | Aco Laekemedel Ab | |
| GB1312918A (en) * | 1969-07-08 | 1973-04-11 | Beecham Group Ltd | Veterinary treatment |
| DK121813B (da) * | 1969-12-10 | 1971-12-06 | C Mangen | Fremgangsmåde til fremstilling af tabletlignende doseringsenheder. |
| DE2426811A1 (de) * | 1974-06-04 | 1976-01-08 | Klinge Co Chem Pharm Fab | Verfahren zur herstellung von retard-tabletten |
-
1980
- 1980-06-28 DE DE3024416A patent/DE3024416C2/de not_active Expired
-
1981
- 1981-06-17 ZA ZA814094A patent/ZA814094B/xx unknown
- 1981-06-22 FI FI811951A patent/FI76928C/fi not_active IP Right Cessation
- 1981-06-23 AU AU72069/81A patent/AU545279B2/en not_active Expired
- 1981-06-24 DK DK278381A patent/DK155711C/da not_active IP Right Cessation
- 1981-06-25 DD DD81231145A patent/DD159966A5/de unknown
- 1981-06-26 SU SU813304330A patent/SU1360575A3/ru active
- 1981-06-26 ES ES503414A patent/ES503414A0/es active Granted
- 1981-06-26 HU HU811873A patent/HU184862B/hu unknown
- 1981-06-26 EP EP81302895A patent/EP0043254B1/en not_active Expired
- 1981-06-26 CA CA000380767A patent/CA1165691A/en not_active Expired
- 1981-06-26 AT AT81302895T patent/ATE7655T1/de not_active IP Right Cessation
- 1981-06-26 JP JP9846481A patent/JPS5738711A/ja active Granted
- 1981-06-26 DE DE8181302895T patent/DE3163868D1/de not_active Expired
- 1981-06-26 IE IE1438/81A patent/IE51353B1/en not_active IP Right Cessation
-
1983
- 1983-09-20 US US06/534,020 patent/US4483847A/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5959632A (ja) * | 1982-09-28 | 1984-04-05 | Teikoku Chem Ind Corp Ltd | 徐放性組成物 |
| JPH0232012A (ja) * | 1988-07-18 | 1990-02-01 | Shionogi & Co Ltd | 徐放性製剤の製造法 |
| JP2021504487A (ja) * | 2017-11-30 | 2021-02-15 | ベーイーテー ファルマ ゲーエムベーハー | 固体分散体を調製するための方法および装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| DK278381A (da) | 1981-12-29 |
| DE3024416A1 (de) | 1982-01-21 |
| ES8301625A1 (es) | 1983-01-01 |
| CA1165691A (en) | 1984-04-17 |
| EP0043254B1 (en) | 1984-05-30 |
| DK155711C (da) | 1989-10-23 |
| SU1360575A3 (ru) | 1987-12-15 |
| DD159966A5 (de) | 1983-04-20 |
| ES503414A0 (es) | 1983-01-01 |
| FI76928B (fi) | 1988-09-30 |
| AU7206981A (en) | 1982-01-07 |
| AU545279B2 (en) | 1985-07-11 |
| HU184862B (en) | 1984-10-29 |
| FI811951L (fi) | 1981-12-29 |
| DE3024416C2 (de) | 1982-04-15 |
| US4483847A (en) | 1984-11-20 |
| IE51353B1 (en) | 1986-12-10 |
| DK155711B (da) | 1989-05-08 |
| ATE7655T1 (de) | 1984-06-15 |
| ZA814094B (en) | 1982-07-28 |
| IE811438L (en) | 1981-12-28 |
| DE3163868D1 (en) | 1984-07-05 |
| JPS6140204B2 (cg-RX-API-DMAC7.html) | 1986-09-08 |
| EP0043254A1 (en) | 1982-01-06 |
| FI76928C (fi) | 1989-01-10 |
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