JPS5492967A - Alpha-tocopherol-13-cis-vitamin a acid ester - Google Patents
Alpha-tocopherol-13-cis-vitamin a acid esterInfo
- Publication number
- JPS5492967A JPS5492967A JP15763077A JP15763077A JPS5492967A JP S5492967 A JPS5492967 A JP S5492967A JP 15763077 A JP15763077 A JP 15763077A JP 15763077 A JP15763077 A JP 15763077A JP S5492967 A JPS5492967 A JP S5492967A
- Authority
- JP
- Japan
- Prior art keywords
- tocopherol
- vitamin
- cis
- acid ester
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:α-Tocopherol-13-cis-vitamin A acid ester of the formula.
USE: Very low-toxicity antitumorigenic agent, it is effective in remedy and prevention of tumor production on epithelial cells
PREPARATION: The esterifecation of 13-cis-vitamin A acid with a natural mixture of tocopherol containing α-tocopherol, (dl-α-tocopherol, d-α-tocopherol, and 1-α- tocopherol) by a conventional method, or the esterification of all-trans vitamin A acid with α-tocopherol and subsequent isomerization of the resulting all-trans vitamin A acid ester by conventional methods give the objective α-tocopherol-13- cis-vitamin A acid ester.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15763077A JPS6056156B2 (en) | 1977-12-29 | 1977-12-29 | α-tocopherol-13-cis-vitamin A acid ester |
US06/154,415 US4320141A (en) | 1977-12-16 | 1978-12-14 | Antitumor agent |
PCT/JP1978/000055 WO1979000401A1 (en) | 1977-12-16 | 1978-12-14 | Anti-tumor agent |
EP79900025A EP0008573A1 (en) | 1977-12-16 | 1978-12-14 | Anti-tumor agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15763077A JPS6056156B2 (en) | 1977-12-29 | 1977-12-29 | α-tocopherol-13-cis-vitamin A acid ester |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5492967A true JPS5492967A (en) | 1979-07-23 |
JPS6056156B2 JPS6056156B2 (en) | 1985-12-09 |
Family
ID=15653912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15763077A Expired JPS6056156B2 (en) | 1977-12-16 | 1977-12-29 | α-tocopherol-13-cis-vitamin A acid ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6056156B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2859961B2 (en) * | 1991-06-04 | 1999-02-24 | マリゲン ソシエテ アノニム | Novel biosurfactant esters and phosphatides of vitamin D and vitamin E compounds, methods for their preparation, natural dispersants containing these compounds, and their use in treating tumors |
JP2005068011A (en) * | 2003-06-24 | 2005-03-17 | Nihon Green & Garden Corp | Mixed microgranule for weeding |
-
1977
- 1977-12-29 JP JP15763077A patent/JPS6056156B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2859961B2 (en) * | 1991-06-04 | 1999-02-24 | マリゲン ソシエテ アノニム | Novel biosurfactant esters and phosphatides of vitamin D and vitamin E compounds, methods for their preparation, natural dispersants containing these compounds, and their use in treating tumors |
JP2005068011A (en) * | 2003-06-24 | 2005-03-17 | Nihon Green & Garden Corp | Mixed microgranule for weeding |
Also Published As
Publication number | Publication date |
---|---|
JPS6056156B2 (en) | 1985-12-09 |
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