JPH11508182A - 微細製造差動抽出デバイスおよびその方法 - Google Patents

微細製造差動抽出デバイスおよびその方法

Info

Publication number
JPH11508182A
JPH11508182A JP9503342A JP50334297A JPH11508182A JP H11508182 A JPH11508182 A JP H11508182A JP 9503342 A JP9503342 A JP 9503342A JP 50334297 A JP50334297 A JP 50334297A JP H11508182 A JPH11508182 A JP H11508182A
Authority
JP
Japan
Prior art keywords
stream
extraction
particles
sample
channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP9503342A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11508182A5 (enExample
Inventor
イェーガー，ポール
ピー． ブロディー，ジェイムズ
アール． ホール，マーク
ケイ． フォースター，フレッド
シー． ガランボス，ポール
Original Assignee
ザ ユニバーシティ オブ ワシントン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21690681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH11508182(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ザ ユニバーシティ オブ ワシントン filed Critical ザ ユニバーシティ オブ ワシントン
Publication of JPH11508182A publication Critical patent/JPH11508182A/ja
Publication of JPH11508182A5 publication Critical patent/JPH11508182A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0492—Applications, solvents used
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0496—Solvent extraction of solutions which are liquid by extraction in microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3039—Micromixers with mixing achieved by diffusion between layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/0005—Field flow fractionation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F2025/91—Direction of flow or arrangement of feed and discharge openings
    • B01F2025/917—Laminar or parallel flow, i.e. every point of the flow moves in layers which do not intermix
    • B01F2025/9171—Parallel flow, i.e. every point of the flow moves in parallel layers where intermixing can occur by diffusion or which do not intermix; Focusing, i.e. compressing parallel layers without intermixing them
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00828—Silicon wafers or plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/0097—Optical sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00993—Design aspects
    • B01J2219/00995—Mathematical modeling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4055—Concentrating samples by solubility techniques
    • G01N2001/4072—Concentrating samples by solubility techniques membraneless transfer of a component between two parallel laminar flows of fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S366/00—Agitating
    • Y10S366/01—Micromixers: continuous laminar flow with laminar boundary mixing in the linear direction parallel to the fluid propagation with or without conduit geometry influences from the pathway
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP9503342A 1995-06-16 1996-06-14 微細製造差動抽出デバイスおよびその方法 Ceased JPH11508182A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26195P 1995-06-16 1995-06-16
US60/000,261 1995-06-16
PCT/US1996/010308 WO1997000442A1 (en) 1995-06-16 1996-06-14 Microfabricated differential extraction device and method

Publications (2)

Publication Number Publication Date
JPH11508182A true JPH11508182A (ja) 1999-07-21
JPH11508182A5 JPH11508182A5 (enExample) 2004-07-29

Family

ID=21690681

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9503342A Ceased JPH11508182A (ja) 1995-06-16 1996-06-14 微細製造差動抽出デバイスおよびその方法

Country Status (7)

Country Link
US (1) US5932100A (enExample)
EP (1) EP0839318B1 (enExample)
JP (1) JPH11508182A (enExample)
AU (1) AU6541596A (enExample)
CA (1) CA2222126A1 (enExample)
DE (1) DE69628016T2 (enExample)
WO (1) WO1997000442A1 (enExample)

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001511520A (ja) * 1997-07-25 2001-08-14 ユニバーシティ オブ ワシントン 参照ｔセンサ装置での同時の分析物測定および参照平衡
WO2003008961A1 (fr) * 2001-07-11 2003-01-30 Kanagawa Academy Of Science And Technology Corps structurel a croisements tridimensionnels de microcanaux et procede de formation d'un ecoulement laminaire multiple a croisements tridimensionnels
JP2004181298A (ja) * 2002-11-29 2004-07-02 National Institute Of Advanced Industrial & Technology マイクロリアクターとそれによる反応方法
JP2005046651A (ja) * 2003-05-30 2005-02-24 Fuji Photo Film Co Ltd マイクロリアクターを用いた反応方法
JP2005518794A (ja) * 2002-02-27 2005-06-30 ミシガン大学リージェンツ 低運動性粒子からの運動性粒子選別方法及びそれに用いる装置
JP2005329364A (ja) * 2004-05-21 2005-12-02 Dkk Toa Corp 気液反応ユニットおよび分析装置
JP2005329365A (ja) * 2004-05-21 2005-12-02 Dkk Toa Corp 気液反応ユニットおよび分析装置
JP2005538727A (ja) * 2002-09-16 2005-12-22 サイトノーム インコーポレーテッド 粒子を分類するための方法及び装置
JP2006520246A (ja) * 2003-03-14 2006-09-07 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク マイクロ流体無膜交換装置を有する血液ベースの治療のためのシステム及び方法
JP2006520190A (ja) * 2003-01-21 2006-09-07 マイクロニクス， インコーポレイテッド 流体の微小流体的な操作、増幅、および分析（例えば、細菌アッセイおよびアンチグロブリン試験）のための方法およびシステム
JP2009001486A (ja) * 2001-04-06 2009-01-08 California Inst Of Technol 物質の結晶化の高スループットスクリーニング
US8087515B2 (en) 2008-09-25 2012-01-03 Fuji Xerox Co., Ltd. Separation method and separation apparatus
JP2012073268A (ja) * 2003-09-04 2012-04-12 Arryx Inc レーザ操縦を用いた多層流に基づく粒子及び細胞の分離
US8365922B2 (en) 2009-03-26 2013-02-05 Fuji Xerox Co., Ltd. Classifying method and classifying device
JP2013536952A (ja) * 2010-09-07 2013-09-26 マルチ−センス テクノロジーズ リミテッド アッセイ装置及び読み取り装置
US8567608B2 (en) 2002-04-17 2013-10-29 Cytonome/St, Llc Method and apparatus for sorting particles
US8933395B2 (en) 2002-07-31 2015-01-13 Premium Genetics (Uk) Ltd. Multiple laminar flow-based particle and cellular identification
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US10029263B2 (en) 2002-04-17 2018-07-24 Cytonome/St, Llc Method and apparatus for sorting particles
US10107797B2 (en) 2008-10-03 2018-10-23 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
WO2019078277A1 (ja) * 2017-10-19 2019-04-25 株式会社 ＴＬ Ｇｅｎｏｍｉｃｓ 細胞分級用チップ
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
JP2020534142A (ja) * 2017-09-19 2020-11-26 ハイファイバイオ エスアエス マイクロ流体システムにおける粒子選別
US10994273B2 (en) 2004-12-03 2021-05-04 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US11187224B2 (en) 2013-07-16 2021-11-30 Abs Global, Inc. Microfluidic chip
US11193879B2 (en) 2010-11-16 2021-12-07 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
US11415503B2 (en) 2013-10-30 2022-08-16 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US11889830B2 (en) 2019-04-18 2024-02-06 Abs Global, Inc. System and process for continuous addition of cryoprotectant
US12135270B2 (en) 2020-11-23 2024-11-05 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples
US12497648B2 (en) 2021-10-21 2025-12-16 Abs Global, Inc. Methods and systems for processing genetic samples to determine identity or detect contamination

Families Citing this family (336)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767510B1 (en) 1992-05-21 2004-07-27 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6905882B2 (en) 1992-05-21 2005-06-14 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US7524456B1 (en) 1992-05-21 2009-04-28 Biosite Incorporated Diagnostic devices for the controlled movement of reagents without membranes
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6454945B1 (en) 1995-06-16 2002-09-24 University Of Washington Microfabricated devices and methods
US6541213B1 (en) * 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US20030211507A1 (en) * 1996-03-29 2003-11-13 Anson Hatch Microscale diffusion immunoassay in hydrogels
US20020090644A1 (en) * 1999-05-21 2002-07-11 Weigl Bernhard H. Microscale diffusion immunoassay
AU2517997A (en) * 1996-04-19 1997-11-12 Central Research Laboratories Limited Method and apparatus for diffusive transfer between immiscible fluids
GB9608129D0 (en) * 1996-04-19 1996-06-26 Central Research Lab Ltd Method and apparatus for diffusive transfer between immiscible fluids
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6998047B1 (en) 1997-02-26 2006-02-14 Millipore Corporation Cast membrane structures for sample preparation
US6159739A (en) * 1997-03-26 2000-12-12 University Of Washington Device and method for 3-dimensional alignment of particles in microfabricated flow channels
TW539918B (en) 1997-05-27 2003-07-01 Tokyo Electron Ltd Removal of photoresist and photoresist residue from semiconductors using supercritical carbon dioxide process
US6500605B1 (en) 1997-05-27 2002-12-31 Tokyo Electron Limited Removal of photoresist and residue from substrate using supercritical carbon dioxide process
US5974867A (en) * 1997-06-13 1999-11-02 University Of Washington Method for determining concentration of a laminar sample stream
US6368871B1 (en) * 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
WO1999017119A1 (en) * 1997-09-26 1999-04-08 University Of Washington Simultaneous particle separation and chemical reaction
US6007775A (en) * 1997-09-26 1999-12-28 University Of Washington Multiple analyte diffusion based chemical sensor
GB9723260D0 (en) 1997-11-05 1998-01-07 British Nuclear Fuels Plc A method of performing a chemical reaction
GB9723262D0 (en) 1997-11-05 1998-01-07 British Nuclear Fuels Plc Reactions of aromatic compounds
GB9800220D0 (en) * 1998-01-06 1998-03-04 Central Research Lab Ltd Method of forming interconnections between channels and chambers
US6109119A (en) 1998-02-27 2000-08-29 Fffractionation, Llc Sample focusing device and method
US6016242A (en) * 1998-03-20 2000-01-18 Seagate Technology, Inc. Narrow top poles for inductive magnetic heads, masks and processes for making the same
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6277753B1 (en) 1998-09-28 2001-08-21 Supercritical Systems Inc. Removal of CMP residue from semiconductors using supercritical carbon dioxide process
US7064070B2 (en) 1998-09-28 2006-06-20 Tokyo Electron Limited Removal of CMP and post-CMP residue from semiconductors using supercritical carbon dioxide process
US6067157A (en) 1998-10-09 2000-05-23 University Of Washington Dual large angle light scattering detection
GB9822242D0 (en) * 1998-10-13 1998-12-09 Zeneca Ltd Device
GB9822185D0 (en) * 1998-10-13 1998-12-02 Zeneca Ltd Device
US6150119A (en) * 1999-01-19 2000-11-21 Caliper Technologies Corp. Optimized high-throughput analytical system
US6379973B1 (en) * 1999-03-05 2002-04-30 The United States Of America As Represented By The Department Of Health And Human Services Chromatographic separation apparatus and method
US7247490B2 (en) * 1999-04-06 2007-07-24 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US20030022383A1 (en) * 1999-04-06 2003-01-30 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7214540B2 (en) * 1999-04-06 2007-05-08 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
DE60034033T2 (de) * 1999-04-06 2007-12-06 University of Alabama, Birmingham Research Foundation, Birmingham Vorrichtung zum screening von kristallisierungsbedingungen in lösungen zur kristallzüchtung
US7250305B2 (en) * 2001-07-30 2007-07-31 Uab Research Foundation Use of dye to distinguish salt and protein crystals under microcrystallization conditions
JP2003501639A (ja) * 1999-06-03 2003-01-14 ユニバーシティ オブ ワシントン 横断電気泳動および等電点電気泳動法のための微小流体デバイス
GB2351245B (en) * 1999-06-21 2003-07-16 Univ Hull Method of controlling liquid movement in a chemical device
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US7244402B2 (en) * 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
US7459022B2 (en) * 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US8052792B2 (en) * 2001-04-06 2011-11-08 California Institute Of Technology Microfluidic protein crystallography techniques
US7306672B2 (en) * 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US7217321B2 (en) * 2001-04-06 2007-05-15 California Institute Of Technology Microfluidic protein crystallography techniques
DE19931901A1 (de) * 1999-07-08 2001-01-11 Basf Ag Verfahren und Vorrichtung zum Parallel-Analysieren von kolloidalen Teilchen mit Feldflußfraktionierung
CA2387341A1 (en) 1999-11-02 2001-05-10 Tokyo Electron Limited Method and apparatus for supercritical processing of multiple workpieces
US6748960B1 (en) 1999-11-02 2004-06-15 Tokyo Electron Limited Apparatus for supercritical processing of multiple workpieces
GB2359765B (en) 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
JP4733331B2 (ja) 2000-03-14 2011-07-27 マイクロニックス、インコーポレーテッド マイクロ流動体分析用デバイス
EP1285106A2 (en) * 2000-03-31 2003-02-26 Micronics, Inc. Protein crystallization in microfluidic structures
US7867763B2 (en) * 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
AU2001255656A1 (en) * 2000-04-25 2001-11-07 Tokyo Electron Limited Method of depositing metal film and metal deposition cluster tool including supercritical drying/cleaning module
US6557427B2 (en) * 2000-05-24 2003-05-06 Micronics, Inc. Capillaries for fluid movement within microfluidic channels
WO2001089696A2 (en) * 2000-05-24 2001-11-29 Micronics, Inc. Microfluidic concentration gradient loop
US20060263888A1 (en) * 2000-06-02 2006-11-23 Honeywell International Inc. Differential white blood count on a disposable card
US7420659B1 (en) 2000-06-02 2008-09-02 Honeywell Interantional Inc. Flow control system of a cartridge
US6970245B2 (en) * 2000-08-02 2005-11-29 Honeywell International Inc. Optical alignment detection system
US6549275B1 (en) 2000-08-02 2003-04-15 Honeywell International Inc. Optical detection system for flow cytometry
US6597438B1 (en) 2000-08-02 2003-07-22 Honeywell International Inc. Portable flow cytometry
US7641856B2 (en) * 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
US7130046B2 (en) * 2004-09-27 2006-10-31 Honeywell International Inc. Data frame selection for cytometer analysis
US6700130B2 (en) 2001-06-29 2004-03-02 Honeywell International Inc. Optical detection system for flow cytometry
US7262838B2 (en) * 2001-06-29 2007-08-28 Honeywell International Inc. Optical detection system for flow cytometry
US8071051B2 (en) * 2004-05-14 2011-12-06 Honeywell International Inc. Portable sample analyzer cartridge
US8383043B2 (en) * 2004-05-14 2013-02-26 Honeywell International Inc. Analyzer system
US7242474B2 (en) * 2004-07-27 2007-07-10 Cox James A Cytometer having fluid core stream position control
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
US7471394B2 (en) * 2000-08-02 2008-12-30 Honeywell International Inc. Optical detection system with polarizing beamsplitter
US7978329B2 (en) * 2000-08-02 2011-07-12 Honeywell International Inc. Portable scattering and fluorescence cytometer
US7016022B2 (en) * 2000-08-02 2006-03-21 Honeywell International Inc. Dual use detectors for flow cytometry
US7283223B2 (en) * 2002-08-21 2007-10-16 Honeywell International Inc. Cytometer having telecentric optics
US7215425B2 (en) * 2000-08-02 2007-05-08 Honeywell International Inc. Optical alignment for flow cytometry
US7630063B2 (en) * 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
EP1161985B1 (en) * 2000-06-05 2005-10-26 STMicroelectronics S.r.l. Process for manufacturing integrated chemical microreactors of semiconductor material, and integrated microreactor
US20010055546A1 (en) * 2000-06-23 2001-12-27 Weigl Bernhard H. Method and apparatus for controlling fluid flow rate in a microfluidic circuit
EP1573416A4 (en) * 2000-07-07 2010-01-27 Fenwal Inc MEDICAL SYSTEM, METHOD AND DEVICE USING MEMS
JP4724353B2 (ja) * 2000-07-26 2011-07-13 東京エレクトロン株式会社 半導体基板のための高圧処理チャンバー
US7277166B2 (en) * 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
US7000330B2 (en) * 2002-08-21 2006-02-21 Honeywell International Inc. Method and apparatus for receiving a removable media member
US7061595B2 (en) * 2000-08-02 2006-06-13 Honeywell International Inc. Miniaturized flow controller with closed loop regulation
US6382228B1 (en) 2000-08-02 2002-05-07 Honeywell International Inc. Fluid driving system for flow cytometry
AU2001281076A1 (en) 2000-08-07 2002-02-18 Nanostream, Inc. Fluidic mixer in microfluidic system
US20020052571A1 (en) * 2000-09-13 2002-05-02 Fazio Frank A. Artificial kidney and methods of using same
US20020041831A1 (en) * 2000-09-18 2002-04-11 Battrell C. Frederick Externally controllable surface coatings for microfluidic devices
US7011791B2 (en) 2000-09-18 2006-03-14 University Of Washington Microfluidic devices for rotational manipulation of the fluidic interface between multiple flow streams
US20030057092A1 (en) * 2000-10-31 2003-03-27 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US20050011761A1 (en) * 2000-10-31 2005-01-20 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US6623984B1 (en) 2000-11-01 2003-09-23 The Cleveland Clinic Foundation MEMS-based integrated magnetic particle identification system
US6770434B2 (en) * 2000-12-29 2004-08-03 The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin Biological assay method
WO2002060754A1 (en) * 2001-01-29 2002-08-08 Caliper Technologies Corp. Non-mechanical valves for fluidic systems
US7670559B2 (en) 2001-02-15 2010-03-02 Caliper Life Sciences, Inc. Microfluidic systems with enhanced detection systems
JP2004530894A (ja) * 2001-02-15 2004-10-07 カリパー・ライフ・サイエンシズ・インコーポレーテッド 強化された検出システムを具備したミクロ流体システム
US7867776B2 (en) * 2001-03-02 2011-01-11 Caliper Life Sciences, Inc. Priming module for microfluidic chips
US7150999B1 (en) 2001-03-09 2006-12-19 Califer Life Sciences, Inc. Process for filling microfluidic channels
US6742661B1 (en) * 2001-04-03 2004-06-01 Micronics, Inc. Well-plate microfluidics
WO2002081934A2 (en) * 2001-04-03 2002-10-17 Micronics, Inc. Pneumatic valve interface for use in microfluidic structures
US7670429B2 (en) 2001-04-05 2010-03-02 The California Institute Of Technology High throughput screening of crystallization of materials
CA2442914A1 (en) * 2001-04-06 2002-10-17 California Institute Of Technology High throughput screening of crystallization of materials
WO2002081729A2 (en) 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6727479B2 (en) 2001-04-23 2004-04-27 Stmicroelectronics S.R.L. Integrated device based upon semiconductor technology, in particular chemical microreactor
WO2002088671A1 (en) * 2001-04-26 2002-11-07 Esytech Ab A separation unit, a method for separation, and a device for mounting a separation unit in a separation apparatus
JP2002361002A (ja) * 2001-06-04 2002-12-17 Minolta Co Ltd 抽出方法および装置、分離方法および装置
US7723123B1 (en) 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US20020187564A1 (en) * 2001-06-08 2002-12-12 Caliper Technologies Corp. Microfluidic library analysis
US6977163B1 (en) 2001-06-13 2005-12-20 Caliper Life Sciences, Inc. Methods and systems for performing multiple reactions by interfacial mixing
AU2002320507A1 (en) * 2001-07-13 2003-01-29 Caliper Technologies Corp. Microfluidic devices and systems for separating components of a mixture
US6825127B2 (en) 2001-07-24 2004-11-30 Zarlink Semiconductor Inc. Micro-fluidic devices
US7060171B1 (en) 2001-07-31 2006-06-13 Caliper Life Sciences, Inc. Methods and systems for reducing background signal in assays
WO2003016547A2 (en) * 2001-08-13 2003-02-27 Vanderbilt University Distribution of solutions across a surface
US20030044766A1 (en) * 2001-08-29 2003-03-06 Anne Scholz Methods and devices for detecting cell-cell interactions
US7153699B2 (en) * 2001-12-21 2006-12-26 Cytonome, Inc. Microfabricated two-pin system for biomolecule crystallization
US20070054408A1 (en) * 2001-09-25 2007-03-08 Cytonome, Inc. Microfabricated two-pin system for biomolecule crystallization
US7247274B1 (en) 2001-11-13 2007-07-24 Caliper Technologies Corp. Prevention of precipitate blockage in microfluidic channels
EP1461606A4 (en) * 2001-12-05 2005-06-29 Univ Washington MICROFLUIDIC DEVICE AND SURFACE DECORATION PROCESS FOR SOLID PHASE AFFINITY BINDING ASSAYS
US7001468B1 (en) 2002-02-15 2006-02-21 Tokyo Electron Limited Pressure energized pressure vessel opening and closing device and method of providing therefor
WO2003070846A2 (en) 2002-02-15 2003-08-28 Supercritical Systems Inc. Drying resist with a solvent bath and supercritical co2
US6924086B1 (en) 2002-02-15 2005-08-02 Tokyo Electron Limited Developing photoresist with supercritical fluid and developer
US7387868B2 (en) 2002-03-04 2008-06-17 Tokyo Electron Limited Treatment of a dielectric layer using supercritical CO2
CN1296771C (zh) 2002-03-04 2007-01-24 东京毅力科创株式会社 在晶片处理中低电介质材料的钝化方法
US7223371B2 (en) 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US7419784B2 (en) * 2002-04-02 2008-09-02 Dubrow Robert S Methods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material
US7169540B2 (en) 2002-04-12 2007-01-30 Tokyo Electron Limited Method of treatment of porous dielectric films to reduce damage during cleaning
BR0309321A (pt) * 2002-04-17 2005-03-29 Cytonome Inc Método e aparelho para selecionar partìculas
US20070065808A1 (en) * 2002-04-17 2007-03-22 Cytonome, Inc. Method and apparatus for sorting particles
US7112444B2 (en) * 2002-04-24 2006-09-26 Wisconsin Alumni Research Foundation Method of performing gradient-based assays in a microfluidic device
US20030203504A1 (en) * 2002-04-26 2003-10-30 John Hefti Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species
WO2003095982A1 (en) * 2002-05-06 2003-11-20 Science And Technology Corporation @ University Of New Mexico Wavy interface mixer
US7161356B1 (en) 2002-06-05 2007-01-09 Caliper Life Sciences, Inc. Voltage/current testing equipment for microfluidic devices
US20040009096A1 (en) * 2002-06-08 2004-01-15 Wellman Parris S. Substantially inertia free hemodialysis
AU2003234566A1 (en) * 2002-06-11 2003-12-22 Kionix, Inc. Methods and devices for microfluidic extraction
US20040007672A1 (en) * 2002-07-10 2004-01-15 Delucas Lawrence J. Method for distinguishing between biomolecule and non-biomolecule crystals
EP1380337B1 (en) * 2002-07-12 2012-11-14 Tosoh Corporation Fine channel device and a chemically operating method for fluid using the device
US7150834B2 (en) * 2003-07-31 2006-12-19 Arryx, Inc. Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components
US6849459B2 (en) * 2002-09-09 2005-02-01 Cytonome, Inc. Microfluidic chip for biomolecule crystallization
EP1540302A4 (en) * 2002-09-11 2008-05-07 Kreido Lab METHOD AND DEVICES FOR MIXING AND REACTING MATERIALS WITH GREAT SHARING
JP2006501056A (ja) 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
JP5695287B2 (ja) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー 微小流体の核酸解析
US7118920B2 (en) 2002-10-22 2006-10-10 Battelle Memorial Institute Multiphasic microchannel reactions
US6722642B1 (en) 2002-11-06 2004-04-20 Tokyo Electron Limited High pressure compatible vacuum chuck for semiconductor wafer including lift mechanism
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
DE20218972U1 (de) * 2002-12-07 2003-02-13 Ehrfeld Mikrotechnik AG, 55234 Wendelsheim Statischer Laminationsmikrovermischer
US7419638B2 (en) 2003-01-14 2008-09-02 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
US7021635B2 (en) 2003-02-06 2006-04-04 Tokyo Electron Limited Vacuum chuck utilizing sintered material and method of providing thereof
US7077917B2 (en) 2003-02-10 2006-07-18 Tokyo Electric Limited High-pressure processing chamber for a semiconductor wafer
US7225820B2 (en) 2003-02-10 2007-06-05 Tokyo Electron Limited High-pressure processing chamber for a semiconductor wafer
US10533998B2 (en) 2008-07-18 2020-01-14 Bio-Rad Laboratories, Inc. Enzyme quantification
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US8075778B2 (en) * 2003-03-25 2011-12-13 Massachusetts Institute Of Technology Fluid separation
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
WO2004094020A2 (en) * 2003-04-17 2004-11-04 Fluidigm Corporation Crystal growth devices and systems, and methods for using same
US7270137B2 (en) * 2003-04-28 2007-09-18 Tokyo Electron Limited Apparatus and method of securing a workpiece during high-pressure processing
DE20306915U1 (de) * 2003-05-05 2003-08-07 HAAGEN & RINAU Mischtechnik GmbH, 28307 Bremen Dispergiervorrichtung
US7220390B2 (en) 2003-05-16 2007-05-22 Velocys, Inc. Microchannel with internal fin support for catalyst or sorption medium
WO2004108287A1 (en) 2003-06-06 2004-12-16 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
US7648835B2 (en) * 2003-06-06 2010-01-19 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
US7217901B2 (en) * 2003-07-02 2007-05-15 Xerox Corporation System for transporting and selectively sorting particles and method of using the same
CA2532530A1 (en) * 2003-07-28 2005-02-10 Fluidigm Corporation Image processing method and system for microfluidic devices
US7163380B2 (en) 2003-07-29 2007-01-16 Tokyo Electron Limited Control of fluid flow in the processing of an object with a fluid
JP5138223B2 (ja) 2003-10-30 2013-02-06 サイトノーム エスティー リミテッド ライアビリティー カンパニー 流体力学的多層シースフロー構造
US7186093B2 (en) 2004-10-05 2007-03-06 Tokyo Electron Limited Method and apparatus for cooling motor bearings of a high pressure pump
WO2005072353A2 (en) * 2004-01-25 2005-08-11 Fluidigm Corporation Crystal forming devices and systems and methods for making and using the same
US9023900B2 (en) 2004-01-28 2015-05-05 Velocys, Inc. Fischer-Tropsch synthesis using microchannel technology and novel catalyst and microchannel reactor
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7155082B2 (en) * 2004-04-12 2006-12-26 Colorado School Of Mines Switchable microfluidic optical waveguides
US8323564B2 (en) 2004-05-14 2012-12-04 Honeywell International Inc. Portable sample analyzer system
US20060024751A1 (en) * 2004-06-03 2006-02-02 Fluidigm Corporation Scale-up methods and systems for performing the same
US7250374B2 (en) 2004-06-30 2007-07-31 Tokyo Electron Limited System and method for processing a substrate using supercritical carbon dioxide processing
US20060118479A1 (en) * 2004-08-24 2006-06-08 Shevkoplyas Sergey S Particle separating devices, systems, and methods
US7612871B2 (en) * 2004-09-01 2009-11-03 Honeywell International Inc Frequency-multiplexed detection of multiple wavelength light for flow cytometry
WO2006036592A1 (en) * 2004-09-23 2006-04-06 University Of Washington Microscale diffusion immunoassay utilizing multivalent reactants
US7630075B2 (en) 2004-09-27 2009-12-08 Honeywell International Inc. Circular polarization illumination based analyzer system
US7307019B2 (en) 2004-09-29 2007-12-11 Tokyo Electron Limited Method for supercritical carbon dioxide processing of fluoro-carbon films
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
DE102004049730B4 (de) * 2004-10-11 2007-05-03 Technische Universität Darmstadt Mikrokapillarreaktor und Verfahren zum kontrollierten Vermengen von nicht homogen mischbaren Fluiden unter Verwendung dieses Mikrokapillarreaktors
US7491036B2 (en) 2004-11-12 2009-02-17 Tokyo Electron Limited Method and system for cooling a pump
CN101099082B (zh) 2004-12-03 2013-03-27 塞通诺米/St有限责任公司 用于粒子处理的整体式盒
US7140393B2 (en) 2004-12-22 2006-11-28 Tokyo Electron Limited Non-contact shuttle valve for flow diversion in high pressure systems
US7434590B2 (en) 2004-12-22 2008-10-14 Tokyo Electron Limited Method and apparatus for clamping a substrate in a high pressure processing system
WO2006079007A2 (en) * 2005-01-21 2006-07-27 President And Fellows Of Harvard College Microconcentrator/microfilter
US7514256B2 (en) * 2005-02-11 2009-04-07 Emilio Barbera-Guillem Bioreactor for selectively controlling the molecular diffusion between fluids
US7291565B2 (en) 2005-02-15 2007-11-06 Tokyo Electron Limited Method and system for treating a substrate with a high pressure fluid using fluorosilicic acid
US7435447B2 (en) 2005-02-15 2008-10-14 Tokyo Electron Limited Method and system for determining flow conditions in a high pressure processing system
US7550075B2 (en) 2005-03-23 2009-06-23 Tokyo Electron Ltd. Removal of contaminants from a fluid
US7767145B2 (en) 2005-03-28 2010-08-03 Toyko Electron Limited High pressure fourier transform infrared cell
US7380984B2 (en) 2005-03-28 2008-06-03 Tokyo Electron Limited Process flow thermocouple
US7399708B2 (en) 2005-03-30 2008-07-15 Tokyo Electron Limited Method of treating a composite spin-on glass/anti-reflective material prior to cleaning
US7442636B2 (en) 2005-03-30 2008-10-28 Tokyo Electron Limited Method of inhibiting copper corrosion during supercritical CO2 cleaning
US7494107B2 (en) 2005-03-30 2009-02-24 Supercritical Systems, Inc. Gate valve for plus-atmospheric pressure semiconductor process vessels
US7314060B2 (en) * 2005-04-23 2008-01-01 Industrial Technology Research Institute Fluid flow conducting module
CN101438143B (zh) * 2005-04-29 2013-06-12 霍尼韦尔国际公司 血细胞计数器细胞计数和尺寸测量方法
US7789971B2 (en) 2005-05-13 2010-09-07 Tokyo Electron Limited Treatment of substrate using functionalizing agent in supercritical carbon dioxide
JP2006346671A (ja) * 2005-05-16 2006-12-28 Dainippon Screen Mfg Co Ltd 液液界面反応装置
CA2608400C (en) 2005-05-25 2014-08-19 Velocys Inc. Support for use in microchannel processing
US7524383B2 (en) 2005-05-25 2009-04-28 Tokyo Electron Limited Method and system for passivating a processing chamber
WO2007005973A2 (en) 2005-07-01 2007-01-11 Honeywell International, Inc. A microfluidic card for rbc analysis
JP4995197B2 (ja) 2005-07-01 2012-08-08 ハネウェル・インターナショナル・インコーポレーテッド ３ｄ流体力学的集束を有する成形カートリッジ
US8361410B2 (en) 2005-07-01 2013-01-29 Honeywell International Inc. Flow metered analyzer
EP1917097A2 (en) * 2005-07-05 2008-05-07 Massachusetts Institute of Technology (MIT) Microfluidic separators for multiphase fluid-flow based on membranes
WO2007024485A2 (en) * 2005-08-11 2007-03-01 Eksigent Technologies, Llc Microfluidic reduction of diffusion and complience effect in a fluid mixing region
US7843563B2 (en) * 2005-08-16 2010-11-30 Honeywell International Inc. Light scattering and imaging optical system
EP2347825B1 (en) * 2005-10-28 2016-10-19 ARKRAY, Inc. Analytical cartridge
KR100843890B1 (ko) * 2005-11-07 2008-07-03 주식회사 하이닉스반도체 리소그래피 공정의 시뮬레이션 방법
US20080241909A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Microfluidic chips for pathogen detection
US20080241910A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Devices for pathogen detection
US20080179255A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic devices
US20080241000A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for pathogen detection
US20080178692A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US8068991B2 (en) 2005-11-30 2011-11-29 The Invention Science Fund I, Llc Systems and methods for transmitting pathogen related information and responding
JP2009521684A (ja) 2005-12-22 2009-06-04 ハネウェル・インターナショナル・インコーポレーテッド 携帯用サンプル分析装置のカートリッジ
CN101389947B (zh) 2005-12-29 2013-08-21 霍尼韦尔国际公司 微流格式的测定工具
EP3913375A1 (en) 2006-01-11 2021-11-24 Bio-Rad Laboratories, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
WO2007084392A2 (en) * 2006-01-13 2007-07-26 Micronics, Inc. Electromagnetically actuated valves for use in microfluidic structures
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
WO2007106580A2 (en) 2006-03-15 2007-09-20 Micronics, Inc. Rapid magnetic flow assays
CA2857176C (en) 2006-03-23 2016-08-30 Velocys, Inc. Process for making styrene using microchannel process technology
CN101472676B (zh) 2006-04-20 2013-09-11 万罗赛斯公司 利用微通道工艺技术处理和/或形成一种非牛顿流体的方法
EP2021113A2 (en) 2006-05-11 2009-02-11 Raindance Technologies, Inc. Microfluidic devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
BRPI0711896A2 (pt) 2006-05-22 2012-07-17 Univ Columbia sistemas e métodos de troca sem membrana microfluida usando filtração da extração de correntes de saìda de fluido.
US20080032390A1 (en) * 2006-08-04 2008-02-07 Ivar Meyvantsson Method and Device for Control of Diffusive Transport
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
CN101657524B (zh) 2007-01-19 2013-02-13 万罗赛斯公司 使用微通道工艺技术将天然气转化为较高分子量的烃的方法和装置
US20080181816A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Systems for allergen detection
US10001496B2 (en) 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
US20090050569A1 (en) * 2007-01-29 2009-02-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US8617903B2 (en) 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
US20080181821A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Microfluidic chips for allergen detection
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US8168140B2 (en) * 2007-01-31 2012-05-01 Agilent Technologies, Inc. Microfluidic apparatuses with nanochannels
US7923592B2 (en) 2007-02-02 2011-04-12 Velocys, Inc. Process for making unsaturated hydrocarbons using microchannel process technology
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US7799656B2 (en) 2007-03-15 2010-09-21 Dalsa Semiconductor Inc. Microchannels for BioMEMS devices
US20090215157A1 (en) * 2007-03-27 2009-08-27 Searete Llc Methods for pathogen detection
US20080237044A1 (en) * 2007-03-28 2008-10-02 The Charles Stark Draper Laboratory, Inc. Method and apparatus for concentrating molecules
CN103977848B (zh) 2007-04-06 2016-08-24 加利福尼亚技术学院 微流体装置
WO2008130618A1 (en) * 2007-04-19 2008-10-30 The Charles Stark Draper Laboratory, Inc. Method and apparatus for separating particles, cells, molecules and particulates
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
EP2175999B1 (en) 2007-06-21 2017-01-04 Gen-Probe Incorporated Receptacles for use in performing processes
EP2171420A1 (en) * 2007-07-31 2010-04-07 Micronics, Inc. Sanitary swab collection system, microfluidic assay device, and methods for diagnostic assays
US7837379B2 (en) * 2007-08-13 2010-11-23 The Charles Stark Draper Laboratory, Inc. Devices for producing a continuously flowing concentration gradient in laminar flow
JP2009083382A (ja) * 2007-10-01 2009-04-23 Brother Ind Ltd 画像形成装置および画像処理プログラム
JP5523327B2 (ja) 2007-10-12 2014-06-18 レオニックス，インコーポレイテッド 統合型マイクロ流体デバイスおよび方法
BRPI0907473A2 (pt) 2008-02-04 2019-09-24 Univ Columbia métodos, sistemas e dispositivos de separação de fluidos
JP2009226296A (ja) * 2008-03-21 2009-10-08 Fuji Xerox Co Ltd 分級方法及び分級装置
AU2009233786B2 (en) 2008-04-09 2014-04-24 Velocys Inc. Process for converting a carbonaceous material to methane, methanol and/or dimethyl ether using microchannel process technology
BRPI0915854A2 (pt) 2008-07-14 2015-08-04 Basf Se Processo para preparar óxido de etileno
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US20100034704A1 (en) * 2008-08-06 2010-02-11 Honeywell International Inc. Microfluidic cartridge channel with reduced bubble formation
WO2010022441A1 (en) * 2008-08-25 2010-03-04 University Of South Australia Extraction processes
US8037354B2 (en) 2008-09-18 2011-10-11 Honeywell International Inc. Apparatus and method for operating a computing platform without a battery pack
BRPI0919785A2 (pt) 2008-10-10 2019-05-21 Velocys Inc processo e equipamento empregando tecnologia de processo de microcanal
US7927904B2 (en) 2009-01-05 2011-04-19 Dalsa Semiconductor Inc. Method of making BIOMEMS devices
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US8524927B2 (en) 2009-07-13 2013-09-03 Velocys, Inc. Process for making ethylene oxide using microchannel process technology
JP5304506B2 (ja) * 2009-07-22 2013-10-02 富士ゼロックス株式会社 分級装置及び分級方法
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
CN102740976B (zh) 2010-01-29 2016-04-20 精密公司 取样-应答微流体盒
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP4484577A3 (en) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
JP5837574B2 (ja) * 2010-05-03 2015-12-24 クリーティービー マイクロテック， インク．Ｃｒｅａｔｖ Ｍｉｃｒｏｔｅｃｈ， Ｉｎｃ． 高分子マイクロフィルタおよびその製造方法
US11175279B2 (en) 2010-05-03 2021-11-16 Creatv Microtech, Inc. Polymer microfilters, devices comprising the same, methods of manufacturing the same, and uses thereof
EP2622103B2 (en) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwich assays in droplets
US8574440B2 (en) * 2010-10-07 2013-11-05 Freeport-Mcmoran Corporation Method and article of manufacture for solvent extraction operation
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
JP5547120B2 (ja) * 2011-03-18 2014-07-09 株式会社神戸製鋼所 流路構造体、流体の混合方法、抽出方法及び反応方法
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US9528987B2 (en) 2011-06-23 2016-12-27 University Of Washington Reagent patterning in capillarity-based analyzers and associated systems and methods
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
CA3125150A1 (en) * 2011-08-01 2013-02-07 Alcyone Lifesciences, Inc. Microfluidic drug delivery devices
US8741235B2 (en) 2011-12-27 2014-06-03 Honeywell International Inc. Two step sample loading of a fluid analysis cartridge
US8663583B2 (en) 2011-12-27 2014-03-04 Honeywell International Inc. Disposable cartridge for fluid analysis
US8741233B2 (en) 2011-12-27 2014-06-03 Honeywell International Inc. Disposable cartridge for fluid analysis
US8741234B2 (en) 2011-12-27 2014-06-03 Honeywell International Inc. Disposable cartridge for fluid analysis
JP2015514425A (ja) 2012-04-17 2015-05-21 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 垂直３ストリームマイクロ流体デバイスのための入口および出口の幾何学的形態
GB201214122D0 (en) 2012-08-07 2012-09-19 Oxford Catalysts Ltd Treating of catalyst support
WO2014026098A2 (en) 2012-08-10 2014-02-13 Massachusetts Institute Of Technology Pressure control in fluidic systems
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
JP1628116S (enExample) 2012-10-24 2019-04-01
EP2932266A4 (en) 2012-12-17 2016-11-30 Leukodx Ltd SYSTEMS AND METHOD FOR DETERMINING A CHEMICAL CONDITION
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
US9919129B2 (en) 2012-12-18 2018-03-20 Alcyone Lifesciences, Inc. Systems and methods for reducing or preventing backflow in a delivery system
KR102102123B1 (ko) 2012-12-21 2020-04-20 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 유체 공학 회로 및 관련 제조 방법
EP2935559B1 (en) 2012-12-21 2020-09-16 PerkinElmer Health Sciences, Inc. Fluorescence detection system
EP2934751B1 (en) 2012-12-21 2019-05-29 Micronics, Inc. Low elasticity films for microfluidic use
EP2948249A1 (en) 2013-01-22 2015-12-02 University of Washington through its Center for Commercialization Sequential delivery of fluid volumes and associated devices, systems and methods
US9676623B2 (en) 2013-03-14 2017-06-13 Velocys, Inc. Process and apparatus for conducting simultaneous endothermic and exothermic reactions
EP4220124A1 (en) 2013-03-14 2023-08-02 Cytonome/ST, LLC Hydrodynamic focusing apparatus and methods
US20160296945A1 (en) 2013-03-15 2016-10-13 Ancera, Inc. Systems and methods for active particle separation
US20160299132A1 (en) 2013-03-15 2016-10-13 Ancera, Inc. Systems and methods for bead-based assays in ferrofluids
WO2014150905A2 (en) 2013-03-15 2014-09-25 Genmark Diagnostics, Inc. Systems, methods, and apparatus for manipulating deformable fluid vessels
WO2014144340A1 (en) * 2013-03-15 2014-09-18 Ancera, Inc. Systems and methods for three-dimensional extraction of target particles ferrofluids
CN105189750B (zh) 2013-05-07 2020-07-28 珀金埃尔默健康科学有限公司 使用粘土矿物和碱性溶液制备含核酸样品的方法
JP6484222B2 (ja) 2013-05-07 2019-03-13 マイクロニクス， インコーポレイテッド 核酸の調製および分析のためのデバイス
WO2014204954A1 (en) 2013-06-17 2014-12-24 Alcyone Lifesciences, Inc. Methods and devices for protecting catheter tips and stereotactic fixtures for microcatheters
ES2738298T3 (es) 2013-07-31 2020-01-21 Alcyone Lifesciences Inc Sistemas y métodos de suministro de fármacos, tratamiento y monitoreo
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
GB201320146D0 (en) 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US20150166956A1 (en) * 2013-12-16 2015-06-18 General Electric Company Devices for separation of particulates, associated methods and systems
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
JP6480210B2 (ja) * 2014-02-28 2019-03-06 アークレイ株式会社 プラズマ発生用チップ、プラズマ発生装置およびプラズマ分光分析方法
EP3119519B1 (en) * 2014-03-21 2021-02-24 DBS System SA Device and method for separating blood
GB2528632A (en) * 2014-04-30 2016-02-03 Cambridge Entpr Ltd Fluidic analysis and separation
CN104792671B (zh) * 2014-06-12 2017-08-08 南京环康电子科技有限公司 颗粒物测量装置及测量方法
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US10806396B2 (en) 2015-01-26 2020-10-20 Alcyone Lifesciences, Inc. Drug delivery methods with tracer
DE102015202667A1 (de) * 2015-02-13 2016-08-18 Postnova Analytics Gmbh Vorrichtung für die Feldflussfraktionierung
US9868659B2 (en) 2015-04-17 2018-01-16 General Electric Company Subsurface water purification method
WO2016201218A2 (en) 2015-06-12 2016-12-15 Velocys, Inc. Synthesis gas conversion process
WO2016210348A2 (en) 2015-06-26 2016-12-29 Ancera, Inc. Background defocusing and clearing in ferrofluid-based capture assays
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
JP2019502473A (ja) 2016-01-04 2019-01-31 アルキオーネ・ライフサイエンシズ・インコーポレイテッドＡｌｃｙｏｎｅ Ｌｉｆｅｓｃｉｅｎｃｅｓ， Ｉｎｃ． 脳卒中を治療するための方法および装置
GB201611442D0 (en) 2016-06-30 2016-08-17 Lumiradx Tech Ltd Fluid control
GB2583115B (en) * 2019-04-17 2022-09-14 Ancon Tech Limited A real-time vapour extracting device
US20230014799A1 (en) * 2019-12-06 2023-01-19 The University Of North Carolina At Chapel Hill Wedge chamber device for mounting samples for microscopy
ES2933618A1 (es) * 2021-05-20 2023-02-10 Univ Malaga Métodos de optimización de diseños asistidos por aprendizaje automático y micromezcladores mecánicos diseñados con dichos métodos

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3449938A (en) * 1967-08-03 1969-06-17 Univ Utah Method for separating and detecting fluid materials
US4147621A (en) * 1977-06-28 1979-04-03 University Of Utah Method and apparatus for flow field-flow fractionation
US4214981A (en) * 1978-10-23 1980-07-29 University Of Utah Steric field-flow fractionation
US4250026A (en) * 1979-05-14 1981-02-10 University Of Utah Continuous steric FFF device for the size separation of particles
EP0189316B1 (en) * 1985-01-25 1993-03-31 Mallinckrodt Sensor Systems, Inc. Measurement or detection of chemical entities
US4894146A (en) * 1986-01-27 1990-01-16 University Of Utah Thin channel split flow process and apparatus for particle fractionation
US4737268A (en) * 1986-03-18 1988-04-12 University Of Utah Thin channel split flow continuous equilibrium process and apparatus for particle fractionation
US5039426A (en) * 1988-05-17 1991-08-13 University Of Utah Process for continuous particle and polymer separation in split-flow thin cells using flow-dependent lift forces
US4830756A (en) * 1988-07-11 1989-05-16 University Of Utah High speed separation of ultra-high molecular weight polymers by hyperlayer field-flow fractionation
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
CA1338505C (en) * 1989-02-03 1996-08-06 John Bruce Findlay Containment cuvette for pcr and method of use
US5141651A (en) * 1989-06-12 1992-08-25 University Of Utah Pinched channel inlet system for reduced relaxation effects and stopless flow injection in field-flow fractionation
US5193688A (en) * 1989-12-08 1993-03-16 University Of Utah Method and apparatus for hydrodynamic relaxation and sample concentration NIN field-flow fraction using permeable wall elements
US5322626A (en) * 1990-03-02 1994-06-21 Hewlett-Packard Company Decoupled flow and pressure setpoints in an extraction instrument using compressible fluids
DE59105165D1 (de) * 1990-11-01 1995-05-18 Ciba Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse.
US5156039A (en) * 1991-01-14 1992-10-20 University Of Utah Procedure for determining the size and size distribution of particles using sedimentation field-flow fractionation
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5240618A (en) * 1992-02-03 1993-08-31 University Of Utah Research Foundation Electrical field-flow fractionation using redox couple added to carrier fluid
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
AU677780B2 (en) * 1992-05-01 1997-05-08 Trustees Of The University Of Pennsylvania, The Microfabricated detection structures
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5288463A (en) * 1992-10-23 1994-02-22 Eastman Kodak Company Positive flow control in an unvented container
CA2155186A1 (en) * 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
JPH06265447A (ja) * 1993-03-16 1994-09-22 Hitachi Ltd 微量反応装置およびこれを使用する微量成分測定装置
FR2710279B1 (fr) * 1993-09-23 1995-11-24 Armand Ajdari Perfectionnements aux procédés et dispositifs de séparation des particules contenues dans un fluide.
EP0722541B1 (en) * 1993-10-04 1998-12-30 Research International, Inc. Micromachined flow switches
DE59410283D1 (de) * 1993-11-11 2003-06-18 Aclara Biosciences Inc Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen
JPH07232097A (ja) * 1994-02-24 1995-09-05 Power Reactor & Nuclear Fuel Dev Corp 磁気クロマトグラフィー法による群分離方法
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5707799A (en) * 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
KR100367064B1 (ko) * 1994-10-22 2003-02-19 브리티쉬 뉴클리어 퓨얼 피엘씨 비혼화성유체들간에물질을확산에의해전달하는방법및장치
WO1996012540A1 (en) * 1994-10-22 1996-05-02 Central Research Laboratories Limited Method and apparatus for diffusive transfer between immiscible fluids
EP0791238B1 (en) * 1994-11-10 2004-09-22 Orchid BioSciences, Inc. Liquid distribution system
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5549819A (en) * 1995-01-17 1996-08-27 Hewlett-Packard Company Portable extraction instrument
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis

Cited By (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001511520A (ja) * 1997-07-25 2001-08-14 ユニバーシティ オブ ワシントン 参照ｔセンサ装置での同時の分析物測定および参照平衡
JP2009001486A (ja) * 2001-04-06 2009-01-08 California Inst Of Technol 物質の結晶化の高スループットスクリーニング
WO2003008961A1 (fr) * 2001-07-11 2003-01-30 Kanagawa Academy Of Science And Technology Corps structurel a croisements tridimensionnels de microcanaux et procede de formation d'un ecoulement laminaire multiple a croisements tridimensionnels
JP2005518794A (ja) * 2002-02-27 2005-06-30 ミシガン大学リージェンツ 低運動性粒子からの運動性粒子選別方法及びそれに用いる装置
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US8567608B2 (en) 2002-04-17 2013-10-29 Cytonome/St, Llc Method and apparatus for sorting particles
US10427159B2 (en) 2002-04-17 2019-10-01 Cytonome/St, Llc Microfluidic device
US11027278B2 (en) 2002-04-17 2021-06-08 Cytonome/St, Llc Methods for controlling fluid flow in a microfluidic system
US10029263B2 (en) 2002-04-17 2018-07-24 Cytonome/St, Llc Method and apparatus for sorting particles
US10029283B2 (en) 2002-04-17 2018-07-24 Cytonome/St, Llc Method and apparatus for sorting particles
US10710120B2 (en) 2002-04-17 2020-07-14 Cytonome/St, Llc Method and apparatus for sorting particles
US9550215B2 (en) 2002-04-17 2017-01-24 Cytonome/St, Llc Method and apparatus for sorting particles
US9339850B2 (en) 2002-04-17 2016-05-17 Cytonome/St, Llc Method and apparatus for sorting particles
US8727131B2 (en) 2002-04-17 2014-05-20 Cytonome/St, Llc Method and apparatus for sorting particles
US9000357B2 (en) 2002-07-31 2015-04-07 Premium Genetics (Uk) Ltd. Multiple laminar flow-based particle and cellular identification
US11415936B2 (en) 2002-07-31 2022-08-16 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US11422504B2 (en) 2002-07-31 2022-08-23 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US8933395B2 (en) 2002-07-31 2015-01-13 Premium Genetics (Uk) Ltd. Multiple laminar flow-based particle and cellular identification
US10216144B2 (en) 2002-07-31 2019-02-26 Premium Genetics (Uk) Ltd Multiple laminar flow-based particle and cellular separation with laser steering
US9140690B2 (en) 2002-07-31 2015-09-22 Premium Genetics (Uk) Ltd. Method of identifying components in a fluid mixture
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US9977401B2 (en) 2002-07-31 2018-05-22 Premium Genetics (Uk) Ltd. Multiple laminar flow-based particle and cellular separation with laser steering
JP2005538727A (ja) * 2002-09-16 2005-12-22 サイトノーム インコーポレーテッド 粒子を分類するための方法及び装置
JP2004181298A (ja) * 2002-11-29 2004-07-02 National Institute Of Advanced Industrial & Technology マイクロリアクターとそれによる反応方法
JP2006520190A (ja) * 2003-01-21 2006-09-07 マイクロニクス， インコーポレイテッド 流体の微小流体的な操作、増幅、および分析（例えば、細菌アッセイおよびアンチグロブリン試験）のための方法およびシステム
US7588550B2 (en) 2003-03-14 2009-09-15 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
JP2006520246A (ja) * 2003-03-14 2006-09-07 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク マイクロ流体無膜交換装置を有する血液ベースの治療のためのシステム及び方法
JP2005046651A (ja) * 2003-05-30 2005-02-24 Fuji Photo Film Co Ltd マイクロリアクターを用いた反応方法
JP2017026629A (ja) * 2003-09-04 2017-02-02 プレミアム ジェネティクス （ユーケー） リミテッド レーザ操縦を用いた多層流に基づく粒子及び細胞の分離
JP2012073268A (ja) * 2003-09-04 2012-04-12 Arryx Inc レーザ操縦を用いた多層流に基づく粒子及び細胞の分離
JP2005329364A (ja) * 2004-05-21 2005-12-02 Dkk Toa Corp 気液反応ユニットおよび分析装置
JP2005329365A (ja) * 2004-05-21 2005-12-02 Dkk Toa Corp 気液反応ユニットおよび分析装置
US10994273B2 (en) 2004-12-03 2021-05-04 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US8087515B2 (en) 2008-09-25 2012-01-03 Fuji Xerox Co., Ltd. Separation method and separation apparatus
US10107797B2 (en) 2008-10-03 2018-10-23 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
US8365922B2 (en) 2009-03-26 2013-02-05 Fuji Xerox Co., Ltd. Classifying method and classifying device
JP2013536952A (ja) * 2010-09-07 2013-09-26 マルチ−センス テクノロジーズ リミテッド アッセイ装置及び読み取り装置
US11965816B2 (en) 2010-11-16 2024-04-23 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US11193879B2 (en) 2010-11-16 2021-12-07 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
US11016108B2 (en) 2013-05-07 2021-05-25 Perkinelmer Health Sciences, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
US11187224B2 (en) 2013-07-16 2021-11-30 Abs Global, Inc. Microfluidic chip
US11512691B2 (en) 2013-07-16 2022-11-29 Abs Global, Inc. Microfluidic chip
US11415503B2 (en) 2013-10-30 2022-08-16 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US11639888B2 (en) 2013-10-30 2023-05-02 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
JP2020534142A (ja) * 2017-09-19 2020-11-26 ハイファイバイオ エスアエス マイクロ流体システムにおける粒子選別
WO2019078277A1 (ja) * 2017-10-19 2019-04-25 株式会社 ＴＬ Ｇｅｎｏｍｉｃｓ 細胞分級用チップ
JPWO2019078277A1 (ja) * 2017-10-19 2019-11-14 株式会社 ＴＬ Ｇｅｎｏｍｉｃｓ 細胞分級用チップ
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
US12337320B2 (en) 2018-05-23 2025-06-24 Abs Global, Inc. Systems and methods for particle focusing in microchannels
US11889830B2 (en) 2019-04-18 2024-02-06 Abs Global, Inc. System and process for continuous addition of cryoprotectant
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US12135270B2 (en) 2020-11-23 2024-11-05 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples
US12497648B2 (en) 2021-10-21 2025-12-16 Abs Global, Inc. Methods and systems for processing genetic samples to determine identity or detect contamination

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