JPH08509493A - プロトンポンプ阻害剤含有獣医薬組成物 - Google Patents
プロトンポンプ阻害剤含有獣医薬組成物Info
- Publication number
- JPH08509493A JPH08509493A JP6524159A JP52415994A JPH08509493A JP H08509493 A JPH08509493 A JP H08509493A JP 6524159 A JP6524159 A JP 6524159A JP 52415994 A JP52415994 A JP 52415994A JP H08509493 A JPH08509493 A JP H08509493A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- gel
- dry
- composition according
- proton pump
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.ペースト様ゲル中に組み入れられているビーズ又は錠剤の形態のプロトンポ ンプ阻害剤よりなり、ビーズ又は錠剤はその1つが腸溶被膜である1つ又はそれ より多くの被膜で被覆されている動物に経口投与するための医薬組成物。 2.ビーズ又は錠剤が一方はサブコートであり、他方は腸溶被膜である少なくと も2つの被膜で被覆されている請求項1記載の医薬組成物。 3.医薬組成物がウマに経口投与することを意図されている請求項1〜2のいず れか一項記載の組成物。 4.場合によっては乾燥成分と混合された、プロトンポンプ阻害剤の乾燥腸溶型 ビーズ又は錠剤である成分よりなり、これら成分は水又は水溶液を添加するとペ ースト様ゲルを生じる請求項1〜2のいずれか一項記載の医薬組成物。 5.プロトンポンプ阻害剤の乾燥腸溶型ビーズ又は錠剤、乾燥ゲル化剤及び場合 によってはpH緩衝及び(又は)香味物質である成分よりなり、これら成分は水を 添加するとペースト様ゲルを生じる請求項1〜2のいずれか一項記載の医薬組成 物。 6.プロトンポンプ阻害剤の乾燥腸溶型ビーズ又は錠剤、乾燥ゲル化剤及び場合 によってはpH緩衝及び(又は)香味物質が混合されて乾燥混合物を得、その後水 又は水溶液を添加する請求項1〜2のいずれか一項記載の医薬組成物。 7.混合物が配列型混合物である請求項6記載の医薬組成物。 8.プロトンポンプ阻害剤の乾燥腸溶型ビーズ又は錠剤、カリウム、カルシウム 、マグネシウム又はアルミニウムの水溶性有機又は無 機塩及び場合によってはpH緩衝及び(又は)香味物質である第一の群の成分、並 びにゲル化剤の水溶液である第二の群の成分よりなり、これら成分の群は混合す るときペースト様ゲルを生じる請求項1〜2のいずれか一項記載の医薬組成物。 9.場合によっては乾燥pH緩衝及び(又は)香味物質と混合された、プロトンポ ンプ阻害剤の乾燥腸溶型ビーズ又は錠剤である第一の群の成分、並びに感温性ゲ ル化剤の水溶液である第二の群の成分 りなり、これら成分の群は混合し、そし てゆるやかに加熱するときペースト様ゲルを生じる請求項1〜2のいずれか一項 記載の医薬組成物。 10.プロトンポンプ阻害剤がオメプラゾールである請求項1記載の医薬組成物。 11.プロトンポンプ阻害剤がランソプラゾールである請求項1記載の医薬組成物 。 12.プロトンポンプ阻害剤がパントプラゾールである請求項1記載の医薬組成物 。 13.プロトンポンプ阻害剤がレミノプラゾールである請求項1記載の医薬組成物 。 14.プロトンポンプ阻害剤の乾燥腸溶型ビーズ又は錠剤及び乾燥成分よりなり、 これら成分は水又は水溶液を添加するとペースト様ゲルを生じるキットの形態の 安定な医薬組成物。 15.プロトンポンプ阻害剤の乾燥腸溶型ビーズ又は錠剤、カリウム、カルシウム 、マグネシウム又はアルミニウムの水溶性有機又は無機塩及び場合によってはpH 緩衝及び(又は)香味物質である第一の群の成分、並びに乾燥ゲル化剤である第 二の群の成分よりなり、 これら成分の群は水の存在下で混合するときペースト様ゲルを生じるキットの形 態の安定な医薬組成物。 16.場合によっては乾燥pH緩衝及び(又は)香味物質と混合された、プロトンポ ンプ阻害剤の乾燥腸溶型ビーズ又は錠剤である第一の群の成分、並びに感温性ゲ ル化剤である第二の群の成分よりなり、これら成分の群は水の存在下で混合し、 そしてゆるやかに加熱するときペースト様ゲルを生じるキットの形態の安定な医 薬組成物。 17.完全な形の組成物又はその部分がシリンジの形態のアプリケーター中に分配 されることを特徴とする請求項1、15又は16のいずれか一項記載の医薬組成物。 18.その1つが腸溶被膜である1つ又はそれより多くの被膜で被覆されているビ ーズの形態のプロトンポンプ阻害剤をペースト様ゲル中に組み入れることを特徴 とする請求項1記載の医薬組成物の製法。 19.動物における胃酸関連疾患の処置のための活性投薬形態の製造における請求 項1、15又は16のいずれか一項記載の組成物の使用。 20.請求項1、15又は16記載の組成物の生理活性量が胃酸関連疾患の処置を必要 とする動物に投与される上記疾患の処置法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9301489-2 | 1993-04-30 | ||
SE19939301489A SE9301489D0 (sv) | 1993-04-30 | 1993-04-30 | Veterinary composition |
PCT/SE1994/000368 WO1994025070A1 (en) | 1993-04-30 | 1994-04-26 | Veterinary composition containing a proton pump inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08509493A true JPH08509493A (ja) | 1996-10-08 |
JP3872509B2 JP3872509B2 (ja) | 2007-01-24 |
Family
ID=20389791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52415994A Expired - Fee Related JP3872509B2 (ja) | 1993-04-30 | 1994-04-26 | プロトンポンプ阻害剤含有獣医薬組成物 |
Country Status (33)
Country | Link |
---|---|
US (1) | US5731002A (ja) |
EP (1) | EP0696921B1 (ja) |
JP (1) | JP3872509B2 (ja) |
KR (1) | KR100324451B1 (ja) |
CN (1) | CN1100570C (ja) |
AT (1) | ATE199060T1 (ja) |
AU (1) | AU678830B2 (ja) |
BR (1) | BR9406363A (ja) |
CZ (1) | CZ285191B6 (ja) |
DE (1) | DE69426669T2 (ja) |
DK (1) | DK0696921T3 (ja) |
EE (1) | EE03137B1 (ja) |
EG (1) | EG20401A (ja) |
ES (1) | ES2155473T3 (ja) |
FI (1) | FI955124A0 (ja) |
GR (1) | GR3035831T3 (ja) |
HR (1) | HRP940267A2 (ja) |
HU (1) | HUT74868A (ja) |
IL (1) | IL109245A (ja) |
IS (1) | IS1694B (ja) |
LT (1) | LT3263B (ja) |
MA (1) | MA23170A1 (ja) |
NO (1) | NO312435B1 (ja) |
NZ (1) | NZ265728A (ja) |
PL (1) | PL176755B1 (ja) |
PT (1) | PT696921E (ja) |
RU (1) | RU2131267C1 (ja) |
SE (1) | SE9301489D0 (ja) |
SG (1) | SG52540A1 (ja) |
SK (1) | SK280465B6 (ja) |
TN (1) | TNSN94035A1 (ja) |
WO (1) | WO1994025070A1 (ja) |
YU (1) | YU22794A (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005533832A (ja) * | 2002-07-03 | 2005-11-10 | アボット・ラボラトリーズ | 酸不安定性薬物の液体剤形 |
JP2005535661A (ja) * | 2002-07-03 | 2005-11-24 | アボット・ラボラトリーズ | プロトンポンプ阻害剤の液体剤形 |
JP2006176461A (ja) * | 2004-12-24 | 2006-07-06 | Dai Ichi Seiyaku Co Ltd | 粒状物 |
JP2008525433A (ja) * | 2004-12-22 | 2008-07-17 | アストラゼネカ・アクチエボラーグ | プロトンポンプインヒビターを包含する固形剤形およびそれから調製された懸濁剤 |
JP2014530855A (ja) * | 2011-10-19 | 2014-11-20 | アール.ピー. シェーラーテクノロジーズ エルエルシー | 二相式薬剤送達システム |
JP2019524815A (ja) * | 2016-08-11 | 2019-09-05 | アダミス ファーマシューティカルズ コーポレーション | 医薬組成物 |
Families Citing this family (54)
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US5708017A (en) * | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
US6699885B2 (en) | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
ES2194515T3 (es) * | 1998-10-06 | 2003-11-16 | Mars Uk Ltd | Estereotipia en animales. |
JP2002537337A (ja) | 1999-02-23 | 2002-11-05 | メルク エンド カムパニー インコーポレーテッド | プロトンポンプ阻害薬を含む医薬組成物 |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6780880B1 (en) * | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
US20020064555A1 (en) * | 2000-09-29 | 2002-05-30 | Dan Cullen | Proton pump inhibitor formulation |
DE10061135C1 (de) * | 2000-12-07 | 2002-11-07 | Byk Gulden Lomberg Chem Fab | Pharmazeutische Zubereitung in Form einer Paste enthaltend einen säurelabilen Wirkstoff |
US7357943B2 (en) | 2000-12-07 | 2008-04-15 | Nycomed Gmbh | Pharmaceutical preparation in the form of a suspension comprising an acid-labile active ingredient |
CA2430816C (en) * | 2000-12-07 | 2012-05-15 | Altana Pharma Ag | Pharmaceutical preparation in the form of a paste comprising an acid-labile active ingredient |
US20020192299A1 (en) * | 2000-12-28 | 2002-12-19 | Rajneesh Taneja | Pharmaceutical compositions of a non-enteric coated proton pump inhibitor with a carbonate salt and bicarbonate salt combination |
CA2472103A1 (en) * | 2002-01-25 | 2003-08-07 | Santarus, Inc. | Transmucosal delivery of proton pump inhibitors |
CO5400144A1 (es) * | 2002-03-11 | 2004-05-31 | Novartis Ag | Compuestos organicos |
US20030228363A1 (en) * | 2002-06-07 | 2003-12-11 | Patel Mahendra R. | Stabilized pharmaceutical compositons containing benzimidazole compounds |
US20040082618A1 (en) * | 2002-07-03 | 2004-04-29 | Rajneesh Taneja | Liquid dosage forms of acid labile drugs |
US20040081671A1 (en) * | 2002-07-03 | 2004-04-29 | Rajneesh Taneja | Liquid dosage forms of non-enterically coated acid-labile drugs |
US20040006109A1 (en) * | 2002-07-03 | 2004-01-08 | Rajneesh Taneja | Liquid dosage forms of non-enterically coated acid-labile drugs |
US20040121004A1 (en) * | 2002-12-20 | 2004-06-24 | Rajneesh Taneja | Dosage forms containing a PPI, NSAID, and buffer |
US20070243251A1 (en) * | 2002-12-20 | 2007-10-18 | Rajneesh Taneja | Dosage Forms Containing A PPI, NSAID, and Buffer |
CA2517005A1 (en) * | 2003-02-20 | 2004-09-02 | Santarus, Inc. | A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
DE602004025113D1 (de) * | 2003-07-11 | 2010-03-04 | Astrazeneca Ab | Feste zusammensetzung mit einem protonenpumpenhemmer |
AR045062A1 (es) * | 2003-07-18 | 2005-10-12 | Santarus Inc | Formulaciones farmaceuticas para inhibir la secrecion de acido y metodos para preparar y utilizarlas |
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GB0403165D0 (en) * | 2004-02-12 | 2004-03-17 | Ct | Novel uses for proton pump inhibitors |
US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
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US7803817B2 (en) * | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
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-
1993
- 1993-04-30 SE SE19939301489A patent/SE9301489D0/xx unknown
-
1994
- 1994-04-06 IS IS4146A patent/IS1694B/is unknown
- 1994-04-07 IL IL10924594A patent/IL109245A/xx not_active IP Right Cessation
- 1994-04-22 HR HR9301489-2A patent/HRP940267A2/hr not_active Application Discontinuation
- 1994-04-22 MA MA23476A patent/MA23170A1/fr unknown
- 1994-04-22 LT LTIP1920A patent/LT3263B/lt not_active IP Right Cessation
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2005533832A (ja) * | 2002-07-03 | 2005-11-10 | アボット・ラボラトリーズ | 酸不安定性薬物の液体剤形 |
JP2005535661A (ja) * | 2002-07-03 | 2005-11-24 | アボット・ラボラトリーズ | プロトンポンプ阻害剤の液体剤形 |
JP2012021008A (ja) * | 2002-07-03 | 2012-02-02 | Abbott Lab | 酸不安定性薬物の液体剤形 |
JP2017206525A (ja) * | 2002-07-03 | 2017-11-24 | タケダ ファーマシューティカルズ ユー.エス.エー. インコーポレイティド | 酸不安定性薬物の液体剤形 |
JP2008525433A (ja) * | 2004-12-22 | 2008-07-17 | アストラゼネカ・アクチエボラーグ | プロトンポンプインヒビターを包含する固形剤形およびそれから調製された懸濁剤 |
JP2006176461A (ja) * | 2004-12-24 | 2006-07-06 | Dai Ichi Seiyaku Co Ltd | 粒状物 |
JP2014530855A (ja) * | 2011-10-19 | 2014-11-20 | アール.ピー. シェーラーテクノロジーズ エルエルシー | 二相式薬剤送達システム |
JP2019524815A (ja) * | 2016-08-11 | 2019-09-05 | アダミス ファーマシューティカルズ コーポレーション | 医薬組成物 |
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