JPH0772175B2 - 窒素含有非芳香族複素環の縮合環類似体 - Google Patents

窒素含有非芳香族複素環の縮合環類似体

Info

Publication number
JPH0772175B2
JPH0772175B2 JP3517076A JP51707691A JPH0772175B2 JP H0772175 B2 JPH0772175 B2 JP H0772175B2 JP 3517076 A JP3517076 A JP 3517076A JP 51707691 A JP51707691 A JP 51707691A JP H0772175 B2 JPH0772175 B2 JP H0772175B2
Authority
JP
Japan
Prior art keywords
phenyl
amino
azabicyclo
formula
methoxybenzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP3517076A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06501267A (ja
Inventor
デイサイ，マノフ・シー
ハワード，ハリー・アール
ローゼン，テリー・ジエイ
Original Assignee
フアイザー・インコーポレイテツド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フアイザー・インコーポレイテツド filed Critical フアイザー・インコーポレイテツド
Publication of JPH06501267A publication Critical patent/JPH06501267A/ja
Publication of JPH0772175B2 publication Critical patent/JPH0772175B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Eye Examination Apparatus (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Electroluminescent Light Sources (AREA)
JP3517076A 1990-09-28 1991-08-20 窒素含有非芳香族複素環の縮合環類似体 Expired - Fee Related JPH0772175B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59042390A 1990-09-28 1990-09-28
US590423 1990-09-28
PCT/US1991/005776 WO1992006079A1 (en) 1990-09-28 1991-08-20 Fused ring analogs of nitrogen containing nonaromatic heterocycles

Publications (2)

Publication Number Publication Date
JPH06501267A JPH06501267A (ja) 1994-02-10
JPH0772175B2 true JPH0772175B2 (ja) 1995-08-02

Family

ID=24362216

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3517076A Expired - Fee Related JPH0772175B2 (ja) 1990-09-28 1991-08-20 窒素含有非芳香族複素環の縮合環類似体

Country Status (22)

Country Link
EP (1) EP0550635B1 (enExample)
JP (1) JPH0772175B2 (enExample)
CN (1) CN1060285A (enExample)
AT (1) ATE121389T1 (enExample)
AU (1) AU651145B2 (enExample)
BR (1) BR9106905A (enExample)
CA (1) CA2089736A1 (enExample)
CZ (1) CZ387492A3 (enExample)
DE (1) DE69109125T2 (enExample)
DK (1) DK0550635T3 (enExample)
ES (1) ES2071334T3 (enExample)
FI (1) FI931370L (enExample)
HU (1) HUT68667A (enExample)
IE (1) IE66042B1 (enExample)
IL (1) IL99525A0 (enExample)
MX (1) MX9101274A (enExample)
NO (1) NO931151D0 (enExample)
PT (1) PT99064A (enExample)
TW (1) TW199144B (enExample)
WO (1) WO1992006079A1 (enExample)
YU (1) YU159291A (enExample)
ZA (1) ZA917744B (enExample)

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JPH07110850B2 (ja) * 1991-06-20 1995-11-29 フアイザー・インコーポレイテツド 窒素含有複素環化合物のフルオロアルコキシベンジルアミノ誘導体
TW202432B (enExample) * 1991-06-21 1993-03-21 Pfizer
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EP0916346A3 (en) * 1991-09-20 2000-12-06 Glaxo Group Limited NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis
WO1993010073A1 (en) * 1991-11-12 1993-05-27 Pfizer Inc. Acyclic ethylenediamine derivatives as substance p receptor antagonists
WO1993023380A1 (en) * 1992-05-18 1993-11-25 Pfizer Inc. Bridged aza-bicyclic derivatives as substance p antagonists
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US6048859A (en) 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
AU4396193A (en) * 1992-08-04 1994-03-03 Pfizer Inc. 3-benzylamino-2-phenyl-piperidine derivatives as substance p receptor antagonists
GB9216911D0 (en) * 1992-08-10 1992-09-23 Merck Sharp & Dohme Therapeutic agents
EP1114823A3 (en) * 1992-08-19 2001-07-18 Pfizer Inc. Substituted benzylamino nitrogen containing non-aromatic heterocycles
US5387595A (en) * 1992-08-26 1995-02-07 Merck & Co., Inc. Alicyclic compounds as tachykinin receptor antagonists
US5344830A (en) * 1992-12-10 1994-09-06 Merck & Co., Inc. N,N-diacylpiperazine tachykinin antagonists
DE69328975T2 (de) * 1992-12-10 2000-11-09 Pfizer Inc., New York Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten
US5830854A (en) * 1992-12-14 1998-11-03 Merck Sharp & Dohme, Limited Method of treating cystic fibrosis using a tachykinin receptor antagonist
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
US5854262A (en) * 1993-10-07 1998-12-29 Pfizer Inc. Aminomethylene substituted non-aromatic heterocycles and use as substance P antagonists
US5610165A (en) * 1994-02-17 1997-03-11 Merck & Co., Inc. N-acylpiperidine tachykinin antagonists
TW385308B (en) * 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
TW397825B (en) * 1994-10-14 2000-07-11 Novartis Ag Aroyl-piperidine derivatives
FR2725900B1 (fr) * 1994-10-21 1997-07-18 Sanofi Sa Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
TW458774B (en) 1995-10-20 2001-10-11 Pfizer Antiemetic pharmaceutical compositions
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US6245817B1 (en) 1997-02-14 2001-06-12 Bayer Corporation NPY5 receptor antagonists and methods for using same
RU2309953C2 (ru) 1999-11-03 2007-11-10 Эймр Текнолоджи, Инк. Арил- и гетероарилзамещенные тетрагидроизохинолины, фармацевтическая композиция и способ лечения на их основе
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
DE60112064T2 (de) * 2000-04-10 2006-06-01 Pfizer Products Inc., Groton Benzoamid-piperidin verbindungen als substanz p-antagonisten
US7119207B2 (en) 2000-04-10 2006-10-10 Pfizer Inc Benzoamide piperidine containing compounds and related compounds
CN100430401C (zh) 2000-07-11 2008-11-05 Amr科技公司 新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
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US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
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Citations (1)

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Publication number Priority date Publication date Assignee Title
US3452026A (en) * 1966-03-15 1969-06-24 Bristol Myers Co Substituted 1,2,3,4-tetrahydroquinolines

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US3452026A (en) * 1966-03-15 1969-06-24 Bristol Myers Co Substituted 1,2,3,4-tetrahydroquinolines

Also Published As

Publication number Publication date
CA2089736A1 (en) 1992-03-29
JPH06501267A (ja) 1994-02-10
CZ387492A3 (en) 1994-02-16
IL99525A0 (en) 1992-08-18
AU651145B2 (en) 1994-07-14
HU9300898D0 (en) 1993-06-28
BR9106905A (pt) 1993-08-17
DE69109125D1 (de) 1995-05-24
FI931370A0 (fi) 1993-03-26
CN1060285A (zh) 1992-04-15
IE913396A1 (en) 1992-04-08
FI931370A7 (fi) 1993-03-26
MX9101274A (es) 1992-05-04
AU8746391A (en) 1992-04-28
NO931151L (no) 1993-03-26
HUT68667A (en) 1995-07-28
EP0550635B1 (en) 1995-04-19
FI931370L (fi) 1993-03-26
DK0550635T3 (da) 1995-09-04
TW199144B (enExample) 1993-02-01
ES2071334T3 (es) 1995-06-16
YU159291A (sh) 1994-01-20
ATE121389T1 (de) 1995-05-15
WO1992006079A1 (en) 1992-04-16
EP0550635A1 (en) 1993-07-14
PT99064A (pt) 1992-08-31
NO931151D0 (no) 1993-03-26
DE69109125T2 (de) 1995-09-28
ZA917744B (en) 1993-03-29
IE66042B1 (en) 1995-12-13

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