JPH0768244B2 - アザビシクロ［２，２，２オクタン−３−イミン類を製造するための方法と中間体 - Google Patents

アザビシクロ［２，２，２オクタン−３−イミン類を製造するための方法と中間体

Info

Publication number
JPH0768244B2
JPH0768244B2 JP4-502391A JP50239192A JPH0768244B2 JP H0768244 B2 JPH0768244 B2 JP H0768244B2 JP 50239192 A JP50239192 A JP 50239192A JP H0768244 B2 JPH0768244 B2 JP H0768244B2
Authority
JP
Japan
Prior art keywords
compound
formula
reaction
alkoxy
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP4-502391A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05508867A (ja
Inventor
ゴデク，デニス・エム
マーティアショー，チャールズ・ダブリュー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPH05508867A publication Critical patent/JPH05508867A/ja
Publication of JPH0768244B2 publication Critical patent/JPH0768244B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP4-502391A 1991-01-03 1991-12-18 アザビシクロ［２，２，２オクタン−３−イミン類を製造するための方法と中間体 Expired - Lifetime JPH0768244B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/637,102 US5138060A (en) 1991-01-03 1991-01-03 Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
US637102 1991-01-03
PCT/US1991/009186 WO1992012152A1 (en) 1991-01-03 1991-12-18 Process and intermediates for preparing azabicyclo[2.2.2]octan-3-imines

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP6322355A Division JP2703193B2 (ja) 1991-01-03 1994-12-26 ２−ジフェニルメチル−ｎ−［（２−メトキシフェニル）メチル］−１−アザビシクロ［２，２，２］オクタン−３−アミンのシス化合物のラセミ混合物の分割方法
JP6322350A Division JP2845425B2 (ja) 1991-01-03 1994-12-26 アザビシクロ［２，２，２］オクタン−３−イミン類を製造するための中間体の製造方法
JP6322353A Division JP2583026B2 (ja) 1991-01-03 1994-12-26 ２−ジフェニルメチル−ｎ−フェニルメチル−１−アザビシクロ［２，２，２］オクタン−３−アミン化合物類のシス化合物の製造方法

Publications (2)

Publication Number Publication Date
JPH05508867A JPH05508867A (ja) 1993-12-09
JPH0768244B2 true JPH0768244B2 (ja) 1995-07-26

Family

ID=24554545

Family Applications (5)

Application Number Title Priority Date Filing Date
JP4-502391A Expired - Lifetime JPH0768244B2 (ja) 1991-01-03 1991-12-18 アザビシクロ［２，２，２オクタン−３−イミン類を製造するための方法と中間体
JP4502391A Pending JPH0768244B1 (enExample) 1991-01-03 1991-12-18
JP6322350A Expired - Fee Related JP2845425B2 (ja) 1991-01-03 1994-12-26 アザビシクロ［２，２，２］オクタン−３−イミン類を製造するための中間体の製造方法
JP6322355A Expired - Fee Related JP2703193B2 (ja) 1991-01-03 1994-12-26 ２−ジフェニルメチル−ｎ−［（２−メトキシフェニル）メチル］−１−アザビシクロ［２，２，２］オクタン−３−アミンのシス化合物のラセミ混合物の分割方法
JP6322353A Expired - Fee Related JP2583026B2 (ja) 1991-01-03 1994-12-26 ２−ジフェニルメチル−ｎ−フェニルメチル−１−アザビシクロ［２，２，２］オクタン−３−アミン化合物類のシス化合物の製造方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP4502391A Pending JPH0768244B1 (enExample) 1991-01-03 1991-12-18
JP6322350A Expired - Fee Related JP2845425B2 (ja) 1991-01-03 1994-12-26 アザビシクロ［２，２，２］オクタン−３−イミン類を製造するための中間体の製造方法
JP6322355A Expired - Fee Related JP2703193B2 (ja) 1991-01-03 1994-12-26 ２−ジフェニルメチル−ｎ−［（２−メトキシフェニル）メチル］−１−アザビシクロ［２，２，２］オクタン−３−アミンのシス化合物のラセミ混合物の分割方法
JP6322353A Expired - Fee Related JP2583026B2 (ja) 1991-01-03 1994-12-26 ２−ジフェニルメチル−ｎ−フェニルメチル−１−アザビシクロ［２，２，２］オクタン−３−アミン化合物類のシス化合物の製造方法

Country Status (21)

Country Link
US (1) US5138060A (enExample)
EP (1) EP0565558B1 (enExample)
JP (5) JPH0768244B2 (enExample)
KR (1) KR970001157B1 (enExample)
AT (1) ATE115580T1 (enExample)
AU (1) AU653380B2 (enExample)
CA (2) CA2098989C (enExample)
DE (1) DE69106003T2 (enExample)
DK (1) DK0565558T3 (enExample)
ES (1) ES2065161T3 (enExample)
FI (3) FI933065A7 (enExample)
GR (1) GR3015021T3 (enExample)
HU (1) HU9301931D0 (enExample)
IE (1) IE65005B1 (enExample)
IL (1) IL100541A0 (enExample)
MX (1) MX9200003A (enExample)
NO (1) NO932431L (enExample)
NZ (1) NZ241161A (enExample)
PT (1) PT99970B (enExample)
WO (1) WO1992012152A1 (enExample)
ZA (1) ZA928B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364943A (en) * 1991-11-27 1994-11-15 Pfizer Inc. Preparation of substituted piperidines
CA2109613C (en) * 1991-06-20 1996-11-19 John Adams Lowe Iii Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
CA2123403C (en) * 1991-11-12 2002-02-05 Brian T. O'neill Acyclic ethylenediamine derivatives as substance p receptor antagonists
ES2164657T3 (es) * 1992-05-18 2002-03-01 Pfizer Derivados aza-biciclicos puenteados como antagonistas de la sustancia p.
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
US6048859A (en) * 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
WO1994003445A1 (en) * 1992-08-04 1994-02-17 Pfizer Inc. 3-benzylamino-2-phenyl-piperidine derivatives as substance p receptor antagonists
US5387595A (en) * 1992-08-26 1995-02-07 Merck & Co., Inc. Alicyclic compounds as tachykinin receptor antagonists
US5518628A (en) * 1993-11-08 1996-05-21 Shipley Company Inc. Purification process
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
US6861526B2 (en) 2002-10-16 2005-03-01 Pfizer Inc. Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
WO2005045395A2 (en) * 2003-10-27 2005-05-19 Meyer Donald W Method of detecting bovine spongiform encephalopathy

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560510A (en) * 1969-03-05 1971-02-02 Aldrich Chem Co Inc 2-benzhydrylquinuclidines
US3993652A (en) * 1973-07-09 1976-11-23 Air Products And Chemicals, Inc. Cyclic quaternary hydroxyalkyl phenoxide catalysts for isocyanate reactions
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
FR2529548A1 (fr) * 1982-07-02 1984-01-06 Delalande Sa Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
JPS59110656A (ja) * 1982-12-15 1984-06-26 Hiroyuki Nohira 光学活性な１―フェニル―２―（パラ―トリル）エチルアミンの製造方法
DE3604591A1 (de) * 1986-02-14 1987-08-20 Degussa Verfahren zur herstellung chiraler glycinderivate
JPS6354342A (ja) * 1986-08-26 1988-03-08 Daicel Chem Ind Ltd （±）−α−エチルベンジルアミンの光学分割方法
JPS63145256A (ja) * 1986-12-09 1988-06-17 Nippon Kayaku Co Ltd 光学活性ホモフエニルアラニンの製造法及び中間体
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
CZ247993A3 (en) * 1991-05-22 1994-07-13 Pfizer Substituted 3-aminoquinuclidine derivatives, process of their preparation and use thereof

Also Published As

Publication number Publication date
ES2065161T3 (es) 1995-02-01
NO932431D0 (no) 1993-07-02
FI933065L (fi) 1993-07-02
GR3015021T3 (en) 1995-05-31
EP0565558A1 (en) 1993-10-20
ATE115580T1 (de) 1994-12-15
AU9129891A (en) 1992-08-17
FI933065A0 (fi) 1993-07-02
KR930703312A (ko) 1993-11-29
JPH0768244B1 (enExample) 1995-07-26
FI20001109A7 (fi) 2000-05-10
CA2158130A1 (en) 1992-07-04
EP0565558B1 (en) 1994-12-14
FI20001108A7 (fi) 2000-05-10
JP2845425B2 (ja) 1999-01-13
HU9301931D0 (en) 1993-12-28
NO932431L (no) 1993-07-02
CA2098989A1 (en) 1992-07-04
CA2158130C (en) 1998-07-14
DK0565558T3 (da) 1995-03-06
IE65005B1 (en) 1995-10-04
US5138060A (en) 1992-08-11
FI933065A7 (fi) 1993-07-02
JPH05508867A (ja) 1993-12-09
JP2583026B2 (ja) 1997-02-19
CA2098989C (en) 1998-02-03
NZ241161A (en) 1994-10-26
IL100541A0 (en) 1992-09-06
IE920001A1 (en) 1992-07-15
FI20001108L (fi) 2000-05-10
JP2703193B2 (ja) 1998-01-26
AU653380B2 (en) 1994-09-29
PT99970A (pt) 1993-02-26
DE69106003D1 (de) 1995-01-26
DE69106003T2 (de) 1995-04-27
JPH07316154A (ja) 1995-12-05
MX9200003A (es) 1992-07-01
KR970001157B1 (ko) 1997-01-29
ZA928B (en) 1993-07-02
WO1992012152A1 (en) 1992-07-23
JPH07316153A (ja) 1995-12-05
JPH07330766A (ja) 1995-12-19
FI20001109L (fi) 2000-05-10
PT99970B (pt) 1999-06-30

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