NO932431L - Fremgangsmaate og mellomprodukter for fremstilling av azabicyklo(2,2,2)oktan-3-iminer - Google Patents

Fremgangsmaate og mellomprodukter for fremstilling av azabicyklo(2,2,2)oktan-3-iminer

Info

Publication number
NO932431L
NO932431L NO93932431A NO932431A NO932431L NO 932431 L NO932431 L NO 932431L NO 93932431 A NO93932431 A NO 93932431A NO 932431 A NO932431 A NO 932431A NO 932431 L NO932431 L NO 932431L
Authority
NO
Norway
Prior art keywords
octan
azabicyclo
imines
intermediates
procedure
Prior art date
Application number
NO93932431A
Other languages
English (en)
Other versions
NO932431D0 (no
Inventor
Dennis M Godek
Charles W Murtiashaw
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO932431D0 publication Critical patent/NO932431D0/no
Publication of NO932431L publication Critical patent/NO932431L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

Azabicyklo[2.2.2]oktan-3-iminer med den generelle formel (I), hvor Rj, Rog Rer som angitt i beskrivelsen, fremstil-les ved omsetning av en forbindelse med formel (II) med en forbindelse med formel (III) hvor A er MgCl, MgBr eller Li.
NO93932431A 1991-01-03 1993-07-02 Fremgangsmaate og mellomprodukter for fremstilling av azabicyklo(2,2,2)oktan-3-iminer NO932431L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/637,102 US5138060A (en) 1991-01-03 1991-01-03 Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
PCT/US1991/009186 WO1992012152A1 (en) 1991-01-03 1991-12-18 Process and intermediates for preparing azabicyclo[2.2.2]octan-3-imines

Publications (2)

Publication Number Publication Date
NO932431D0 NO932431D0 (no) 1993-07-02
NO932431L true NO932431L (no) 1993-07-02

Family

ID=24554545

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93932431A NO932431L (no) 1991-01-03 1993-07-02 Fremgangsmaate og mellomprodukter for fremstilling av azabicyklo(2,2,2)oktan-3-iminer

Country Status (21)

Country Link
US (1) US5138060A (no)
EP (1) EP0565558B1 (no)
JP (5) JPH05508867A (no)
KR (1) KR970001157B1 (no)
AT (1) ATE115580T1 (no)
AU (1) AU653380B2 (no)
CA (2) CA2098989C (no)
DE (1) DE69106003T2 (no)
DK (1) DK0565558T3 (no)
ES (1) ES2065161T3 (no)
FI (3) FI933065A (no)
GR (1) GR3015021T3 (no)
HU (1) HU9301931D0 (no)
IE (1) IE65005B1 (no)
IL (1) IL100541A0 (no)
MX (1) MX9200003A (no)
NO (1) NO932431L (no)
NZ (1) NZ241161A (no)
PT (1) PT99970B (no)
WO (1) WO1992012152A1 (no)
ZA (1) ZA928B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364943A (en) * 1991-11-27 1994-11-15 Pfizer Inc. Preparation of substituted piperidines
RU2114848C1 (ru) * 1991-06-20 1998-07-10 Пфайзер Инк. Фторалкоксибензиламинные производные азотсодержащих гетероциклов, фармацевтическая композиция, способ ингибирования действия вещества р у млекопитающих
AU2681392A (en) * 1991-11-12 1993-06-15 Pfizer Inc. Acyclic ethylenediamine derivatives as substance p receptor antagonists
CA2134964C (en) * 1992-05-18 1997-12-30 Manoj C. Desai Bridged aza-bicyclic derivatives as substance p antagonists
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US6048859A (en) 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
US5688804A (en) * 1992-08-04 1997-11-18 Pfizer Inc. 3-Benzylamino-2-phenyl-piperidine derivatives as substance P receptor antagonists
US5387595A (en) * 1992-08-26 1995-02-07 Merck & Co., Inc. Alicyclic compounds as tachykinin receptor antagonists
US5518628A (en) * 1993-11-08 1996-05-21 Shipley Company Inc. Purification process
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
US6861526B2 (en) 2002-10-16 2005-03-01 Pfizer Inc. Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
US20050136487A1 (en) * 2003-10-27 2005-06-23 Meyer Donald W. Transmissible spongiform encephalopathy detection in cervids, sheep and goats

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560510A (en) * 1969-03-05 1971-02-02 Aldrich Chem Co Inc 2-benzhydrylquinuclidines
US3993652A (en) * 1973-07-09 1976-11-23 Air Products And Chemicals, Inc. Cyclic quaternary hydroxyalkyl phenoxide catalysts for isocyanate reactions
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
FR2529548A1 (fr) * 1982-07-02 1984-01-06 Delalande Sa Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
JPS59110656A (ja) * 1982-12-15 1984-06-26 Hiroyuki Nohira 光学活性な１―フェニル―２―（パラ―トリル）エチルアミンの製造方法
DE3604591A1 (de) * 1986-02-14 1987-08-20 Degussa Verfahren zur herstellung chiraler glycinderivate
JPS6354342A (ja) * 1986-08-26 1988-03-08 Daicel Chem Ind Ltd （±）−α−エチルベンジルアミンの光学分割方法
JPS63145256A (ja) * 1986-12-09 1988-06-17 Nippon Kayaku Co Ltd 光学活性ホモフエニルアラニンの製造法及び中間体
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
AU658898B2 (en) * 1991-05-22 1995-05-04 Pfizer Inc. Substituted 3-aminoquinuclidines

Also Published As

Publication number Publication date
PT99970B (pt) 1999-06-30
IE65005B1 (en) 1995-10-04
AU653380B2 (en) 1994-09-29
HU9301931D0 (en) 1993-12-28
JPH05508867A (ja) 1993-12-09
JPH07330766A (ja) 1995-12-19
KR970001157B1 (ko) 1997-01-29
ATE115580T1 (de) 1994-12-15
EP0565558B1 (en) 1994-12-14
AU9129891A (en) 1992-08-17
JP2845425B2 (ja) 1999-01-13
NO932431D0 (no) 1993-07-02
CA2098989C (en) 1998-02-03
FI20001108A (fi) 2000-05-10
CA2158130A1 (en) 1992-07-04
DE69106003T2 (de) 1995-04-27
US5138060A (en) 1992-08-11
WO1992012152A1 (en) 1992-07-23
CA2098989A1 (en) 1992-07-04
JP2703193B2 (ja) 1998-01-26
JPH0768244B1 (no) 1995-07-26
IE920001A1 (en) 1992-07-15
JP2583026B2 (ja) 1997-02-19
FI933065A0 (fi) 1993-07-02
IL100541A0 (en) 1992-09-06
FI933065A (fi) 1993-07-02
FI20001109A (fi) 2000-05-10
MX9200003A (es) 1992-07-01
KR930703312A (ko) 1993-11-29
DE69106003D1 (de) 1995-01-26
ES2065161T3 (es) 1995-02-01
CA2158130C (en) 1998-07-14
DK0565558T3 (da) 1995-03-06
ZA928B (en) 1993-07-02
JPH07316154A (ja) 1995-12-05
GR3015021T3 (en) 1995-05-31
JPH07316153A (ja) 1995-12-05
EP0565558A1 (en) 1993-10-20
PT99970A (pt) 1993-02-26
NZ241161A (en) 1994-10-26

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