JPH07507548A - 生物分解性放出制御溶融紡糸デリバリーシステム - Google Patents
生物分解性放出制御溶融紡糸デリバリーシステムInfo
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- JPH07507548A JPH07507548A JP6500877A JP50087794A JPH07507548A JP H07507548 A JPH07507548 A JP H07507548A JP 6500877 A JP6500877 A JP 6500877A JP 50087794 A JP50087794 A JP 50087794A JP H07507548 A JPH07507548 A JP H07507548A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/43—Hormones, e.g. dexamethasone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/13—Burn treatment
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/15—Suppositories
Abstract
Description
Claims (26)
- 1.非サッカライド生物分解性ポリマー及び生体作用薬剤を含有することを特徴 とする、フラッシューフロー溶融紡糸により形成された生物分解性放出制御組成 物。
- 2.ポリマーが、ポリ(グリコール酸)、ポリ(乳酸)、ポリジオキサン、ポリ オキザレート、ポリ(α−エステル)、ポリカーボネート、ポリ酸無水物、ポリ アセタール、ポリカブロラクトン、ポリ(オルトエステル)、ポリアミノ酸、ポ リウレタン、ポリイミノカーボネート、ポリアミド、ポリ(アルキルシアノアク リレート)、セバシン酸、ポリエチレングリコール、ポリフォスファゼン、ビス −(p−カルボキシフェノキシ)プロパン、ビス(p−カルボキシフェノキシ) メタン及びそれらのコポリマー及び混合物からなる群より選ばれる、請求項1記 載の組成物。
- 3.生体作用薬剤が、動物の予防又は治療処置に有用である、請求項2記載の組 成物。
- 4.生体作用薬剤か、ace阻害剤、抗喘息薬、抗コレステロール薬、抗痙攣薬 、抗うっ薬、下痢止め製剤、抗感染症薬、抗炎症薬、制吐剤、抗卒中剤、抗甲状 腺製剤、抗腫瘍剤、鎮咳薬、抗尿酸血症薬、座瘡薬、アルカロイド、アミノ酸製 剤、同化薬、鎮吐薬、抗肥満薬、駆虫薬、解熱作用剤、鎮痙薬、食欲刺激薬、脳 血管拡張薬、キレート剤、コレシストキニン拮抗薬、認識活性薬、避妊薬、脱臭 剤、皮膚用薬剤、糖尿病薬、利尿剤、エリスロポイエチン薬剤、排卵誘発剤、合 成ホルモン置換剤、高血糖症剤、緩下剤、無機質補足剤、神経弛緩薬、神経節用 薬剤、末梢血拡張薬、プロスタグランジン類、膣用製剤、血管収縮薬及び眩暈用 薬剤からなる群より選ばれる、請求項3記載の組成物。
- 5.生体作用薬剤が、アセトアミノフェン、酢酸、アセチルサリチル酸、緩衝ア セチルサリチル酸、アルブテロール、アルブテロールスルフェート、エタノール 、イソプロパノール、アラントイン、アロエ、酢酸アルミニウム、炭酸アルミニ ウム、アルミニウムクロロヒドレート、水酸化アルミニウム、アルプロゾラム、 アミノ酸、アミノ安息香酸、アモキシリン、アンピシリン、アムサクリン、アム サログ、アネトール、アスパルテーム、アテノロール、バシトラシン、ペルーバ ルサム、ベクロメタゾンジプロピオネート、ベンゾカイン、安息香酸、ベンゾフ ェノン、ベンゾイルペルオキシド、ビオチン、ビサコジル、酢酸ボルニル、マレ イン酸ブロモフェニラミン、ブスピロン、カフェイン、カラミン、カルシウム、 炭酸カルシウム、カルシウムカシネート、水酸化カルシウム、カンファ、カプト プリル、カスカラサグラダ、ヒマシ油、セファクロル、セファドロキシル、セフ ァレキシン、エタノール、塩化セチルピリジニウム、キレート化した無機質、ク ロラムフェニコール、塩酸クロルシクリジン、グルコン酸クロロヘキシジン、ク ロロキシレノール、クロロベントスクチン、マレイン酸クロロフェニラミン、コ レスチラミン樹脂、コリンビタルトレート、塩酸シメチジン、塩酸シンナメドリ ン、シタロブラム、クエン酸、カカオ脂、タラ肝油、コデイン及びリン酸コデイ ン、クロニジン、塩酸クロニジン、クロロフィブレート、シプロフロキサシンH Cl、シアノコバラミン、塩酸シクリジン、ダントロン、マレイン酸デキシブロ ムフェニラミン、臭化水素酸デキストロメトルファン、ジアゼパン、ジブカイン 、ジクロフェナクナトリウム、ジゴキシン、ジルチアゼム、ジメチコン、ジオキ シベンゾン、クエン酸ジフェンヒドラミン、塩酸ジフェンヒドラミン、ドクセー トカルシウム、ドクセートカリウム、ドクセートナトリウム、ドキシサイクリン ヒクレート、コハク酸ドキシルアミン、エファロキサン、エナルプリル、エノキ サシン、エリスロマイシン、エストロピペート、エチニルエストラジオール、エ フェドリン、エピネフリンビタルトレート、エリスロポイエチン、ユーカリブト ール、フマル酸第一鉄、グルコン酸第一鉄、硫酸第一鉄、葉酸、フォスフェニト イン、フルオキセチンHCl、フルオセミド、ギャバペンクン、ゲンタマイシン 、ゲムフィブロジル、グリピジド、グリセリン、グリセリルステアレート、グリ セオフルビン、グアイフェネシン、ヘキシルレソルシノール、ヒドロクロロチァ キシド、ヒドロコドンビタルトレート、ヒドロコルチゾン、ヒドロコルチゾンア セテート、8−ヒドロキシキノリンスルフェート、イブプロフェン、インドメタ シン、イノシトール、インシュリン、ヨード、トコン、鉄、イソキシカム、ケタ ミン、カオリン、乳酸、ラノリン、レシチン、リドカイン、塩酸リドカイン、リ フィノブリル、リオトリックス、ロバスタチン、カルボン酸マグネシウム、水酸 化マグネシウム、サリチル酸マグネシウム、マグネシウムトリシロケート、メフ ェナム酸、メクロフェナム酸、メクロフェナム酸ナトリウム、メドロキシプロゲ ステロンアセテート、メテナミンマンデレート、メントール、塩酸メペリジン、 メタプロテレノールスルフェート、メチルニコチネート、サリチル酸メチル、メ チルセルロース、メトスクシミド、メトロニダゾール、塩酸メトロニダゾール、 酒石酸メトプロロール、硝酸ミコナゾール、鉱油、ミノキシジル、モルフィネ、 ナプロキセン、ナプロキセンナトリウム、ニフェジピン、硫酸ミオマイシン、ナ イアシン、ナイアシンアミド、ニコチン、ニコチン酸アミド、ニトログリセリン 、ノンオキシノール−9、ノルエチンドン、ノルエチンドンアセテート、ナイス タチン、オクトキシノール、オクトキシノール9、オクチルジメチルPABA、 オクチルメトキシケイ皮酸、オメガ−3 ポリ不飽和脂肪酸、オメプラゾール、 オキソリン酸、オキシベンゾン、オキシトリフィリン、パラ−アミノ安息香酸( PABA)、パジメート0、パラメタジオン、ペンタスタチン、ペパーミントオ イル、ペンクエリスリオールテトラニトレート、ペントバルビタールナトリウム 、マレイン酸フェニラミン、フェノバルビタール、フェノール、フェノールフタ レイン、塩酸フェニレフリン、フェニルプロパノールアミン、塩酸フェニルプロ パノールアミン、フェニトイン、硫酸フェネルジン、ピルメノール、ピロキシカ ム、ポリマイシンB スルフェート、塩化カリウム、硝酸カリウム、プラゼパム 、塩酸プロカインアミド、プロカテロール、プロポキシフェン、プロポキシフェ ンHCl、プロポキシフェンナプシレート、プラミラセチン、プラモキシン、塩 酸ブラモキシン、プロプラノロールHC1、塩酸プソイドエフェドリン、硫酸プ ソイドエフェドリン、ピリドキシン、キナプリル、グルコン酸キニジン、キネス トロール、ラリトリン、ラニタジン、レゾルシノール、リボフラビン、サリチル 酸、ゴマ油、サメ肝油、シメチコン、重炭酸ナトリウム、クエン酸ナトリウム、 フッ化ナトリウム、ナトリウムモノフルオロフォスフェート、スルファンエトキ シサゾール、サルファー、タクリン、タクリンHCl、テオフィリン、テルフェ ニジン、チオペリドン、トリメトレキサート、トリアゾラム、マレイン酸チモロ ール、トレチノイン、塩酸テトラサイクリン、トルメチン、トルナフテート、ト リクロサン、塩酸トリプロリジン、ウンデシレン酸、バンコマイシン、ベラパミ ルHCI、ビダリビンフォスフェート、ビタミンA、ビタミンB、ビタミンC、 ビタミンD、ビタミンE、ビタミンK、ハマメリス、塩酸キシロメクゾリン、亜 鉛、硫酸亜鉛、ウンデシレン酸亜鉛からなる群より選ばれる、請求項4記載の組 成物。
- 6.経口投与形態である、請求項3記載の組成物。
- 7.植込可能な投与形態である、請求項3記載の組成物。
- 8.創傷治療投与形態に有用である、請求項3記載の組成物。
- 9.(a)胃部を通過する有効薬剤を物理的に保護し、小腸において有効薬剤を 放出することか可能な非サッカライド生物分解性ポリマー及び(b)生体作用薬 剤 を含むことを特徴とする放出制御溶融紡糸組成物。
- 10.ポリマーが、ポリ(グリコール酸)、ポリ(乳酸)、ポリジオキサン、ポ リオキザレート、ポリ(α−エステル)、ポリカーボネート、ポリ酸無水物、ポ リアセタール、ポリカプロラクトン、ポリ(オルトエステル)、ポリアミノ酸、 ポリウレタン、ポリイミノカーポネート、ポリアミド、ポリ(アルキルシアノア クリレート)、セバシン酸、ポリエチレングリコール、ポリフォスファゼン、ビ ス(p−カルボキシフェノキシ)プロパン、ビス(p−カルボキシフェノキシ) メタン、及びそれらのコポリマー及び混合物からなる群より選ばれる、請求項9 記載の組成物。
- 11.生体作用薬剤が、ペプチド、抗生物質、ホルモン、成長調節因子及びそれ らの混合物からなる群より選ばれる、請求項9記載の組成物。
- 12.生体作用薬剤がインシュリンである、請求項11記載の組成物。
- 13.a)pH約5以上で第1胃の環境において有効成分の保護剤であるが、p H約3.5以下で第4胃の環境において有効成分を放出する、非サッカライド生 物分解性ポリマー及び b)生体作用有効成分 を含むことを特徴とする反芻動物の治療用放出制御フラッシュフロー溶融紡糸組 成物。
- 14.有効成分が、治療剤、予防剤又は栄養剤である、請求項13記載の組成 物。
- 15.有効成分が、抗生物質、駆良剤、アミノ酸、タンパク質、成長調節因子、 ホルモン及びそれらの混合物からなる群より選ばれる、請求項13記載の組成物 。
- 16.非サッカライド生物分解性ポリマー及び生体作用治療用又は予防用有効成 分を含む溶融紡糸放出制御組成物の有効量を動物に投与することを特徴とする、 動物の治療方法。
- 17.ポリマーが、ポリ(グリコール酸)、ポリ(乳酸)、ポリジオキサン、ポ リオキザレート、ポリ(α−エステル)、ポリカーボネート、ポリ酸無水物、ポ リアセタール、ポリカプロラクトン、ポリ(オルトエステル)、ポリアミノ酸、 ポリウレタン、ポリイミノカーボネート、ポリアミド、ポリ(アルキルシアノア クリレート)、セバシン酸、ポリエチレングリコール、ポリフォスファゼン、ビ ス(p−カルボキシフェノキシ)プロパン、ビス(p−カルボキシフェノキシ) メタン及びそれらのコポリマー及びそれらの混合物からなる群より選ばれる、請 求項16記載の方法。
- 18.生体作用薬剤が、アセトアミノフェン、酢酸、アセチルサリチル酸及びそ の緩衝形態、アルブテロール、アルブテロールスルフエート、エタノール、イソ プロパノール、アラントイン、アロエ、酢酸アルミニウム、炭酸アルミニウム、 アルミニウムクロロヒドレート、水酸化アルミニウム、アルプロゾラム、アミノ 酸、アミノ安息香酸、アモキシリン、アンピシリン、アムサクリン、アムサログ 、アネトール、アスパルテーム、アテノロール、バシトラシン、ペルーバルサム 、ベクロメタゾンジプロピオネート、ベンゾカイン、安息香酸、ベンゾフェノン 、ベンゾイルペルオキシド、ビオチン、ビサコジル、酢酸ボルニル、マレイン酸 ブロモフェニラミン、ブスピロン、カフェイン、カラミン、カルシウム、炭酸カ ルシウム、カルシウムカシネート、水酸化カルシウム、カンファ、カプトプリル 、カスカラサグラダ、ヒマシ油、セファクロル、セファドロキシル、セファレキ シン、エタノール、塩化セチルピリジニウム、キレート化した無機質、クロラム フェニコール、塩酸クロルシクリジン、グルコン酸クロロヘキシジン、クロロキ シレノール、クロロペントスタチン、マレイン酸クロルフェニラミン、コレスチ ラミン樹脂、コリンビタルトレート、塩酸シメチジン、塩酸シンナメドリン、シ タロプラム、クエン酸、カカオ脂、タラ肝油、コデイン及びリン酸コデイン、ク ロニジン、塩酸クロニジン、クロロフィブレート、シプロフロキサシンHC1、 シアノコパラミン、塩酸シクリジン、ダントロン、マレイン酸デキシブロムフェ ニラミン、臭化水素酸デキストロメトルファン、ジアゼパン、ジブカイン、ジク ロフェナクナトリウム、ジゴキシン、ジルチアゼム、ジメチコン、ジオキシベン ゾン、クエン酸ジフェンヒドラミン、塩酸ジフェンヒドラミン、ドクセートカル シウム、ドクセートカリウム、ドクセートナトリウム、ドキシサイクリンヒクレ ート、コハク酸ドキシルアミン、エファロキサン、エナルプリル、エノキサシン 、エリスロマイシン、エストロピペート、エチニルエストラジオール、エフェド リン、エピネフリンビタルトレート、エリスロポイエチン、ユーカリブトール、 フマル酸第一鉄、グルコン酸第一鉄、硫酸第一鉄、葉酸、フォスフェニトイン、 フルオキセチンHCl、フルオセミド、ギャバペンタン、ゲンタマイシン、ゲム フィブロジル、グリピジド、グリセリン、グリセリルステアレート、グリセオフ ルビン、グアイフェネシン、ヘキシルエレソルシノール、ヒドロクロロチアキシ ド、ヒドロコドンビタルトレート、ヒドロコルチゾン、ヒドロコルチゾンアセテ ート、8−ヒドロキシキノリンスルフェート、イブプロフェン、インドメタシン 、イノシトール、インシュリン、ヨード、トコン、鉄、イソキシカム、ケタミン 、カオリン、乳酸、ラノリン、レシチン、リドカイン、塩酸リドカイン、リフィ ノブリル、リオトリックス、ロバスタチン、カルボン酸マグネシウム、水酸化マ グネシウム、サリチル酸マグネシウム、マグネシウムトリシロケート、メフェナ ム酸、メクロフェナム酸、メクロフェナム酸ナトリウム、メドロキシプロゲステ ロンアセテート、メテナミンマンデレート、メントール、塩酸メペリジン、メタ ブロテレノールスルフェート、メチルニコチネート、サリチル酸メチル、メチル セルロース、メトスクシミド、メトロミダゾール、塩酸メトロミダゾール、酒石 酸メトプロロール、硝酸ミコナゾール、鉱油、ミノキシジル、モルフィネ、ナプ ロキセン、ナプロキセンナトリウム、ニフェジピン、硫酸ネオマイシン、ナイア シン、ナイアシンアミド、ニコチン、ニコチン酸アミド、ニトログリセリン、ノ ンオキシノール−9、ノルエチンドン、ノルエチンドンアセテート、ナイスタチ ン、オクトキシノール、オクトキシノール9、オクチルジメチルPABA、オク チルメトキシケイ皮酸、オメガ−3 ポリ不飽和脂肪酸、オメプラゾール、オキ ソリン酸、オキシベンゾン、オキシトリフィリン、パラ−アミノ安息香酸(PA BA)、パジメート0、パラメタジオン、ペンタスタチン、ペパーミントオイル 、ペンタエリスリオールテトラニトレート、ペントバルビタールナトリウム、マ レイン酸フェニラミン、フェノバルビタール、フェノール、フェノールフタレイ ン、塩酸フェニレフリン、フェニルプロパノールアミン、塩酸フェニルプロパノ ールアミン、フェニトイン、硫酸フェネルジン、ピルメノール、ピロキシカム、 ポリマイシンB スルフェート、塩化カリウム、硝酸カリウム、プラゼパム、塩 酸プロカインアミド、プロカテロール、プロポキシフェン、ブロポキシフェンH Cl、ブロポキシフェンナブシレート、プラミラセチン、ブラモキシン、塩酸ブ ラモキシン、プロプラノロールHCl、塩酸プソイドエフェドリン、硫酸プソイ ドエフェドリン、ピリドキシン、キナプリル、グルコン酸キニジン、キネストロ ール、ラリトリン、ラニタジン、レゾルシノール、リボフラビン、サリチル酸、 ゴマ油、サメ肝油、シメチコン、重炭酸ナトリウム、クエン酸ナトリウム、フッ 化ナトリウム、ナトリウムモノフルオロフォスフェート、スルファンエトキシサ ゾール、サルファー、タクリン、タクリンHCl、テオフィリン、テルフェニジ ン、チオペリドン、トリメトレキサート、トリアゾラム、マレイン酸チモロール 、トレチノイン、塩酸テトラサイクリン、トルメチン、トルナフテート、トリク ロサン、塩酸トリブロリジン、ウンデシレン酸、バンコマイシン、ベラパミノレ HCl、ビダリビンフォスフェート、ビタミンA、ビタミンB、ビタミンC、ビ タミンD、ビタミンE、ビタミンK、ハマメリス、塩酸キシロメタゾリン、亜鉛 、硫酸亜鉛、ウンデシレン酸亜鉛からなる群より選ばれる、請求項16記載の組 成物。
- 19.ポリマーが、動物の体液の存在において浸食可能である、請求項16記載 の方法。
- 20.非サッカライド生物分解性ポリマー及び医薬用有効薬剤を含み、該ポリマ ーが実質的に非晶形態であることを特徴とする、動物において医薬用有効薬剤の 放出を制御することかできるフラッシュフロー溶融紡糸デリバリーシステム。
- 21.生物分解性非サッカライドポリマー及び医薬用有効薬剤の混合物をフラッ シューフロー溶融紡糸にかけ、動物において有効薬剤を放出することができる固 体を製造する条件下で該ポリマーと有効成分を一体にすることを含むことを特徴 とする、放出制御医薬組成物の製造方法。
- 22.非サッカライド生物分解性ポリマー及び生体作用薬剤を含む生物分解性放 出制御フラッシューフロー溶融紡糸組成物により含浸するか又は被覆した生体適 合性又は植込可能なサポート構造を含むことを特徴とする、生体組織の成長を促 進する装置。
- 23.生体作用薬剤が、ヒト、ウシ及びブタの成長ホルモンからなる群より選は れる、請求項22記載の装置。
- 24.(i)非サッカライド生物分解性ポリマー及び生体作用薬剤を含む組成物 をフラッシューフロー溶融紡糸し、(ii)該組成物をサポート構造上に収集す ることを含むことを特徴とする、生体組織の成長を促進する装置の製造方法。
- 25.生体作用薬剤が、抗ヒスタミン剤、抗躁病剤、抗ウイルス剤、麻酔薬、制 酸剤、抗関節炎剤、抗生物質、血液凝固阻止薬、抗精神病薬、鎮痙薬、抗血栓薬 、抗不安薬、食欲抑制薬、心血管用薬剤、咳抑制薬、皮膚軟化剤、胃腸薬、成長 調節因子、低血糖症用薬剤、呼吸與奮薬及びビタミンからなる群より選ばれる、 請求項3記載の組成物。
- 26.生体作用薬剤が、抗ヒスタミン剤、抗躁病剤、抗ウイルス剤、麻酔薬、制 酸剤、抗関節炎剤、抗生物質、血液凝固阻止薬、抗精神病薬、鎮痙薬、抗血栓薬 、抗不安薬、食欲抑制薬、心血管用薬剤、咳抑制薬、皮膚軟化剤、胃腸薬、成長 調節因子、低血糖症用薬剤、呼吸與奮薬及びビタミンからなる群より選ばれる、 請求項16記載の方法。
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US07/893,238 US5518730A (en) | 1992-06-03 | 1992-06-03 | Biodegradable controlled release flash flow melt-spun delivery system |
PCT/US1993/005307 WO1993024154A1 (en) | 1992-06-03 | 1993-06-02 | Biodegradable controlled release melt-spun delivery system |
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CA (1) | CA2137268A1 (ja) |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000237297A (ja) * | 1999-02-24 | 2000-09-05 | Taki Chem Co Ltd | 生体材料 |
JP2012531898A (ja) * | 2009-06-30 | 2012-12-13 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 無煙タバコ製品 |
JP2014517070A (ja) * | 2011-06-21 | 2014-07-17 | ビーブイダブリュ ホールディング エージー | ボスウェル酸を含む医療デバイス |
JP2015522001A (ja) * | 2012-06-27 | 2015-08-03 | メドインセルル | 疎水性組成物のための生分解性薬物送達 |
US11865205B2 (en) | 2015-11-16 | 2024-01-09 | Medincell S.A. | Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
Families Citing this family (275)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07502050A (ja) * | 1991-05-17 | 1995-03-02 | フイズ テクノロジーズ リミテッド | 新熱可塑性高分子物質及びその製法 |
WO1993024110A1 (de) * | 1992-05-22 | 1993-12-09 | Gödecke Aktiengesellschaft | Verfahren zur herstellung retardierter arzneimittelzubereitungen |
US5548064A (en) * | 1993-05-24 | 1996-08-20 | Biotech Australia Pty Limited | Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions |
US5773025A (en) | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US6726930B1 (en) | 1993-09-09 | 2004-04-27 | Penwest Pharmaceuticals Co. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
HU212428B (en) * | 1994-05-13 | 1996-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process to prepare pharmaceutical compositions containing gemfibrozyl |
US6020002A (en) * | 1994-06-14 | 2000-02-01 | Fuisz Technologies Ltd. | Delivery of controlled-release system(s) |
US5698224A (en) * | 1994-06-27 | 1997-12-16 | Alza Corporation | Tacrine therapy |
US5582855A (en) | 1994-07-01 | 1996-12-10 | Fuisz Technologies Ltd. | Flash flow formed solloid delivery systems |
US6491945B1 (en) * | 1994-09-16 | 2002-12-10 | Alza Corporation | Hydrocodone therapy |
US5683720A (en) * | 1994-10-28 | 1997-11-04 | Fuisz Technologies Ltd. | Liquiflash particles and method of making same |
US5855915A (en) | 1995-06-30 | 1999-01-05 | Baylor University | Tablets or biologically acceptable implants for long-term antiinflammatory drug release |
US6548084B2 (en) | 1995-07-20 | 2003-04-15 | Smithkline Beecham Plc | Controlled release compositions |
ATE185949T1 (de) * | 1995-07-28 | 1999-11-15 | Herbert Schlachter | Zwei-phasen-präparat |
ES2112765B1 (es) * | 1995-08-02 | 1999-03-01 | Cantabria Ind Farmaceutica Sa | Procedimiento para la obtencion de formulaciones de constraste radiologico, para exploraciones gastrointestinales de uso extemporaneo y directo. |
AU7106996A (en) * | 1995-09-07 | 1997-03-27 | Fuisz Technologies Ltd. | System for rendering substantially non-dissoluble bio-affecting agents bio-available |
KR0180334B1 (ko) * | 1995-09-21 | 1999-03-20 | 김윤 | 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 |
US5968543A (en) * | 1996-01-05 | 1999-10-19 | Advanced Polymer Systems, Inc. | Polymers with controlled physical state and bioerodibility |
SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
ATE302599T1 (de) * | 1996-05-24 | 2005-09-15 | Angiotech Pharm Inc | Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege |
US20030077317A1 (en) * | 1996-06-25 | 2003-04-24 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
US5955096A (en) * | 1996-06-25 | 1999-09-21 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
KR100321489B1 (ko) | 1996-07-08 | 2002-10-09 | 에드워드 멘델 컴파니 인코포레이티드 | 고용량의불용성약물용서방성매트릭스 |
US5709878A (en) * | 1996-08-02 | 1998-01-20 | Rosenbaum; Jerry | Transdermal delivery of dehydroepiandrosterone |
US5952226A (en) * | 1996-11-05 | 1999-09-14 | Modex Therapeutiques | Hypoxia responsive EPO producing cells |
ES2318869T3 (es) | 1997-02-20 | 2009-05-01 | Massachusetts Institute Of Technology | Forma de dosificacion que presenta propiedades de dispersion rapida, metodos de uso y procedimiento para su fabricacion. |
US5807594A (en) * | 1997-02-26 | 1998-09-15 | Ducoa, L.P. | Method for enhancing feed efficiency in ruminants with an encapsulating choline composition |
US5919499A (en) * | 1997-03-03 | 1999-07-06 | Lawley, Inc. | Aiding fermentation digestion and metabolism in mammals |
US5961997A (en) * | 1997-03-25 | 1999-10-05 | Swinehart; James M. | Antipruritic composition |
US10028851B2 (en) * | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
US6240616B1 (en) | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US8172897B2 (en) | 1997-04-15 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Polymer and metal composite implantable medical devices |
US5910319A (en) * | 1997-05-29 | 1999-06-08 | Eli Lilly And Company | Fluoxetine enteric pellets and methods for their preparation and use |
WO1998058549A1 (en) * | 1997-06-24 | 1998-12-30 | Fuisz Technologies Ltd. | Positive hydration method of preparing confectionery and product therefrom |
US6329429B1 (en) | 1997-06-25 | 2001-12-11 | Warner-Lambert Company | Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases |
IL152330A0 (en) | 1997-07-01 | 2003-05-29 | Pfizer | Sertraline salts and sustained-release dosage forms of sertraline |
US5874110A (en) * | 1997-07-22 | 1999-02-23 | Fuisz Technologies Ltd. | Entrapping additives in carbohydrate bodies |
US6486214B1 (en) * | 1997-09-10 | 2002-11-26 | Rutgers, The State University Of New Jersey | Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby |
US7122615B1 (en) | 1998-09-10 | 2006-10-17 | Rutgers, The State University Of New Jersey | Polyanhydrides with therapeutically useful degradation products |
IN186245B (ja) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
US6056977A (en) * | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
US6270464B1 (en) * | 1998-06-22 | 2001-08-07 | Artemis Medical, Inc. | Biopsy localization method and device |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
WO1999026556A1 (en) * | 1997-11-21 | 1999-06-03 | Interag | Biodegradable intra vaginal devices |
NZ330596A (en) * | 1998-06-05 | 2001-02-23 | Dec Res | Intravaginal devices allowing for increased uptake of active ingredients |
US8679534B2 (en) * | 1997-12-12 | 2014-03-25 | Andrx Labs, Llc | HMG-CoA reductase inhibitor extended release formulation |
US5916595A (en) * | 1997-12-12 | 1999-06-29 | Andrx Pharmaceutials, Inc. | HMG co-reductase inhibitor |
US20040029962A1 (en) * | 1997-12-12 | 2004-02-12 | Chih-Ming Chen | HMG-COA reductase inhibitor extended release formulation |
US6159968A (en) * | 1998-01-15 | 2000-12-12 | University Of Cincinnati | Activation of chloride channels for correction of defective chloride transport |
US5869090A (en) * | 1998-01-20 | 1999-02-09 | Rosenbaum; Jerry | Transdermal delivery of dehydroepiandrosterone |
US5908838A (en) * | 1998-02-19 | 1999-06-01 | Medics Pharmaceutical Corporation | Method for the treatment of acne |
US6475528B1 (en) | 1998-04-16 | 2002-11-05 | Georg Dietz | Preparation for regenerating collagen |
BR9909670A (pt) * | 1998-04-16 | 2000-12-19 | Georg Dietz | Preparação composta de hidróxido de cálcio, um álcool dihìdrico ou polihìdrico e um óleo fixo de orìgem vegetal ou animal e seu uso para regeneração de colágeno |
US5939453A (en) * | 1998-06-04 | 1999-08-17 | Advanced Polymer Systems, Inc. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
DE19825499C2 (de) * | 1998-06-08 | 2003-07-17 | Beiersdorf Ag | Wirkstoffhaltige Pflaster |
US6524620B2 (en) | 1998-07-20 | 2003-02-25 | Andrx Pharmaceuticals, Inc. | Diltiazem controlled release formulation and method of manufacture |
US6200590B1 (en) | 1998-08-10 | 2001-03-13 | Naphcare, Inc. | Controlled, phased-release suppository and its method of production |
US5976603A (en) * | 1998-08-26 | 1999-11-02 | Fuisz Technologies Ltd. | Fiber and vitamin-fortified drink composition and beverage and method of making |
US6733778B1 (en) | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
JP2002524410A (ja) * | 1998-09-08 | 2002-08-06 | スミスクライン・ビーチャム・コーポレイション | リプスタチン誘導体−可溶性繊維錠剤 |
GT199900148A (es) * | 1998-09-10 | 2001-02-28 | Desnaturalizantes para las sales aminas simpaticomimeticas. | |
US6171607B1 (en) * | 1998-09-28 | 2001-01-09 | Fuisz Technologies Ltd. | Process and apparatus for producing shearform matrix material |
US6174873B1 (en) | 1998-11-04 | 2001-01-16 | Supergen, Inc. | Oral administration of adenosine analogs |
US6596401B1 (en) | 1998-11-10 | 2003-07-22 | C. R. Bard Inc. | Silane copolymer compositions containing active agents |
US6356782B1 (en) * | 1998-12-24 | 2002-03-12 | Vivant Medical, Inc. | Subcutaneous cavity marking device and method |
US9669113B1 (en) | 1998-12-24 | 2017-06-06 | Devicor Medical Products, Inc. | Device and method for safe location and marking of a biopsy cavity |
US6371904B1 (en) | 1998-12-24 | 2002-04-16 | Vivant Medical, Inc. | Subcutaneous cavity marking device and method |
US6498153B1 (en) | 1998-12-31 | 2002-12-24 | Akzo Nobel N.V. | Extended release growth promoting two component composition |
JP4754693B2 (ja) | 1999-01-22 | 2011-08-24 | エラン ファーマシューティカルズ,インコーポレイテッド | Vla−4関連障害を処置するアシル誘導体 |
US6866861B1 (en) | 1999-01-29 | 2005-03-15 | Land O'lakes, Inc. | Method and composition for enhancing milk component concentrations |
US20040228887A1 (en) * | 1999-05-11 | 2004-11-18 | Champ Charles W. | Host-guest processes and formulations for delivering bio-affecting compounds |
US6676951B1 (en) * | 1999-05-11 | 2004-01-13 | Charles Walton Champ | Host-guest processes and formulations for delivering bio-affecting compounds |
CA2373630A1 (en) * | 1999-05-11 | 2000-11-16 | Charles Walton Champ | Host-guest processes and formulations for delivering bio-affecting compounds |
US6187822B1 (en) * | 1999-06-11 | 2001-02-13 | University Of Medicine & Dentistry Of Nj | Wound treatment through inhibition of adenosine diphosphate ribosyl transferase |
US6440447B1 (en) | 1999-06-22 | 2002-08-27 | Land O'lakes, Inc. | Method and composition for enhancing milk production |
US6726922B1 (en) | 1999-06-28 | 2004-04-27 | Minu, L.L.C. | Process and composition for temporarily suppressing pain |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
IL143375A0 (en) * | 1999-09-30 | 2002-04-21 | Penwest Pharmaceuticals Co | Sustained release matrix systems for highly soluble drugs |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
KR101476574B1 (ko) | 1999-10-29 | 2014-12-24 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
GB2371748B (en) * | 1999-11-08 | 2004-12-01 | Andrx Corp | HMG-COA reductase inhibitor extended release formulation |
US20040038948A1 (en) * | 1999-12-07 | 2004-02-26 | Uhrich Kathryn E. | Therapeutic compositions and methods |
US6685928B2 (en) * | 1999-12-07 | 2004-02-03 | Rutgers, The State University Of New Jersey | Therapeutic compositions and methods |
ES2169980B1 (es) | 1999-12-17 | 2003-11-01 | Lipotec Sa | Microcapsulas para la liberacion prolongada de farmacos. |
US6579539B2 (en) | 1999-12-22 | 2003-06-17 | C. R. Bard, Inc. | Dual mode antimicrobial compositions |
BR0007360A (pt) * | 1999-12-23 | 2001-08-14 | Johnson & Johnson | Composição de liberação controlada |
US6207193B1 (en) * | 1999-12-27 | 2001-03-27 | Stephen E. Feldman | Transdermal drug delivery system |
US6544553B1 (en) * | 1999-12-28 | 2003-04-08 | Watson Pharmaceuticals, Inc. | Dosage forms and methods for oral delivery of progesterone |
WO2001076650A1 (en) | 2000-04-06 | 2001-10-18 | University Technology Corporation | Compositions and methods for promoting wound healing |
EP1157708A3 (en) * | 2000-05-25 | 2002-07-10 | Ethicon, Inc. | Anti-microbial surgical devices |
WO2002003966A2 (en) * | 2000-07-10 | 2002-01-17 | Therics, Inc. | Method and materials for controlling migration of binder liquid in a powder |
US6602915B2 (en) | 2000-07-27 | 2003-08-05 | Rutgers, The State University Of New Jersey | Therapeutic azo-compounds for drug delivery |
CA2771263A1 (en) | 2000-07-27 | 2002-02-07 | Rutgers, The State University | Therapeutic polyesters and polyamides |
AU2001251651A1 (en) * | 2000-10-11 | 2002-04-22 | Union Carbide Chemicals And Plastics Technology Corporation | Compositions comprising crystalline condensation polymers and nucleating agents |
US6620829B2 (en) * | 2000-10-17 | 2003-09-16 | Warner-Lambert Company | Method of treating noninflammatory cartilage damage |
MXPA03003895A (es) | 2000-10-30 | 2003-07-28 | Euro Celtique Sa | Formulaciones de hidrocodona de liberacion controlada. |
WO2002036077A2 (en) * | 2000-11-06 | 2002-05-10 | Andrx Pharmaceuticals, Inc. | Once a day antihistamine and decongestant formulation |
MXPA03007081A (es) * | 2001-02-08 | 2004-10-15 | Pharmacia Corp | Medicamento de accion rapida para el tratamiento de disfuncion sexual. |
US6590059B2 (en) * | 2001-05-11 | 2003-07-08 | Ap Pharma, Inc. | Bioerodible polyorthoesters from dioxolane-based diketene acetals |
WO2003000156A1 (en) * | 2001-06-22 | 2003-01-03 | Southern Biosystems, Inc. | Zero-order prolonged release coaxial implants |
WO2003002100A1 (en) * | 2001-06-26 | 2003-01-09 | Farrell John J | Tamper-proof narcotic delivery system |
US7268190B2 (en) * | 2001-08-03 | 2007-09-11 | Toray Industries, Inc. | Resin composition comprising polylactic acid and polyacetal and a molded article, film, and fiber each comprising the same |
US20040219208A1 (en) * | 2001-08-03 | 2004-11-04 | Ryu Kawamura | Sustained-release medicines |
CN101220952B (zh) | 2001-08-06 | 2011-06-08 | 西南研究会 | 测试催化式排气净化器耐用性的方法和装置 |
US6881482B2 (en) | 2001-08-16 | 2005-04-19 | Southwest Research Institute | Microencapsulation using electromagnetic energy and core and shell materials with different dielectric constants and dissipation factors |
HUP0500791A2 (en) * | 2001-08-29 | 2006-09-28 | Ranbaxy Lab Ltd | Controlled release formulation of clarithromycin or tinidazol |
US20030124174A1 (en) * | 2001-10-25 | 2003-07-03 | Endo Pharmaceuticals, Inc | Method for treating non-neuropathic pain |
US6524606B1 (en) * | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
AU2002362069A1 (en) * | 2001-12-14 | 2003-06-30 | Syed Rizvi | Feminine wipe for symptomatic treatment of vaginitis |
US7255874B1 (en) | 2001-12-21 | 2007-08-14 | Closure Medical Corporation | Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto |
EP1552827A4 (en) * | 2002-06-19 | 2006-08-30 | Maruha Corp | PROPHYLACTIC OR THERAPEUTIC ORAL AGENT FOR CUTANEOUS LESIONS BASED ON DIACYLGLYCERYL ETHER |
US20040005359A1 (en) * | 2002-06-27 | 2004-01-08 | Cheng Xiu Xiu | Controlled release oral dosage form |
US20040096476A1 (en) * | 2002-07-17 | 2004-05-20 | Uhrich Kathryn E. | Therapeutic devices for patterned cell growth |
US20030017208A1 (en) * | 2002-07-19 | 2003-01-23 | Francis Ignatious | Electrospun pharmaceutical compositions |
US20040120991A1 (en) * | 2002-09-07 | 2004-06-24 | Mars Incorporated | Edible films having distinct regions |
US20050020613A1 (en) * | 2002-09-20 | 2005-01-27 | Alpharma, Inc. | Sustained release opioid formulations and method of use |
US8133437B2 (en) * | 2002-10-04 | 2012-03-13 | Ethicon, Inc. | Method of preparing an antimicrobial packaged medical device |
US9474524B2 (en) | 2002-10-04 | 2016-10-25 | Ethicon, Inc. | Packaged antimicrobial medical device having improved shelf life and method of preparing same |
US20040220614A1 (en) * | 2002-10-04 | 2004-11-04 | Howard Scalzo | Packaged antimicrobial medical device and method of preparing same |
US7513093B2 (en) | 2002-10-04 | 2009-04-07 | Ethicon, Inc. | Method of preparing a packaged antimicrobial medical device |
US20040068293A1 (en) * | 2002-10-04 | 2004-04-08 | Howard Scalzo | Packaged antimicrobial medical device and method of preparing same |
WO2004032853A2 (en) * | 2002-10-04 | 2004-04-22 | Pharmacia Corporation | Compositions and methods for treating sexual dysfunction |
US9597067B2 (en) | 2002-10-04 | 2017-03-21 | Ethicon, Inc. | Packaged antimicrobial medical device and method of preparing same |
US8112973B2 (en) | 2002-10-04 | 2012-02-14 | Ethicon, Inc. | Method of making a packaged antimicrobial suture |
AU2003295384A1 (en) * | 2002-11-02 | 2004-06-07 | Venture Management Alliance, Llc | Aqueous activated components conveyed in a non-aqueous carrier system |
US8092831B2 (en) * | 2002-11-08 | 2012-01-10 | Andrx Pharmaceuticals, Llc | Antihistamine and decongestant system |
US7045589B2 (en) * | 2002-11-15 | 2006-05-16 | A.P. Pharma, Inc. | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them |
MXPA05006182A (es) * | 2002-12-10 | 2005-08-26 | Venture Man Alliance Llc | Material encapsulado liberado para generar indicios sensoriales perceptibles de la ocurrencia de eventos distintos. |
US8519008B2 (en) | 2003-01-22 | 2013-08-27 | Purina Animal Nutrition Llc | Method and composition for improving the health of young monogastric mammals |
US20040185250A1 (en) * | 2003-02-07 | 2004-09-23 | John Amy T. | Triclosan containing absorbable sutures with extended antimicrobial properties |
WO2004073033A2 (en) * | 2003-02-11 | 2004-08-26 | Venture Management Alliance, Llc | Material incapsulation system |
US20040185119A1 (en) * | 2003-02-26 | 2004-09-23 | Theuer Richard C. | Method and compositions for treating gastric hyperacidity while diminishing the likelihood of producing vitamin deficiency |
US6932930B2 (en) * | 2003-03-10 | 2005-08-23 | Synecor, Llc | Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same |
US20040219229A1 (en) * | 2003-04-30 | 2004-11-04 | Tim Clarot | Migraine relief composition and methods of using and forming same |
US20050042196A1 (en) * | 2003-06-03 | 2005-02-24 | Ian Askill | Antimicrobial phenol containing cyanoacrylate compositions |
US7314640B2 (en) * | 2003-07-11 | 2008-01-01 | Mongkol Sriwongjanya | Formulation and process for drug loaded cores |
US20050042266A1 (en) * | 2003-08-21 | 2005-02-24 | Closure Medical Corporation | Cyanoacrylate compositions containing anti-microbial agent |
JP4931596B2 (ja) | 2003-11-07 | 2012-05-16 | ユーエス スモークレス タバコ カンパニー リミテッド ライアビリティ カンパニー | タバコ組成物 |
US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
US20050143350A1 (en) * | 2003-11-19 | 2005-06-30 | Seed John C. | Combination drug therapy to treat obesity |
US6984403B2 (en) * | 2003-12-04 | 2006-01-10 | Pfizer Inc. | Azithromycin dosage forms with reduced side effects |
RU2006119453A (ru) * | 2003-12-04 | 2007-12-20 | Пфайзер Продактс Инк. (Us) | Получение посредством основанных на применении жидкостей способов лекарственные формы азитромицина с большим количеством частиц |
WO2005053655A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Method for making pharmaceutical multiparticulates |
WO2005053651A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate compositions with improved stability |
CA2547773A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride |
WO2005053639A2 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Controlled release multiparticulates formed with dissolution enhancers |
WO2005053656A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride |
WO2005053652A1 (en) | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride |
US20050136112A1 (en) * | 2003-12-19 | 2005-06-23 | Pediamed Pharmaceuticals, Inc. | Oral medicament delivery system |
US8110214B2 (en) | 2003-12-23 | 2012-02-07 | Land O'lakes Purina Feed Llc | Method and composition for enhancing milk production and milk component concentrations |
US20050163843A1 (en) * | 2003-12-31 | 2005-07-28 | Garth Boehm | Alprazolam formulations |
US7892218B2 (en) * | 2004-03-03 | 2011-02-22 | Rostam Ltd. | pH reducing formulation |
JP2008507341A (ja) * | 2004-07-21 | 2008-03-13 | メドトロニック,インコーポレイティド | 限局性繊維症を低減するための医療装置及び方法 |
CA2573671A1 (en) * | 2004-07-21 | 2006-02-23 | Medtronic, Inc. | Methods for reducing or preventing localized fibrosis using sirna |
ES2432556T3 (es) | 2004-08-04 | 2013-12-04 | Evonik Corporation | Métodos para fabricar dispositivos de suministro y sus dispositivos |
US20070281007A1 (en) * | 2004-08-27 | 2007-12-06 | Jacob Jules S | Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs |
US20060062811A1 (en) * | 2004-09-21 | 2006-03-23 | Szymczak Christopher E | Medicinal cooling emulsions |
WO2006034414A2 (en) | 2004-09-21 | 2006-03-30 | Hypnion, Inc. | Loxapine analogs and methods of use thereof |
US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
US20060083724A1 (en) * | 2004-10-01 | 2006-04-20 | Hilst Todd W | Compositions for the treatment of femal sexual dysfunction |
DE102005004318A1 (de) * | 2005-01-31 | 2006-08-10 | Ethicon Gmbh | Chirurgisches Nahtsystem |
WO2006107390A2 (en) | 2005-04-04 | 2006-10-12 | Kronos Advanced Technologies, Inc. | An electrostatic fluid accelerator for and method of controlling a fluid flow |
US9192615B2 (en) | 2008-08-06 | 2015-11-24 | Medicis Pharmaceutical Corporation | Method for the treatment of acne and certain dosage forms thereof |
US8252776B2 (en) * | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US8722650B1 (en) | 2005-06-24 | 2014-05-13 | Medicis Pharmaceutical Corporation | Extended-release minocycline dosage forms |
US7541347B2 (en) * | 2007-04-02 | 2009-06-02 | Medicis Pharmaceutical Coropration | Minocycline oral dosage forms for the treatment of acne |
US7544373B2 (en) | 2007-04-02 | 2009-06-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US7919483B2 (en) | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
US20080241235A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US20080242642A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
EP1924298B1 (de) * | 2005-09-15 | 2010-07-14 | Aesculap AG | Bioverträgliches antimikrobielles nahtmaterial |
DK1940826T3 (da) | 2005-09-29 | 2011-04-18 | Elan Pharm Inc | Pyrimidinylamidforbindelser, der inhiberer leukocytadhæsion medieret gennem BLA-4 |
AU2006297180A1 (en) | 2005-09-29 | 2007-04-12 | Elan Pharmaceuticals, Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US8882747B2 (en) * | 2005-11-09 | 2014-11-11 | The Invention Science Fund I, Llc | Substance delivery system |
US20070167925A1 (en) * | 2006-01-19 | 2007-07-19 | William Jacqmein | Catheter with releasably coupled distal legs |
EA017110B1 (ru) | 2006-02-27 | 2012-09-28 | Элан Фамэсьютикэлс, Инк. | ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА |
WO2007100883A2 (en) * | 2006-02-28 | 2007-09-07 | Tyco Healthcare Group Lp | Antimicrobial releasing polymers |
AU2007221050B2 (en) * | 2006-02-28 | 2012-08-30 | Covidien Lp | Antimicrobial medical devices |
BRPI0708842A2 (pt) * | 2006-03-28 | 2011-06-14 | Gelesis Inc | uso de materiais polimÉricos com outras substÂncias para aumento do desempenho |
PE20120075A1 (es) * | 2006-06-01 | 2012-02-20 | Merck Sharp & Dohme | Composiciones farmaceuticas para la liberacion sostenida de fenilefrina |
RU2008151945A (ru) * | 2006-06-01 | 2010-07-20 | Шеринг Корпорейшн (US) | Лекарственные формы с пульсирующим высвобождением и фармацевтические композиции фенилэфрина |
NZ573174A (en) * | 2006-06-01 | 2012-01-12 | Msd Consumer Care Inc | Sustained release pharmaceutical dosage form containing phenylephrine |
JP5175278B2 (ja) * | 2006-06-01 | 2013-04-03 | エムエスディー コンシューマー ケア, インコーポレイテッド | 結腸吸収のためのフェニレフリン薬学的製剤および組成物 |
JP2009538901A (ja) * | 2006-06-01 | 2009-11-12 | デクセル ファーマ テクノロジーズ エルティーディー. | 複式ユニット製薬的製剤 |
PT2041071E (pt) | 2006-06-29 | 2014-09-23 | Kinex Pharmaceuticals Llc | Composições de biarilo e processos para a regulação de uma cascata de cinases |
US20080014252A1 (en) * | 2006-07-14 | 2008-01-17 | Delprete Keith | Topical compositions with long lasting effect |
US9265866B2 (en) * | 2006-08-01 | 2016-02-23 | Abbott Cardiovascular Systems Inc. | Composite polymeric and metallic stent with radiopacity |
EP2102144A4 (en) | 2006-09-13 | 2011-03-23 | Univ Rutgers | ACTIVE SUBSTANCES AND THEIR OLIGOMERS AND POLYMERS |
AU2007313630B2 (en) * | 2006-10-31 | 2013-07-04 | Bio-Tec Environmental, Llc | Chemical additives to make polymeric materials biodegradable |
US8513329B2 (en) | 2006-10-31 | 2013-08-20 | Bio-Tec Environmental, Llc | Chemical additives to make polymeric materials biodegradable |
RU2009148862A (ru) * | 2007-06-01 | 2011-07-20 | Шеринг-Плау Хельскер Продактс, Инк. (Us) | Фармацевтическая композиция, включающая субстрат и покрытие, содержащее активный ингридиент и поливиниловый спирт |
WO2009051848A1 (en) | 2007-10-20 | 2009-04-23 | Kinex Pharmaceuticals, Llc | Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof |
PE20091084A1 (es) * | 2007-12-07 | 2009-07-23 | Schering Plough Healthcare | Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal |
US8728528B2 (en) | 2007-12-20 | 2014-05-20 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
US10064819B2 (en) | 2008-05-12 | 2018-09-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
CN102026599A (zh) | 2008-05-12 | 2011-04-20 | 犹他大学研究基金会 | 眼内药物递送装置及相关方法 |
US9095404B2 (en) | 2008-05-12 | 2015-08-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
US9877973B2 (en) | 2008-05-12 | 2018-01-30 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
CA2737461A1 (en) | 2008-09-19 | 2010-03-25 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
US8367836B2 (en) | 2009-04-27 | 2013-02-05 | Elan Pharmaceuticals, Inc. | Pyridinone antagonists of alpha-4 integrins |
EP2459251B1 (en) | 2009-07-30 | 2014-03-12 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
ES2560218T3 (es) | 2010-07-02 | 2016-02-17 | The Procter & Gamble Company | Proceso para fabricar películas a partir de bandas de material no tejido |
EP2588589B2 (en) | 2010-07-02 | 2023-07-19 | The Procter & Gamble Company | Process for the production of a detergent product |
RU2535040C2 (ru) | 2010-07-02 | 2014-12-10 | Дзе Проктер Энд Гэмбл Компани | Способы доставки медицинского активного агента путем введения индивидуальных медицинских изделий, содержащих филамент |
BR112013000101A2 (pt) | 2010-07-02 | 2016-05-17 | Procter & Gamble | filamentos compreendendo mantas de não tecido com agente ativo e métodos de fabricação dos mesmos |
CA2803382C (en) | 2010-07-02 | 2015-03-31 | The Procter & Gamble Company | Method for delivering an active agent |
EP2588659B1 (en) | 2010-07-02 | 2016-03-16 | The Procter and Gamble Company | Filaments comprising an ingestible active agent nonwoven webs and methods for making same |
US8741317B2 (en) | 2010-08-19 | 2014-06-03 | Rutgers, The State University Of New Jersey | Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery |
WO2012056319A1 (en) | 2010-10-27 | 2012-05-03 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of pkm2 |
WO2012088438A1 (en) | 2010-12-22 | 2012-06-28 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
EP2684167B1 (en) | 2011-03-08 | 2020-09-09 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
US20120302609A1 (en) | 2011-05-25 | 2012-11-29 | Dynamix Pharmaceuticals Ltd. | Pyrazolines for the Modulation of PKM2 |
MX355415B (es) | 2011-06-07 | 2018-04-18 | Clevexel Pharma | Composiciones y metodos para tratar enfermedades y trastornos que son modulados por una vía de transducción de señales. |
US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
US8658199B2 (en) | 2012-02-01 | 2014-02-25 | Purina Animal Nutrition Llc | Systems and methods for feeding sugar alcohol to ruminants during periods of heat stress |
US10245025B2 (en) | 2012-04-06 | 2019-04-02 | Ethicon, Inc. | Packaged antimicrobial medical device having improved shelf life and method of preparing same |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9555186B2 (en) | 2012-06-05 | 2017-01-31 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
EP2863920B1 (en) | 2012-06-20 | 2023-03-22 | Eutropics Pharmaceuticals, Inc. | Quinoline derivatives for use in the tratment of breast cancer |
US9144579B2 (en) | 2012-08-17 | 2015-09-29 | Rutgers, The State University Of New Jersey | Polyesters and methods of use thereof |
JP6499076B2 (ja) | 2012-08-30 | 2019-04-10 | アセネックス インコーポレイテッド | タンパク質チロシンキナーゼ調節因子としてのn−(3−フルオロベンジル)−2−(5−(4−モルホリノフェニル)ピリジン−2−イル)アセトアミド |
US20140120057A1 (en) | 2012-10-25 | 2014-05-01 | Rutgers, The State University Of New Jersey | Polymers and methods thereof for wound healing |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
WO2014144512A1 (en) | 2013-03-15 | 2014-09-18 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
WO2014143935A1 (en) | 2013-03-15 | 2014-09-18 | Aprecia Pharmaceuticals Company | Rapidly dispersible dosage form of oxcarbazepine |
US9387250B2 (en) | 2013-03-15 | 2016-07-12 | Rutgers, The State University Of New Jersey | Therapeutic compositions for bone repair |
JP6466399B2 (ja) | 2013-03-15 | 2019-02-06 | アプレシア・ファーマスーティカルズ・カンパニー | トピラマートの急速分散性の剤形 |
WO2014197137A1 (en) * | 2013-04-29 | 2014-12-11 | Howard Brooks-Korn | Diversion-resistant formulation |
US9862672B2 (en) | 2013-05-29 | 2018-01-09 | Rutgers, The State University Of New Jersey | Antioxidant-based poly(anhydride-esters) |
WO2015023675A2 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
CA2920835A1 (en) | 2013-08-20 | 2015-02-26 | Anutra Medical, Inc. | Syringe fill system and method |
WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
EP2944565B1 (en) | 2014-05-13 | 2017-09-27 | Entrotech, Inc. | Erosion protective sleeve |
USD774182S1 (en) | 2014-06-06 | 2016-12-13 | Anutra Medical, Inc. | Anesthetic delivery device |
USD763433S1 (en) | 2014-06-06 | 2016-08-09 | Anutra Medical, Inc. | Delivery system cassette |
USD750768S1 (en) | 2014-06-06 | 2016-03-01 | Anutra Medical, Inc. | Fluid administration syringe |
WO2015191742A1 (en) | 2014-06-13 | 2015-12-17 | Rutgers, The State University Of New Jersey | Process and intermediates for preparing poly(anhydride-esters) |
CA2897038C (en) | 2014-07-14 | 2016-10-04 | Novicol International Holding Inc. | Microbicidal composition comprising an octoxynol and a quinolizidine alkaloid compound or a source thereof |
WO2016010771A1 (en) | 2014-07-17 | 2016-01-21 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
JP2017531026A (ja) | 2014-10-20 | 2017-10-19 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ,インコーポレーテッド | 徐放性乱用抑止性液体充填剤形 |
CA2977387C (en) * | 2015-03-04 | 2020-04-28 | The Procter & Gamble Company | Fibrous elements, fibrous structures, and products comprising a deterrent agent and methods for making same |
US10543162B2 (en) | 2015-04-10 | 2020-01-28 | Rutgers, The State University Of New Jersey | Kojic acid polymers |
EP3288556A4 (en) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
BR112017027750B8 (pt) * | 2015-06-22 | 2022-08-09 | Johnson & Johnson Consumer Inc | Artigo de múltiplas camadas aplicado topicamente para fornecer um benefício cosmético e/ou terapêutico sobre a pele, método não-terapêutico para fornecer um benefício cosmético à pele e agente terapêutico |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
DK3497099T3 (da) | 2016-08-12 | 2022-05-23 | Athenex Inc | Biarylsammensætninger og fremgangsmåder til modulering af en kinasekaskade |
CA3086689C (en) | 2018-01-26 | 2023-05-09 | The Procter & Gamble Company | Process for making water-soluble articles by cutting a fibrous web in a tessellated pattern |
US11053466B2 (en) | 2018-01-26 | 2021-07-06 | The Procter & Gamble Company | Water-soluble unit dose articles comprising perfume |
CA3087284C (en) | 2018-01-26 | 2023-05-02 | The Procter & Gamble Company | Water-soluble unit dose articles comprising enzyme |
KR20200085891A (ko) | 2018-01-26 | 2020-07-15 | 더 프록터 앤드 갬블 캄파니 | 향료를 포함하는 수용성 단위 용량 물품 |
WO2019168829A1 (en) | 2018-02-27 | 2019-09-06 | The Procter & Gamble Company | A consumer product comprising a flat package containing unit dose articles |
US11504268B2 (en) * | 2018-06-27 | 2022-11-22 | Ethicon, Inc. | Wound treatment system |
US10982176B2 (en) | 2018-07-27 | 2021-04-20 | The Procter & Gamble Company | Process of laundering fabrics using a water-soluble unit dose article |
EP3883546A1 (en) | 2018-11-21 | 2021-09-29 | Rosemont Pharmaceuticals Ltd | Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability |
WO2020159860A1 (en) | 2019-01-28 | 2020-08-06 | The Procter & Gamble Company | Recycleable, renewable, or biodegradable package |
EP3712237A1 (en) | 2019-03-19 | 2020-09-23 | The Procter & Gamble Company | Fibrous water-soluble unit dose articles comprising water-soluble fibrous structures |
JP7381613B2 (ja) | 2019-06-28 | 2023-11-15 | ザ プロクター アンド ギャンブル カンパニー | アニオン性界面活性剤を含有する溶解性固体繊維性物品 |
CA3183295A1 (en) | 2020-06-26 | 2021-12-30 | Jaedeok Yoo | Rapidly-orodispersible tablets having an interior cavity |
WO2022027067A1 (en) | 2020-07-31 | 2022-02-03 | The Procter & Gamble Company | Water-soluble fibrous pouch containing prills for hair care |
AU2021396978A1 (en) | 2020-12-08 | 2023-02-23 | Ruminant Biotech Corp Limited | Improvements to devices and methods for delivery of substances to animals |
CN113304307B (zh) * | 2021-05-21 | 2022-03-25 | 浙江大学 | 具有抗菌和湿表面粘附性能的聚磷腈基水凝胶伤口敷料及制备方法 |
Family Cites Families (227)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2918404A (en) * | 1956-07-30 | 1959-12-22 | Ortho Pharma Corp | Solid compressed amino acid spermicidal vehicle |
US3131428A (en) * | 1958-12-19 | 1964-05-05 | Celanese Corp | Spinneret and spinning method |
NL136087C (ja) * | 1962-01-15 | |||
GB1043406A (en) * | 1962-05-23 | 1966-09-21 | Nippon Oil Co Ltd | The preparation of petroleum resins |
US3308221A (en) * | 1963-05-14 | 1967-03-07 | Allied Chem | Melt spinning of modified cross section yarn |
US3332926A (en) * | 1964-02-21 | 1967-07-25 | Allied Chem | Thermal degradation of polyolefins in the presence of a metal salt carboxylic acid catalyst |
DE1486334A1 (de) * | 1964-11-16 | 1969-04-17 | Eastman Kodak Co | Verwendung von synthetischen Polymeren zur Herstellung von Verpackungen und Verpackungsmaterialien,insbesondere fuer Nahrungsmittel |
US3740391A (en) * | 1965-07-12 | 1973-06-19 | American Cyanamid Co | Thermosetting glyoxalated ionic glucopyranosyl polymer and wet strength paper having a content thereof |
US3299568A (en) * | 1966-03-01 | 1967-01-24 | Research Corp | Compositions plasticized with sulphur |
US3454510A (en) * | 1966-03-03 | 1969-07-08 | Eastman Kodak Co | Polyolefin compositions and degradable films made therefrom |
DE1811024A1 (de) * | 1967-12-06 | 1969-10-16 | Chisso Corp | Abbaubare Polyolefinmischungen |
US3592792A (en) * | 1968-07-24 | 1971-07-13 | Eastman Kodak Co | Agricultural plastic film |
US3887699A (en) * | 1969-03-24 | 1975-06-03 | Seymour Yolles | Biodegradable polymeric article for dispensing drugs |
GB1311855A (en) * | 1969-07-23 | 1973-03-28 | Dow Corning Ltd | Polypropylene |
GB1282512A (en) * | 1969-09-05 | 1972-07-19 | Ethylene Plastique Sa | Polyolefin compositions |
US3590528A (en) * | 1969-09-25 | 1971-07-06 | Princeton Chemical Res Inc | Decomposable polybutene-1 agricultural mulch film |
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US3853814A (en) * | 1970-04-27 | 1974-12-10 | J Guillet | Photodegradable polymers of methyl methacrylate and unsaturated ketones |
GB1362363A (en) * | 1970-04-27 | 1974-08-07 | Univ Toronto | Photodegradable polymers |
US3625214A (en) * | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
US3647111A (en) * | 1970-06-01 | 1972-03-07 | Biocor Corp | Biodegradable container |
GB1356107A (en) | 1970-07-22 | 1974-06-12 | Scott G | Polymer compositions |
US3673134A (en) * | 1970-08-03 | 1972-06-27 | Du Pont | Agricultural mulch |
US3864293A (en) * | 1970-08-25 | 1975-02-04 | Seikisui Chemical Co Ltd | Photo-Degradable Styrene Resin Composition |
GB1346650A (en) | 1970-09-18 | 1974-02-13 | Sekisui Chemical Co Ltd | Photo-degradable resin compositions |
AU3476771A (en) * | 1970-11-02 | 1973-05-03 | Imperial Chemical Industries Limited | Plastics composition |
US3886683A (en) * | 1970-11-27 | 1975-06-03 | Princeton Chemical Res Inc | Degradable plastic |
US3686000A (en) * | 1971-01-11 | 1972-08-22 | Gen Foods Corp | Moisture resistant sugar filaments |
US3707056A (en) * | 1971-05-10 | 1972-12-26 | Texaco Inc | Decomposable polyolefin agricultural mulch |
GB1382062A (en) * | 1971-06-10 | 1975-01-29 | Ici Ltd | Plastics composition |
BE785814A (fr) * | 1971-07-06 | 1973-01-04 | Dow Chemical Co | Compositions de polymere d'ethylene photo-degradables |
US3981303A (en) * | 1971-09-09 | 1976-09-21 | Alza Corporation | Bioerodible ocular device |
US3960150A (en) * | 1971-09-09 | 1976-06-01 | Alza Corporation | Bioerodible ocular device |
US3986510A (en) * | 1971-09-09 | 1976-10-19 | Alza Corporation | Bioerodible ocular device |
SE372024B (ja) * | 1971-09-14 | 1974-12-09 | Akerlund & Rausing Ab | |
DE2160223A1 (de) * | 1971-12-04 | 1973-06-07 | Hoechst Ag | Lichtabbaubare thermoplastische formmassen auf polyacetalbasis |
US4476255A (en) | 1971-11-01 | 1984-10-09 | Owens-Illinois, Inc. | Photoreactive plastic composition and articles degradable by ultraviolet radiation and a process for their manufacture |
US3888804A (en) * | 1971-11-02 | 1975-06-10 | Bio Degradable Plastics | Photodegradable hydrocarbon polymers |
GB1370286A (en) * | 1971-11-08 | 1974-10-16 | Ici Ltd | Wrapping material string and containers made form polyolefine compositions |
US4038228A (en) | 1971-11-19 | 1977-07-26 | Owens-Illinois, Inc. | Degradable plastic composition containing a transition metal salt of a highly unsaturated organic acid |
US3839297A (en) * | 1971-11-22 | 1974-10-01 | Ethicon Inc | Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures |
US3797690A (en) * | 1971-12-08 | 1974-03-19 | Owens Illinois Inc | Preparation of degradable polymeric material |
US4056499A (en) | 1971-12-08 | 1977-11-01 | Owens-Illinois, Inc. | Degradable polymeric composition |
BE793006A (fr) * | 1971-12-20 | 1973-06-19 | Union Carbide Corp | Pellicule de polyolefine degradable |
JPS518411B2 (ja) * | 1971-12-28 | 1976-03-16 | ||
US3835108A (en) * | 1972-02-15 | 1974-09-10 | American Home Prod | Process for preparing the releasing hormone of luteinizing hormone(lh)and of follicle stimulating hormone(fsh),salts and compositions thereof,and intermediates therefor |
US3941759A (en) * | 1972-03-01 | 1976-03-02 | Owens-Illinois, Inc. | Degradable plastics containing dual-function additive system |
US4101720A (en) | 1972-03-01 | 1978-07-18 | Owens-Illinois, Inc. | Degradable plastic |
JPS5118265B2 (ja) * | 1972-03-14 | 1976-06-08 | ||
JPS527014B2 (ja) * | 1972-03-24 | 1977-02-26 | ||
US3994855A (en) * | 1972-04-18 | 1976-11-30 | Ab Akerlund & Rausing | Degradable polymer composition and process for preparing the same |
NO139560C (no) * | 1972-04-29 | 1979-04-04 | Takeda Chemical Industries Ltd | Analogifremgangsmaate til fremstilling av terapeutisk virksomme nonapeptidamid-derivater |
US4021388A (en) | 1972-05-18 | 1977-05-03 | Coloroll Limited | Synthetic resin sheet material |
US4016117A (en) | 1972-05-18 | 1977-04-05 | Coloroll Limited | Biodegradable synthetic resin sheet material containing starch and a fatty material |
US4067836A (en) | 1972-06-28 | 1978-01-10 | Union Carbide Corporation | Environmentally degradable compositions exposed to actinic or ionizing radiation and process |
US3830764A (en) * | 1972-07-06 | 1974-08-20 | Princeton Polymer Lab | Degradable hydrocarbon polymers |
US4495311A (en) | 1972-07-06 | 1985-01-22 | Princeton Polymer Laboratories, Inc. | Degradable hydrocarbon polymers |
US3951821A (en) * | 1972-07-14 | 1976-04-20 | The Dow Chemical Company | Disintegrating agent for tablets |
US3844987A (en) * | 1972-07-28 | 1974-10-29 | Union Carbide Corp | Contour adapted passenger loading ramp biodegradable transplanter containers |
US3931068A (en) * | 1972-07-28 | 1976-01-06 | Union Carbide Corporation | Blends of biodegradable thermoplastic oxyalkanoyl polymer, a naturally occurring biodegradable product, filler and plastic additive |
US3901838A (en) * | 1972-07-28 | 1975-08-26 | Union Carbide Corp | Environmentally degradable biodegradable blends of a dialkanoyl polymer and an environmentally degradable ethylene polymer |
US3932319A (en) * | 1972-07-28 | 1976-01-13 | Union Carbide Corporation | Blends of biodegradable thermoplastic dialkanoyl polymer, a naturally occurring biodegradable product, a plastic additive and a filler |
US3921333A (en) * | 1972-07-28 | 1975-11-25 | Union Carbide Corp | Transplanter containers made from biodegradable-environmentally degradable blends |
US3867324A (en) * | 1972-07-28 | 1975-02-18 | Union Carbide Corp | Environmentally degradable-biodegradable blend of an oxyalkanoyl polymer and an environmentally degradable ethylene polymer |
US3923729A (en) * | 1972-07-28 | 1975-12-02 | Union Carbide Corp | Biodegradable transplanter containers |
US3850862A (en) * | 1972-07-28 | 1974-11-26 | Union Carbide Corp | Blends of a biodegradable thermoplastic dialkanoyl polymer and a naturally occurring biodegradable product |
US3847852A (en) * | 1972-08-23 | 1974-11-12 | Bell & Richardson Inc De | Outdoor degradable hydrocarbon plastic |
US3839311A (en) * | 1972-09-06 | 1974-10-01 | Phillips Petroleum Co | Polymer pro-oxidant comprising hydroxy-substituted 2,4-pentadienophenones |
US4207221A (en) | 1972-09-13 | 1980-06-10 | Owens-Illinois, Inc. | Degradable plastic composition containing unsaturated wax |
FR2199757A5 (ja) * | 1972-09-20 | 1974-04-12 | Ethylene Plastique Sa | |
US4360606A (en) | 1972-10-26 | 1982-11-23 | Owens-Illinois, Inc. | Photo-degradable polymer compositions |
US4056665A (en) | 1972-10-26 | 1977-11-01 | Owens-Illinois, Inc. | Composition and process |
US3840512A (en) * | 1972-11-09 | 1974-10-08 | Ici Ltd | Degradable plastics composition |
US3875300A (en) * | 1972-12-18 | 1975-04-01 | Ortho Pharma Corp | Composition for sustained release of a medicament and method of using same |
US3826796A (en) * | 1972-12-20 | 1974-07-30 | American Home Prod | P-glu-his-leu-arg-pro-gly-nh2 and intermediates |
US3989611A (en) * | 1973-01-08 | 1976-11-02 | The Firestone Tire & Rubber Company | Radiation treatment of polymers containing isobutylene |
US4100334A (en) | 1973-01-15 | 1978-07-11 | Snam Progetti S.P.A. | Process for rendering polymers degradable and polymers obtained thereby |
US3832312A (en) * | 1973-03-12 | 1974-08-27 | Arco Polymers Inc | Process for making foamed styrene polymers photodegradable |
JPS49119972A (ja) * | 1973-03-19 | 1974-11-15 | ||
US3903029A (en) * | 1973-03-20 | 1975-09-02 | Hall Howard E C | Biodegradable alpha polyolefin compositions containing a mixture of para-alkanolamino phenols |
US3917545A (en) * | 1973-04-05 | 1975-11-04 | Arco Polymers Inc | Photodegradable styrene polymer foams containing a hydrocarbon photosensitizer |
US3824227A (en) * | 1973-04-11 | 1974-07-16 | American Home Prod | Decapeptide (d-phe)2 analog of luteinizing hormones releasing factor and intermediates thereof |
US3991766A (en) * | 1973-05-31 | 1976-11-16 | American Cyanamid Company | Controlled release of medicaments using polymers from glycolic acid |
GB1458817A (en) | 1973-07-09 | 1976-12-15 | Charbonnages Ste Chimique | Photodegradable olefin polymer compositions |
US3850363A (en) * | 1973-07-16 | 1974-11-26 | L Jacobs | Carton |
FR2238700B1 (ja) | 1973-07-24 | 1977-10-14 | Takeda Chemical Industries Ltd | |
US3925525A (en) * | 1973-08-10 | 1975-12-09 | Celanese Corp | Spinning method |
GB1424747A (en) * | 1973-08-28 | 1976-02-11 | Ucb Sa | Method and apparatus for the continuous dehydration of maleic acid |
AT347054B (de) * | 1973-09-29 | 1978-12-11 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von neuen nonapeptidamid-derivaten |
JPS5726506B2 (ja) * | 1974-03-08 | 1982-06-04 | ||
IT998905B (it) * | 1973-10-24 | 1976-02-20 | Snam Progetti | Procedimento per rendere degrada bili i polimeri e polimeri degradabili cosi ottenuti |
IT998906B (it) * | 1973-10-24 | 1976-02-20 | Snam Progetti | Procedimento per bendere degrada bili i polimeri |
NL157021B (nl) * | 1973-11-15 | 1978-06-15 | Degussa | Werkwijze ter bereiding van polycarboxylaten met verbeterde biologische afbreekbaarheid. |
DE2453886A1 (de) * | 1973-11-16 | 1975-05-28 | Ciba Geigy Ag | Verfahren zur einkapselung von mit wasser nicht mischbaren substanzen |
AU7496074A (en) * | 1973-11-21 | 1976-05-06 | Snam Progetti | Transforming hydrocarbon polymers into photodegradable |
US3892723A (en) * | 1974-02-04 | 1975-07-01 | American Home Prod | P-Glu-Trp-Ser-Tyr-D-Pgl-Leu-Arg-Pro-Gly-NH{HD 2 {B and intermediates |
NL174734C (nl) * | 1974-02-18 | 1984-08-01 | Tno | Werkwijze voor het bereiden van onder invloed van water afbreekbare kunststofmaterialen, alsmede voorwerpen, gevormd uit kunststofmaterialen verkregen onder toepassing van de werkwijze. |
US3981856A (en) * | 1974-03-07 | 1976-09-21 | Princeton Polymer Laboratories, Incorporated | Degradable hydrocarbon polymers containing a metal compound and a benzotriazole |
US3968095A (en) * | 1974-03-22 | 1976-07-06 | The United States Of America As Represented By The Secretary Of Agriculture | Photodegradable plastics containing an N-halo amide |
JPS5214170B2 (ja) * | 1974-03-30 | 1977-04-20 | ||
US3896105A (en) * | 1974-04-01 | 1975-07-22 | American Home Prod | (n-propionyl) -gly-cys-lys-asn-phe-phe-trp-lys-thr-phe-thr-ser-cys-oh and intermediates |
LU69892A1 (ja) * | 1974-04-19 | 1976-03-17 | ||
IT1015654B (it) | 1974-07-03 | 1977-05-20 | Montedison Spa | Composizioni polimeriche fotodegra dabili dotate di elevata stabilita termica |
US4136145A (en) | 1974-07-05 | 1979-01-23 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
DE2436260B1 (de) | 1974-07-27 | 1975-04-30 | Bayer Ag, 5090 Leverkusen | Abbaubare Kunststoffzusammensetzung |
US3932338A (en) * | 1974-08-22 | 1976-01-13 | The United States Of America As Represented By The Secretary Of Agriculture | Photodegradable plastics containing β-halophenyl ketones |
US4011375A (en) * | 1974-11-26 | 1977-03-08 | The United States Of America As Represented By The Secretary Of Agriculture | Photodegradable plastics containing halogenated diphenyl ethanes |
US3968094A (en) * | 1974-11-26 | 1976-07-06 | The United States Of America As Represented By The Secretary Of The Department Of Agriculture | Photodegradable plastics containing haloolefins |
US3954104A (en) | 1974-11-27 | 1976-05-04 | Personal Products Company | Water-dispersible, biodegradable compositions and containers and the like made therefrom |
US4038227A (en) | 1975-01-03 | 1977-07-26 | Bio-Degradable Plastics, Inc. | Photodegradable polyolefins containing an aromatic ketone, ferric stearate, and a pigment |
US3968096A (en) * | 1975-01-23 | 1976-07-06 | The United States Of America As Represented By The Secretary Of Agriculture | Photodegradable polyolefins containing an halogenated nitrile |
US3929723A (en) * | 1975-01-23 | 1975-12-30 | Us Agriculture | Photodegradable polyolefins containing sulfenyl halides |
US4093709A (en) | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
US4131648A (en) | 1975-01-28 | 1978-12-26 | Alza Corporation | Structured orthoester and orthocarbonate drug delivery devices |
US3991033A (en) * | 1975-01-30 | 1976-11-09 | E. I. Du Pont De Nemours & Company | Photosensitive and degradable polyoxymethylene polymers and their application in imaging |
US3994869A (en) * | 1975-02-18 | 1976-11-30 | Ici United States Inc. | Photodegradable polyolefins containing aryl-substituted 1,3-diones |
US4037034A (en) | 1975-03-27 | 1977-07-19 | Exxon Research And Engineering Company | Photodegradable polyolefin composition containing a dinaphthylphthalate |
US4042765A (en) | 1975-03-27 | 1977-08-16 | Exxon Research And Engineering Co. | Photodegradable plastic compositions containing nitrogen heterocyclic compounds |
FR2307840A1 (fr) | 1975-04-17 | 1976-11-12 | Charbonnages Ste Chimique | Compositions polymeres degradables a la lumiere |
US3978033A (en) * | 1975-04-23 | 1976-08-31 | Ici United States Inc. | Difurfurylidene cycloalkanones as photoactive prodegradants for polyolefins |
US4076798A (en) | 1975-05-29 | 1978-02-28 | American Cyanamid Company | High molecular weight polyester resin, the method of making the same and the use thereof as a pharmaceutical composition |
US4017668A (en) | 1975-05-30 | 1977-04-12 | The United States Of America As Represented By The Secretary Of Agriculture | Photodegradable polyolefin composition containing an halogenated isocyanuric acid |
US4012565A (en) | 1975-05-30 | 1977-03-15 | The United States Of America As Represented By The Secretary Of Agriculture | Photodegradable polyolefin composition containing an N-halo hydantoin |
US4017667A (en) | 1975-05-30 | 1977-04-12 | The United States Of America As Represented By The Secretary Of Agriculture | Photodegradable polyolefin composition containing an N-halo benzenesulphonamide |
US4009325A (en) * | 1975-05-30 | 1977-02-22 | The United States Of America As Represented By The Secretary Of Agriculture | Photodegradable polyolefin composition containing an N-halo urethane |
US4010125A (en) * | 1975-06-12 | 1977-03-01 | Schally Andrew Victor | [D-Trp6 ]-LH-RH and intermediates therefor |
US4010196A (en) * | 1975-06-25 | 1977-03-01 | American Home Products Corporation | Linear polyester salts |
US3967623A (en) * | 1975-06-30 | 1976-07-06 | Johnson & Johnson | Disposable absorbent pad |
US3992342A (en) * | 1975-07-10 | 1976-11-16 | Ricoh Co., Ltd. | Non-aqueous dispersion and process of preparing same |
US4066568A (en) | 1975-08-07 | 1978-01-03 | Nippon Pulp Industry Company Limited | Method of producing microcapsules |
US4020249A (en) | 1975-08-08 | 1977-04-26 | The United States Of America As Represented By The Secretary Of Agriculture | Photodegradable polyolefins containing haloalkyl- or halobenzene-sulfonyl halides |
US4039731A (en) | 1975-08-08 | 1977-08-02 | The United States Of America As Represented By The Secretary Of Agriculture | Photodegradable polyolefins containing nitrohaloalkanes |
US4017666A (en) | 1975-08-08 | 1977-04-12 | The United States Of America As Represented By The Secretary Of Agriculture | Photodegradable polyolefins containing an haloalkyl disulfide |
US4156666A (en) | 1975-10-31 | 1979-05-29 | Shiseido Company, Ltd. | Degradable synthetic resin compositions |
US4098728A (en) | 1976-01-02 | 1978-07-04 | Solomon Rosenblatt | Medical surgical sponge and method of making same |
US4072326A (en) | 1976-07-19 | 1978-02-07 | Velo-Bind, Inc. | Wrap-around cover for books |
GB1548022A (en) | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
US4042763A (en) | 1976-10-08 | 1977-08-16 | Gulf Research & Development Company | Photodegradable resin compositions |
US4218409A (en) | 1977-02-07 | 1980-08-19 | Eastman Kodak Company | Encapsulating method |
US4107071A (en) | 1977-02-16 | 1978-08-15 | Capsulated Systems, Inc. | Method of producing microcapsules and resulting product |
US4147683A (en) | 1977-03-07 | 1979-04-03 | E. I. Du Pont De Nemours And Company | Fluorocarbon polymer-polymeric adjunct coating compositions stabilized against discoloration |
US4108470A (en) | 1977-05-18 | 1978-08-22 | Caterpillar Tractor Co. | Suspension system for tandem axle vehicles |
US4211769A (en) | 1977-08-24 | 1980-07-08 | Takeda Chemical Industries, Ltd. | Preparations for vaginal administration |
US4166800A (en) | 1977-08-25 | 1979-09-04 | Sandoz, Inc. | Processes for preparation of microspheres |
US4181708A (en) | 1977-09-02 | 1980-01-01 | Eastman Kodak Company | Rumen-stable pellets |
US4177255A (en) | 1977-09-02 | 1979-12-04 | Eastman Kodak Company | Rumen-stable pellets |
US4181710A (en) | 1977-09-02 | 1980-01-01 | Eastman Kodak Company | Rumen-stable pellets |
US4196187A (en) | 1977-09-02 | 1980-04-01 | Eastman Kodak Company | Rumen-stable pellets |
US4181709A (en) | 1977-09-02 | 1980-01-01 | Eastman Kodak Company | Rumen-stable pellets |
GB1600496A (en) | 1977-09-16 | 1981-10-14 | Coloroll Ltd | Plasticsbased composition |
IL52974A0 (en) | 1977-09-21 | 1977-11-30 | Plastopil Hazorea | Agricultural process film products for carrying out the process and controllably degradable polymer compositions for making said film products |
US4133784A (en) | 1977-09-28 | 1979-01-09 | The United States Of America As Represented By The Secretary Of Agriculture | Biodegradable film compositions prepared from starch and copolymers of ethylene and acrylic acid |
US4256851A (en) | 1977-12-12 | 1981-03-17 | Owens-Illinois, Inc. | Degradable plastic composition containing unsaturated alcohol or ester thereof |
US4197375A (en) | 1977-12-12 | 1980-04-08 | Chevron Research Company | Photodegradability of plastic polyolefins |
US4212955A (en) | 1978-01-19 | 1980-07-15 | Owens-Illinois, Inc. | Degradable plastic composition containing ortho ester |
US4224416A (en) | 1978-04-10 | 1980-09-23 | Owens-Illinois, Inc. | Degradable plastic composition containing amine |
US4215495A (en) | 1978-09-11 | 1980-08-05 | Wagner Donald G | Road grade attachment |
US4234571A (en) | 1979-06-11 | 1980-11-18 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone |
US4256785A (en) | 1979-07-25 | 1981-03-17 | Eastman Kodak Company | Pellet coating process |
US4291015A (en) | 1979-08-14 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing a vasodilator |
US4293539A (en) | 1979-09-12 | 1981-10-06 | Eli Lilly And Company | Controlled release formulations and method of treatment |
US4337181A (en) | 1980-01-17 | 1982-06-29 | The United States Of America As Represented By The Secretary Of Agriculture | Biodegradable starch-based blown films |
US4439199A (en) | 1980-02-19 | 1984-03-27 | Alza Corporation | Method for administering immunopotentiator |
DE3160242D1 (en) | 1980-02-29 | 1983-06-16 | Akzo Nv | Process for carrying out radical reactions and shaped articles of the reaction product |
US4318905A (en) | 1980-06-23 | 1982-03-09 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues |
US4341767A (en) | 1980-10-06 | 1982-07-27 | Syntex Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
US4500546A (en) | 1980-10-31 | 1985-02-19 | International Telephone And Telegraph Corporation | Suspensions containing microfibrillated cellulose |
US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
US4585797A (en) | 1981-04-13 | 1986-04-29 | Seton Company | Cosmetic and pharmaceutical sheet material containing polypeptides |
US4376743A (en) | 1981-06-12 | 1983-03-15 | Fiber Industries, Inc. | Melt spinning process |
US4451589A (en) | 1981-06-15 | 1984-05-29 | Kimberly-Clark Corporation | Method of improving processability of polymers and resulting polymer compositions |
US4499223A (en) | 1981-10-17 | 1985-02-12 | Nippon Paint Co., Ltd. | Hydrolyzable polyester resins and coating compositions containing the same |
DE3378250D1 (en) | 1982-04-22 | 1988-11-24 | Ici Plc | Continuous release formulations |
DE3218151A1 (de) | 1982-05-14 | 1983-11-17 | Akzo Gmbh, 5600 Wuppertal | Mikroporoese, pulverfoermige polylactide und verfahren zu deren herstellung |
US4687676A (en) | 1982-07-12 | 1987-08-18 | Eastman Kodak Company | Rumen-stable pellets |
US4595584A (en) | 1983-05-26 | 1986-06-17 | Eastman Kodak Company | Rumen-stable pellets |
US4542025A (en) | 1982-07-29 | 1985-09-17 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
US4426500A (en) | 1982-08-23 | 1984-01-17 | Phillips Petroleum Company | Polymer solubilization |
JPS5966841A (ja) | 1982-10-05 | 1984-04-16 | Meiji Seika Kaisha Ltd | 複合繊維状チユ−インガムの製造方法 |
US4469613A (en) | 1983-02-23 | 1984-09-04 | International Flavors & Fragrances Inc. | Detergent bar containing poly(epsilon caprolactone) and aromatizing agent |
US4888176A (en) | 1984-05-21 | 1989-12-19 | Massachusetts Institute Of Technology | Controlled drug delivery high molecular weight polyanhydrides |
US4946929A (en) | 1983-03-22 | 1990-08-07 | Massachusetts Institute Of Technology | Bioerodible articles useful as implants and prostheses having predictable degradation rates |
US4757128A (en) | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
US4906474A (en) | 1983-03-22 | 1990-03-06 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
US4886870A (en) | 1984-05-21 | 1989-12-12 | Massachusetts Institute Of Technology | Bioerodible articles useful as implants and prostheses having predictable degradation rates |
US4891225A (en) | 1984-05-21 | 1990-01-02 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
US4779806A (en) | 1984-07-23 | 1988-10-25 | Massachusetts Institute Of Technology | Ultrasonically modulated polymeric devices for delivering compositions |
DE3428640A1 (de) | 1984-08-03 | 1986-02-06 | Akzo Gmbh, 5600 Wuppertal | Mikroporoese, pulverfoermige polylactide |
US4637931A (en) | 1984-10-09 | 1987-01-20 | The United States Of America As Represented By The Secretary Of The Army | Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material |
US4634720A (en) | 1985-02-19 | 1987-01-06 | The Dow Chemical Company | Process for the preparation of hard tissue prosthetics |
JPS61291984A (ja) | 1985-06-18 | 1986-12-22 | Ichiro Shibauchi | 防錆材の製造方法 |
US4780319A (en) | 1985-07-08 | 1988-10-25 | Merck & Co., Inc. | Organic acids as catalysts for the erosion of polymers |
US4889119A (en) | 1985-07-17 | 1989-12-26 | Ethicon, Inc. | Surgical fastener made from glycolide-rich polymer blends |
US4686790A (en) | 1985-10-29 | 1987-08-18 | Kuwait Institute For Scientific Research | Degradable agricultural plastic articles, e.g., mulching film, comprising slowly released multinutrients in matrix of thermoplastic, and process for preparing same |
US4717567A (en) | 1985-11-25 | 1988-01-05 | Eastman Kodak Company | Rumen-stable pellets |
GB2187193B (en) | 1986-02-27 | 1989-11-08 | Gerald Scott | Controllably and swiftly degradable polymer compositions and films and other products made therefrom |
US4789724A (en) | 1986-10-17 | 1988-12-06 | Massachusetts Institute Of Technology | Preparation of anhydride copolymers |
US4719246A (en) | 1986-12-22 | 1988-01-12 | E. I. Du Pont De Nemours And Company | Polylactide compositions |
FR2610635B1 (fr) | 1987-02-10 | 1989-06-23 | Extrusion Calandrage Ste Fse | Compositions a base de polyurethanne permettant l'obtention par calandrage de materiaux biodegradables |
CH671961A5 (ja) | 1987-02-27 | 1989-10-13 | Amrotex Ag | |
US4985251A (en) | 1987-04-01 | 1991-01-15 | Lee County Mosquito Control District | Flowable insecticidal delivery compositions and methods for controlling insect populations in an aquatic environment |
US4873085A (en) | 1987-04-20 | 1989-10-10 | Fuisz Pharmaceutical Ltd. | Spun fibrous cosmetic and method of use |
US4855326A (en) | 1987-04-20 | 1989-08-08 | Fuisz Pharmaceutical Ltd. | Rapidly dissoluble medicinal dosage unit and method of manufacture |
US5028632A (en) | 1987-04-20 | 1991-07-02 | Fuisz Pharmaceutical Ltd. | Taste masked medicated pharmaceutical |
US5011532A (en) | 1988-03-18 | 1991-04-30 | Fuisz Pharmaceutical Ltd. | Dispersed systems and method of manufacture |
US5096492A (en) | 1987-04-20 | 1992-03-17 | Fuisz Technologies Ltd. | Dispersed systems and method of manufacture |
US5034421A (en) | 1988-12-13 | 1991-07-23 | Fuisz Pharmaceutical Ltd. | Moderated spun fibrous system and method of manufacture |
US4997856A (en) | 1987-04-20 | 1991-03-05 | Fuisz Pharmaceutical Ltd. | Method of producing compacted dispersable systems |
RU2056835C1 (ru) | 1987-04-20 | 1996-03-27 | Фьюиз Фармасьютикал Лтд. | Способ получения растворимого лекарственного средства |
US4861627A (en) | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
US4933431A (en) | 1987-07-31 | 1990-06-12 | Massachusetts Institute Of Technology | One step preparation of poly(amide-anhydride) |
US4857311A (en) | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
JPS6465129A (en) | 1987-09-04 | 1989-03-10 | Mitsubishi Gas Chemical Co | Production of aromatic polyether |
DE3730487A1 (de) | 1987-09-11 | 1989-03-23 | Hollingsworth Gmbh | Vorrichtung zum abtragen von fasergut, insbesondere von ballen aus spinngut |
US4839450A (en) | 1987-11-17 | 1989-06-13 | The United States Of America As Represented By The Secretary Of Agriculture | Moisture-shrinkable films from starch graft copolymers |
IT1216719B (it) | 1988-01-28 | 1990-03-08 | Milano | Composizioni termodegradabili abase di omo o copolimeri cristallini del propilene eprocedimento per effettuare la degradazione selettiva di tali omo e copolimeri. |
US4898734A (en) | 1988-02-29 | 1990-02-06 | Massachusetts Institute Of Technology | Polymer composite for controlled release or membrane formation |
US4891404A (en) | 1988-05-27 | 1990-01-02 | Purdue Research Foundation | Biodegradable graft copolymers |
US4999417A (en) | 1989-03-30 | 1991-03-12 | Nova Pharmaceutical Corporation | Biodegradable polymer compositions |
US5010167A (en) | 1989-03-31 | 1991-04-23 | Massachusetts Institute Of Technology | Poly(amide-and imide-co-anhydride) for biological application |
US5070122A (en) | 1989-06-15 | 1991-12-03 | Eastman Kodak Company | Environmentally degradable polymer blends |
US4983645A (en) | 1989-07-11 | 1991-01-08 | Mobil Oil Corporation | Photoinitiators as light sensitive degradants for polyethylene |
US4997904A (en) | 1989-08-25 | 1991-03-05 | Nova Pharmaceutical Corporation | Aromatic polyanhydride compositions |
US5015293A (en) | 1989-09-18 | 1991-05-14 | The United States Of America As Represented By The Secretary Of The Army | Method of forming a crosslinked chitosan polymer and product thereof |
ZA908406B (en) | 1990-10-19 | 1991-08-28 | Fuisz Pharmaceutical Ltd | Taste masked medicated floss |
JPH07502050A (ja) * | 1991-05-17 | 1995-03-02 | フイズ テクノロジーズ リミテッド | 新熱可塑性高分子物質及びその製法 |
-
1992
- 1992-06-03 US US07/893,238 patent/US5518730A/en not_active Expired - Lifetime
-
1993
- 1993-06-02 EP EP93914373A patent/EP0746342B1/en not_active Expired - Lifetime
- 1993-06-02 AU AU44058/93A patent/AU665844B2/en not_active Ceased
- 1993-06-02 JP JP50087794A patent/JP3941878B2/ja not_active Expired - Fee Related
- 1993-06-02 CA CA002137268A patent/CA2137268A1/en not_active Abandoned
- 1993-06-02 DE DE69332210T patent/DE69332210T2/de not_active Expired - Lifetime
- 1993-06-02 WO PCT/US1993/005307 patent/WO1993024154A1/en active IP Right Grant
Cited By (9)
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JP2000237297A (ja) * | 1999-02-24 | 2000-09-05 | Taki Chem Co Ltd | 生体材料 |
JP4548623B2 (ja) * | 1999-02-24 | 2010-09-22 | 多木化学株式会社 | 生体材料 |
JP2012531898A (ja) * | 2009-06-30 | 2012-12-13 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 無煙タバコ製品 |
JP2015180229A (ja) * | 2009-06-30 | 2015-10-15 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 無煙タバコ製品 |
US9848634B2 (en) | 2009-06-30 | 2017-12-26 | Philip Morris Products S.A. | Smokeless tobacco product |
US10602769B2 (en) | 2009-06-30 | 2020-03-31 | Philip Morris Products S.A. | Smokeless tobacco product |
JP2014517070A (ja) * | 2011-06-21 | 2014-07-17 | ビーブイダブリュ ホールディング エージー | ボスウェル酸を含む医療デバイス |
JP2015522001A (ja) * | 2012-06-27 | 2015-08-03 | メドインセルル | 疎水性組成物のための生分解性薬物送達 |
US11865205B2 (en) | 2015-11-16 | 2024-01-09 | Medincell S.A. | Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
Also Published As
Publication number | Publication date |
---|---|
CA2137268A1 (en) | 1993-12-09 |
EP0746342A1 (en) | 1996-12-11 |
DE69332210D1 (de) | 2002-09-19 |
EP0746342B1 (en) | 2002-08-14 |
JP3941878B2 (ja) | 2007-07-04 |
DE69332210T2 (de) | 2003-04-24 |
EP0746342A4 (en) | 1996-01-11 |
AU4405893A (en) | 1993-12-30 |
US5518730A (en) | 1996-05-21 |
WO1993024154A1 (en) | 1993-12-09 |
AU665844B2 (en) | 1996-01-18 |
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