JPH0694476B2 - 蛋白質の相互分離方法 - Google Patents
蛋白質の相互分離方法Info
- Publication number
- JPH0694476B2 JPH0694476B2 JP60205873A JP20587385A JPH0694476B2 JP H0694476 B2 JPH0694476 B2 JP H0694476B2 JP 60205873 A JP60205873 A JP 60205873A JP 20587385 A JP20587385 A JP 20587385A JP H0694476 B2 JPH0694476 B2 JP H0694476B2
- Authority
- JP
- Japan
- Prior art keywords
- protein
- methionine residue
- separation method
- separation
- glycosylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07—ORGANIC CHEMISTRY
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- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/24—Extraction; Separation; Purification by electrochemical means
- C07K1/26—Electrophoresis
- C07K1/28—Isoelectric focusing
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1984/000460 WO1986002068A1 (en) | 1984-09-26 | 1984-09-26 | Mutual separation of proteins |
| WO84/00460 | 1984-09-26 | ||
| PCT/JP1985/000274 WO1986007063A1 (en) | 1985-05-21 | 1985-05-21 | Mutual separation of proteins |
| WO85/00274 | 1985-05-21 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6105210A Division JPH07165792A (ja) | 1984-09-26 | 1994-05-19 | 精製された蛋白質 |
| JP8186491A Division JPH09100296A (ja) | 1984-09-26 | 1996-07-17 | 蛋白質の相互分離方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6178799A JPS6178799A (ja) | 1986-04-22 |
| JPH0694476B2 true JPH0694476B2 (ja) | 1994-11-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP60205873A Expired - Lifetime JPH0694476B2 (ja) | 1984-09-26 | 1985-09-17 | 蛋白質の相互分離方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0176299B1 (en, 2012) |
| JP (1) | JPH0694476B2 (en, 2012) |
| KR (1) | KR860002526A (en, 2012) |
| AU (1) | AU599575B2 (en, 2012) |
| DE (1) | DE3585657D1 (en, 2012) |
| DK (1) | DK431485A (en, 2012) |
| IL (1) | IL76360A0 (en, 2012) |
| NZ (1) | NZ213615A (en, 2012) |
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|---|---|---|---|---|
| DE3526096A1 (de) * | 1985-07-22 | 1987-01-22 | Basf Ag | Verfahren zur reinigung von htnf |
| CN86104525A (zh) * | 1985-07-31 | 1987-02-25 | 武田药品工业株式会社 | 人类白细胞介素-2的分析方法和试剂 |
| DK585886A (da) * | 1985-12-24 | 1987-06-25 | Takeda Chemical Industries Ltd | Immunstimulerende middel og anvendelse deraf |
| US5451662A (en) * | 1987-10-23 | 1995-09-19 | Schering Corporation | Method of purifying protein |
| EP0313343B2 (en) * | 1987-10-23 | 2003-07-23 | Schering Corporation | Method of purifying protein |
| US5250296A (en) * | 1990-11-29 | 1993-10-05 | Takeda Chemical Industries, Ltd. | Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine |
| US5416071A (en) * | 1991-03-12 | 1995-05-16 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release containing epo and hyaluronic acid |
| CN1253435C (zh) | 2001-03-29 | 2006-04-26 | 先灵公司 | 可用作ccr5拮抗剂的芳基肟－哌嗪 |
| JP4485520B2 (ja) | 2003-03-24 | 2010-06-23 | エフ．ホフマン−ラ ロシュ アーゲー | 逆転写酵素阻害剤としてのベンジル−ピリダジノン類 |
| KR20080056220A (ko) | 2005-10-19 | 2008-06-20 | 에프. 호프만-라 로슈 아게 | 페닐-아세트아마이드 ｎｎｒｔ 저해제 |
| MX2009001198A (es) | 2006-08-16 | 2009-02-11 | Hoffmann La Roche | Inhibidores no nucleosidicos de la transcriptasa inversa. |
| KR101475091B1 (ko) | 2006-12-13 | 2014-12-22 | 에프. 호프만-라 로슈 아게 | 비뉴클레오시드 역전사 효소 억제제로서 2-(피페리딘-4-일)-4-페녹시- 또는 페닐아미노-피리미딘 유도체 |
| KR101542629B1 (ko) | 2007-05-30 | 2015-08-06 | 에프. 호프만-라 로슈 아게 | 비-뉴클레오사이드 역전사효소 억제제 |
| ES2526649T3 (es) | 2007-12-21 | 2015-01-14 | F. Hoffmann-La Roche Ag | Compuestos heterocíclicos antivíricos |
| NZ598381A (en) | 2009-09-10 | 2013-10-25 | Lonza Biologics Plc | Method and system for polypeptide purification |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL60184A (en) * | 1979-05-31 | 1984-05-31 | Schering Ag | Process for the specific cleavage of protein sequences from proteins |
| ES8308534A1 (es) * | 1980-01-08 | 1983-09-01 | Biogen Nv | Un metodo de producir un polipeptido que exhibe actividad inmunologica o biologica del interferon de leucocitos humanos. |
| CH657141A5 (de) | 1980-07-01 | 1986-08-15 | Hoffmann La Roche | Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen. |
| JPS58116498A (ja) * | 1981-12-28 | 1983-07-11 | Takeda Chem Ind Ltd | Ｉｌ‐２をコードする新規伝令ｒｎａの製造法 |
| CA1210714A (en) * | 1982-03-23 | 1986-09-02 | Alan Sloma | .alpha.-INTERFERON GX-1 |
| CA1341562C (en) * | 1982-03-31 | 2007-11-27 | Tadatsugu Taniguchi | Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell |
| EP0091539B2 (en) | 1982-03-31 | 1996-11-27 | Ajinomoto Co., Inc. | Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells |
| DE3378128D1 (en) * | 1982-04-20 | 1988-11-03 | Sloan Kettering Inst Cancer | Purification of interleukin 2 |
| JPS58198293A (ja) * | 1982-05-12 | 1983-11-18 | Shionogi & Co Ltd | インタ−ロイキン等免疫調節因子の製造方法 |
| FI82266C (fi) | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
| IL90047A (en) | 1982-10-19 | 1992-12-01 | Cetus Oncology Corp | Cysteine-depleted biologically active muteins other than interferon - ' |
| JPS59116231A (ja) * | 1982-12-13 | 1984-07-05 | スロ−ン−ケツタリング・インステイテユ−ト・フオ−・キヤンサ−・リサ−チ | 抗−インタ−ロイキン−２単クロ−ン抗体 |
| ZA841395B (en) * | 1983-03-03 | 1984-10-31 | Hoffmann La Roche | Purification of interferon |
| US4755465A (en) * | 1983-04-25 | 1988-07-05 | Genentech, Inc. | Secretion of correctly processed human growth hormone in E. coli and Pseudomonas |
| WO1985000606A1 (en) | 1983-07-19 | 1985-02-14 | Takeda Chemical Industries, Ltd. | Human il-2 and process for its preparation |
| JPS60115528A (ja) | 1983-11-28 | 1985-06-22 | Takeda Chem Ind Ltd | ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物 |
| JPS60126088A (ja) | 1983-12-13 | 1985-07-05 | Takeda Chem Ind Ltd | 新規ｄνａおよびその用途 |
| JPS60172999A (ja) * | 1983-12-20 | 1985-09-06 | Suntory Ltd | 新規な塩基性ポリペプチドおよびその製造法 |
| NZ210634A (en) * | 1983-12-23 | 1989-05-29 | Hoffmann La Roche | Purification of recombinant human interleukin - 2; pharmaceutical compositions |
| DE3586773T2 (de) * | 1984-08-16 | 1993-03-18 | Bio Technology General Corp | Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide. |
-
1985
- 1985-09-10 IL IL76360A patent/IL76360A0/xx not_active IP Right Cessation
- 1985-09-16 EP EP19850306559 patent/EP0176299B1/en not_active Expired - Lifetime
- 1985-09-16 DE DE8585306559A patent/DE3585657D1/de not_active Expired - Lifetime
- 1985-09-16 AU AU47496/85A patent/AU599575B2/en not_active Ceased
- 1985-09-17 JP JP60205873A patent/JPH0694476B2/ja not_active Expired - Lifetime
- 1985-09-24 DK DK431485A patent/DK431485A/da not_active Application Discontinuation
- 1985-09-25 NZ NZ213615A patent/NZ213615A/xx unknown
- 1985-09-25 KR KR1019850007049A patent/KR860002526A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DK431485D0 (da) | 1985-09-24 |
| AU4749685A (en) | 1986-04-10 |
| DE3585657A1 (en, 2012) | 1992-04-23 |
| EP0176299B1 (en) | 1992-03-18 |
| DK431485A (da) | 1986-03-27 |
| EP0176299A2 (en) | 1986-04-02 |
| JPS6178799A (ja) | 1986-04-22 |
| AU599575B2 (en) | 1990-07-26 |
| KR860002526A (ko) | 1986-04-26 |
| IL76360A0 (en) | 1986-01-31 |
| NZ213615A (en) | 1989-08-29 |
| DE3585657D1 (de) | 1992-04-23 |
| EP0176299A3 (en) | 1987-07-15 |
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| EXPY | Cancellation because of completion of term |