JPH0694476B2 - 蛋白質の相互分離方法 - Google Patents
蛋白質の相互分離方法Info
- Publication number
- JPH0694476B2 JPH0694476B2 JP60205873A JP20587385A JPH0694476B2 JP H0694476 B2 JPH0694476 B2 JP H0694476B2 JP 60205873 A JP60205873 A JP 60205873A JP 20587385 A JP20587385 A JP 20587385A JP H0694476 B2 JPH0694476 B2 JP H0694476B2
- Authority
- JP
- Japan
- Prior art keywords
- protein
- methionine residue
- separation method
- separation
- glycosylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07K1/24—Extraction; Separation; Purification by electrochemical means
- C07K1/26—Electrophoresis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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| PCT/JP1984/000460 WO1986002068A1 (en) | 1984-09-26 | 1984-09-26 | Mutual separation of proteins |
| PCT/JP1985/000274 WO1986007063A1 (en) | 1985-05-21 | 1985-05-21 | Mutual separation of proteins |
| WO85/00274 | 1985-05-21 | ||
| WO84/00460 | 1985-05-21 |
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| JP6105210A Division JPH07165792A (ja) | 1984-09-26 | 1994-05-19 | 精製された蛋白質 |
| JP8186491A Division JPH09100296A (ja) | 1984-09-26 | 1996-07-17 | 蛋白質の相互分離方法 |
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| JPS6178799A JPS6178799A (ja) | 1986-04-22 |
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| DE3526096A1 (de) * | 1985-07-22 | 1987-01-22 | Basf Ag | Verfahren zur reinigung von htnf |
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| DK585886A (da) * | 1985-12-24 | 1987-06-25 | Takeda Chemical Industries Ltd | Immunstimulerende middel og anvendelse deraf |
| HU204537B (en) * | 1987-10-23 | 1992-01-28 | Schering Corp | Process for purifying gm-csf |
| US5451662A (en) * | 1987-10-23 | 1995-09-19 | Schering Corporation | Method of purifying protein |
| US5250296A (en) * | 1990-11-29 | 1993-10-05 | Takeda Chemical Industries, Ltd. | Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine |
| US5416071A (en) * | 1991-03-12 | 1995-05-16 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release containing epo and hyaluronic acid |
| KR20030083015A (ko) | 2001-03-29 | 2003-10-23 | 쉐링 코포레이션 | Ｃｃｒ5 길항제로서 유용한 아릴 옥심-피페라진 |
| KR20050119652A (ko) | 2003-03-24 | 2005-12-21 | 에프. 호프만-라 로슈 아게 | 역전사 효소 저해제로서의 벤질-피리다진온 |
| CA2625047A1 (en) | 2005-10-19 | 2007-04-26 | F. Hoffmann-La Roche Ag | Phenyl-acetamide nnrt inhibitors |
| CN101501002B (zh) | 2006-08-16 | 2012-06-27 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
| WO2008071587A2 (en) | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors |
| CN101679294B (zh) | 2007-05-30 | 2012-08-08 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
| RU2495878C2 (ru) | 2007-12-21 | 2013-10-20 | Ф.Хоффманн-Ля Рош Аг | Гетероциклические антивирусные соединения |
| CN102906104B (zh) | 2009-09-10 | 2015-04-22 | 朗萨生物制剂有限公司 | 用于多肽纯化的方法和系统 |
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|---|---|---|---|---|
| IL60184A (en) * | 1979-05-31 | 1984-05-31 | Schering Ag | Process for the specific cleavage of protein sequences from proteins |
| NZ195980A (en) * | 1980-01-08 | 1984-10-19 | Biogen Nv | Dna sequences,recombinant dna molecules and processes for producing leukocyte interferon-like polypeptides;pharmaceutical and veterinary compositions |
| CH651308A5 (de) | 1980-07-01 | 1985-09-13 | Hoffmann La Roche | Interferone und deren herstellung. |
| JPS58116498A (ja) * | 1981-12-28 | 1983-07-11 | Takeda Chem Ind Ltd | Ｉｌ‐２をコードする新規伝令ｒｎａの製造法 |
| CA1210714A (en) * | 1982-03-23 | 1986-09-02 | Alan Sloma | .alpha.-INTERFERON GX-1 |
| DE3377363D1 (en) | 1982-03-31 | 1988-08-18 | Ajinomoto Kk | Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells |
| CA1341562C (en) * | 1982-03-31 | 2007-11-27 | Tadatsugu Taniguchi | Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell |
| EP0092163B1 (en) * | 1982-04-20 | 1988-09-28 | Sloan-Kettering Institute For Cancer Research | Purification of interleukin 2 |
| JPS58198293A (ja) * | 1982-05-12 | 1983-11-18 | Shionogi & Co Ltd | インタ−ロイキン等免疫調節因子の製造方法 |
| IL90047A (en) | 1982-10-19 | 1992-12-01 | Cetus Oncology Corp | Cysteine-depleted biologically active muteins other than interferon - ' |
| FI82266C (fi) | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
| JPS59116231A (ja) * | 1982-12-13 | 1984-07-05 | スロ−ン−ケツタリング・インステイテユ−ト・フオ−・キヤンサ−・リサ−チ | 抗−インタ−ロイキン−２単クロ−ン抗体 |
| ZA841395B (en) * | 1983-03-03 | 1984-10-31 | Hoffmann La Roche | Purification of interferon |
| US4755465A (en) * | 1983-04-25 | 1988-07-05 | Genentech, Inc. | Secretion of correctly processed human growth hormone in E. coli and Pseudomonas |
| WO1985000606A1 (en) | 1983-07-19 | 1985-02-14 | Takeda Chemical Industries, Ltd. | Human il-2 and process for its preparation |
| JPS60115528A (ja) | 1983-11-28 | 1985-06-22 | Takeda Chem Ind Ltd | ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物 |
| JPS60126088A (ja) | 1983-12-13 | 1985-07-05 | Takeda Chem Ind Ltd | 新規ｄνａおよびその用途 |
| JPS60172999A (ja) * | 1983-12-20 | 1985-09-06 | Suntory Ltd | 新規な塩基性ポリペプチドおよびその製造法 |
| DK174501B1 (da) * | 1983-12-23 | 2003-04-28 | Hoffmann La Roche | Fremgangsmåde til fremstilling af interleukin-2 |
| DE3586773T2 (de) * | 1984-08-16 | 1993-03-18 | Bio Technology General Corp | Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide. |
-
1985
- 1985-09-10 IL IL76360A patent/IL76360A0/xx not_active IP Right Cessation
- 1985-09-16 AU AU47496/85A patent/AU599575B2/en not_active Ceased
- 1985-09-16 EP EP19850306559 patent/EP0176299B1/en not_active Expired - Lifetime
- 1985-09-16 DE DE8585306559A patent/DE3585657D1/de not_active Expired - Lifetime
- 1985-09-17 JP JP60205873A patent/JPH0694476B2/ja not_active Expired - Lifetime
- 1985-09-24 DK DK431485A patent/DK431485A/da not_active Application Discontinuation
- 1985-09-25 KR KR1019850007049A patent/KR860002526A/ko not_active Ceased
- 1985-09-25 NZ NZ213615A patent/NZ213615A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3585657D1 (de) | 1992-04-23 |
| EP0176299A2 (en) | 1986-04-02 |
| JPS6178799A (ja) | 1986-04-22 |
| IL76360A0 (en) | 1986-01-31 |
| DK431485A (da) | 1986-03-27 |
| EP0176299A3 (en) | 1987-07-15 |
| EP0176299B1 (en) | 1992-03-18 |
| DK431485D0 (da) | 1985-09-24 |
| AU4749685A (en) | 1986-04-10 |
| KR860002526A (ko) | 1986-04-26 |
| DE3585657A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-04-23 |
| AU599575B2 (en) | 1990-07-26 |
| NZ213615A (en) | 1989-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |