JPH0578377A - ラパマイシンのシリルエーテル類 - Google Patents

ラパマイシンのシリルエーテル類

Info

Publication number
JPH0578377A
JPH0578377A JP4067035A JP6703592A JPH0578377A JP H0578377 A JPH0578377 A JP H0578377A JP 4067035 A JP4067035 A JP 4067035A JP 6703592 A JP6703592 A JP 6703592A JP H0578377 A JPH0578377 A JP H0578377A
Authority
JP
Japan
Prior art keywords
rapamycin
ether
dimethylsilyl
useful
dimethylethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4067035A
Other languages
English (en)
Japanese (ja)
Inventor
Amedeo A Failli
アメデオ・アルツロ・フエイリー
Robert J Steffan
ロバート・ジヨン・ステフアン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of JPH0578377A publication Critical patent/JPH0578377A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP4067035A 1991-04-01 1992-03-25 ラパマイシンのシリルエーテル類 Pending JPH0578377A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US678380 1991-04-01
US07/678,380 US5120842A (en) 1991-04-01 1991-04-01 Silyl ethers of rapamycin

Publications (1)

Publication Number Publication Date
JPH0578377A true JPH0578377A (ja) 1993-03-30

Family

ID=24722543

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4067035A Pending JPH0578377A (ja) 1991-04-01 1992-03-25 ラパマイシンのシリルエーテル類

Country Status (15)

Country Link
US (1) US5120842A (OSRAM)
EP (1) EP0507556A1 (OSRAM)
JP (1) JPH0578377A (OSRAM)
KR (1) KR920019797A (OSRAM)
AU (1) AU1389392A (OSRAM)
CA (1) CA2063962A1 (OSRAM)
CS (1) CS97392A3 (OSRAM)
FI (1) FI921328A7 (OSRAM)
HU (1) HUT62299A (OSRAM)
IE (1) IE921022A1 (OSRAM)
IL (1) IL101354A0 (OSRAM)
MX (1) MX9201381A (OSRAM)
NO (1) NO921217L (OSRAM)
NZ (1) NZ242160A (OSRAM)
ZA (1) ZA922308B (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007262057A (ja) * 2006-02-28 2007-10-11 Cordis Corp ラパマイシンアルキルエーテル類似体の異性体および４２−エピマー、同物質の製造法および使用法
JP2008150392A (ja) * 1993-11-19 2008-07-03 Abbott Lab ラパミシン（マクロライド）の半合成類似体免疫調節剤

Families Citing this family (286)

* Cited by examiner, † Cited by third party
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