JP7723666B2 - 環式化合物およびその使用方法 - Google Patents

環式化合物およびその使用方法

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Publication number
JP7723666B2
JP7723666B2 JP2022539348A JP2022539348A JP7723666B2 JP 7723666 B2 JP7723666 B2 JP 7723666B2 JP 2022539348 A JP2022539348 A JP 2022539348A JP 2022539348 A JP2022539348 A JP 2022539348A JP 7723666 B2 JP7723666 B2 JP 7723666B2
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triazol
methyl
cancer
compound
protein
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Japanese (ja)
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JP2023509886A5 (https=
JP2023509886A (ja
Inventor
シュル フェン，
モーガン ローレンツ，
ゴラン クリロフ，
アンドリュー プラチェック，
ジェ ニエ，
リニー トルゾス，
マイケル トルゾス，
ハイフェン タン，
エイチ． レイチェル ラギアコス，
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シュレーディンガー， インコーポレイテッド
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Priority to JP2023212834A priority Critical patent/JP2024023699A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
JP2022539348A 2019-12-27 2020-12-24 環式化合物およびその使用方法 Active JP7723666B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023212834A JP2024023699A (ja) 2019-12-27 2023-12-18 環式化合物およびその使用方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962954262P 2019-12-27 2019-12-27
US62/954,262 2019-12-27
US202063040582P 2020-06-18 2020-06-18
US63/040,582 2020-06-18
US202063119521P 2020-11-30 2020-11-30
US63/119,521 2020-11-30
PCT/US2020/066999 WO2021134004A1 (en) 2019-12-27 2020-12-24 Cyclic compounds and methods of using same

Related Child Applications (1)

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JP2023212834A Division JP2024023699A (ja) 2019-12-27 2023-12-18 環式化合物およびその使用方法

Publications (3)

Publication Number Publication Date
JP2023509886A JP2023509886A (ja) 2023-03-10
JP2023509886A5 JP2023509886A5 (https=) 2023-12-26
JP7723666B2 true JP7723666B2 (ja) 2025-08-14

Family

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JP2022539348A Active JP7723666B2 (ja) 2019-12-27 2020-12-24 環式化合物およびその使用方法
JP2023212834A Pending JP2024023699A (ja) 2019-12-27 2023-12-18 環式化合物およびその使用方法

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Country Status (14)

Country Link
US (1) US20240018157A1 (https=)
EP (1) EP4081526A1 (https=)
JP (2) JP7723666B2 (https=)
KR (1) KR20220123023A (https=)
CN (1) CN114945571B (https=)
AU (1) AU2020413333A1 (https=)
BR (1) BR112022012684A2 (https=)
CA (1) CA3161339A1 (https=)
CL (1) CL2022001741A1 (https=)
IL (1) IL294214B2 (https=)
MX (1) MX2022007171A (https=)
PH (1) PH12022551523A1 (https=)
TW (1) TWI878423B (https=)
WO (1) WO2021134004A1 (https=)

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CN117120442A (zh) * 2021-01-26 2023-11-24 薛定谔公司 用于治疗癌症、自身免疫性病症和炎性病症的三环化合物
TW202320755A (zh) * 2021-09-30 2023-06-01 大陸商上海拓界生物醫藥科技有限公司 三環化合物及其製備方法
EP4444340A4 (en) * 2021-12-10 2025-12-24 Rarefied Biosciences Inc METHODS OF TREATING DISEASES USING MALT1 INHIBITORS
EP4473966A4 (en) 2022-02-02 2026-01-21 Ono Pharmaceutical Co CANCER TREATMENT AGENT COMPRISING A MALT1 INHIBITOR DRUG AS THE ACTIVE INGREDIENT
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EP4638458A1 (en) * 2022-12-23 2025-10-29 Janssen Pharmaceutica NV Malt1 inhibitors
CN117624189B (zh) * 2023-11-24 2025-11-11 上海馨远医药科技有限公司 一种6-氧杂-3-氮杂双环[3.1.1]庚烷盐酸盐的制备方法
WO2026003045A1 (en) * 2024-06-26 2026-01-02 Janssen Pharmaceutica Nv Synthesis of a malt1 inhibitor
WO2026050766A1 (en) * 2024-09-02 2026-03-05 Blueprint Medicines Corporation Intermediate salts for synthesis of a cdk2 inhibitor
CN119285519B (zh) * 2024-10-11 2025-04-18 无锡科华生物科技有限公司 一种5,5’-二甲基吡咯烷-3-醇的制备方法

Citations (1)

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WO2018226150A1 (en) 2017-06-05 2018-12-13 Medivir Aktiebolag Pyrazolopyrimidine as malt-1 inhibitors

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BR112022012684A2 (pt) 2023-03-07
US20240018157A1 (en) 2024-01-18
EP4081526A1 (en) 2022-11-02
CN114945571B (zh) 2025-02-25
CN114945571A (zh) 2022-08-26
IL294214B1 (en) 2025-12-01
PH12022551523A1 (en) 2024-01-29
TW202136270A (zh) 2021-10-01
IL294214A (en) 2022-08-01
MX2022007171A (es) 2022-08-22
JP2023509886A (ja) 2023-03-10
WO2021134004A1 (en) 2021-07-01
AU2020413333A1 (en) 2022-06-16
CA3161339A1 (en) 2021-07-01
JP2024023699A (ja) 2024-02-21
CL2022001741A1 (es) 2023-01-27
KR20220123023A (ko) 2022-09-05
IL294214B2 (en) 2026-04-01
TWI878423B (zh) 2025-04-01

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