JP7471818B2 - ピペラジン誘導体、医薬組成物、及びその使用方法 - Google Patents
ピペラジン誘導体、医薬組成物、及びその使用方法 Download PDFInfo
- Publication number
- JP7471818B2 JP7471818B2 JP2019506346A JP2019506346A JP7471818B2 JP 7471818 B2 JP7471818 B2 JP 7471818B2 JP 2019506346 A JP2019506346 A JP 2019506346A JP 2019506346 A JP2019506346 A JP 2019506346A JP 7471818 B2 JP7471818 B2 JP 7471818B2
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- Prior art keywords
- cancer
- compound
- carcinoma
- hepatocellular carcinoma
- formula
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/38—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
- C07D335/12—Thioxanthenes
- C07D335/14—Thioxanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662376396P | 2016-08-18 | 2016-08-18 | |
| US62/376,396 | 2016-08-18 | ||
| PCT/IL2017/050909 WO2018033918A1 (en) | 2016-08-18 | 2017-08-17 | Piperazine derivatives, pharmaceutical compositions and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524789A JP2019524789A (ja) | 2019-09-05 |
| JP2019524789A5 JP2019524789A5 (https=) | 2024-02-14 |
| JP7471818B2 true JP7471818B2 (ja) | 2024-04-22 |
Family
ID=61196523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019506346A Active JP7471818B2 (ja) | 2016-08-18 | 2017-08-17 | ピペラジン誘導体、医薬組成物、及びその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11084807B2 (https=) |
| JP (1) | JP7471818B2 (https=) |
| CN (1) | CN109641884B (https=) |
| AU (1) | AU2017311691B2 (https=) |
| CA (1) | CA3034211A1 (https=) |
| WO (1) | WO2018033918A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11084807B2 (en) * | 2016-08-18 | 2021-08-10 | Vidac Pharama Ltd. | Piperazine derivatives, pharmaceutical compositions and methods of use thereof |
| US10682346B2 (en) | 2016-11-07 | 2020-06-16 | Vidac Pharma Ltd. | Use of hexokinase 2/mitochondria-detaching compounds for activating immune responses |
| EP4464334A3 (en) | 2016-11-07 | 2025-01-08 | VIDAC Pharma Ltd. | Use of compounds for treating hk2-expressing cancers |
| EP3554494A4 (en) | 2016-12-19 | 2021-02-17 | Cellixbio Private Limited | INFLAMMATION TREATMENT COMPOSITIONS AND METHODS |
| CN110003204B (zh) * | 2019-04-30 | 2020-08-11 | 上海勋和医药科技有限公司 | 一种bet蛋白抑制剂、其制备方法及用途 |
| WO2025163633A1 (en) * | 2024-01-30 | 2025-08-07 | Vidac Pharma Ltd. | Synergistic therapies for treating cancer |
| CN118063410B (zh) * | 2024-03-04 | 2026-03-13 | 河南省锐达医药科技有限公司 | 一种哌嗪萘甲酰胺类化合物、其制备方法及应用 |
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| CN104497013B (zh) | 2014-12-11 | 2017-05-31 | 石家庄诚志永华显示材料有限公司 | 氮杂咔唑类oled材料及其制备方法与应用 |
| CN104557875A (zh) | 2015-01-21 | 2015-04-29 | 石家庄诚志永华显示材料有限公司 | 茚并吲哚环状化合物与在有机发光二极管中的应用 |
| US11084807B2 (en) * | 2016-08-18 | 2021-08-10 | Vidac Pharama Ltd. | Piperazine derivatives, pharmaceutical compositions and methods of use thereof |
| EP4464334A3 (en) * | 2016-11-07 | 2025-01-08 | VIDAC Pharma Ltd. | Use of compounds for treating hk2-expressing cancers |
| US10682346B2 (en) | 2016-11-07 | 2020-06-16 | Vidac Pharma Ltd. | Use of hexokinase 2/mitochondria-detaching compounds for activating immune responses |
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2017
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- 2017-08-17 CA CA3034211A patent/CA3034211A1/en active Pending
- 2017-08-17 AU AU2017311691A patent/AU2017311691B2/en active Active
- 2017-08-17 WO PCT/IL2017/050909 patent/WO2018033918A1/en not_active Ceased
- 2017-08-17 JP JP2019506346A patent/JP7471818B2/ja active Active
- 2017-08-17 CN CN201780050775.1A patent/CN109641884B/zh active Active
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| WO2018033918A1 (en) | 2018-02-22 |
| CA3034211A1 (en) | 2018-02-22 |
| US20220098179A1 (en) | 2022-03-31 |
| US11084807B2 (en) | 2021-08-10 |
| AU2017311691B2 (en) | 2021-12-02 |
| US20200031815A1 (en) | 2020-01-30 |
| JP2019524789A (ja) | 2019-09-05 |
| AU2017311691A1 (en) | 2019-04-04 |
| US12162868B2 (en) | 2024-12-10 |
| CN109641884A (zh) | 2019-04-16 |
| CN109641884B (zh) | 2024-01-02 |
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