JP7381492B2 - Ｍｔｏｒ阻害剤としてのｃ２６－連結ラパマイシン類似体 - Google Patents

Ｍｔｏｒ阻害剤としてのｃ２６－連結ラパマイシン類似体 Download PDF

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JP7381492B2
JP7381492B2 JP2020561075A JP2020561075A JP7381492B2 JP 7381492 B2 JP7381492 B2 JP 7381492B2 JP 2020561075 A JP2020561075 A JP 2020561075A JP 2020561075 A JP2020561075 A JP 2020561075A JP 7381492 B2 JP7381492 B2 JP 7381492B2
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cancer
disease
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pharmaceutically acceptable
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JP2021523113A (ja
JP2021523113A5 (enExample
Inventor
クリストファー・マイケル・セムコ
ギャング・ワン
レズリー・ジー・バーネット
ジェームズ・ブラッドリー・アッジェン
ガート・キス
ジェームズ・ジョセフ・クレッグ
マイカー・ジェームズ・エヴァンス・グリート
ジェニファー・ピッツェン
ジュリー・チュゥ－リ・リー
ウォルター・ウォン
アラン・ピー・ソートゥムカラ
アドリアン・リアム・ジル
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Revolution Medicines Inc
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Revolution Medicines Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2020561075A 2018-05-01 2019-04-29 Ｍｔｏｒ阻害剤としてのｃ２６－連結ラパマイシン類似体 Active JP7381492B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862665426P 2018-05-01 2018-05-01
US62/665,426 2018-05-01
US201862752881P 2018-10-30 2018-10-30
US62/752,881 2018-10-30
US201962836040P 2019-04-18 2019-04-18
US62/836,040 2019-04-18
PCT/US2019/029738 WO2019212991A1 (en) 2018-05-01 2019-04-29 C26-linked rapamycin analogs as mtor inhibitors

Publications (3)

Publication Number Publication Date
JP2021523113A JP2021523113A (ja) 2021-09-02
JP2021523113A5 JP2021523113A5 (enExample) 2022-05-02
JP7381492B2 true JP7381492B2 (ja) 2023-11-15

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JP2020561075A Active JP7381492B2 (ja) 2018-05-01 2019-04-29 Ｍｔｏｒ阻害剤としてのｃ２６－連結ラパマイシン類似体

Country Status (11)

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US (2) US11685749B2 (enExample)
EP (1) EP3788050B1 (enExample)
JP (1) JP7381492B2 (enExample)
KR (1) KR102859103B1 (enExample)
CN (1) CN112368289B (enExample)
AU (2) AU2019262979B2 (enExample)
CA (1) CA3098698A1 (enExample)
IL (2) IL312291A (enExample)
MX (2) MX2020011564A (enExample)
SG (1) SG11202010560QA (enExample)
WO (1) WO2019212991A1 (enExample)

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US20180179202A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
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JP7361693B2 (ja) 2017-12-15 2023-10-16 レヴォリューション・メディスンズ，インコーポレイテッド アロステリックｓｈｐ２阻害剤としての多環式化合物
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