AU2019262979B2 - C26-linked rapamycin analogs as mTOR inhibitors - Google Patents

C26-linked rapamycin analogs as mTOR inhibitors Download PDF

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Publication number
AU2019262979B2
AU2019262979B2 AU2019262979A AU2019262979A AU2019262979B2 AU 2019262979 B2 AU2019262979 B2 AU 2019262979B2 AU 2019262979 A AU2019262979 A AU 2019262979A AU 2019262979 A AU2019262979 A AU 2019262979A AU 2019262979 B2 AU2019262979 B2 AU 2019262979B2
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equiv
tert
mmol
pyrimidin
butyl
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AU2019262979A1 (en
Inventor
James Bradley Aggen
G. Leslie BURNETT
James Joseph CREGG
Adrian Liam Gill
Micah James Evans GLIEDT
Gert KISS
Julie Chu-li LEE
Jennifer PITZEN
Christopher Michael Semko
Arun P. Thottumkara
Gang Wang
Walter Won
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Revolution Medicines Inc
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Revolution Medicines Inc
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Priority to AU2023241273A priority Critical patent/AU2023241273A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2019262979A 2018-05-01 2019-04-29 C26-linked rapamycin analogs as mTOR inhibitors Active AU2019262979B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023241273A AU2023241273A1 (en) 2018-05-01 2023-10-03 C26-linked rapamycin analogs as mTOR inhibitors

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862665426P 2018-05-01 2018-05-01
US62/665,426 2018-05-01
US201862752881P 2018-10-30 2018-10-30
US62/752,881 2018-10-30
US201962836040P 2019-04-18 2019-04-18
US62/836,040 2019-04-18
PCT/US2019/029738 WO2019212991A1 (en) 2018-05-01 2019-04-29 C26-linked rapamycin analogs as mtor inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023241273A Division AU2023241273A1 (en) 2018-05-01 2023-10-03 C26-linked rapamycin analogs as mTOR inhibitors

Publications (2)

Publication Number Publication Date
AU2019262979A1 AU2019262979A1 (en) 2020-12-10
AU2019262979B2 true AU2019262979B2 (en) 2023-07-06

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2019262979A Active AU2019262979B2 (en) 2018-05-01 2019-04-29 C26-linked rapamycin analogs as mTOR inhibitors
AU2023241273A Abandoned AU2023241273A1 (en) 2018-05-01 2023-10-03 C26-linked rapamycin analogs as mTOR inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2023241273A Abandoned AU2023241273A1 (en) 2018-05-01 2023-10-03 C26-linked rapamycin analogs as mTOR inhibitors

Country Status (11)

Country Link
US (2) US11685749B2 (enExample)
EP (1) EP3788050B1 (enExample)
JP (1) JP7381492B2 (enExample)
KR (1) KR102859103B1 (enExample)
CN (1) CN112368289B (enExample)
AU (2) AU2019262979B2 (enExample)
CA (1) CA3098698A1 (enExample)
IL (2) IL278335B2 (enExample)
MX (2) MX2020011564A (enExample)
SG (1) SG11202010560QA (enExample)
WO (1) WO2019212991A1 (enExample)

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