JP6963882B2 - 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 - Google Patents
胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 Download PDFInfo
- Publication number
- JP6963882B2 JP6963882B2 JP2018550724A JP2018550724A JP6963882B2 JP 6963882 B2 JP6963882 B2 JP 6963882B2 JP 2018550724 A JP2018550724 A JP 2018550724A JP 2018550724 A JP2018550724 A JP 2018550724A JP 6963882 B2 JP6963882 B2 JP 6963882B2
- Authority
- JP
- Japan
- Prior art keywords
- signaling pathway
- cells
- hfgo
- period
- fundus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/0609—Oocytes, oogonia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
- C12N2506/025—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells from extra-embryonic cells, e.g. trophoblast, placenta
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021169192A JP7463326B2 (ja) | 2016-05-05 | 2021-10-15 | 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 |
| JP2024050953A JP2024095710A (ja) | 2016-05-05 | 2024-03-27 | 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662332194P | 2016-05-05 | 2016-05-05 | |
| US62/332,194 | 2016-05-05 | ||
| PCT/US2017/031309 WO2017192997A1 (en) | 2016-05-05 | 2017-05-05 | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021169192A Division JP7463326B2 (ja) | 2016-05-05 | 2021-10-15 | 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514354A JP2019514354A (ja) | 2019-06-06 |
| JP2019514354A5 JP2019514354A5 (https=) | 2020-03-26 |
| JP6963882B2 true JP6963882B2 (ja) | 2021-11-10 |
Family
ID=60203655
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550724A Active JP6963882B2 (ja) | 2016-05-05 | 2017-05-05 | 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 |
| JP2021169192A Active JP7463326B2 (ja) | 2016-05-05 | 2021-10-15 | 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 |
| JP2024050953A Pending JP2024095710A (ja) | 2016-05-05 | 2024-03-27 | 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021169192A Active JP7463326B2 (ja) | 2016-05-05 | 2021-10-15 | 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 |
| JP2024050953A Pending JP2024095710A (ja) | 2016-05-05 | 2024-03-27 | 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11066650B2 (https=) |
| EP (2) | EP4177335A1 (https=) |
| JP (3) | JP6963882B2 (https=) |
| CN (2) | CN109415685B (https=) |
| CA (1) | CA3016641A1 (https=) |
| ES (1) | ES2929758T3 (https=) |
| WO (1) | WO2017192997A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| CN106661548B (zh) | 2014-05-28 | 2020-12-11 | 儿童医院医疗中心 | 用于经由定向分化将前体细胞转化为胃组织的方法和系统 |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のin vivoモデル、並びにそれを作製、及び使用する方法 |
| ES2929758T3 (es) | 2016-05-05 | 2022-12-01 | Childrens Hospital Med Ct | Métodos para la fabricación in vitro de tejido del fondo gástrico y composiciones relacionadas con el mismo |
| KR102729404B1 (ko) | 2016-11-04 | 2024-11-14 | 칠드런즈 호스피탈 메디칼 센터 | 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법 |
| JP7068305B2 (ja) | 2016-12-05 | 2022-05-16 | チルドレンズ ホスピタル メディカル センター | 結腸オルガノイドならびにその作製方法および使用方法 |
| US12281334B2 (en) | 2017-04-14 | 2025-04-22 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| KR102887406B1 (ko) | 2018-07-26 | 2025-11-19 | 칠드런즈 호스피탈 메디칼 센터 | 간-담도-췌장 조직 및 이를 제조하는 방법 |
| AU2019339410A1 (en) | 2018-09-12 | 2021-04-15 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| WO2020160371A1 (en) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| WO2020243633A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| WO2020243613A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| WO2025072803A1 (en) | 2023-09-29 | 2025-04-03 | Children's Hospital Medical Center | Ntrk2 signaling-mediated alveolar capillary injury and repair |
Family Cites Families (289)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1095990B (de) | 1957-08-22 | 1960-12-29 | Chemiewerk Homburg Zweignieder | Verfahren zur Herstellung von wasserloeslichen Praeparaten und konzentrierten, bestaendigen waessrigen Loesungen von Digoxin |
| WO1992007615A1 (en) | 1990-10-29 | 1992-05-14 | Regents Of The University Of Minnesota | A bioartificial liver |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US5912227A (en) | 1995-01-27 | 1999-06-15 | North Carolina State University | Method of enhancing nutrient uptake |
| WO1998021312A1 (en) | 1996-11-08 | 1998-05-22 | Rpms Technology Limited | Human hepatocytes in three-dimensional support systems |
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| US20020035459A1 (en) | 1998-09-14 | 2002-03-21 | George M. Grass | Pharmacokinetic-based drug design tool and method |
| US7759113B2 (en) | 1999-04-30 | 2010-07-20 | The General Hospital Corporation | Fabrication of tissue lamina using microfabricated two-dimensional molds |
| US6607501B2 (en) | 2001-05-14 | 2003-08-19 | Reynolds G. Gorsuch | Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications |
| US20030129751A1 (en) | 2001-05-16 | 2003-07-10 | Grikscheit Tracy C. | Tissue-engineered organs |
| CA2470539C (en) | 2001-12-07 | 2011-10-04 | Geron Corporation | Islet cells from human embryonic stem cells |
| US20050170506A1 (en) | 2002-01-16 | 2005-08-04 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
| US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| US7160719B2 (en) | 2002-06-07 | 2007-01-09 | Mayo Foundation For Medical Education And Research | Bioartificial liver system |
| JP4187167B2 (ja) | 2002-08-28 | 2008-11-26 | 和守 船津 | 異形断面中空糸膜型細胞含有デバイス |
| TW571101B (en) | 2003-01-21 | 2004-01-11 | Ind Tech Res Inst | Fluid analysis apparatus |
| WO2004071573A2 (en) | 2003-02-07 | 2004-08-26 | The Johns Hopkins University | Hypoxia induced mitogenic factor |
| US7727998B2 (en) | 2003-02-10 | 2010-06-01 | Banyu Pharmaceutical Co., Ltd. | Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient |
| DE10362002B4 (de) | 2003-06-23 | 2006-10-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Adulte pluripotente Stammzellen |
| US7985585B2 (en) | 2004-07-09 | 2011-07-26 | Viacyte, Inc. | Preprimitive streak and mesendoderm cells |
| US7625753B2 (en) | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
| CN103898047B (zh) | 2003-12-23 | 2020-03-03 | 维亚希特公司 | 定形内胚层 |
| US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| US7541185B2 (en) | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| WO2007059007A2 (en) | 2005-11-14 | 2007-05-24 | Cythera, Inc. | Markers of definitive endoderm |
| US8647873B2 (en) | 2004-04-27 | 2014-02-11 | Viacyte, Inc. | PDX1 expressing endoderm |
| WO2005081970A2 (en) | 2004-02-24 | 2005-09-09 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
| DE102004017476B4 (de) | 2004-04-08 | 2009-03-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung einer Epithelzellen enthaltenden Zellzusammensetzung |
| CA2564114C (en) | 2004-04-27 | 2018-10-09 | Cythera, Inc. | Pdx1 expressing endoderm |
| JP4650608B2 (ja) | 2004-05-18 | 2011-03-16 | 信越化学工業株式会社 | フォトマスクブランク及びフォトマスクの製造方法 |
| US9375514B2 (en) | 2004-05-21 | 2016-06-28 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Multicellular tissue and organ culture systems |
| JP4971149B2 (ja) | 2004-06-17 | 2012-07-11 | スラソス セラピューティックス インコーポレーテッド | Tdf関連化合物およびその類似体 |
| CA2573283C (en) | 2004-07-09 | 2023-03-14 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| US9399054B2 (en) | 2004-07-12 | 2016-07-26 | Emisphere Technologies, Inc. | Compositions for delivering peptide YY and PYY agonists |
| JP2008507280A (ja) | 2004-07-21 | 2008-03-13 | アンブレツクス・インコーポレイテツド | 非天然コードアミノ酸を用いた生合成ポリペプチド |
| EP1791952A4 (en) | 2004-08-13 | 2008-06-11 | Univ Georgia Res Found | COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS |
| US20060236415A1 (en) | 2005-03-09 | 2006-10-19 | Silversides David W | Neural crest cells specific promoters; isolated neural crest cells; and methods of isolating and of using same |
| US7604929B2 (en) | 2005-04-21 | 2009-10-20 | In Vitro Technologies, Inc. | Cellular compositions and methods for their preparation |
| WO2006126219A1 (en) | 2005-05-26 | 2006-11-30 | Fresenius Medical Care Deutschland G.M.B.H. | Liver progenitor cells |
| GB0517382D0 (en) | 2005-08-26 | 2005-10-05 | Plasticell Ltd | Cell culture |
| US7776592B2 (en) | 2005-08-31 | 2010-08-17 | Stc.Unm | Human renal stem cells |
| AU2006305879B2 (en) | 2005-10-27 | 2012-05-10 | Viacyte, Inc. | PDX1-expressing dorsal and ventral foregut endoderm |
| US7927869B2 (en) | 2005-11-29 | 2011-04-19 | Spencer Z Rosero | System and method for supporting a biological chip device |
| US20070239083A1 (en) | 2006-01-18 | 2007-10-11 | Axel Voss | Shock wave generators |
| US20070238169A1 (en) | 2006-04-11 | 2007-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Cell sorter and culture system |
| US8685730B2 (en) | 2006-05-02 | 2014-04-01 | Wisconsin Alumni Research Foundation | Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage |
| WO2007136707A2 (en) | 2006-05-17 | 2007-11-29 | University Of Utah Research Foundation | Methods and compositions related to eosinophil regulation |
| US7932244B2 (en) | 2006-06-27 | 2011-04-26 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions |
| CA2658768C (en) | 2006-07-21 | 2016-05-17 | Massachusetts Institute Of Technology | End-modified poly(beta-amino esters) and uses thereof |
| US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| AU2007335753B2 (en) | 2006-12-18 | 2013-12-05 | Ben Gurion University Of The Negev | Scaffolding for tissue regeneration or repair |
| FR2917425B1 (fr) | 2007-06-18 | 2010-11-19 | Univ Nancy 1 Henri Poincare | Procede de proliferation de cellules sur des multicouches de polyelectrolytes et son application, notamment a la preparation de biomateriaux cellularises |
| EP2022848A1 (en) | 2007-08-10 | 2009-02-11 | Hubrecht Institut | A method for identifying, expanding, and removing adult stem cells and cancer stem cells |
| US7695963B2 (en) | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
| CA2708780A1 (en) | 2007-12-11 | 2009-06-18 | Research Development Foundation | Small molecules for neuronal differentiation of embryonic stem cells |
| CA2711549C (en) | 2008-01-08 | 2016-08-23 | The University Of Queensland | Method of producing a population of cells |
| US20110218512A1 (en) | 2008-06-03 | 2011-09-08 | Aethlon Medical, Inc. | Enhanced antiviral therapy methods and devices |
| WO2009146911A2 (en) | 2008-06-04 | 2009-12-10 | Uwe Marx | Organ-on-a-chip-device |
| KR101711354B1 (ko) | 2008-06-24 | 2017-02-28 | 더 큐레이터스 오브 더 유니버시티 오브 미주리 | 자가-조립가능 다세포체 및 이들을 이용하여 3차원 생물학적 구조체를 생산하는 방법 |
| US20130115673A1 (en) | 2008-07-16 | 2013-05-09 | Biotime, Inc. | Methods of Screening Embryonic Progenitor Cell Lines |
| WO2010053830A1 (en) | 2008-11-05 | 2010-05-14 | Merck Sharp & Dohme Corp. | Mechanism of neuromedin u action and uses thereof |
| JP5351601B2 (ja) | 2008-12-26 | 2013-11-27 | 矢崎総業株式会社 | 絶縁キャップの製造方法及び絶縁キャップの製造装置 |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| ES2579909T3 (es) | 2009-02-03 | 2016-08-17 | Koninklijke Nederlandse Akademie Van Wetenschappen | Medio de cultivo para células madre epiteliales y organoides que comprenden dichas células madre |
| GB201111244D0 (en) | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| WO2010094694A1 (en) | 2009-02-23 | 2010-08-26 | F. Hoffmann-La Roche Ag | Assays to predict cardiotoxicity |
| WO2010105204A2 (en) | 2009-03-13 | 2010-09-16 | Mayo Foundation For Medical Education And Research | Bioartificial liver |
| KR20120008034A (ko) | 2009-03-17 | 2012-01-25 | 엡탈리스 파마 캐나다 아이엔씨. | 우르소데옥시콜산의 증가된 투여량으로 비알콜성 지방간염을 치료하는 방법 |
| WO2010127399A1 (en) | 2009-05-06 | 2010-11-11 | Walter And Eliza Hall Institute Of Medical Research | Gene expression profiles and uses thereof |
| US12371522B2 (en) | 2011-10-12 | 2025-07-29 | The Johns Hopkins University | Bioreducible poly (beta-amino ester)s for siRNA delivery |
| AU2010251151B2 (en) | 2009-05-20 | 2015-08-20 | Cardio3 Biosciences S.A. | Pharmaceutical Composition for the Treatment of Heart Diseases |
| US20120135519A1 (en) | 2009-05-29 | 2012-05-31 | Cellartis Ab | INDUCED DERIVATION OF SPECIFIC ENDODERM FROM hPS CELL-DERIVED DEFINITIVE ENDODERM |
| WO2010143747A1 (ja) | 2009-06-10 | 2010-12-16 | 公立大学法人奈良県立医科大学 | 人工腸管の作製法 |
| CN105796601A (zh) | 2009-07-16 | 2016-07-27 | 生物时代股份有限公司 | 用于体外和体内软骨发生的方法和组合物 |
| EP3284494A1 (en) | 2009-07-30 | 2018-02-21 | Tandem Diabetes Care, Inc. | Portable infusion pump system |
| US8501476B2 (en) | 2009-10-07 | 2013-08-06 | Brown University | Assays and methods for fusing cell aggregates to form proto-tissues |
| EP2504424A1 (en) | 2009-11-25 | 2012-10-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for hepatic differentiation of definitive endoderm cells |
| CA2784425A1 (en) | 2009-12-23 | 2011-06-30 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells |
| EP2550355B1 (en) | 2010-03-22 | 2016-11-16 | Takara Bio Europe AB | Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of wnt-signalling pathway |
| EP2380920A1 (en) | 2010-04-22 | 2011-10-26 | QGel SA | Hydrogel precursor formulation and production process thereof |
| EP2563908B1 (en) | 2010-04-25 | 2019-01-09 | Icahn School of Medicine at Mount Sinai | Generation of anterior foregut endoderm from pluripotent cells |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP2609191B1 (en) | 2010-08-24 | 2017-11-22 | Regents Of The University Of Minnesota | Non-static suspension culture of cell aggregates |
| EP2611907B1 (en) | 2010-08-31 | 2016-05-04 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| WO2012068170A2 (en) | 2010-11-15 | 2012-05-24 | Jau-Nan Lee | Generation of neural stem cells from human trophoblast stem cells |
| PT2658965E (pt) | 2010-12-31 | 2016-06-06 | Universität Für Bodenkultur Wien | Método para a generação de células induzidas e células diferenciadas |
| US8951781B2 (en) | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
| US9200258B2 (en) | 2011-01-27 | 2015-12-01 | University Of Maryland, Baltimore | Multicellular organotypic model of human intestinal mucosa |
| EP2484750A1 (en) | 2011-02-07 | 2012-08-08 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Monitoring system for cell culture |
| KR102117921B1 (ko) | 2011-02-28 | 2020-06-03 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 세포 배양 시스템 |
| GB201106395D0 (en) | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
| US20140158233A1 (en) | 2011-05-09 | 2014-06-12 | President And Fellows Of Harvard College | Aerosol delivery to a microfluidic device |
| US10260039B2 (en) | 2011-05-11 | 2019-04-16 | Massachusetts Institute Of Technology | Microgels and microtissues for use in tissue engineering |
| KR101970634B1 (ko) | 2011-06-02 | 2019-04-19 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 생체외 조직 배양 시스템을 위한 방법 및 용도 |
| WO2012178215A1 (en) * | 2011-06-23 | 2012-12-27 | The Children's Hospital Of Philadelphia | Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof |
| AU2012308724A1 (en) | 2011-09-12 | 2014-04-24 | Organovo, Inc. | Platform for engineered implantable tissues and organs and methods of making the same |
| JP2013066414A (ja) | 2011-09-22 | 2013-04-18 | National Institute Of Advanced Industrial Science & Technology | 胃前駆細胞の表面マーカー |
| US20140302491A1 (en) * | 2011-10-28 | 2014-10-09 | The Board Of Trustees Of The Leland Stanford Junior University | Ex Vivo Culture, Proliferation and Expansion of Primary Tissue Organoids |
| ES2689265T3 (es) | 2011-11-04 | 2018-11-12 | Inregen | Cribado de fármacos y ensayos de potencia |
| US9725687B2 (en) | 2011-12-09 | 2017-08-08 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
| WO2013086502A1 (en) | 2011-12-09 | 2013-06-13 | President And Fellows Of Harvard College | Organ chips and uses thereof |
| US10006904B2 (en) | 2011-12-19 | 2018-06-26 | Umc Utrecht Holding B.V. | Rapid quantitative assay to measure CFTR function in a primary intestinal culture model |
| CN104411318A (zh) | 2011-12-23 | 2015-03-11 | 人类起源公司 | 包含脱细胞并再群体化的胎盘血管支架的类器官 |
| US9828583B2 (en) | 2012-01-13 | 2017-11-28 | The General Hospital Corporation | Isolated human lung progenitor cells and uses thereof |
| US9675646B2 (en) | 2012-01-31 | 2017-06-13 | Wake Forest University Health Sciences | Tubular bioengineered smooth muscle structures |
| EP2816893A1 (en) | 2012-02-22 | 2014-12-31 | Amgen Inc. | Autologous mammalian models derived from induced pluripotent stem cells and related methods |
| EP2634251A1 (en) | 2012-02-29 | 2013-09-04 | Technische Universität Berlin | 3D in vitro bi-phasic cartilage-bone construct |
| AU2013246084B2 (en) | 2012-04-09 | 2018-03-29 | Thomas J. Goodwin | Alternating ionic magnetic resonance (AIMR) multiple-chambered culture apparatus and methods of use |
| JP6301316B2 (ja) | 2012-05-23 | 2018-03-28 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 内胚葉細胞および肝実質細胞の組成物ならびにそれらの細胞を入手および使用する方法 |
| SI3336097T1 (sl) | 2012-06-19 | 2021-07-30 | Intercept Pharmaceuticals, Inc. | Priprava nekristalinične oblike obetiholne kisline |
| US20140099709A1 (en) | 2012-06-19 | 2014-04-10 | Organovo, Inc. | Engineered three-dimensional connective tissue constructs and methods of making the same |
| DE102012105540A1 (de) | 2012-06-26 | 2014-04-24 | Karlsruher Institut für Technologie | Gefäßmodell, Verfahren zu seiner Herstellung und seine Verwendung |
| EP2875360B1 (en) | 2012-07-20 | 2018-08-08 | Agency For Science, Technology And Research | In vitro assay for predicting renal proximal tubular cell toxicity |
| GB201216796D0 (en) | 2012-09-20 | 2012-11-07 | Cambridge Entpr Ltd | In vitro pancreatic differentiation |
| EP2712918B1 (en) | 2012-09-28 | 2014-11-12 | TissUse GmbH | Multi-organ-chip with improved life time and homoeostasis |
| EP2716298A1 (en) | 2012-10-03 | 2014-04-09 | Institut Pasteur | A nod2-dependant pathway of cytoprotection of stem cells |
| ES2625510T3 (es) | 2012-11-26 | 2017-07-19 | Gambro Lundia Ab | Sistema de soporte hepático |
| WO2014082096A1 (en) | 2012-11-26 | 2014-05-30 | The Trustees Of Columbia University In The City Of New York | Method for culture of human and mouse prostate organoids and uses thereof |
| DK2931897T3 (en) | 2012-12-12 | 2018-02-05 | Broad Inst Inc | CONSTRUCTION, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTICAL APPLICATIONS |
| EP2743345A1 (en) | 2012-12-13 | 2014-06-18 | IMBA-Institut für Molekulare Biotechnologie GmbH | Three dimensional heterogeneously differentiated tissue culture |
| WO2014121083A1 (en) | 2013-01-31 | 2014-08-07 | President And Fellows Of Harvard College | Methods of increasing neuronal connectivity and/or treating a neurodegenerative condition |
| EP2956538B1 (en) | 2013-02-13 | 2018-11-14 | Wake Forest University Health Sciences | Bioengineered liver constructs and methods relating thereto |
| GB201304245D0 (en) | 2013-03-08 | 2013-04-24 | Inst Quimic De Sarria | Chemical compounds |
| WO2014165056A1 (en) | 2013-03-12 | 2014-10-09 | Board Of Regents, The University Of Texas System | High throughput mechanical strain generating system for cell cultures and applications thereof |
| JP6677631B2 (ja) | 2013-03-13 | 2020-04-08 | ウイスコンシン アラムナイ リサーチ ファウンデーシヨンWisconsin Alumni Research Foundation | 定義された条件下におけるヒト多能性幹細胞の造血内皮分化のための方法及び材料 |
| WO2014152906A2 (en) | 2013-03-14 | 2014-09-25 | Research Institute At Nationwide Children's Hospital, Inc. | Tissue engineered intestine |
| CN105431522B (zh) | 2013-03-14 | 2021-08-03 | 加利福尼亚大学董事会 | 内侧神经节隆起前体细胞的体外产生 |
| LT2970890T (lt) * | 2013-03-14 | 2020-07-10 | The Brigham And Women`S Hospital, Inc. | Kompozicijos ir būdai, skirti epitelinių kamieninių ląstelių padauginimui ir kultivavimui |
| US20160237400A1 (en) | 2013-03-15 | 2016-08-18 | The Jackson Laboratory | Isolation of non-embryonic stem cells and uses thereof |
| US9442105B2 (en) | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
| WO2014153294A1 (en) | 2013-03-17 | 2014-09-25 | The Regents Of The University Of California | Method to expand and transduce cultured human small and large intestinal stem cells |
| WO2014153346A1 (en) | 2013-03-18 | 2014-09-25 | Massachusetts Institute Of Technology | Engineering a heterogeneous tissue pluripotent stem cells |
| EP2796873A1 (en) | 2013-04-25 | 2014-10-29 | QGel SA | Method for a cell-based drug screening assay and the use thereof |
| US20160245653A1 (en) | 2013-04-30 | 2016-08-25 | Sangtae Park | Cylindrical resonator gyroscope |
| EP4299721A3 (en) | 2013-05-08 | 2024-04-24 | ProKidney | Organoids comprising isolated renal cells and uses thereof |
| US10545133B2 (en) | 2013-05-13 | 2020-01-28 | The Johns Hopkins University | Molecular signatures of invasive cancer subpopulations |
| PL3009506T3 (pl) | 2013-06-10 | 2020-06-29 | Corning Incorporated | Struktura tkankowa i sposób jej wytwarzania |
| RU2016100232A (ru) | 2013-06-14 | 2017-07-17 | Дзе Юниверсити Оф Квинсленд | Почечные клетки-предшественники |
| US20160177270A1 (en) | 2013-07-23 | 2016-06-23 | Public University Corporation Yokohama City- University | Method for integrating biological tissues with a vascular system |
| KR102456567B1 (ko) | 2013-08-09 | 2022-10-19 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
| DK3039123T3 (da) | 2013-08-28 | 2020-01-20 | Promethera Biosciences S A / N V | Fremgangsmåde til at fremstille voksne leverprogenitorceller |
| GB201317869D0 (en) | 2013-10-09 | 2013-11-20 | Cambridge Entpr Ltd | In vitro production of foregut stem cells |
| CN105849252B (zh) | 2013-10-25 | 2020-03-17 | 新加坡科技研究局 | 培养多能干细胞 |
| US10357515B2 (en) | 2013-11-22 | 2019-07-23 | Cellectis | Method for generating batches of allogeneic T-cells with averaged potency |
| JP6499084B2 (ja) | 2013-11-22 | 2019-04-10 | 国立研究開発法人理化学研究所 | 終脳又はその前駆組織の製造方法 |
| EP2876441B1 (en) | 2013-11-26 | 2017-10-25 | Bergen Teknologioverforing AS | Quantitative analysis of contact-depending cell-to-cell transfer and disease transmission |
| GB2583047B (en) | 2013-12-20 | 2021-03-24 | Harvard College | Organomimetic devices and methods of use and manufacturing thereof |
| JP6702876B2 (ja) | 2014-01-14 | 2020-06-03 | イエール ユニバーシティ | 気道細胞を作製するための組成物および方法 |
| US11648335B2 (en) | 2014-01-31 | 2023-05-16 | Wake Forest University Health Sciences | Organ/tissue decellularization, framework maintenance and recellularization |
| JP2017507935A (ja) | 2014-02-11 | 2017-03-23 | アントフロゲネシス コーポレーション | マイクロオルガノイド、並びにその製造方法及び使用方法 |
| US10369254B2 (en) | 2014-02-26 | 2019-08-06 | The Regents Of The University Of California | Method and apparatus for in vitro kidney organogenesis |
| SG10202107992XA (en) | 2014-02-27 | 2021-09-29 | Public Univ Corp Yokohama City Univ | Method for generating cell condensate for self-organization |
| DE102014003465A1 (de) | 2014-03-11 | 2015-09-17 | NeuroProof GmbH | Gewinnung von Gehirnregion-spezifischen neuronalen Kulturen aus dreidimensionalen Gewebekulturen von Stammzellen |
| WO2015140257A1 (en) | 2014-03-19 | 2015-09-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for inducing human cholangiocyte differentiation |
| HK1232147A1 (zh) | 2014-03-21 | 2018-01-05 | Tobira Therapeutics, Inc. | 用於治疗纤维化的赛尼克韦罗 |
| CN106536720B (zh) | 2014-04-04 | 2021-04-30 | 奥加诺沃公司 | 工程化的三维乳腺组织,脂肪组织和肿瘤疾病模型 |
| WO2015156929A1 (en) | 2014-04-07 | 2015-10-15 | The Trustees Of Columbia University In The City Of New York | Method for culture of human bladder cell lines and organoids and uses thereof |
| WO2015157163A1 (en) | 2014-04-07 | 2015-10-15 | Rush University Medical Center | Screening assay for choice of prebiotic to prevent/treat gastrointestinal and systemic diseases |
| BR112016023269A8 (pt) | 2014-04-11 | 2021-06-29 | Cymabay Therapeutics Inc | uso de ácido (r)-2-(4-((2-etóxi-3-(4-(trifluormetil)fenóxi)propil)-tio)-2-metilfenóxi)-acético ou sal do mesmo na fabricação de um medicamento para tratar doença hepática gordurosa não alcoólica ou esteato-hepatite não alcoólica |
| MX388202B (es) | 2014-04-27 | 2025-03-19 | Univ New York State Res Found | Métodos para generar productos de esmalte in vitro. |
| AU2015261380B2 (en) | 2014-05-16 | 2021-04-15 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method for organoids |
| CN106661548B (zh) | 2014-05-28 | 2020-12-11 | 儿童医院医疗中心 | 用于经由定向分化将前体细胞转化为胃组织的方法和系统 |
| CN106536707B (zh) | 2014-05-29 | 2018-12-25 | 西奈山伊坎医学院 | 在生物反应器系统中制造心脏类器官的方法和装置 |
| WO2015184375A2 (en) | 2014-05-29 | 2015-12-03 | Whitehead Institute For Biomedical Research | Compositions and methods for promoting intestinal stem cell and/or non-stem progenitor cell function |
| US20170107498A1 (en) | 2014-06-05 | 2017-04-20 | Cedars-Sinai Medical Center | Novel and efficient method for reprogramming immortalized lymphoblastoid cell lines to induced pluripotent stem cells |
| ES2897553T3 (es) | 2014-06-06 | 2022-03-01 | Univ Brussel Vrije | Modelo de cocultivo 3D hepático humano y usos del mismo |
| FR3022110B1 (fr) | 2014-06-13 | 2016-07-01 | Liphatech Inc | Appat rodonticide et procede de lutte contre des rongeurs cibles nuisibles mettant en œuvre un tel appat |
| EP3158056B1 (en) | 2014-06-20 | 2021-10-06 | Rutgers, the State University of New Jersey | Single cell-derived organoids |
| EP3160503B1 (en) | 2014-06-26 | 2021-02-17 | The Trustees of Columbia University in the City of New York | Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells |
| SG11201700303UA (en) | 2014-07-17 | 2017-02-27 | Celmatix Inc | Methods and systems for assessing infertility and related pathologies |
| CA2945609C (en) | 2014-07-29 | 2023-05-23 | Shenzhen Hightide Biopharmaceutical, Ltd. | Berberine-ursodeoxycholic salt, method of preparation and application therof |
| US12247224B2 (en) | 2014-07-30 | 2025-03-11 | Senthil Muthuswamy | Organoids for drug screening and personalized medicine |
| EP3183336B2 (en) | 2014-08-22 | 2025-07-09 | Cambridge Enterprise Limited | Resetting pluripotent stem cells |
| MA39959A (fr) | 2014-08-28 | 2017-03-15 | Promethera Biosciences S A /N V | Procédé de production de cellules progénitrices de foie adulte |
| WO2016033163A1 (en) | 2014-08-29 | 2016-03-03 | Immunomedics, Inc. | Identification of cancer genes by in-vivo fusion of human cancer cells and animal cells |
| BR112017004708A2 (pt) | 2014-09-12 | 2017-12-05 | Tobira Therapeutics Inc | terapia de combinação de cenicriviroc para o tratamento de fibrose |
| MA40495A (fr) | 2014-10-06 | 2016-04-14 | Organovo Inc | Tissus rénaux produits par génie génétique, réseaux correspondants, et procédés de production |
| CN107075471A (zh) | 2014-10-08 | 2017-08-18 | 新加坡科技研究局 | 将干细胞分化为肝细胞谱系的方法 |
| EP3207122B1 (en) | 2014-10-14 | 2019-05-08 | FUJIFILM Cellular Dynamics, Inc. | Generation of keratinocytes from pluripotent stem cells and maintenance of keratinocyte cultures |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のin vivoモデル、並びにそれを作製、及び使用する方法 |
| US20160121023A1 (en) | 2014-10-30 | 2016-05-05 | Massachusetts Institute Of Technology | Materials and Methods for Rescue of Ischemic Tissue and Regeneration of Tissue Integrity During Resection, Engraftment and Transplantation |
| WO2016073989A2 (en) | 2014-11-07 | 2016-05-12 | The Trustees Of Columbia University In The City Of New York | Osteochondroreticular stem cells for bone and cartilage regeneration |
| EP3223831B1 (en) | 2014-11-25 | 2020-06-24 | President and Fellows of Harvard College | Methods for generation of podocytes from pluripotent stem cells and cells produced by the same |
| US20170260501A1 (en) | 2014-11-25 | 2017-09-14 | International Stem Cell Corporation | Derivation of neural crest stem cells and uses thereof |
| GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| AU2014277667B2 (en) | 2014-12-15 | 2022-07-14 | The University Of Queensland | Differentiation of pluripotent stem cells to form renal organoids |
| US11583860B2 (en) | 2014-12-22 | 2023-02-21 | Ecole Polytechnique Federale De Lausanne (Epfl) | Microstructured thin hydrogel films |
| WO2016103269A1 (en) | 2014-12-23 | 2016-06-30 | Ramot At Tel-Aviv University Ltd. | Populations of neural progenitor cells and methods of producing and using same |
| JP2018501276A (ja) | 2015-01-09 | 2018-01-18 | ギリアド アポロ, エルエルシー | 非アルコール性脂肪肝疾患の処置のためのacc阻害剤併用療法 |
| WO2016121512A1 (ja) | 2015-01-28 | 2016-08-04 | 公立大学法人横浜市立大学 | 骨髄細胞凝集体の作製方法 |
| US20160256672A1 (en) | 2015-02-10 | 2016-09-08 | Cedars-Sinai Medical Center | Induced pluripotent stem cell-derived hepatocyte based bioartificial liver device |
| CN105985395A (zh) | 2015-02-13 | 2016-10-05 | 江苏奥赛康药业股份有限公司 | 一种奥贝胆酸化合物及含有该化合物的药物组合物 |
| WO2016140716A1 (en) | 2015-03-02 | 2016-09-09 | The Trustees Of Columbia University In The City Of New York | Injectable microtissue systems, devices, and methods |
| JP6807853B2 (ja) | 2015-03-03 | 2021-01-06 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 機能的ヒト組織の作製方法 |
| GB2554181B (en) | 2015-03-06 | 2021-09-08 | Micromass Ltd | Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("REIMS") device |
| EP3265180A4 (en) | 2015-03-06 | 2019-04-24 | The University of North Carolina at Chapel Hill | HUMAN FIBROLAMELLAR Liver Cell Carcinomas (HFL-HCCS) |
| EA201791982A1 (ru) | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
| US10023922B2 (en) | 2015-03-23 | 2018-07-17 | Whitehead Institute For Biomedical Research | Reporter of genomic methylation and uses thereof |
| US10894054B2 (en) | 2015-04-07 | 2021-01-19 | Intercept Pharmaceuticals, Inc. | FXR agonist compositions for combination therapy |
| US10087417B2 (en) | 2015-04-22 | 2018-10-02 | William J. Freed | Three-dimensional model of human cortex |
| US10557124B2 (en) | 2015-04-22 | 2020-02-11 | The Regents Of The University Of Michigan | Compositions and methods for obtaining stem cell derived lung tissue, and related uses thereof |
| CN104877964A (zh) | 2015-04-24 | 2015-09-02 | 赵振民 | 一种唾液腺类器官和类腺泡的体外构建方法 |
| PE20180690A1 (es) | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
| EP3289072B1 (en) | 2015-04-30 | 2023-08-16 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Means and methods for generation of breast stem cells |
| US11299714B2 (en) | 2015-05-11 | 2022-04-12 | The Trustees Of Columbia University In The City Of New York | Engineered adult-like human heart tissue |
| EP3303566B1 (en) | 2015-06-03 | 2020-10-14 | Takara Bio Europe AB | Maturation of mammalian hepatocytes |
| GB201510950D0 (en) | 2015-06-22 | 2015-08-05 | Cambridge Entpr Ltd | In vitro Production of Cholangiocytes |
| US11136548B2 (en) | 2015-06-24 | 2021-10-05 | Whitehead Institute For Biomedical Research | Culture medium for generating microglia from pluripotent stem cells and related methods |
| EP3313416A4 (en) | 2015-06-26 | 2019-02-20 | The Trustees of Columbia University in the City of New York | GENETICALLY MODIFIED IPS CELLS WITH A MARKER FOR THE EXPRESSION OF NEUROGENIN3, TPH2, FOXO1 AND / OR INSULINGENES |
| WO2017009263A1 (en) | 2015-07-10 | 2017-01-19 | Etablissement Francais Du Sang | Method for obtaining human brown/beige adipocytes |
| US10449221B2 (en) | 2015-07-29 | 2019-10-22 | Trustees Of Boston University | Differentiation of stem cells into thyroid tissue |
| WO2017041041A1 (en) | 2015-09-03 | 2017-03-09 | The Brigham And Women's Hospital, Inc. | Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease |
| WO2017036533A1 (en) | 2015-09-03 | 2017-03-09 | Ecole Polytechnique Federale De Lausanne (Epfl) | Three-dimensional hydrogels for culturing adult epithelial stem cells and organoids |
| WO2017048193A1 (en) | 2015-09-15 | 2017-03-23 | Agency For Science, Technology And Research (A*Star) | Derivation of liver organoids from human pluripotent stem cells |
| US20180360846A1 (en) | 2015-09-16 | 2018-12-20 | Tobira Therapeutics, Inc. | Cenicriviroc combination therapy for the treatment of fibrosis |
| JP2018527007A (ja) | 2015-09-17 | 2018-09-20 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | ヒト多能性幹細胞からネフロンを生成する方法 |
| KR20180055894A (ko) | 2015-10-02 | 2018-05-25 | 웨이크 포리스트 유니버시티 헬스 사이언시즈 | 자발적으로 박동하는 심장 오르가노이드 구조체 및 그를 포함하는 통합된 바디-온-칩 장치 |
| LU92845B1 (en) | 2015-10-08 | 2017-05-02 | Univ Du Luxembourg Campus Belval | Means and methods for generating midbrain organoids |
| US10993433B2 (en) | 2015-10-15 | 2021-05-04 | Wake Forest University Health Sciences | Method of producing in vitro testicular constructs and uses thereof |
| AU2016340819B2 (en) | 2015-10-15 | 2023-04-06 | Wake Forest University Health Sciences | Methods of producing in vitro liver constructs and uses thereof |
| WO2017066659A1 (en) | 2015-10-16 | 2017-04-20 | The Trustees Of Columbia University In The City Of New York | Jag1 expression predicts therapeutic response in nash |
| CA3001342A1 (en) | 2015-10-16 | 2017-04-20 | Wake Forest University Health Sciences | Multi-layer airway organoids and methods of making and using the same |
| US12209253B2 (en) | 2016-08-29 | 2025-01-28 | EMULATE, Inc. | Development of spinal cord on a microfluidic chip |
| AU2016341880B2 (en) | 2015-10-19 | 2021-01-21 | Cedars-Sinai Medical Center | Microfluidic model of the blood brain barrier |
| CN108431211B (zh) | 2015-10-20 | 2026-03-24 | 富士胶片细胞动力公司 | 通过遗传编程的多谱系造血前体细胞产生 |
| US20190093072A1 (en) | 2015-10-21 | 2019-03-28 | Indiana University Research And Technology Corporation | Methods of generating human inner ear sensory epithelia and sensory neurons |
| JP7018875B2 (ja) | 2015-10-21 | 2022-02-14 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | 多能性幹細胞からのヒト皮膚オルガノイドの誘導 |
| MX2018005274A (es) | 2015-10-30 | 2019-09-19 | The Regents Of The Universtiy Of California | Metodos para la generacion de celulas-t a partir de celulas madre y metodos inmunoterapeuticos que utilizan las celulas-t. |
| US11866409B2 (en) | 2015-11-02 | 2024-01-09 | Carmel-Haifa University Economic Corporation Ltd. | Apoptosis related protein in the tgf-beta signaling pathway (ARTS) mimetic compounds, compositions, methods and uses thereof in induction of differentiation and/or apoptosis of premalignant and malignant cells, thereby restoring their normal-like phenotype |
| WO2017079632A1 (en) | 2015-11-04 | 2017-05-11 | Cedars-Sinai Medical Center | Patient-derived ctc-xenograft models |
| AU2016348638A1 (en) | 2015-11-06 | 2018-06-07 | Gemphire Therapeutics Inc. | Gemcabene combinations for the treatment of cardiovascular disease |
| JP7209541B2 (ja) | 2015-11-12 | 2023-01-20 | バイオステージ,インコーポレーテッド | 胃腸組織の生成のためのシステムおよび方法 |
| WO2017083705A1 (en) | 2015-11-13 | 2017-05-18 | The Johns Hopkins University | Cell culture system and method of use thereof |
| WO2017096282A1 (en) | 2015-12-04 | 2017-06-08 | EMULATE, Inc. | Devices and methods for simulating a function of a liver tissue |
| CA3013309A1 (en) | 2015-12-04 | 2017-06-08 | President And Fellows Of Harvard College | Devices for simulating a function of a liver tissue and methods of use and manufacturing thereof |
| CN108699528A (zh) | 2015-12-23 | 2018-10-23 | 纪念斯隆-凯特琳癌症中心 | 在先天性巨结肠症中通过衍生自多能干细胞的人肠神经嵴谱系可行的基于细胞的治疗和药物开发 |
| KR101733137B1 (ko) | 2015-12-30 | 2017-05-08 | (주)엑셀세라퓨틱스 | 연골조직 제조를 위한 3차원 오가노이드 블록 제작 방법 |
| JP6694512B2 (ja) | 2015-12-30 | 2020-05-13 | フジフィルム セルラー ダイナミクス,インコーポレイテッド | 幹細胞由来ヒト肝細胞を使用した微小組織形成 |
| US20190367868A1 (en) | 2015-12-31 | 2019-12-05 | President And Fellows Of Harvard College | Neurons and compositions and methods for producing the same |
| WO2017117547A1 (en) | 2015-12-31 | 2017-07-06 | President And Fellows Of Harvard College | Methods for generating neural tissue and uses thereof |
| CN108779437A (zh) | 2016-01-08 | 2018-11-09 | 麻省理工学院 | 分化的肠内分泌细胞和胰岛素产生细胞的制备 |
| EP3190176A1 (en) | 2016-01-11 | 2017-07-12 | IMBA-Institut für Molekulare Biotechnologie GmbH | Method for tissue culture development on scaffold and differentiated tissue culture |
| CN108883137A (zh) | 2016-01-14 | 2018-11-23 | 俄亥俄州国家创新基金会 | 神经类器官组合物及使用方法 |
| US20170205396A1 (en) | 2016-01-15 | 2017-07-20 | Salk Institute For Biological Studies | Systems and methods for culturing nephron progenitor cells |
| US11473061B2 (en) | 2016-02-01 | 2022-10-18 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells in microfluidic devices |
| WO2017139455A1 (en) | 2016-02-10 | 2017-08-17 | Wake Forest University Health Sciences | Model system of liver fibrosis and method of making and using the same |
| WO2017139638A1 (en) | 2016-02-11 | 2017-08-17 | The Johns Hopkins University | Compositions and methods for neuralgenesis |
| US10179176B2 (en) | 2016-02-16 | 2019-01-15 | The Board Of Trustees Of The Leland Stanford Junior University | Recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies |
| WO2017142069A1 (ja) | 2016-02-18 | 2017-08-24 | 学校法人慶應義塾 | 細胞培養培地、培養方法、及びオルガノイド |
| PT3417073T (pt) | 2016-02-19 | 2023-10-26 | Procella Therapeutics Ab | Marcadores genéticos para enxerto de células progenitoras ventriculares cardíacas humanas |
| US20170267970A1 (en) | 2016-02-29 | 2017-09-21 | Whitehead Institute For Biomedical Research | Three-Dimensional Hydrogels that Support Growth of Physiologically Relevant Tissue and Methods of Use Thereof |
| GB201603569D0 (en) | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
| EP3426766B1 (en) | 2016-03-08 | 2022-12-28 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Method for continuous biosensing |
| SG11201807487WA (en) | 2016-03-14 | 2018-09-27 | Agency Science Tech & Res | Generation of midbrain-specific organoids from human pluripotent stem cells |
| US10772863B2 (en) | 2016-03-15 | 2020-09-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Methods of inducing metabolic maturation of human pluripotent stem cells— derived hepatocytes |
| US20190076482A1 (en) | 2016-03-15 | 2019-03-14 | The Johns Hopkins University | Enhanced organoid formation and intestinal stem cell renewal |
| US20170285002A1 (en) | 2016-03-16 | 2017-10-05 | Public University Corporation Yokohama City University | Method for reconstituting tumor with microenvironment |
| WO2017172638A1 (en) | 2016-03-29 | 2017-10-05 | Smsbiotech, Inc. | Compositions and methods for using small mobile stem cells |
| CA3019357A1 (en) | 2016-04-04 | 2017-10-12 | Biotime, Inc. | Pluripotent stem cell-derived 3d retinal tissue and uses thereof |
| AU2017245629A1 (en) | 2016-04-04 | 2018-11-22 | Humeltis | Diagnostic methods for patient specific therapeutic decision making in cancer care |
| EP3228306A1 (en) | 2016-04-04 | 2017-10-11 | ratiopharm GmbH | Complex compound comprising obeticholic acid and cyclodextrin and pharmaceutical formulation comprising the complex compound |
| JP6935101B2 (ja) | 2016-04-05 | 2021-09-15 | 学校法人自治医科大学 | 幹細胞を再樹立する方法 |
| WO2017184586A1 (en) | 2016-04-18 | 2017-10-26 | The Trustees Of Columbia University In The City Of New York | Therapeutic targets involved in the progression of nonalcoholic steatohepatitis (nash) |
| EP3445363A1 (en) | 2016-04-22 | 2019-02-27 | Taiwanj Pharmaceuticals Co., Ltd. | Nalmefene, naltrexone or derivatives thereof for use in treating (non)-alcoholic steatohepatitis or non-alcoholic fatty liver disease |
| US20170321188A1 (en) | 2016-05-04 | 2017-11-09 | The Research Foundation For The State University Of New York | Methods of generating retinal progenitor cell preparations and uses thereof |
| ES2929758T3 (es) | 2016-05-05 | 2022-12-01 | Childrens Hospital Med Ct | Métodos para la fabricación in vitro de tejido del fondo gástrico y composiciones relacionadas con el mismo |
| AU2017269364B2 (en) | 2016-05-25 | 2023-08-31 | Salk Institute For Biological Studies | Compositions and methods for organoid generation and disease modeling |
| US20170349659A1 (en) | 2016-06-03 | 2017-12-07 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt signaling agonist molecules |
| WO2017218287A1 (en) | 2016-06-15 | 2017-12-21 | Children's Medical Center Corporation | Methods and compositions relating to lung cell differentiation |
| GB201610748D0 (en) | 2016-06-20 | 2016-08-03 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved diffrentation method |
| GB201611982D0 (en) | 2016-07-11 | 2016-08-24 | Cellesce Ltd | Cell culture |
| EP3275997A1 (en) | 2016-07-28 | 2018-01-31 | QGel SA | Hydrogel precursor formulation and the use thereof |
| CA3029653A1 (en) | 2016-08-02 | 2018-02-08 | Memorial Sloan-Kettering Cancer Center | Treating metastatic cancer and model systems for metastatic disease |
| EP4478049A3 (en) | 2016-08-03 | 2024-12-25 | Wake Forest University Health Sciences | Cancer modeling platforms and methods of using the same |
| WO2018027112A1 (en) | 2016-08-04 | 2018-02-08 | Wake Forest University Health Sciences | Blood brain barrier model and methods of making and using the same |
| KR102417262B1 (ko) | 2016-08-24 | 2022-07-07 | 각고호우징 게이오기주크 | 인간 설사병 바이러스의 감염·증식 배양용 2d 오가노이드 및 그 사용 |
| JP7262385B2 (ja) | 2016-08-26 | 2023-04-21 | ザ・カウンシル・オブ・ザ・クィーンズランド・インスティテュート・オブ・メディカル・リサーチ | 心筋細胞の成熟 |
| EP3503902A4 (en) | 2016-08-28 | 2020-04-22 | Baylor College of Medicine | A novel chicken egg-based metastasis model for cancer |
| JP2019530733A (ja) | 2016-08-30 | 2019-10-24 | ベス イスラエル デアコネス メディカル センター インコーポレイティッド | 腫瘍抑制因子欠損がんを処置するための組成物および方法 |
| EP3507360A4 (en) | 2016-08-30 | 2020-07-29 | Beth Israel Deaconess Medical Center Inc. | COMPOSITIONS AND TREATMENT METHODS FOR TUMOR SUPPRESSOR-DEFICIENT CANCER |
| KR102729404B1 (ko) | 2016-11-04 | 2024-11-14 | 칠드런즈 호스피탈 메디칼 센터 | 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법 |
| WO2018094522A1 (en) | 2016-11-23 | 2018-05-31 | Valorisation-Hsj, Limited Partnership | Encapsulated liver tissue |
| JP7068305B2 (ja) | 2016-12-05 | 2022-05-16 | チルドレンズ ホスピタル メディカル センター | 結腸オルガノイドならびにその作製方法および使用方法 |
| GB201622222D0 (en) | 2016-12-23 | 2017-02-08 | Cs Genetics Ltd | Reagents and methods for molecular barcoding of nucleic acids of single cells |
| US12281334B2 (en) | 2017-04-14 | 2025-04-22 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| EP3395942A1 (en) | 2017-04-25 | 2018-10-31 | IMBA-Institut für Molekulare Biotechnologie GmbH | Bi- or multi-differentiated organoid |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
-
2017
- 2017-05-05 ES ES17793451T patent/ES2929758T3/es active Active
- 2017-05-05 CN CN201780024903.5A patent/CN109415685B/zh not_active Expired - Fee Related
- 2017-05-05 WO PCT/US2017/031309 patent/WO2017192997A1/en not_active Ceased
- 2017-05-05 US US16/084,599 patent/US11066650B2/en active Active
- 2017-05-05 JP JP2018550724A patent/JP6963882B2/ja active Active
- 2017-05-05 EP EP22189427.2A patent/EP4177335A1/en not_active Withdrawn
- 2017-05-05 CN CN202310699246.1A patent/CN116790476A/zh active Pending
- 2017-05-05 CA CA3016641A patent/CA3016641A1/en active Pending
- 2017-05-05 EP EP17793451.0A patent/EP3452578B1/en active Active
-
2021
- 2021-07-14 US US17/375,293 patent/US20220064602A1/en not_active Abandoned
- 2021-10-15 JP JP2021169192A patent/JP7463326B2/ja active Active
-
2024
- 2024-03-27 JP JP2024050953A patent/JP2024095710A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017192997A1 (en) | 2017-11-09 |
| JP7463326B2 (ja) | 2024-04-08 |
| EP4177335A1 (en) | 2023-05-10 |
| EP3452578A4 (en) | 2019-12-04 |
| US20220064602A1 (en) | 2022-03-03 |
| JP2022025087A (ja) | 2022-02-09 |
| US20190078055A1 (en) | 2019-03-14 |
| CN109415685B (zh) | 2023-07-04 |
| CN116790476A (zh) | 2023-09-22 |
| US11066650B2 (en) | 2021-07-20 |
| CA3016641A1 (en) | 2017-11-09 |
| ES2929758T3 (es) | 2022-12-01 |
| JP2019514354A (ja) | 2019-06-06 |
| EP3452578B1 (en) | 2022-08-10 |
| CN109415685A (zh) | 2019-03-01 |
| JP2024095710A (ja) | 2024-07-10 |
| EP3452578A1 (en) | 2019-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6963882B2 (ja) | 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 | |
| JP7698080B2 (ja) | 前駆細胞を指向性分化によって胃組織に変換するための方法及びシステム | |
| JP7506657B2 (ja) | 肝胆膵組織およびその作製方法 | |
| HK40092378A (en) | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same | |
| HK40001580B (en) | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same | |
| HK40057032A (en) | Methods and systems for converting precursor cells into gastric tissues through directed differentiation | |
| HK40001580A (en) | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same | |
| HK40057032B (zh) | 用於经由定向分化将前体细胞转化为胃组织的方法和系统 | |
| HK40006077B (en) | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same | |
| HK40006077A (en) | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200210 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200210 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210302 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210529 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210719 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20211005 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20211015 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6963882 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |