JP6917978B2 - Ｐｒｍｔ５阻害剤として使用するための新規な６−６二環式芳香環置換ヌクレオシド類似体 - Google Patents

Ｐｒｍｔ５阻害剤として使用するための新規な６−６二環式芳香環置換ヌクレオシド類似体 Download PDF

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JP6917978B2
JP6917978B2 JP2018510334A JP2018510334A JP6917978B2 JP 6917978 B2 JP6917978 B2 JP 6917978B2 JP 2018510334 A JP2018510334 A JP 2018510334A JP 2018510334 A JP2018510334 A JP 2018510334A JP 6917978 B2 JP6917978 B2 JP 6917978B2
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alkyl
hydrogen
group
halo
substituted
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JP2018528946A (ja
JP2018528946A5 (enExample
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ウ，トンフェイ
ブレマー，ダーク
ビーク，リジュス
ブークス，アン
ディエルス，ガストン，スタニスラス，マーセラ
ギリッセン，ロナルダス，アルノドゥス，ヘンドリカ，ヨセフ
ローソン，エドワード，チャールス
パンデ，ヴィニート
パレード，マーカス，コーネリス，ベルナルデュス，カタリナ
スケペンス，ウィム，バート，グリエット
ターリング，ヨハネ，ウィルヘルムス，ジョン，エフ
ビルボアイ，マーセル
サン，ウェイメイ
ミーアポエル，リエヴェン
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ヤンセン ファーマシューティカ エヌ．ベー．
ヤンセン ファーマシューティカ エヌ．ベー．
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JP2018510334A 2015-08-26 2016-08-25 Ｐｒｍｔ５阻害剤として使用するための新規な６−６二環式芳香環置換ヌクレオシド類似体 Active JP6917978B2 (ja)

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JP2021120042A JP7720732B2 (ja) 2015-08-26 2021-07-20 Ｐｒｍｔ５阻害剤として使用するための新規な６－６二環式芳香環置換ヌクレオシド類似体
JP2023184701A JP2024012405A (ja) 2015-08-26 2023-10-27 Ｐｒｍｔ５阻害剤として使用するための新規な６－６二環式芳香環置換ヌクレオシド類似体

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US201562209941P 2015-08-26 2015-08-26
US62/209,941 2015-08-26
EP15184011 2015-09-07
EP15184011.3 2015-09-07
US201662306233P 2016-03-10 2016-03-10
US62/306,233 2016-03-10
PCT/EP2016/070097 WO2017032840A1 (en) 2015-08-26 2016-08-25 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as prmt5 inhibitors

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JP2021120042A Active JP7720732B2 (ja) 2015-08-26 2021-07-20 Ｐｒｍｔ５阻害剤として使用するための新規な６－６二環式芳香環置換ヌクレオシド類似体
JP2023184701A Withdrawn JP2024012405A (ja) 2015-08-26 2023-10-27 Ｐｒｍｔ５阻害剤として使用するための新規な６－６二環式芳香環置換ヌクレオシド類似体

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JP2023184701A Withdrawn JP2024012405A (ja) 2015-08-26 2023-10-27 Ｐｒｍｔ５阻害剤として使用するための新規な６－６二環式芳香環置換ヌクレオシド類似体

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CN (2) CN107922413B (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
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JP2021169520A (ja) * 2015-08-26 2021-10-28 ヤンセン ファーマシューティカ エヌ．ベー． Ｐｒｍｔ５阻害剤として使用するための新規な６−６二環式芳香環置換ヌクレオシド類似体

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ES2891320T3 (es) * 2016-03-10 2022-01-27 Janssen Pharmaceutica Nv Análogos de nucleósidos sustituidos para su uso como inhibidores de PRMT5
CA2969295A1 (en) * 2016-06-06 2017-12-06 Pfizer Inc. Substituted carbonucleoside derivatives, and use thereof as a prmt5 inhibitor
EP3512858B1 (en) 2016-09-14 2023-11-08 Janssen Pharmaceutica NV Fused bicyclic inhibitors of menin-mll interaction
ES2872003T3 (es) 2016-09-14 2021-11-02 Janssen Pharmaceutica Nv Inhibidores espirobicíclicos de la interacción de menina-MLL
US12084462B2 (en) 2016-09-14 2024-09-10 Janssen Pharmaceutica Nv Spiro bicyclic inhibitors of menin-MLL interaction
KR102531344B1 (ko) * 2016-10-03 2023-05-10 얀센 파마슈티카 엔.브이. Prmt5 억제제로서 사용하기 위한 신규의 모노사이클릭 및 바이사이클릭 고리 시스템 치환된 카르바뉴클레오시드 유사체
KR102513564B1 (ko) 2016-12-15 2023-03-22 얀센 파마슈티카 엔.브이. 메닌-mll 상호작용의 아제판 억제제
GB201700526D0 (en) * 2017-01-12 2017-03-01 Univ Of Hull Therapeutic use
EA201990851A1 (ru) 2017-02-24 2019-09-30 Янссен Фармацевтика Нв Новые аналоги карбануклеозида, замещенные моноциклической и бициклической кольцевой системой, для применения в качестве ингибиторов prmt5
CA3049739A1 (en) 2017-02-27 2018-08-30 Janssen Pharmaceutica Nv Use of biomarkers in identifying cancer patients that will be responsive to treatment with a prmt5 inhibitor
AU2018313910B2 (en) 2017-08-09 2022-12-08 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
CN111542525B (zh) * 2017-10-26 2023-06-27 普莱鲁德疗法有限公司 蛋白质精氨酸甲基转移酶5(prmt5)的选择性抑制剂
SG11202005112TA (en) * 2017-12-05 2020-06-29 Angex Pharmaceutical Inc Heterocyclic compounds as prmt5 inhibitors
JP7352544B2 (ja) 2017-12-08 2023-09-28 ヤンセン ファーマシューティカ エヌ．ベー． 新規なスピロ二環式類似体
CR20200263A (es) * 2017-12-13 2020-07-26 Lupin Ltd Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5
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