AU2016311295B2 - Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors - Google Patents

Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors Download PDF

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AU2016311295B2
AU2016311295B2 AU2016311295A AU2016311295A AU2016311295B2 AU 2016311295 B2 AU2016311295 B2 AU 2016311295B2 AU 2016311295 A AU2016311295 A AU 2016311295A AU 2016311295 A AU2016311295 A AU 2016311295A AU 2016311295 B2 AU2016311295 B2 AU 2016311295B2
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4alkyl
cancer
halo
hydrogen
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AU2016311295A1 (en
Inventor
Lijs Beke
An Boeckx
Dirk Brehmer
Gaston Stanislas Marcella Diels
Ronaldus Arnodus Hendrika Joseph Gilissen
Edward Charles LAWSON
Lieven Meerpoel
Vineet PANDE
Marcus Cornelis Bernardus Catharina Parade
Wim Bert Griet Schepens
Weimei SUN
Johannes Wilhelmus John F. Thuring
Marcel Viellevoye
Tongfei Wu
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Janssen Pharmaceutica NV
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AU2016311295A 2015-08-26 2016-08-25 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors Active AU2016311295B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2021200345A AU2021200345B2 (en) 2015-08-26 2021-01-20 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
AU2022215260A AU2022215260B2 (en) 2015-08-26 2022-08-11 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
AU2024202052A AU2024202052A1 (en) 2015-08-26 2024-03-28 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562209941P 2015-08-26 2015-08-26
US62/209941 2015-08-26
EP15184011.3 2015-09-07
EP15184011 2015-09-07
US201662306233P 2016-03-10 2016-03-10
US62/306233 2016-03-10
PCT/EP2016/070097 WO2017032840A1 (en) 2015-08-26 2016-08-25 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as prmt5 inhibitors

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AU2016311295B2 true AU2016311295B2 (en) 2020-10-22

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AU2016311295A Active AU2016311295B2 (en) 2015-08-26 2016-08-25 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
AU2021200345A Active AU2021200345B2 (en) 2015-08-26 2021-01-20 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
AU2022215260A Active AU2022215260B2 (en) 2015-08-26 2022-08-11 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
AU2024202052A Pending AU2024202052A1 (en) 2015-08-26 2024-03-28 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors

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AU2021200345A Active AU2021200345B2 (en) 2015-08-26 2021-01-20 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
AU2022215260A Active AU2022215260B2 (en) 2015-08-26 2022-08-11 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
AU2024202052A Pending AU2024202052A1 (en) 2015-08-26 2024-03-28 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors

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EA201892031A1 (ru) * 2016-03-10 2019-02-28 Янссен Фармацевтика Нв Замещенные аналоги нуклеозидов для применения в качестве ингибиторов prmt5
CA2969295A1 (en) * 2016-06-06 2017-12-06 Pfizer Inc. Substituted carbonucleoside derivatives, and use thereof as a prmt5 inhibitor
CA3033020A1 (en) 2016-09-14 2018-03-22 Janssen Pharmaceutica Nv Fused bicyclic inhibitors of menin-mll interaction
JP6975791B2 (ja) 2016-09-14 2021-12-01 ヤンセン ファーマシューティカ エヌ．ベー． メニン−ｍｌｌ相互作用のスピロ二環式阻害剤
US12084462B2 (en) 2016-09-14 2024-09-10 Janssen Pharmaceutica Nv Spiro bicyclic inhibitors of menin-MLL interaction
KR102531344B1 (ko) 2016-10-03 2023-05-10 얀센 파마슈티카 엔.브이. Prmt5 억제제로서 사용하기 위한 신규의 모노사이클릭 및 바이사이클릭 고리 시스템 치환된 카르바뉴클레오시드 유사체
CN110248946B (zh) 2016-12-15 2023-05-23 詹森药业有限公司 Menin-MLL相互作用的氮杂环庚烷抑制剂
GB201700526D0 (en) * 2017-01-12 2017-03-01 Univ Of Hull Therapeutic use
EA201990851A1 (ru) 2017-02-24 2019-09-30 Янссен Фармацевтика Нв Новые аналоги карбануклеозида, замещенные моноциклической и бициклической кольцевой системой, для применения в качестве ингибиторов prmt5
UA127679C2 (uk) 2017-02-27 2023-11-29 Янссен Фармацевтика Нв Спосіб ідентифікації пацієнта, що характеризується наявністю сприйнятливості до лікування недрібноклітинного раку легені інгібітором prmt5
JP2020530496A (ja) * 2017-08-09 2020-10-22 プレリュード セラピューティクス，インコーポレイティド タンパク質アルギニンメチルトランスフェラーゼ５（ｐｒｍｔ５）の選択的阻害剤
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PE20211444A1 (es) 2017-12-13 2021-08-05 Lupin Ltd Componentes heterociclicos biciclicos sustituidos como inhibidores de prmt5
US11396517B1 (en) 2017-12-20 2022-07-26 Janssen Pharmaceutica Nv Exo-aza spiro inhibitors of menin-MLL interaction
US10711007B2 (en) 2018-03-14 2020-07-14 Prelude Therapeutics Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
ES2963436T3 (es) * 2018-03-14 2024-03-27 Prelude Therapeutics Inc Inhibidores selectivos de la proteína arginina metiltransferasa 5 (PRMT5)
EP3833667B1 (en) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Prmt5 inhibitors
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US12173026B2 (en) 2018-08-07 2024-12-24 Merck Sharp & Dohme Llc PRMT5 inhibitors
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