BR112021024457A2 - Intermediários espirobicíclicos - Google Patents

Intermediários espirobicíclicos

Info

Publication number
BR112021024457A2
BR112021024457A2 BR112021024457A BR112021024457A BR112021024457A2 BR 112021024457 A2 BR112021024457 A2 BR 112021024457A2 BR 112021024457 A BR112021024457 A BR 112021024457A BR 112021024457 A BR112021024457 A BR 112021024457A BR 112021024457 A2 BR112021024457 A2 BR 112021024457A2
Authority
BR
Brazil
Prior art keywords
spirobicyclic
intermediates
synthesis
relates
present
Prior art date
Application number
BR112021024457A
Other languages
English (en)
Inventor
Alfons F Verniest Guido
Julien A Hullaert Jan
Maurits Winne Johan
Wilhelmus John F Thuring Johannes
Jonas Verhoeven
Lieven Meerpoel
Marguerite Jouffroy Lucile
Marta Brambilla
Nagaraju Chinta
Zeïna Neouchy
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112021024457A2 publication Critical patent/BR112021024457A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Abstract

intermediários espirobicíclicos. a presente invenção refere-se a intermediários espirobicíclicos úteis na síntese de análogos de nucleosídeos espirobicíclicos.
BR112021024457A 2019-06-12 2020-06-11 Intermediários espirobicíclicos BR112021024457A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201911023295 2019-06-12
EP19193707 2019-08-27
PCT/EP2020/066182 WO2020249663A1 (en) 2019-06-12 2020-06-11 Novel spirobicyclic intermediates

Publications (1)

Publication Number Publication Date
BR112021024457A2 true BR112021024457A2 (pt) 2022-01-18

Family

ID=71120144

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021024457A BR112021024457A2 (pt) 2019-06-12 2020-06-11 Intermediários espirobicíclicos

Country Status (16)

Country Link
US (1) US20220275018A1 (pt)
EP (1) EP3983393A1 (pt)
JP (1) JP2022536712A (pt)
KR (1) KR20220019766A (pt)
CN (1) CN113966328A (pt)
AU (1) AU2020290672A1 (pt)
BR (1) BR112021024457A2 (pt)
CA (1) CA3138349A1 (pt)
CR (1) CR20220012A (pt)
EC (1) ECSP21089373A (pt)
IL (1) IL288741A (pt)
JO (1) JOP20210327A1 (pt)
MA (1) MA56185A (pt)
MX (1) MX2021015363A (pt)
PE (1) PE20220433A1 (pt)
WO (1) WO2020249663A1 (pt)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143749A (en) 1995-06-07 2000-11-07 Abbott Laboratories Heterocyclic substituted cyclopentane compounds
US7144871B2 (en) 2002-02-19 2006-12-05 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
US20040043959A1 (en) 2002-03-04 2004-03-04 Bloom Laura A. Combination therapies for treating methylthioadenosine phosphorylase deficient cells
RU2013130253A (ru) 2010-12-03 2015-01-10 Эпизайм, Инк. 7-деазапуриновые регуляторы метилтрансферазы гистонов и способы их применения
AU2011341441A1 (en) 2010-12-03 2013-06-20 Epizyme, Inc. Modulators of histone methyltransferase, and methods of use thereof
WO2014035140A2 (en) 2012-08-30 2014-03-06 Kainos Medicine, Inc. Compounds and compositions for modulating histone methyltransferase activity
HUE040323T2 (hu) 2012-12-21 2019-02-28 Epizyme Inc PRMT5-inhibitorok és alkalmazásaik
WO2014100695A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
EP2935243B1 (en) 2012-12-21 2018-03-14 Epizyme, Inc. Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
US20170198006A1 (en) 2014-06-25 2017-07-13 Epizyme, Inc. Prmt5 inhibitors and uses thereof
BR112017017396A2 (pt) 2015-02-24 2018-04-03 Pfizer derivados substituídos de nucleosídeos substituídos úteis como agentes anticancerígenos
TW202321249A (zh) * 2015-08-26 2023-06-01 比利時商健生藥品公司 使用作為ｐｒｍｔ５抑制劑之新穎經６－６雙環芳香環取代之核苷類似物
WO2017153186A1 (en) 2016-03-10 2017-09-14 Janssen Pharmaceutica Nv Substituted nucleoside analogues for use as prmt5 inhibitors
EA201990851A1 (ru) 2017-02-24 2019-09-30 Янссен Фармацевтика Нв Новые аналоги карбануклеозида, замещенные моноциклической и бициклической кольцевой системой, для применения в качестве ингибиторов prmt5
CA3084449A1 (en) * 2017-12-08 2019-06-13 Janssen Pharmaceutica Nv Novel spirobicyclic analogues

Also Published As

Publication number Publication date
MX2021015363A (es) 2022-04-06
WO2020249663A1 (en) 2020-12-17
CA3138349A1 (en) 2020-12-17
KR20220019766A (ko) 2022-02-17
EP3983393A1 (en) 2022-04-20
MA56185A (fr) 2022-04-20
CR20220012A (es) 2022-03-11
ECSP21089373A (es) 2022-01-31
CN113966328A (zh) 2022-01-21
AU2020290672A1 (en) 2022-02-10
JOP20210327A1 (ar) 2023-01-30
JP2022536712A (ja) 2022-08-18
US20220275018A1 (en) 2022-09-01
IL288741A (en) 2022-02-01
PE20220433A1 (es) 2022-03-29

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