JP6667453B2 - 成長ホルモン受容体発現を調節するための組成物及び方法 - Google Patents
成長ホルモン受容体発現を調節するための組成物及び方法 Download PDFInfo
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- JP6667453B2 JP6667453B2 JP2016565461A JP2016565461A JP6667453B2 JP 6667453 B2 JP6667453 B2 JP 6667453B2 JP 2016565461 A JP2016565461 A JP 2016565461A JP 2016565461 A JP2016565461 A JP 2016565461A JP 6667453 B2 JP6667453 B2 JP 6667453B2
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- 0 COC[C@](C[C@@](C1)OC)N1C(C*)=O Chemical compound COC[C@](C[C@@](C1)OC)N1C(C*)=O 0.000 description 4
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/351—Conjugate
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- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3525—MOE, methoxyethoxy
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- Biomedical Technology (AREA)
- Molecular Biology (AREA)
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- Biotechnology (AREA)
- Wood Science & Technology (AREA)
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- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
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- General Chemical & Material Sciences (AREA)
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- Analytical Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461987470P | 2014-05-01 | 2014-05-01 | |
| US61/987,470 | 2014-05-01 | ||
| US201462061071P | 2014-10-07 | 2014-10-07 | |
| US62/061,071 | 2014-10-07 | ||
| US201462082511P | 2014-11-20 | 2014-11-20 | |
| US62/082,511 | 2014-11-20 | ||
| PCT/US2015/028887 WO2015168618A2 (en) | 2014-05-01 | 2015-05-01 | Compositions and methods for modulating growth hormone receptor expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019182797A Division JP6882411B2 (ja) | 2014-05-01 | 2019-10-03 | 成長ホルモン受容体発現を調節するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518278A JP2017518278A (ja) | 2017-07-06 |
| JP2017518278A5 JP2017518278A5 (enExample) | 2018-01-18 |
| JP6667453B2 true JP6667453B2 (ja) | 2020-03-18 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565461A Expired - Fee Related JP6667453B2 (ja) | 2014-05-01 | 2015-05-01 | 成長ホルモン受容体発現を調節するための組成物及び方法 |
| JP2019182797A Expired - Fee Related JP6882411B2 (ja) | 2014-05-01 | 2019-10-03 | 成長ホルモン受容体発現を調節するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019182797A Expired - Fee Related JP6882411B2 (ja) | 2014-05-01 | 2019-10-03 | 成長ホルモン受容体発現を調節するための組成物及び方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US9994855B2 (enExample) |
| EP (3) | EP3757215A3 (enExample) |
| JP (2) | JP6667453B2 (enExample) |
| KR (2) | KR20200102553A (enExample) |
| CN (2) | CN106459969B (enExample) |
| AU (2) | AU2015252841B2 (enExample) |
| BR (2) | BR112016022742B1 (enExample) |
| CA (1) | CA2942570A1 (enExample) |
| DK (1) | DK3137604T3 (enExample) |
| ES (1) | ES2812099T3 (enExample) |
| IL (2) | IL247716B (enExample) |
| MX (2) | MX373283B (enExample) |
| RU (1) | RU2724527C2 (enExample) |
| WO (1) | WO2015168618A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013159108A2 (en) * | 2012-04-20 | 2013-10-24 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
| DK2991656T3 (da) | 2013-05-01 | 2020-03-23 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression |
| KR20200102553A (ko) | 2014-05-01 | 2020-08-31 | 아이오니스 파마수티컬즈, 인코포레이티드 | 성장 호르몬 수용체 발현을 조절하기 위한 조성물 및 방법 |
| CA2961993A1 (en) | 2014-10-10 | 2016-04-14 | F. Hoffmann-La Roche Ag | Galnac phosphoramidites, nucleic acid conjugates thereof and their use |
| CA3006015A1 (en) * | 2015-12-31 | 2017-07-06 | Ionis Pharmaceuticals, Inc. | Methods for reducing ataxin-2 expression |
| CA3011946A1 (en) | 2016-03-07 | 2017-09-14 | Arrowhead Pharmaceuticals, Inc. | Targeting ligands for therapeutic compounds |
| US10781175B2 (en) | 2016-07-15 | 2020-09-22 | Am Chemicals Llc | Solid supports and phosphoramidite building blocks for oligonucleotide conjugates |
| KR102403408B1 (ko) | 2016-09-02 | 2022-05-30 | 애로우헤드 파마슈티컬스 인코포레이티드 | 표적화 리간드 |
| WO2018067900A1 (en) | 2016-10-06 | 2018-04-12 | Ionis Pharmaceuticals, Inc. | Method of conjugating oligomeric compounds |
| JP2020537518A (ja) * | 2017-10-12 | 2020-12-24 | ウェーブ ライフ サイエンシーズ リミテッド | オリゴヌクレオチド組成物及びその方法 |
| US11459564B2 (en) | 2017-12-21 | 2022-10-04 | Ionis Pharmaceuticals, Inc. | Modulation of frataxin expression |
| CA3152529A1 (en) * | 2019-09-03 | 2021-03-11 | Arcturus Therapeutics, Inc. | Asialoglycoprotein receptor mediated delivery of therapeutically active conjugates |
| JP7668032B2 (ja) * | 2019-10-24 | 2025-04-24 | ジェネヴァント サイエンシズ ゲーエムベーハー | 先端巨大症を処置するためのコンジュゲート及び方法 |
| WO2021178725A1 (en) | 2020-03-04 | 2021-09-10 | Verve Therapeutics, Inc. | Compositions and methods for targeted rna delivery |
| WO2022246195A1 (en) * | 2021-05-20 | 2022-11-24 | Olix Us, Inc. | Functional moieties and their uses and synthetic preparation |
| EP4380576A2 (en) * | 2021-08-03 | 2024-06-12 | Verve Therapeutics, Inc. | Compositions and methods for targeted rna delivery |
| US11692001B2 (en) | 2021-08-30 | 2023-07-04 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| EP4448540A1 (en) | 2021-12-15 | 2024-10-23 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| WO2024001172A1 (en) * | 2022-06-27 | 2024-01-04 | Ractigen Therapeutics | Oligonucleotide modulators activating complement factor h expression |
| US12116382B2 (en) | 2022-11-28 | 2024-10-15 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
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| FR2567892B1 (fr) | 1984-07-19 | 1989-02-17 | Centre Nat Rech Scient | Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons |
| US5367066A (en) | 1984-10-16 | 1994-11-22 | Chiron Corporation | Oligonucleotides with selectably cleavable and/or abasic sites |
| FR2575751B1 (fr) | 1985-01-08 | 1987-04-03 | Pasteur Institut | Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques |
| US4751219A (en) | 1985-02-05 | 1988-06-14 | Nederlandse Centrale Organisatie Voor Toegepast-Natuur-Wetenschappelijk Onderzoek | Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides |
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| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
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| EP0366685B1 (en) | 1987-06-24 | 1994-10-19 | Howard Florey Institute Of Experimental Physiology And Medicine | Nucleoside derivatives |
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