AU2015252841B2 - Compositions and methods for modulating growth hormone receptor expression - Google Patents

Compositions and methods for modulating growth hormone receptor expression Download PDF

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Publication number
AU2015252841B2
AU2015252841B2 AU2015252841A AU2015252841A AU2015252841B2 AU 2015252841 B2 AU2015252841 B2 AU 2015252841B2 AU 2015252841 A AU2015252841 A AU 2015252841A AU 2015252841 A AU2015252841 A AU 2015252841A AU 2015252841 B2 AU2015252841 B2 AU 2015252841B2
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Australia
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certain embodiments
antisense
compound
group
oligonucleotide
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AU2015252841A1 (en
Inventor
Sanjay Bhanot
Huynh-Hoa Bui
Susan M. Freier
Thazha P. Prakash
Punit P. Seth
Eric E. Swayze
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/30—Chemical structure
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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AU2015252841A 2014-05-01 2015-05-01 Compositions and methods for modulating growth hormone receptor expression Ceased AU2015252841B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020204024A AU2020204024A1 (en) 2014-05-01 2020-06-17 Compositions and methods for modulating growth hormone receptor expression

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461987470P 2014-05-01 2014-05-01
US61/987,470 2014-05-01
US201462061071P 2014-10-07 2014-10-07
US62/061,071 2014-10-07
US201462082511P 2014-11-20 2014-11-20
US62/082,511 2014-11-20
PCT/US2015/028887 WO2015168618A2 (en) 2014-05-01 2015-05-01 Compositions and methods for modulating growth hormone receptor expression

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AU2015252841A1 AU2015252841A1 (en) 2016-09-22
AU2015252841B2 true AU2015252841B2 (en) 2020-03-19

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US (5) US9994855B2 (enExample)
EP (3) EP3974534A1 (enExample)
JP (2) JP6667453B2 (enExample)
KR (2) KR102149571B1 (enExample)
CN (2) CN110903337A (enExample)
AU (2) AU2015252841B2 (enExample)
BR (2) BR112016022742B1 (enExample)
CA (1) CA2942570A1 (enExample)
DK (1) DK3137604T3 (enExample)
ES (1) ES2812099T3 (enExample)
IL (2) IL247716B (enExample)
MX (2) MX373283B (enExample)
RU (1) RU2724527C2 (enExample)
WO (1) WO2015168618A2 (enExample)

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CN110903337A (zh) 2014-05-01 2020-03-24 Ionis制药公司 用于调节生长激素受体表达的组合物和方法
KR20170068469A (ko) 2014-10-10 2017-06-19 에프. 호프만-라 로슈 아게 ＧａｌＮＡｃ 포스포라미다이트, 그의 핵산 컨쥬게이트 및 그의 용도
EP3397288A4 (en) * 2015-12-31 2019-09-11 Ionis Pharmaceuticals, Inc. PROCESS FOR REDUCING ATAXIN-2 EXPRESSION
CN109069529B (zh) 2016-03-07 2021-08-20 箭头药业股份有限公司 用于治疗性化合物的靶向配体
US10781175B2 (en) 2016-07-15 2020-09-22 Am Chemicals Llc Solid supports and phosphoramidite building blocks for oligonucleotide conjugates
CN109462981B (zh) 2016-09-02 2023-07-07 箭头药业股份有限公司 靶向配体
CN109661233A (zh) 2016-10-06 2019-04-19 Ionis 制药公司 缀合低聚化合物的方法
WO2019075357A1 (en) * 2017-10-12 2019-04-18 Wave Life Sciences Ltd. OLIGONUCLEOTIDE COMPOSITIONS AND RELATED METHODS
WO2019126641A2 (en) * 2017-12-21 2019-06-27 Ionis Pharmaceuticals, Inc. Modulation of frataxin expression
KR20220058578A (ko) 2019-09-03 2022-05-09 아크투루스 쎄라퓨틱스, 인크. 치료 활성 접합체의 아시알로당단백질 수용체 매개 전달
AU2020371736A1 (en) * 2019-10-24 2022-06-02 Genevant Sciences Gmbh Conjugates and methods for treating acromegaly
MX2022010980A (es) 2020-03-04 2022-12-02 Verve Therapeutics Inc Composiciones y metodos para el suministro de arn dirigido.
WO2022246195A1 (en) * 2021-05-20 2022-11-24 Olix Us, Inc. Functional moieties and their uses and synthetic preparation
EP4380576A2 (en) * 2021-08-03 2024-06-12 Verve Therapeutics, Inc. Compositions and methods for targeted rna delivery
JP2024532271A (ja) 2021-08-30 2024-09-05 ホンジーン バイオテック コーポレイション 官能化ｎ－アセチルガラクトサミンアナログ
WO2023114746A1 (en) 2021-12-15 2023-06-22 Hongene Biotech Corporation Functionalized n-acetylgalactosamine analogs
CN119654412A (zh) * 2022-06-27 2025-03-18 中美瑞康核酸技术(南通)研究院有限公司 激活补体因子h表达的寡核苷酸调节剂
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