JP6576325B2 - ヘテロアリール化合物およびそれらの使用 - Google Patents

ヘテロアリール化合物およびそれらの使用 Download PDF

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Publication number
JP6576325B2
JP6576325B2 JP2016503031A JP2016503031A JP6576325B2 JP 6576325 B2 JP6576325 B2 JP 6576325B2 JP 2016503031 A JP2016503031 A JP 2016503031A JP 2016503031 A JP2016503031 A JP 2016503031A JP 6576325 B2 JP6576325 B2 JP 6576325B2
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compound
pharmaceutically acceptable
acceptable salt
ring
substituted
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JP2016519673A5 (enExample
JP2016519673A (ja
Inventor
ローラ アクリアン ディーアゴスティーノ，
ローラ アクリアン ディーアゴスティーノ，
ロバート ジン タム シン，
ロバート ジン タム シン，
デチャン ニウ，
デチャン ニウ，
ジョセフ ジョン マクドナルド，
ジョセフ ジョン マクドナルド，
ゼンドン ズー，
ゼンドン ズー，
ハイボウ リウ，
ハイボウ リウ，
ホルモズ マズディヤスニ，
ホルモズ マズディヤスニ，
ラッセル シー． ペター，
ラッセル シー． ペター，
ジャスウィンダー シン，
ジャスウィンダー シン，
マシュー バラーグ，
マシュー バラーグ，
グロス，　アレクサンダー
アレクサンダー グロス，
マーク ムンソン，
マーク ムンソン，
ダレン ハービー，
ダレン ハービー，
アンドリュー ショルト，
アンドリュー ショルト，
サチン マニアー，
サチン マニアー，
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2016503031A 2013-03-15 2014-03-14 ヘテロアリール化合物およびそれらの使用 Expired - Fee Related JP6576325B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361793113P 2013-03-15 2013-03-15
US61/793,113 2013-03-15
EP14305361 2014-03-13
EP14305361.9 2014-03-13
PCT/US2014/029270 WO2014144737A1 (en) 2013-03-15 2014-03-14 Heteroaryl compounds and uses thereof

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JP2016519673A JP2016519673A (ja) 2016-07-07
JP2016519673A5 JP2016519673A5 (enExample) 2017-04-20
JP6576325B2 true JP6576325B2 (ja) 2019-09-18

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US (1) US9663524B2 (enExample)
EP (1) EP2968337B1 (enExample)
JP (1) JP6576325B2 (enExample)
KR (1) KR102219695B1 (enExample)
CN (2) CN111793068A (enExample)
AU (1) AU2014228746B2 (enExample)
BR (1) BR112015022191A8 (enExample)
EA (1) EA036160B1 (enExample)
MA (1) MA38393B1 (enExample)
MX (1) MX374558B (enExample)
PE (1) PE20151776A1 (enExample)
SG (1) SG11201507478VA (enExample)
WO (1) WO2014144737A1 (enExample)

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AU2014228746A1 (en) 2015-09-10
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US9663524B2 (en) 2017-05-30
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