JP2016519673A5 - - Google Patents
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- JP2016519673A5 JP2016519673A5 JP2016503031A JP2016503031A JP2016519673A5 JP 2016519673 A5 JP2016519673 A5 JP 2016519673A5 JP 2016503031 A JP2016503031 A JP 2016503031A JP 2016503031 A JP2016503031 A JP 2016503031A JP 2016519673 A5 JP2016519673 A5 JP 2016519673A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- ring
- substituted
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C*/C=C/[N+]C*C=C Chemical compound *C*/C=C/[N+]C*C=C 0.000 description 27
- CJDYFMIDIQXELO-UHFFFAOYSA-N CC(C)(C)OC(N1CCN(C)CC1)=O Chemical compound CC(C)(C)OC(N1CCN(C)CC1)=O CJDYFMIDIQXELO-UHFFFAOYSA-N 0.000 description 1
- XLZMWNWNBXSZKF-UHFFFAOYSA-N CC(C)N1CCOCC1 Chemical compound CC(C)N1CCOCC1 XLZMWNWNBXSZKF-UHFFFAOYSA-N 0.000 description 1
- LPZLRRWRPQSVBW-UHFFFAOYSA-O CC([NH2+]C=C)=CON Chemical compound CC([NH2+]C=C)=CON LPZLRRWRPQSVBW-UHFFFAOYSA-O 0.000 description 1
- IMFLCBVIUVVSKA-UHFFFAOYSA-O CC([NH2+]C=C)=CSN Chemical compound CC([NH2+]C=C)=CSN IMFLCBVIUVVSKA-UHFFFAOYSA-O 0.000 description 1
- JLAUIBFZZUVOBB-UHFFFAOYSA-N CCC(C)CCN Chemical compound CCC(C)CCN JLAUIBFZZUVOBB-UHFFFAOYSA-N 0.000 description 1
- QAWMTMJZJZJODC-UHFFFAOYSA-N CCC(NC1CCN(C)CC1)=O Chemical compound CCC(NC1CCN(C)CC1)=O QAWMTMJZJZJODC-UHFFFAOYSA-N 0.000 description 1
- OXHNLMTVIGZXSG-UHFFFAOYSA-N C[n]1cccc1 Chemical compound C[n]1cccc1 OXHNLMTVIGZXSG-UHFFFAOYSA-N 0.000 description 1
- MCTWTZJPVLRJOU-UHFFFAOYSA-N C[n]1cncc1 Chemical compound C[n]1cncc1 MCTWTZJPVLRJOU-UHFFFAOYSA-N 0.000 description 1
- XBOCMRIDGWVTQR-UHFFFAOYSA-N NC(C(CC1)CCN1N)=O Chemical compound NC(C(CC1)CCN1N)=O XBOCMRIDGWVTQR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361793113P | 2013-03-15 | 2013-03-15 | |
| US61/793,113 | 2013-03-15 | ||
| EP14305361.9 | 2014-03-13 | ||
| EP14305361 | 2014-03-13 | ||
| PCT/US2014/029270 WO2014144737A1 (en) | 2013-03-15 | 2014-03-14 | Heteroaryl compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519673A JP2016519673A (ja) | 2016-07-07 |
| JP2016519673A5 true JP2016519673A5 (enExample) | 2017-04-20 |
| JP6576325B2 JP6576325B2 (ja) | 2019-09-18 |
Family
ID=50390019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503031A Expired - Fee Related JP6576325B2 (ja) | 2013-03-15 | 2014-03-14 | ヘテロアリール化合物およびそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9663524B2 (enExample) |
| EP (1) | EP2968337B1 (enExample) |
| JP (1) | JP6576325B2 (enExample) |
| KR (1) | KR102219695B1 (enExample) |
| CN (2) | CN111793068A (enExample) |
| AU (1) | AU2014228746B2 (enExample) |
| BR (1) | BR112015022191A8 (enExample) |
| EA (1) | EA036160B1 (enExample) |
| MA (1) | MA38393B1 (enExample) |
| MX (1) | MX374558B (enExample) |
| PE (1) | PE20151776A1 (enExample) |
| SG (1) | SG11201507478VA (enExample) |
| WO (1) | WO2014144737A1 (enExample) |
Families Citing this family (71)
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| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| GB201204384D0 (en) | 2012-03-13 | 2012-04-25 | Univ Dundee | Anti-flammatory agents |
| ES2984771T3 (es) | 2012-06-13 | 2024-10-31 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| RU2019102203A (ru) * | 2012-07-11 | 2019-03-05 | Блюпринт Медсинс Корпорейшн | Ингибиторы рецептора фактора роста фибробластов |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| CN111793068A (zh) | 2013-03-15 | 2020-10-20 | 西建卡尔有限责任公司 | 杂芳基化合物和其用途 |
| TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
| KR102350704B1 (ko) | 2013-03-15 | 2022-01-13 | 셀젠 카르 엘엘씨 | 헤테로아릴 화합물 및 이의 용도 |
| EA035095B1 (ru) | 2013-04-19 | 2020-04-27 | Инсайт Холдингс Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| AR098048A1 (es) | 2013-10-18 | 2016-04-27 | Eisai R&D Man Co Ltd | Inhibidores de fgfr4 |
| TR201810944T4 (tr) | 2013-10-25 | 2018-08-27 | Novartis Ag | Fgfr4 inhibitörleri olarak halka-füzyonlu bisiklik piridil türevleri. |
| PT3395814T (pt) | 2013-10-25 | 2022-07-27 | Blueprint Medicines Corp | Inibidores do recetor do fator de crescimento de fibroblastos |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| CA2954187C (en) | 2014-07-21 | 2022-08-16 | Dana-Farber Cancer Institute, Inc. | Macrocyclic kinase inhibitors and uses thereof |
| WO2016014542A1 (en) | 2014-07-21 | 2016-01-28 | Dana-Farber Cancer Institute, Inc. | Imidazolyl kinase inhibitors and uses thereof |
| CA2955082A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Uses of salt-inducible kinase (sik) inhibitors |
| ES2756748T3 (es) | 2014-10-03 | 2020-04-27 | Novartis Ag | Uso de derivados de piridilo bicíclicos de anillo fusionado como inhibidores de fgfr4 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| EA038045B1 (ru) | 2015-02-20 | 2021-06-28 | Инсайт Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9802917B2 (en) | 2015-03-25 | 2017-10-31 | Novartis Ag | Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide |
| MX2017012295A (es) | 2015-03-25 | 2018-01-09 | Novartis Ag | Derivados formilados n-heterociclicos como inhibidores de fgfr4. |
| JP6431622B2 (ja) | 2015-04-14 | 2018-11-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 結晶性ｆｇｆｒ４阻害剤化合物およびその使用 |
| US11357769B2 (en) | 2016-05-10 | 2022-06-14 | Eisai R&D Management Co., Ltd. | Drug combinations for reducing cell viability and/or cell proliferation |
| KR20180002053A (ko) * | 2016-06-28 | 2018-01-05 | 한미약품 주식회사 | 신규한 헤테로시클릭 유도체 화합물 및 이의 용도 |
| KR20190075043A (ko) * | 2016-07-05 | 2019-06-28 | 더 브로드 인스티튜트, 인코퍼레이티드 | 비시클릭 우레아 키나제 억제제 및 그의 용도 |
| US11241435B2 (en) | 2016-09-16 | 2022-02-08 | The General Hospital Corporation | Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis |
| WO2018055503A1 (en) | 2016-09-20 | 2018-03-29 | Novartis Ag | Combination comprising a pd-1 antagonist and an fgfr4 inhibitor |
| US11229643B2 (en) | 2016-11-02 | 2022-01-25 | Novartis Ag | Combinations of FGFR4 inhibitors and bile acid sequestrants |
| RU2747260C2 (ru) | 2016-12-19 | 2021-04-29 | Аббиско Тхерапеутицс Цо., Лтд. | Ингибитор рфрф4, способ его получения и его фармацевтическое применение |
| EP3589284A4 (en) | 2017-02-28 | 2020-12-16 | The General Hospital Corporation | USES OF PYRIMIDOPYRIMIDINONES AS SIK INHIBITORS |
| CN108503593B (zh) * | 2017-02-28 | 2021-04-27 | 暨南大学 | 2-氨基嘧啶类化合物及其应用 |
| WO2018213219A1 (en) * | 2017-05-15 | 2018-11-22 | University Of Houston System | Pyrido[2,3-d]pyrimidin-7ones and related compounds as inhibitors of protein kinases |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| CN110914267B (zh) * | 2017-07-19 | 2022-07-12 | 江苏奥赛康药业有限公司 | 嘧啶并吡啶酮或者吡啶并吡啶酮类化合物及其应用 |
| CN109384790B (zh) * | 2017-08-08 | 2022-05-10 | 药捷安康(南京)科技股份有限公司 | 成纤维细胞生长因子受体抑制剂及其用途 |
| CN109745325B (zh) * | 2017-11-08 | 2022-02-15 | 上海翰森生物医药科技有限公司 | Fgfr4抑制剂、其制备方法和用途 |
| CN110386921A (zh) * | 2018-04-23 | 2019-10-29 | 南京药捷安康生物科技有限公司 | 成纤维细胞生长因子受体抑制剂化合物 |
| US11174257B2 (en) | 2018-05-04 | 2021-11-16 | Incyte Corporation | Salts of an FGFR inhibitor |
| RS66310B1 (sr) | 2018-05-04 | 2025-01-31 | Incyte Corp | Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu |
| CN111868058B (zh) * | 2018-05-25 | 2023-06-13 | 上海和誉生物医药科技有限公司 | 一种fgfr抑制剂、其制备方法和在药学上的应用 |
| CN110577524B (zh) * | 2018-06-07 | 2022-01-28 | 北京大学深圳研究生院 | 一种激酶选择性抑制剂 |
| WO2019242587A1 (zh) * | 2018-06-19 | 2019-12-26 | 上海和誉生物医药科技有限公司 | 一种高选择性FGFR i抑制剂及其制备方法和应用 |
| KR102531596B1 (ko) | 2018-09-14 | 2023-05-11 | 아비스코 테라퓨틱스 컴퍼니 리미티드 | Fgfr억제제, 그 제조 방법 및 용도 |
| EP3902805A4 (en) | 2018-12-28 | 2023-03-01 | SPV Therapeutics Inc. | CYCLINE-DEPENDENT KINASE INHIBITORS |
| WO2020177067A1 (en) | 2019-03-05 | 2020-09-10 | Bioardis Llc | Aromatic derivatives, preparation methods, and medical uses thereof |
| KR20210131369A (ko) * | 2019-03-08 | 2021-11-02 | 쇼우야오 홀딩스 (베이징) 코., 엘티디. | Fgfr4 키나아제 억제제 및 이의 제조 방법과 용도 |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| PH12022550892A1 (en) | 2019-10-14 | 2023-05-03 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| KR102333854B1 (ko) | 2019-10-24 | 2021-12-06 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리디닐트리아진 유도체 및 이를 포함하는 암의 예방, 개선 또는 치료용 약학 조성물 |
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| EP4065578A1 (en) | 2019-11-26 | 2022-10-05 | Theravance Biopharma R&D IP, LLC | Fused pyrimidine pyridinone compounds as jak inhibitors |
| AU2020395185A1 (en) | 2019-12-04 | 2022-06-02 | Incyte Corporation | Derivatives of an FGFR inhibitor |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| KR102382613B1 (ko) * | 2020-01-15 | 2022-04-06 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 7-아미노-3,4-디히드로피리미도피리미딘-2-온 유도체 및 이를 포함하는 치료용 약학 조성물 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| MX2023011342A (es) * | 2021-03-26 | 2023-10-04 | Hangzhou Apeloa Medicine Res Institute Co Ltd | Inhibidor heterociclico biciclico de fgfr4, su composicion farmaceutica y formulacion, y sus aplicaciones. |
| JP2024513575A (ja) | 2021-04-12 | 2024-03-26 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法 |
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| TW202313610A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之三環雜環 |
| CN113527311B (zh) * | 2021-08-23 | 2022-05-06 | 中南大学湘雅医院 | Fgfr4抑制剂、组合物及其在药物制备中的用途 |
| WO2023039828A1 (en) * | 2021-09-17 | 2023-03-23 | Nutshell Biotech (Shanghai) Co., Ltd. | Fused ring compounds as inhibitors of fgfr4 tyrosine kinases |
| CN113912602B (zh) * | 2021-10-14 | 2023-05-05 | 温州医科大学 | 一种2-氧代-1,2-二氢-1,6-萘啶-7-基类化合物及其制备方法和用途 |
| WO2024199388A1 (zh) * | 2023-03-29 | 2024-10-03 | 微境生物医药科技(上海)有限公司 | 作为myt1抑制剂的化合物 |
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-
2014
- 2014-03-14 CN CN202010661205.XA patent/CN111793068A/zh active Pending
- 2014-03-14 US US14/776,373 patent/US9663524B2/en active Active
- 2014-03-14 JP JP2016503031A patent/JP6576325B2/ja not_active Expired - Fee Related
- 2014-03-14 WO PCT/US2014/029270 patent/WO2014144737A1/en not_active Ceased
- 2014-03-14 KR KR1020157029048A patent/KR102219695B1/ko not_active Expired - Fee Related
- 2014-03-14 AU AU2014228746A patent/AU2014228746B2/en not_active Ceased
- 2014-03-14 CN CN201480016170.7A patent/CN105307657B/zh not_active Expired - Fee Related
- 2014-03-14 EA EA201591420A patent/EA036160B1/ru not_active IP Right Cessation
- 2014-03-14 SG SG11201507478VA patent/SG11201507478VA/en unknown
- 2014-03-14 BR BR112015022191A patent/BR112015022191A8/pt active Search and Examination
- 2014-03-14 MA MA38393A patent/MA38393B1/fr unknown
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