EA036160B1 - Гетероарильные соединения и их применение - Google Patents
Гетероарильные соединения и их применение Download PDFInfo
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- EA036160B1 EA036160B1 EA201591420A EA201591420A EA036160B1 EA 036160 B1 EA036160 B1 EA 036160B1 EA 201591420 A EA201591420 A EA 201591420A EA 201591420 A EA201591420 A EA 201591420A EA 036160 B1 EA036160 B1 EA 036160B1
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- EA
- Eurasian Patent Office
- Prior art keywords
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- 101000917134 Homo sapiens Fibroblast growth factor receptor 4 Proteins 0.000 claims description 49
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- CIUYJYRQKYGNQP-UHFFFAOYSA-N (3-nitrophenyl)methanamine Chemical compound NCC1=CC=CC([N+]([O-])=O)=C1 CIUYJYRQKYGNQP-UHFFFAOYSA-N 0.000 description 16
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- KVCQTKNUUQOELD-UHFFFAOYSA-N 4-amino-n-[1-(3-chloro-2-fluoroanilino)-6-methylisoquinolin-5-yl]thieno[3,2-d]pyrimidine-7-carboxamide Chemical compound N=1C=CC2=C(NC(=O)C=3C4=NC=NC(N)=C4SC=3)C(C)=CC=C2C=1NC1=CC=CC(Cl)=C1F KVCQTKNUUQOELD-UHFFFAOYSA-N 0.000 description 15
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 15
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- FEECMUCDEXAFQK-SFYZADRCSA-N tert-butyl n-[(3r,4r)-4-aminooxan-3-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H]1COCC[C@H]1N FEECMUCDEXAFQK-SFYZADRCSA-N 0.000 description 1
- SAHCRZHMDWJEMU-UHFFFAOYSA-N tert-butyl n-[2-amino-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1N SAHCRZHMDWJEMU-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
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| US201361793113P | 2013-03-15 | 2013-03-15 | |
| EP14305361 | 2014-03-13 | ||
| PCT/US2014/029270 WO2014144737A1 (en) | 2013-03-15 | 2014-03-14 | Heteroaryl compounds and uses thereof |
Publications (2)
| Publication Number | Publication Date |
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| EA201591420A1 EA201591420A1 (ru) | 2016-02-29 |
| EA036160B1 true EA036160B1 (ru) | 2020-10-08 |
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| EA201591420A EA036160B1 (ru) | 2013-03-15 | 2014-03-14 | Гетероарильные соединения и их применение |
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| EP (1) | EP2968337B1 (enExample) |
| JP (1) | JP6576325B2 (enExample) |
| KR (1) | KR102219695B1 (enExample) |
| CN (2) | CN111793068A (enExample) |
| AU (1) | AU2014228746B2 (enExample) |
| BR (1) | BR112015022191A8 (enExample) |
| EA (1) | EA036160B1 (enExample) |
| MA (1) | MA38393B1 (enExample) |
| MX (1) | MX374558B (enExample) |
| PE (1) | PE20151776A1 (enExample) |
| SG (1) | SG11201507478VA (enExample) |
| WO (1) | WO2014144737A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2827699C1 (ru) * | 2021-03-26 | 2024-10-01 | Ханчжоу Апелоа Медсин Рисерч Инститьют Ко., Лтд. | Бициклические гетероциклические ингибиторы fgfr4, фармацевтические композиции и составы, содержащие их, и их применение |
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| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| GB201204384D0 (en) | 2012-03-13 | 2012-04-25 | Univ Dundee | Anti-flammatory agents |
| SI2861595T1 (sl) | 2012-06-13 | 2017-04-26 | Incyte Holdings Corporation | Substituirane triciklične spojine kot inhibitorji fgfr |
| SMT202100451T1 (it) | 2012-07-11 | 2021-09-14 | Blueprint Medicines Corp | Inibitori del recettore di crescita dei fibroblasti |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| UA120248C2 (uk) | 2013-03-15 | 2019-11-11 | Селджен Кар Ллс | Гетероарильні сполуки та їх застосування |
| US9663524B2 (en) | 2013-03-15 | 2017-05-30 | Celgene Car Llc | Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors |
| TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
| LT2986610T (lt) | 2013-04-19 | 2018-04-10 | Incyte Holdings Corporation | Bicikliniai heterociklai, kaip fgfr inhibitoriai |
| CA2924206C (en) * | 2013-10-18 | 2022-10-25 | Eisai R&D Management Co., Ltd. | Pyrimidine fgfr4 inhibitors |
| AU2014339972B9 (en) | 2013-10-25 | 2019-05-30 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| EP3060563B1 (en) | 2013-10-25 | 2018-05-02 | Novartis AG | Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
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Also Published As
| Publication number | Publication date |
|---|---|
| MX2015011514A (es) | 2016-08-11 |
| CN105307657B (zh) | 2020-07-10 |
| PE20151776A1 (es) | 2015-12-11 |
| KR102219695B1 (ko) | 2021-02-25 |
| WO2014144737A1 (en) | 2014-09-18 |
| AU2014228746A1 (en) | 2015-09-10 |
| US20160046634A1 (en) | 2016-02-18 |
| JP6576325B2 (ja) | 2019-09-18 |
| JP2016519673A (ja) | 2016-07-07 |
| KR20150131237A (ko) | 2015-11-24 |
| EP2968337B1 (en) | 2021-07-21 |
| EA201591420A1 (ru) | 2016-02-29 |
| SG11201507478VA (en) | 2015-10-29 |
| BR112015022191A2 (pt) | 2017-10-10 |
| CN105307657A (zh) | 2016-02-03 |
| CN111793068A (zh) | 2020-10-20 |
| US9663524B2 (en) | 2017-05-30 |
| EP2968337A1 (en) | 2016-01-20 |
| AU2014228746B2 (en) | 2018-08-30 |
| MA38393B1 (fr) | 2018-11-30 |
| EP2968337A4 (en) | 2016-10-19 |
| MA38393A3 (fr) | 2018-05-31 |
| BR112015022191A8 (pt) | 2018-01-23 |
| MX374558B (es) | 2025-03-06 |
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