JP6496733B2 - （ｓ）−（２−（６−クロロ−７−メチル−１ｈ−ベンゾ［ｄ］イミダゾール−２−イル）−２−メチルピロリジン−１−イル）（５−メトキシ−２−（２ｈ−１，２，３−トリアゾール−２−イル）フェニル）メタノンの結晶形及びオレキシン受容体アンタゴニストとしてのその使用 - Google Patents

（ｓ）−（２−（６−クロロ−７−メチル−１ｈ−ベンゾ［ｄ］イミダゾール−２−イル）−２−メチルピロリジン−１−イル）（５−メトキシ−２−（２ｈ−１，２，３−トリアゾール−２−イル）フェニル）メタノンの結晶形及びオレキシン受容体アンタゴニストとしてのその使用 Download PDF

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JP6496733B2
JP6496733B2 JP2016536109A JP2016536109A JP6496733B2 JP 6496733 B2 JP6496733 B2 JP 6496733B2 JP 2016536109 A JP2016536109 A JP 2016536109A JP 2016536109 A JP2016536109 A JP 2016536109A JP 6496733 B2 JP6496733 B2 JP 6496733B2
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methyl
chloro
triazol
benzo
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JP2016539136A (ja
JP2016539136A5 (https=
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クリストフ　ボス
ボス クリストフ
ブロッチ クリスティーン
ブロッチ クリスティーン
グーデ マルクス
グーデ マルクス
ハイドマン ビビア
ハイドマン ビビア
シファーレン ティエリー
シファーレン ティエリー
フォン ラウマー マルクス
フォン ラウマー マルクス
ティー ウィリアムズ ジョディ
ティー ウィリアムズ ジョディ
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Idorsia Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2016536109A 2013-12-03 2014-12-02 （ｓ）−（２−（６−クロロ−７−メチル−１ｈ−ベンゾ［ｄ］イミダゾール−２−イル）−２−メチルピロリジン−１−イル）（５−メトキシ−２−（２ｈ−１，２，３−トリアゾール−２−イル）フェニル）メタノンの結晶形及びオレキシン受容体アンタゴニストとしてのその使用 Active JP6496733B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2013/060596 2013-12-03
IB2013060596 2013-12-03
PCT/IB2014/066508 WO2015083070A1 (en) 2013-12-03 2014-12-02 Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists

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JP2016539136A JP2016539136A (ja) 2016-12-15
JP2016539136A5 JP2016539136A5 (https=) 2018-01-11
JP6496733B2 true JP6496733B2 (ja) 2019-04-03

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EP (1) EP3077389B1 (https=)
JP (1) JP6496733B2 (https=)
KR (1) KR102361418B1 (https=)
CN (1) CN105793257B (https=)
AU (1) AU2014358742B2 (https=)
CA (1) CA2929423C (https=)
CL (1) CL2016001342A1 (https=)
CY (1) CY1119695T1 (https=)
DK (1) DK3077389T3 (https=)
EA (1) EA030137B1 (https=)
ES (1) ES2651475T3 (https=)
HK (1) HK1225731B (https=)
HR (1) HRP20171773T1 (https=)
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IL (1) IL245923B (https=)
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MA (1) MA39163B1 (https=)
MX (1) MX364208B (https=)
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PH (1) PH12016500988A1 (https=)
PL (1) PL3077389T3 (https=)
PT (1) PT3077389T (https=)
SA (1) SA516371231B1 (https=)
SI (1) SI3077389T1 (https=)
TW (1) TWI664177B (https=)
UA (1) UA119549C2 (https=)
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PT3077389T (pt) 2017-12-15
MY179862A (en) 2020-11-18
SA516371231B1 (ar) 2018-02-20
MX364208B (es) 2019-04-16
IL245923A0 (en) 2016-08-02
EA030137B1 (ru) 2018-06-29
ZA201604499B (en) 2019-04-24
LT3077389T (lt) 2017-12-11
EA201600435A1 (ru) 2016-11-30
NO3077389T3 (https=) 2018-02-10
HUE035731T2 (hu) 2018-05-28
KR102361418B1 (ko) 2022-02-09
US20160368901A1 (en) 2016-12-22
MX2016007215A (es) 2016-09-07
WO2015083070A1 (en) 2015-06-11
CL2016001342A1 (es) 2016-11-18
CN105793257A (zh) 2016-07-20
BR112016012628A8 (pt) 2017-12-26
BR112016012628A2 (https=) 2017-08-22
AU2014358742A1 (en) 2016-07-07
IL245923B (en) 2019-09-26
PH12016500988B1 (en) 2016-06-20
PL3077389T3 (pl) 2018-03-30
CA2929423C (en) 2021-12-07
MA39163B1 (fr) 2018-09-28
SI3077389T1 (en) 2018-01-31
EP3077389B1 (en) 2017-09-13
JP2016539136A (ja) 2016-12-15
EP3077389A1 (en) 2016-10-12
TWI664177B (zh) 2019-07-01
CN105793257B (zh) 2018-11-13
TW201605838A (zh) 2016-02-16
PH12016500988A1 (en) 2016-06-20
HK1225731B (en) 2017-09-15
ES2651475T3 (es) 2018-01-26
MA39163A1 (fr) 2017-11-30
AU2014358742B2 (en) 2019-02-07
CY1119695T1 (el) 2018-04-04
UA119549C2 (uk) 2019-07-10
NZ721438A (en) 2021-12-24
DK3077389T3 (da) 2017-11-13
CA2929423A1 (en) 2015-06-11
KR20160092015A (ko) 2016-08-03
US9914720B2 (en) 2018-03-13
HRP20171773T1 (hr) 2017-12-29

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