JP6492003B2 - 発作を減少させるためおよび神経変性症候群を改質するためにタウ発現を調節する方法 - Google Patents

発作を減少させるためおよび神経変性症候群を改質するためにタウ発現を調節する方法 Download PDF

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JP6492003B2
JP6492003B2 JP2015503306A JP2015503306A JP6492003B2 JP 6492003 B2 JP6492003 B2 JP 6492003B2 JP 2015503306 A JP2015503306 A JP 2015503306A JP 2015503306 A JP2015503306 A JP 2015503306A JP 6492003 B2 JP6492003 B2 JP 6492003B2
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tau
certain embodiments
antisense
modified
nucleic acid
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JP2015516953A (ja
JP2015516953A5 (enExample
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ミラー，ティモシー・エム
ドゥボス，サラ
ベネット，シー・フランク
リゴ，フランク
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Ionis Pharmaceuticals Inc
Washington University in St Louis WUSTL
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Washington University in St Louis WUSTL
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JP2015503306A 2012-03-30 2013-03-14 発作を減少させるためおよび神経変性症候群を改質するためにタウ発現を調節する方法 Active JP6492003B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261618435P 2012-03-30 2012-03-30
US61/618,435 2012-03-30
US201261660676P 2012-06-15 2012-06-15
US61/660,676 2012-06-15
US201261719149P 2012-10-26 2012-10-26
US61/719,149 2012-10-26
PCT/US2013/031500 WO2013148260A1 (en) 2012-03-30 2013-03-14 Methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome

Publications (3)

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JP2015516953A JP2015516953A (ja) 2015-06-18
JP2015516953A5 JP2015516953A5 (enExample) 2016-04-28
JP6492003B2 true JP6492003B2 (ja) 2019-03-27

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US (2) US10273474B2 (enExample)
EP (2) EP2831232A4 (enExample)
JP (1) JP6492003B2 (enExample)
AU (3) AU2013202595B2 (enExample)
CA (1) CA2866392C (enExample)
WO (2) WO2013148260A1 (enExample)

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WO2013148260A1 (en) 2012-03-30 2013-10-03 Washington University Methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome
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TW202246503A (zh) 2013-07-19 2022-12-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
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US10357543B2 (en) 2015-11-16 2019-07-23 Ohio State Innovation Foundation Methods and compositions for treating disorders and diseases using Survival Motor Neuron (SMN) protein
US10370667B2 (en) 2015-11-18 2019-08-06 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
WO2017087282A1 (en) 2015-11-18 2017-05-26 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (lrrk2) for the treatment of parkinsons disease
JOP20200228A1 (ar) * 2015-12-21 2017-06-16 Novartis Ag تركيبات وطرق لخفض تعبير البروتين tau
JOP20190065A1 (ar) 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن tau
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MY206038A (en) * 2018-07-03 2024-11-26 Hoffmann La Roche Oligonucleotides for modulating tau expression
JP7340794B2 (ja) * 2018-07-04 2023-09-08 学校法人 愛知医科大学 タウのスプライシングを制御するアンチセンスオリゴヌクレオチド及びその用途
WO2020037234A1 (en) * 2018-08-16 2020-02-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Nucleic acids and nucleic acid analogs for treating, preventing, and disrupting pathological polynucleotide-binding protein inclusions
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