JP6404339B2 - 月経前症候群及び月経痛緩和の機能を持つ組成物 - Google Patents
月経前症候群及び月経痛緩和の機能を持つ組成物 Download PDFInfo
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- JP6404339B2 JP6404339B2 JP2016523631A JP2016523631A JP6404339B2 JP 6404339 B2 JP6404339 B2 JP 6404339B2 JP 2016523631 A JP2016523631 A JP 2016523631A JP 2016523631 A JP2016523631 A JP 2016523631A JP 6404339 B2 JP6404339 B2 JP 6404339B2
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- ginseng
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- ginsenoside
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Description
(a)朝鮮人参の実を前処理する段階;及び
(b)前記段階で前処理した朝鮮人参の実を、水又は有機溶媒で抽出して朝鮮人参の実抽出物を得る段階;を含む方法によって製造されていてよい。
(d)脂溶性成分を除去する段階をさらに含んでいてよい。
(e)脂溶性成分の除去後に有機溶媒を加えて抽出する段階をさらに含んでいてよい。
(1)朝鮮人参の実を、水、有機溶媒、又はこれらの組み合わせで抽出して朝鮮人参の実抽出物を得る段階を含む製造方法によって調製されていてよい。
(i)朝鮮人参の実を、水、有機溶媒、又はこれらの組み合わせで抽出する段階;及び
(ii)前記抽出物から脂溶性成分を除去する段階;を含む製造方法によって調製されていてよい。
朝鮮人参の実の前処理
生の朝鮮人参の実を収穫して種子を分離し除去してから朝鮮人参の実の果肉と果皮を日光乾燥または熱風乾燥をすることで朝鮮人参の実乾燥原料を製造した。
朝鮮人参の実乾燥物1kgにエタノール3Lを加え、室温で4時間還流抽出し、ろ過した後、45℃で減圧濃縮することで朝鮮人参の実抽出物300gを得た。
生の朝鮮人参(Panax ginseng C.A. Meyer)の実を収穫して種子を分離し除去してから朝鮮人参の実の果汁、果肉、及び果皮を混合することで朝鮮人参の実原料を製造した。このようにして製造された朝鮮人参の実原料1kgにエタノール3Lを加え、室温で4時間還流抽出し、ろ過した後、45℃で減圧濃縮することで朝鮮人参の実抽出物30gを得た。
前記実施例1において朝鮮人参の実の代わりに朝鮮人参の根を用いたことを除いては、実施例1と同法にて製造した。
朝鮮人参の根(4年根)の乾燥物1kgにエタノール3Lを加え、室温4時間還流抽出し、ろ過した後、45℃で減圧濃縮することで紅参抽出物300gを得た。
<朝鮮人参の実と朝鮮人参の根のジンセノサイド(朝鮮人参のサポニン)成分の分析>
本発明の一実施例に係る実施例1、実施例2の朝鮮人参の実抽出物と比較例1の朝鮮人参の根抽出物をそれぞれ製造した後、これらの抽出物にエーテル(ether)処理を施して脂溶性成分を除去した後にブタノール(BuOH)で粗サポニンを抽出し、濃縮して、HPLCによるジンセノサイド成分の分析を実施し、その結果を図1及び下の表2に表した。
実施例1及び実施例2に従い製造した朝鮮人参の実抽出物が朝鮮人参とは異なる「果実」としての特徴を持つことを区分するために、ビタミンをはじめとしたネラル成分の分析を実施し、その結果を下の表3に表した。
本発明の一実施例に従い製造した実施例1の朝鮮人参の実抽出物に含有されたアントシアニンの成分を定量分析した。
生理前症侯群の診断にあたって、米国精神医学会(American Psychiatric Association)では次のような診断基準を提示した。
(2)持続的且つ激しく腹が立ち、不安を感じる。
(3)不安、緊張感
(4)憂鬱な感情、希望がないように感じる。
(5)日常的な活動時に憂鬱な感情を感じる。
(6)疲れやすく、気力がなくなる。
(7)集中力がなくなるような感じがする。
(8)食欲に変化がある。
(9)過眠または不眠症である。
(10)感情が調節できない。
(11)乳房痛、頭痛、むくみ、筋肉や関節の痛み、体重増加
実施例1に従う朝鮮人参の実抽出物の製造の際は、固形分60質量%以上になるように濃縮し、低温で熟成した後、液状の100質量%エキス製品を製造した。
実施例1に従う朝鮮人参の実抽出物110mg、パーム油0.8mg、植物性硬化油0.48mg、黄ロウ2.4mg及びレシチン3.6mgを混合し、通常の方法にて充填して軟質カプセルを製造した。
実施例1に従う朝鮮人参の実抽出物160mg、ブドウ糖200mg及びデキストリン196mgを混合し、流動層乾燥機を利用して顆粒に造粒した後、糖エステル(sugar ester)7mgを添加し、打錠機で打錠して錠剤を製造した。
実施例1に従う朝鮮人参の実抽出物0.9g、糖0.3g、澱粉1.91g及びグリセリン0.56gを混合し、製丸機を利用して丸を製造した。
実施例1に従う朝鮮人参の実抽出物160mg、ブドウ糖200mg及びデキストリン196mgを混合し、流動層乾燥機を利用して顆粒に造粒した後、包みに充填して顆粒剤を製造した。
実施例1に従う朝鮮人参の実抽出物110mg、ブドウ糖10g及びクエン酸2gを混合した後、精製水188gを加えて、各ビンに200mlずつ充填した。ビンに充填した後、90℃で2〜3時間殺菌してドリンク剤を製造した。
下記の表7に表した組成にて通常の方法で健康機能食品を製造した。
下記の表8に表した組成及び含量にて通常の方法でチューイングガムを製造した。
下記の表9に表した組成及び含量にて通常の方法でキャンデーを製造した。
実施例1の朝鮮人参の実抽出物5質量部を小麦粉100質量部に添加し、この混合物を利用してパン、ケーキ、クッキー、クラッカー及び麺類を製造し、健康増進用食品を製造した。
実施例1の朝鮮人参の実抽出物5〜10質量部を牛乳100質量部に添加し、該牛乳を利用してバター及びアイスクリームのような多様な乳製品を製造した。
玄米、麦、もち米、鳩麦を公知の方法でアルファ化させて乾燥させたものを焙煎した後、粉砕機で粒度60メッシュの粉末に製造した。黒豆、黒ごま、荏胡麻も公知の方法で蒸して乾燥させたものを焙煎した後、粉砕機で粒度60メッシュの粉末に製造した。そのようにして製造した穀物類及び種実類と実施例1の朝鮮人参の実抽出物を下記の表10のような割合で配合して製造した。
下記の表11に表した組成にて通常の方法で健康飲料を製造した。
Claims (10)
- ジンセノサイドRe、ビタミン、ミネラル、及びアントシアニンを含む朝鮮人参の実抽出物を有効成分として含む月経前症候群または月経痛緩和用の組成物であって、
前記朝鮮人参の実抽出物は、朝鮮人参の実の室温還流エタノール抽出物の減圧濃縮物である、組成物。 - ミネラルは、抽出物の全質量を基準にして、カリウム4000mg/100g以上、カルシウム600mg/100g以上、鉄40mg/100g以上、リン150mg/100g以上、マグネシウム250mg/100g以上、及び亜鉛140mg/100g以上のうちの少なくとも一つの特徴を有するものである請求項1に記載の組成物。
- ビタミンは、抽出物の全質量を基準にして、ビタミンA 150μg/100g以上、ビタミンB1 8mg/100g以上、ビタミンB2 5mg/100g以上、ビタミンB6 8mg/100g以上、ビタミンC 3mg/100g以上、ビタミンK 180μg/100g以上、ナイアシン3.5mg/100g以上、パントテン酸4mg/100g以上、及び葉酸250μg/100g以上のうちの少なくとも一つの特徴を有するものである請求項1又は2に記載の組成物。
- アントシアニンは、抽出物の全質量を基準にして20ppm以上である請求項1〜3のいずれか1項に記載の組成物。
- ジンセノサイドReは、抽出物の総質量に対して5〜30質量%である請求項1〜4のいずれか1項に記載の組成物。
- 朝鮮人参の実抽出物は、プロトパナキシジオール系ジンセノサイド(PD)とプロトパナキシトリオール系ジンセノサイド(PT)との質量比(PD/PT)が0.1〜1.5である請求項1〜5のいずれか1項に記載の組成物。
- ジンセノサイドReまたはそれを含む朝鮮人参の実抽出物は、組成物の総質量に対して0.01〜100質量%の量で含む請求項1〜6のいずれか1項に記載の組成物。
- 朝鮮人参の実抽出物は、粗サポニンの含量が朝鮮人参の実抽出物の総質量を基準にして20質量%以上である請求項1〜7のいずれか1項に記載の組成物。
- 組成物は薬学組成物である請求項1〜8のいずれか1項に記載の組成物。
- 組成物は食品組成物である請求項1〜8のいずれか1項に記載の組成物。
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KR101221417B1 (ko) * | 2010-07-08 | 2013-01-11 | 세명대학교 산학협력단 | 인삼 열매 추출물을 포함하는 모발 성장 촉진용 조성물 |
KR101314762B1 (ko) * | 2011-09-27 | 2013-10-04 | 주식회사 한국지네틱팜 | 인삼열매 또는 씨앗을 발효시켜 추출한 발효물의 제조방법 및 이를 이용한 발효식품 |
CN102727548A (zh) * | 2012-07-03 | 2012-10-17 | 吉林省宏久生物科技股份有限公司 | 一种人参茎叶总皂苷提取新技术及方法 |
CN104870003A (zh) | 2013-04-02 | 2015-08-26 | 株式会社爱茉莉太平洋 | 含有人参果提取物的用于改善女性健康和生活质量的组合物 |
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WO2015002391A1 (ko) | 2015-01-08 |
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EP3017821A4 (en) | 2017-03-15 |
KR102262306B1 (ko) | 2021-06-09 |
US20160367614A1 (en) | 2016-12-22 |
TWI648057B (zh) | 2019-01-21 |
HK1215172A1 (zh) | 2016-08-19 |
US10342836B2 (en) | 2019-07-09 |
CN105358168B (zh) | 2021-11-30 |
EP3017821B1 (en) | 2019-02-20 |
CN105358168A (zh) | 2016-02-24 |
KR20150005430A (ko) | 2015-01-14 |
EP3017821A1 (en) | 2016-05-11 |
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