JP6389194B2 - ナトリウムチャネルの調節剤としてのピリドンアミド - Google Patents

ナトリウムチャネルの調節剤としてのピリドンアミド Download PDF

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Publication number
JP6389194B2
JP6389194B2 JP2015556109A JP2015556109A JP6389194B2 JP 6389194 B2 JP6389194 B2 JP 6389194B2 JP 2015556109 A JP2015556109 A JP 2015556109A JP 2015556109 A JP2015556109 A JP 2015556109A JP 6389194 B2 JP6389194 B2 JP 6389194B2
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Japan
Prior art keywords
oxo
dihydropyridin
benzamide
trifluoromethyl
alkyl
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JP2015556109A
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English (en)
Japanese (ja)
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JP2016506963A5 (OSRAM
JP2016506963A (ja
Inventor
サラ サビナ ハディダ−ルアー，
サラ サビナ ハディダ−ルアー，
コーリー アンダーソン，
コーリー アンダーソン，
ビジャヤラクスミ アルムガム，
ビジャヤラクスミ アルムガム，
イウリアナ ルチ アスギアン，
イウリアナ ルチ アスギアン，
ブライアン リチャード ベアー，
ブライアン リチャード ベアー，
アンドレアス ピー． テルミン，
アンドレアス ピー． テルミン，
ジェイムズ フィリップ ジョンソン，
ジェイムズ フィリップ ジョンソン，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
    • C07C63/06—Benzoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Ink Jet (AREA)
JP2015556109A 2013-01-31 2014-01-29 ナトリウムチャネルの調節剤としてのピリドンアミド Active JP6389194B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361759059P 2013-01-31 2013-01-31
US61/759,059 2013-01-31
PCT/US2014/013652 WO2014120808A1 (en) 2013-01-31 2014-01-29 Pyridone amides as modulators of sodium channels

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018027902A Division JP6741704B2 (ja) 2013-01-31 2018-02-20 ナトリウムチャネルの調節剤としてのピリドンアミド

Publications (3)

Publication Number Publication Date
JP2016506963A JP2016506963A (ja) 2016-03-07
JP2016506963A5 JP2016506963A5 (OSRAM) 2017-03-09
JP6389194B2 true JP6389194B2 (ja) 2018-09-12

Family

ID=50073531

Family Applications (4)

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JP2015556109A Active JP6389194B2 (ja) 2013-01-31 2014-01-29 ナトリウムチャネルの調節剤としてのピリドンアミド
JP2018027902A Active JP6741704B2 (ja) 2013-01-31 2018-02-20 ナトリウムチャネルの調節剤としてのピリドンアミド
JP2019056505A Withdrawn JP2019089861A (ja) 2013-01-31 2019-03-25 ナトリウムチャネルの調節剤としてのピリドンアミド
JP2020169731A Pending JP2021001232A (ja) 2013-01-31 2020-10-07 ナトリウムチャネルの調節剤としてのピリドンアミド

Family Applications After (3)

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JP2018027902A Active JP6741704B2 (ja) 2013-01-31 2018-02-20 ナトリウムチャネルの調節剤としてのピリドンアミド
JP2019056505A Withdrawn JP2019089861A (ja) 2013-01-31 2019-03-25 ナトリウムチャネルの調節剤としてのピリドンアミド
JP2020169731A Pending JP2021001232A (ja) 2013-01-31 2020-10-07 ナトリウムチャネルの調節剤としてのピリドンアミド

Country Status (34)

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US (6) US9051270B2 (OSRAM)
EP (3) EP2953931B1 (OSRAM)
JP (4) JP6389194B2 (OSRAM)
KR (2) KR102227592B1 (OSRAM)
CN (2) CN108164457B (OSRAM)
AP (1) AP2015008633A0 (OSRAM)
AR (1) AR094667A1 (OSRAM)
AU (3) AU2014212509B2 (OSRAM)
BR (1) BR112015018289A2 (OSRAM)
CA (1) CA2898866C (OSRAM)
CL (1) CL2015002147A1 (OSRAM)
CY (1) CY1119163T1 (OSRAM)
DK (2) DK3239134T3 (OSRAM)
ES (2) ES2626555T3 (OSRAM)
GE (2) GEP20217286B (OSRAM)
HR (2) HRP20170787T1 (OSRAM)
HU (2) HUE033370T2 (OSRAM)
IL (2) IL269964B1 (OSRAM)
LT (2) LT2953931T (OSRAM)
MX (2) MX2021003687A (OSRAM)
NZ (2) NZ750187A (OSRAM)
PE (2) PE20151781A1 (OSRAM)
PH (1) PH12015501661B1 (OSRAM)
PL (2) PL2953931T3 (OSRAM)
PT (2) PT2953931T (OSRAM)
RS (2) RS56015B1 (OSRAM)
RU (1) RU2662223C2 (OSRAM)
SG (2) SG11201505953TA (OSRAM)
SI (2) SI3239134T1 (OSRAM)
SM (2) SMT201700256T1 (OSRAM)
TW (2) TWI655187B (OSRAM)
UA (1) UA120589C2 (OSRAM)
UY (1) UY35288A (OSRAM)
WO (1) WO2014120808A1 (OSRAM)

Cited By (1)

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CN114437062B (zh) * 2020-04-30 2024-05-17 成都海博为药业有限公司 一种可作为钠通道调节剂的化合物及其用途
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