JP6212485B2 - プロスタグランジンアミドの新規製造方法 - Google Patents

プロスタグランジンアミドの新規製造方法 Download PDF

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JP6212485B2
JP6212485B2 JP2014513258A JP2014513258A JP6212485B2 JP 6212485 B2 JP6212485 B2 JP 6212485B2 JP 2014513258 A JP2014513258 A JP 2014513258A JP 2014513258 A JP2014513258 A JP 2014513258A JP 6212485 B2 JP6212485 B2 JP 6212485B2
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formula
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halogen atom
compound
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JP2014527026A (ja
JP2014527026A5 (enExample
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ハバシ，ガボール
キツシユ，テイボル
ホルトバージ，イレーン
カルドシユ，ジユジヤンナ
ラースローフイ，イシユトバーン
ビシユコフ，ゾルターン
ボーデイシユ，アーダーム
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キノイン・ゼー・エル・テー
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Priority claimed from HU1100292A external-priority patent/HU231134B1/hu
Priority claimed from HU1100291A external-priority patent/HU230703B1/hu
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/50—Iso-indoles; Hydrogenated iso-indoles with oxygen and nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
JP2014513258A 2011-06-02 2012-05-25 プロスタグランジンアミドの新規製造方法 Active JP6212485B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
HUP1100291 2011-06-02
HUP1100292 2011-06-02
HU1100292A HU231134B1 (hu) 2011-06-02 2011-06-02 Eljárás a bimatoprost kémiailag stabil új kristályformájának előállítására
HU1100291A HU230703B1 (hu) 2011-06-02 2011-06-02 Új eljárás prosztaglandin amidok előállítására
PCT/HU2012/000045 WO2012164324A1 (en) 2011-06-02 2012-05-25 Novel processes for the preparation of prostaglandin amides

Related Child Applications (2)

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JP2016234694A Division JP6693859B2 (ja) 2011-06-02 2016-12-02 プロスタグランジンアミドの新規製造方法
JP2016234693A Division JP6487410B2 (ja) 2011-06-02 2016-12-02 プロスタグランジンアミドの新規製造方法

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JP2014527026A JP2014527026A (ja) 2014-10-09
JP2014527026A5 JP2014527026A5 (enExample) 2015-03-12
JP6212485B2 true JP6212485B2 (ja) 2017-10-11

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JP2014513258A Active JP6212485B2 (ja) 2011-06-02 2012-05-25 プロスタグランジンアミドの新規製造方法
JP2016234694A Active JP6693859B2 (ja) 2011-06-02 2016-12-02 プロスタグランジンアミドの新規製造方法
JP2016234693A Active JP6487410B2 (ja) 2011-06-02 2016-12-02 プロスタグランジンアミドの新規製造方法

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JP2016234693A Active JP6487410B2 (ja) 2011-06-02 2016-12-02 プロスタグランジンアミドの新規製造方法

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US (3) US9238621B2 (enExample)
EP (1) EP2723714B1 (enExample)
JP (3) JP6212485B2 (enExample)
KR (3) KR102038048B1 (enExample)
CN (4) CN106316910A (enExample)
BR (3) BR112013030973B1 (enExample)
CA (3) CA3209613A1 (enExample)
ES (1) ES2636756T3 (enExample)
HU (1) HUE033642T2 (enExample)
IL (1) IL229647A (enExample)
MX (1) MX341839B (enExample)
PL (1) PL2723714T3 (enExample)
PT (1) PT2723714T (enExample)
RU (1) RU2618223C2 (enExample)
TW (3) TWI632131B (enExample)
WO (1) WO2012164324A1 (enExample)
ZA (1) ZA201309357B (enExample)

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HU231214B1 (hu) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására
US10273206B2 (en) 2014-06-27 2019-04-30 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
WO2015199729A1 (en) * 2014-06-27 2015-12-30 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
WO2016168141A1 (en) 2015-04-13 2016-10-20 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
HU231185B1 (hu) * 2017-07-11 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás Misoprostol előállítására és tisztítására
CN113548993B (zh) * 2021-09-01 2022-05-27 河北化工医药职业技术学院 一种卡前列素的制备方法

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PT2723714T (pt) 2017-08-18
TWI653223B (zh) 2019-03-11
WO2012164324A9 (en) 2014-01-09
MX341839B (es) 2016-09-05
KR102038048B1 (ko) 2019-10-30
CN106349138A (zh) 2017-01-25
JP6487410B2 (ja) 2019-03-20
IL229647A (en) 2017-09-28
TWI632131B (zh) 2018-08-11
CA2837261C (en) 2020-12-15
TW201311629A (zh) 2013-03-16
TW201708190A (zh) 2017-03-01
BR122021008946B1 (pt) 2021-08-10
ES2636756T3 (es) 2017-10-09
PL2723714T3 (pl) 2018-02-28
CN106278982A (zh) 2017-01-04
BR112013030973A8 (pt) 2021-03-30
TW201708191A (zh) 2017-03-01
US9238621B2 (en) 2016-01-19
CN106316910A (zh) 2017-01-11
CA3094762C (en) 2023-09-26
CN106278982B (zh) 2019-06-14
KR20190124804A (ko) 2019-11-05
JP6693859B2 (ja) 2020-05-13
HUE033642T2 (en) 2017-12-28
EP2723714A1 (en) 2014-04-30
JP2014527026A (ja) 2014-10-09
BR112013030973A2 (pt) 2016-08-16
BR112013030973B1 (pt) 2021-08-10
KR20200087871A (ko) 2020-07-21
IL229647A0 (en) 2014-01-30
CA3094762A1 (en) 2012-12-06
KR102135550B1 (ko) 2020-07-21
KR20140053941A (ko) 2014-05-08
MX2013014034A (es) 2015-06-17
US20160145207A1 (en) 2016-05-26
US9573892B2 (en) 2017-02-21
US9856213B2 (en) 2018-01-02
JP2017075165A (ja) 2017-04-20
CN103649047A (zh) 2014-03-19
ZA201309357B (en) 2014-08-27
CA3209613A1 (en) 2012-12-06
JP2017061555A (ja) 2017-03-30
US20160137602A1 (en) 2016-05-19
RU2618223C2 (ru) 2017-05-03
RU2013158952A (ru) 2015-07-20
WO2012164324A1 (en) 2012-12-06
CA2837261A1 (en) 2012-12-06
US20140135503A1 (en) 2014-05-15
TWI653222B (zh) 2019-03-11
EP2723714B1 (en) 2017-06-21
CN103649047B (zh) 2017-01-11
KR102277188B1 (ko) 2021-07-15
BR122021008918B1 (pt) 2021-08-10

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