JP6182600B2 - 線維芽細胞増殖因子２１タンパク質 - Google Patents

線維芽細胞増殖因子２１タンパク質 Download PDF

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JP6182600B2
JP6182600B2 JP2015517297A JP2015517297A JP6182600B2 JP 6182600 B2 JP6182600 B2 JP 6182600B2 JP 2015517297 A JP2015517297 A JP 2015517297A JP 2015517297 A JP2015517297 A JP 2015517297A JP 6182600 B2 JP6182600 B2 JP 6182600B2
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seq
protein
homodimer
polypeptide
amino acid
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JP2015527974A (ja
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ジェームス ダーリン，ライアン
ジェームス ダーリン，ライアン
デュアン ディキンソン，クレイグ
デュアン ディキンソン，クレイグ
アルバート ドライバー，デイビッド
アルバート ドライバー，デイビッド
ドナタ ゴンシャルツ，マルゴジャータ
ドナタ ゴンシャルツ，マルゴジャータ
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イーライ リリー アンド カンパニー
イーライ リリー アンド カンパニー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide
    • Y10S530/814—Cellulose or derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2015517297A 2012-06-11 2013-06-05 線維芽細胞増殖因子２１タンパク質 Active JP6182600B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261658104P 2012-06-11 2012-06-11
US61/658,104 2012-06-11
US201361777386P 2013-03-12 2013-03-12
US61/777,386 2013-03-12
PCT/US2013/044190 WO2013188181A1 (en) 2012-06-11 2013-06-05 Fibroblast growth factor 21 proteins

Publications (2)

Publication Number Publication Date
JP2015527974A JP2015527974A (ja) 2015-09-24
JP6182600B2 true JP6182600B2 (ja) 2017-08-16

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US (2) US8741841B2 (enExample)
EP (1) EP2858662B1 (enExample)
JP (1) JP6182600B2 (enExample)
KR (1) KR20150006060A (enExample)
CN (1) CN104394882B (enExample)
AR (1) AR091216A1 (enExample)
AU (1) AU2013274638A1 (enExample)
BR (1) BR112014029966A2 (enExample)
CA (1) CA2871145A1 (enExample)
CL (1) CL2014003078A1 (enExample)
CO (1) CO7151525A2 (enExample)
EA (1) EA201492053A1 (enExample)
EC (1) ECSP14030742A (enExample)
ES (1) ES2644787T3 (enExample)
HK (1) HK1203357A1 (enExample)
IL (1) IL235832A0 (enExample)
IN (1) IN2014MN02132A (enExample)
MX (1) MX2014015257A (enExample)
PE (1) PE20150201A1 (enExample)
PH (1) PH12014502766A1 (enExample)
SG (1) SG11201408095XA (enExample)
TN (1) TN2014000439A1 (enExample)
TW (1) TWI513705B (enExample)
WO (1) WO2013188181A1 (enExample)

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US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
EP3798228A1 (en) 2012-11-28 2021-03-31 NGM Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
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Also Published As

Publication number Publication date
WO2013188181A1 (en) 2013-12-19
PE20150201A1 (es) 2015-02-19
EP2858662A1 (en) 2015-04-15
CO7151525A2 (es) 2014-12-29
CA2871145A1 (en) 2013-12-19
JP2015527974A (ja) 2015-09-24
IN2014MN02132A (enExample) 2015-09-11
CN104394882A (zh) 2015-03-04
EP2858662B1 (en) 2017-08-09
TWI513705B (zh) 2015-12-21
HK1203357A1 (en) 2015-10-30
SG11201408095XA (en) 2015-01-29
TW201408693A (zh) 2014-03-01
PH12014502766A1 (en) 2015-02-09
ES2644787T3 (es) 2017-11-30
BR112014029966A2 (pt) 2017-09-12
US8927492B2 (en) 2015-01-06
KR20150006060A (ko) 2015-01-15
TN2014000439A1 (en) 2016-03-30
IL235832A0 (en) 2015-01-29
CL2014003078A1 (es) 2015-02-27
AU2013274638A1 (en) 2014-11-06
US20140228282A1 (en) 2014-08-14
AR091216A1 (es) 2015-01-21
CN104394882B (zh) 2016-06-22
ECSP14030742A (es) 2015-09-30
EA201492053A1 (ru) 2015-02-27
MX2014015257A (es) 2015-03-05
US8741841B2 (en) 2014-06-03
US20130330336A1 (en) 2013-12-12

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