ECSP14030742A - Proteínas del factor 21 de crecimiento del fibroblasto - Google Patents
Proteínas del factor 21 de crecimiento del fibroblastoInfo
- Publication number
- ECSP14030742A ECSP14030742A ECIEPI201430742A ECPI201430742A ECSP14030742A EC SP14030742 A ECSP14030742 A EC SP14030742A EC IEPI201430742 A ECIEPI201430742 A EC IEPI201430742A EC PI201430742 A ECPI201430742 A EC PI201430742A EC SP14030742 A ECSP14030742 A EC SP14030742A
- Authority
- EC
- Ecuador
- Prior art keywords
- proteins
- growth factor
- fibroblast growth
- fgf21
- dyslipidemia
- Prior art date
Links
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title abstract 3
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 101000846529 Homo sapiens Fibroblast growth factor 21 Proteins 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 102000056713 human FGF21 Human genes 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/813—Carrier is a saccharide
- Y10S530/814—Cellulose or derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a proteínas del factor 21 de crecimiento del fibroblasto humano (FGF21) farmacológicamente potentes y estables, composiciones farmacéuticas que comprenden las proteínas del FGF21, y métodos para tratar diabetes tipo 2, obesidad, dislipidemia, y/o síndrome metabólico usando tales proteínas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261658104P | 2012-06-11 | 2012-06-11 | |
US201361777386P | 2013-03-12 | 2013-03-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP14030742A true ECSP14030742A (es) | 2015-09-30 |
Family
ID=48670814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECIEPI201430742A ECSP14030742A (es) | 2012-06-11 | 2014-12-11 | Proteínas del factor 21 de crecimiento del fibroblasto |
Country Status (24)
Country | Link |
---|---|
US (2) | US8741841B2 (es) |
EP (1) | EP2858662B1 (es) |
JP (1) | JP6182600B2 (es) |
KR (1) | KR20150006060A (es) |
CN (1) | CN104394882B (es) |
AR (1) | AR091216A1 (es) |
AU (1) | AU2013274638A1 (es) |
BR (1) | BR112014029966A2 (es) |
CA (1) | CA2871145A1 (es) |
CL (1) | CL2014003078A1 (es) |
CO (1) | CO7151525A2 (es) |
EA (1) | EA201492053A1 (es) |
EC (1) | ECSP14030742A (es) |
ES (1) | ES2644787T3 (es) |
HK (1) | HK1203357A1 (es) |
IL (1) | IL235832A0 (es) |
IN (1) | IN2014MN02132A (es) |
MX (1) | MX2014015257A (es) |
PE (1) | PE20150201A1 (es) |
PH (1) | PH12014502766A1 (es) |
SG (1) | SG11201408095XA (es) |
TN (1) | TN2014000439A1 (es) |
TW (1) | TWI513705B (es) |
WO (1) | WO2013188181A1 (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008121563A2 (en) | 2007-03-30 | 2008-10-09 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
WO2013006486A2 (en) | 2011-07-01 | 2013-01-10 | Ngm Biopharmaceuticals, Inc. | Compositions, uses and methods for treatment of metabolic disorders and diseases |
EA201492064A1 (ru) * | 2012-06-11 | 2015-02-27 | Эли Лилли Энд Компани | Варианты фактора роста фибробластов 21 |
TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子21蛋白質 |
US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
WO2014085365A2 (en) | 2012-11-28 | 2014-06-05 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
CA2895517C (en) | 2012-12-27 | 2022-10-11 | Ngm Biopharmaceuticals, Inc. | Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
CN105828878A (zh) | 2013-10-28 | 2016-08-03 | 恩格姆生物制药公司 | 癌症模型及相关方法 |
AU2015209131B2 (en) | 2014-01-24 | 2020-06-25 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
EP3107937A4 (en) * | 2014-02-21 | 2017-11-15 | MedImmune, LLC | Anti-pcsk9~glp-1 fusions and methods for use |
JP6712230B2 (ja) | 2014-03-11 | 2020-06-17 | ノバルティス アーゲー | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
CA2943355C (en) | 2014-03-25 | 2023-09-05 | Regeneron Pharmaceuticals, Inc. | Fgf21 receptor agonists and uses thereof |
WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
WO2015195509A2 (en) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
JP6308699B2 (ja) * | 2014-09-08 | 2018-04-11 | 国立大学法人大阪大学 | 脱髄疾患の予防又は治療剤 |
CA2964782A1 (en) | 2014-10-23 | 2016-04-28 | Ngm Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising peptide variants and methods of use thereof |
EP3909596A1 (en) | 2014-10-24 | 2021-11-17 | Bristol-Myers Squibb Company | Modified fgf-21 polypeptides and uses thereof |
WO2016073855A1 (en) | 2014-11-07 | 2016-05-12 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
KR20160088656A (ko) * | 2015-01-16 | 2016-07-26 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
US11638745B2 (en) | 2015-05-20 | 2023-05-02 | University of Pittsburgh—Of the Commonwealth Cvctom of Hierher Education | Method to improve neurologic outcomes in temperature managed patients |
US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
KR102670157B1 (ko) | 2015-10-28 | 2024-05-29 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
KR102668200B1 (ko) * | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
CA3082794A1 (en) | 2015-11-09 | 2017-05-18 | Ngm Biopharmaceuticals Inc. | Methods for treatment of bile acid-related disorders |
CN105348380B (zh) * | 2015-12-28 | 2019-03-01 | 江苏康缘瑞翱生物医药科技有限公司 | 犬成纤维细胞生长因子21及其在治疗犬内分泌疾病中的用途 |
CN106317226B (zh) | 2016-08-19 | 2017-09-05 | 安源医药科技(上海)有限公司 | 用于构建融合蛋白的连接肽 |
US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技(上海)有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
WO2018039557A1 (en) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
CA3042512A1 (en) | 2016-11-10 | 2018-05-17 | Yuhan Corporation | Pharmaceutical composition for preventing or treating hepatitis, hepatic fibrosis, and hepatic cirrhosis comprising fusion proteins |
JP7181886B2 (ja) | 2017-03-14 | 2022-12-01 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | 免疫グロブリンのFc部分を含む二重標的融合タンパク質 |
EA201992516A1 (ru) | 2017-04-21 | 2020-04-09 | Юхан Корпорейшн | Способ получения бифункциональных белков и их производных |
CN107385020A (zh) * | 2017-06-23 | 2017-11-24 | 西安医学院 | 瘦素在人重组fgf21蛋白活性检测中的应用 |
CA3072903A1 (en) | 2017-09-08 | 2019-03-14 | Bristol-Myers Squibb Company | Modified fibroblast growth factor 21 (fgf-21) for use in methods for treating nonalcoholic steatohepatitis (nash) |
CN110128525B (zh) | 2018-02-08 | 2022-08-26 | 广东东阳光药业有限公司 | Fgf21变体、融合蛋白及其应用 |
PE20210632A1 (es) | 2018-07-03 | 2021-03-23 | Bristol Myers Squibb Co | Formulaciones de fgf-21 |
CN111195234B (zh) * | 2018-11-16 | 2022-08-26 | 鲁南制药集团股份有限公司 | 一种重组FGF21-Fc融合蛋白冻干粉制剂 |
US20220064244A1 (en) * | 2019-03-05 | 2022-03-03 | Sunshine Lake Pharma Co., Ltd. | A polypeptide molecule and application thereof |
IL294534A (en) | 2020-01-08 | 2022-09-01 | Bristol Myers Squibb Co | Formulations of fgf-21 conjugates |
US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
WO2022032187A1 (en) | 2020-08-07 | 2022-02-10 | Bristol-Myers Squibb Company | Fgf21 combined with ccr2/5 antagonists for the treatment of fibrosis |
KR20220021207A (ko) | 2020-08-13 | 2022-02-22 | 주식회사 나이벡 | 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물 |
KR102495299B1 (ko) * | 2020-11-03 | 2023-02-06 | 토드제약 주식회사 | Fgf21의 열탄력성을 이용한 fgf21 생산 방법 |
US20240123031A1 (en) | 2020-11-25 | 2024-04-18 | Bristol-Myers Squibb Company | Methods of treating liver diseases |
KR102631925B1 (ko) * | 2021-06-10 | 2024-02-01 | 토드제약 주식회사 | 신규 fgf21 변이체 개발 및 이의 생산기법과 용도 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
AU2002322394A1 (en) | 2001-07-30 | 2003-02-17 | Eli Lilly And Company | Method for treating diabetes and obesity |
EA200601121A1 (ru) * | 2003-12-10 | 2006-10-27 | Эли Лилли Энд Компани | Мутеины фактора роста фибробластов 21 |
EP2194064A1 (en) | 2004-05-13 | 2010-06-09 | Eli Lilly & Company | FGF-21 fusion proteins |
WO2008121563A2 (en) | 2007-03-30 | 2008-10-09 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
JOP20190083A1 (ar) * | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
CH699521A2 (de) | 2008-09-09 | 2010-03-15 | Rotorcraft Ag | Streckwerk für eine Strickmaschine. |
JP5878757B2 (ja) | 2008-10-10 | 2016-03-08 | アムジエン・インコーポレーテツド | Fgf21変異体およびその使用 |
WO2010065439A1 (en) | 2008-12-05 | 2010-06-10 | Eli Lilly And Company | Variants of fibroblast growth factor 21 |
KR20110117666A (ko) | 2009-01-23 | 2011-10-27 | 노보 노르디스크 에이/에스 | 알부민 바인더 a-b-c-d-e-를 갖는 fgf21 유도체 및 그것의 사용 |
UY32607A (es) | 2009-05-05 | 2010-12-31 | Amgen Inc | Mutantes de fgf21 y usos del mismo |
MX2011011815A (es) | 2009-05-05 | 2012-01-27 | Amgen Inc | Mutantes fgf21 y usos de los mismos. |
JP2013533227A (ja) * | 2010-06-08 | 2013-08-22 | ノヴォ ノルディスク アー/エス | Fgf21類似体および誘導体 |
AR087973A1 (es) * | 2011-10-04 | 2014-04-30 | Lilly Co Eli | Variantes del factor 21 del crecimiento de fibroblastos |
TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子21蛋白質 |
-
2013
- 2013-05-27 TW TW102118698A patent/TWI513705B/zh not_active IP Right Cessation
- 2013-05-30 AR ARP130101904 patent/AR091216A1/es unknown
- 2013-06-05 EP EP13730733.6A patent/EP2858662B1/en active Active
- 2013-06-05 PE PE2014002236A patent/PE20150201A1/es not_active Application Discontinuation
- 2013-06-05 EA EA201492053A patent/EA201492053A1/ru unknown
- 2013-06-05 AU AU2013274638A patent/AU2013274638A1/en not_active Abandoned
- 2013-06-05 CN CN201380030788.4A patent/CN104394882B/zh not_active Expired - Fee Related
- 2013-06-05 BR BR112014029966A patent/BR112014029966A2/pt not_active IP Right Cessation
- 2013-06-05 US US13/910,149 patent/US8741841B2/en active Active
- 2013-06-05 MX MX2014015257A patent/MX2014015257A/es unknown
- 2013-06-05 JP JP2015517297A patent/JP6182600B2/ja active Active
- 2013-06-05 ES ES13730733.6T patent/ES2644787T3/es active Active
- 2013-06-05 WO PCT/US2013/044190 patent/WO2013188181A1/en active Application Filing
- 2013-06-05 SG SG11201408095XA patent/SG11201408095XA/en unknown
- 2013-06-05 IN IN2132MUN2014 patent/IN2014MN02132A/en unknown
- 2013-06-05 KR KR20147034366A patent/KR20150006060A/ko active IP Right Grant
- 2013-06-05 CA CA2871145A patent/CA2871145A1/en not_active Abandoned
-
2014
- 2014-04-23 US US14/259,210 patent/US8927492B2/en active Active
- 2014-10-20 TN TN2014000439A patent/TN2014000439A1/fr unknown
- 2014-11-13 CL CL2014003078A patent/CL2014003078A1/es unknown
- 2014-11-20 IL IL235832A patent/IL235832A0/en unknown
- 2014-11-27 CO CO14261559A patent/CO7151525A2/es unknown
- 2014-12-10 PH PH12014502766A patent/PH12014502766A1/en unknown
- 2014-12-11 EC ECIEPI201430742A patent/ECSP14030742A/es unknown
-
2015
- 2015-04-20 HK HK15103818.7A patent/HK1203357A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2858662A1 (en) | 2015-04-15 |
US8741841B2 (en) | 2014-06-03 |
CL2014003078A1 (es) | 2015-02-27 |
CN104394882B (zh) | 2016-06-22 |
CN104394882A (zh) | 2015-03-04 |
KR20150006060A (ko) | 2015-01-15 |
TWI513705B (zh) | 2015-12-21 |
PH12014502766A1 (en) | 2015-02-09 |
US20130330336A1 (en) | 2013-12-12 |
JP6182600B2 (ja) | 2017-08-16 |
IL235832A0 (en) | 2015-01-29 |
MX2014015257A (es) | 2015-03-05 |
EA201492053A1 (ru) | 2015-02-27 |
IN2014MN02132A (es) | 2015-09-11 |
CA2871145A1 (en) | 2013-12-19 |
PE20150201A1 (es) | 2015-02-19 |
JP2015527974A (ja) | 2015-09-24 |
AU2013274638A1 (en) | 2014-11-06 |
HK1203357A1 (en) | 2015-10-30 |
US20140228282A1 (en) | 2014-08-14 |
AR091216A1 (es) | 2015-01-21 |
BR112014029966A2 (pt) | 2017-09-12 |
CO7151525A2 (es) | 2014-12-29 |
EP2858662B1 (en) | 2017-08-09 |
WO2013188181A1 (en) | 2013-12-19 |
TN2014000439A1 (en) | 2016-03-30 |
US8927492B2 (en) | 2015-01-06 |
TW201408693A (zh) | 2014-03-01 |
ES2644787T3 (es) | 2017-11-30 |
SG11201408095XA (en) | 2015-01-29 |
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