CN104394882B - 成纤维细胞生长因子21蛋白 - Google Patents

成纤维细胞生长因子21蛋白 Download PDF

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Publication number
CN104394882B
CN104394882B CN201380030788.4A CN201380030788A CN104394882B CN 104394882 B CN104394882 B CN 104394882B CN 201380030788 A CN201380030788 A CN 201380030788A CN 104394882 B CN104394882 B CN 104394882B
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Prior art keywords
homodimer
seq
fgf21
protein
polypeptide
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Expired - Fee Related
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CN201380030788.4A
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English (en)
Chinese (zh)
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CN104394882A (zh
Inventor
R·J·达林
C·D·迪金森
D·A·德赖弗
M·D·贡西亚茨
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Eli Lilly and Co
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Eli Lilly and Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide
    • Y10S530/814—Cellulose or derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201380030788.4A 2012-06-11 2013-06-05 成纤维细胞生长因子21蛋白 Expired - Fee Related CN104394882B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261658104P 2012-06-11 2012-06-11
US61/658,104 2012-06-11
US201361777386P 2013-03-12 2013-03-12
US61/777,386 2013-03-12
PCT/US2013/044190 WO2013188181A1 (en) 2012-06-11 2013-06-05 Fibroblast growth factor 21 proteins

Publications (2)

Publication Number Publication Date
CN104394882A CN104394882A (zh) 2015-03-04
CN104394882B true CN104394882B (zh) 2016-06-22

Family

ID=48670814

Family Applications (1)

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CN201380030788.4A Expired - Fee Related CN104394882B (zh) 2012-06-11 2013-06-05 成纤维细胞生长因子21蛋白

Country Status (24)

Country Link
US (2) US8741841B2 (enExample)
EP (1) EP2858662B1 (enExample)
JP (1) JP6182600B2 (enExample)
KR (1) KR20150006060A (enExample)
CN (1) CN104394882B (enExample)
AR (1) AR091216A1 (enExample)
AU (1) AU2013274638A1 (enExample)
BR (1) BR112014029966A2 (enExample)
CA (1) CA2871145A1 (enExample)
CL (1) CL2014003078A1 (enExample)
CO (1) CO7151525A2 (enExample)
EA (1) EA201492053A1 (enExample)
EC (1) ECSP14030742A (enExample)
ES (1) ES2644787T3 (enExample)
HK (1) HK1203357A1 (enExample)
IL (1) IL235832A0 (enExample)
IN (1) IN2014MN02132A (enExample)
MX (1) MX2014015257A (enExample)
PE (1) PE20150201A1 (enExample)
PH (1) PH12014502766A1 (enExample)
SG (1) SG11201408095XA (enExample)
TN (1) TN2014000439A1 (enExample)
TW (1) TWI513705B (enExample)
WO (1) WO2013188181A1 (enExample)

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JP6181752B2 (ja) * 2012-06-11 2017-08-16 イーライ リリー アンド カンパニー 線維芽細胞増殖因子２１変異体
CA2892152A1 (en) 2012-11-28 2014-06-05 Ngm Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
SG10202100667SA (en) 2012-12-27 2021-02-25 Ngm Biopharmaceuticals Inc Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
RU2707531C2 (ru) 2013-10-28 2019-11-27 ЭнДжиЭм БАЙОФАРМАСЬЮТИКАЛЗ, ИНК. Модели рака и соответствующие способы
KR102489475B1 (ko) 2014-01-24 2023-01-20 엔지엠 바이오파마슈티컬스, 아이엔씨. 결합 단백질 및 그의 사용 방법
CA2935285A1 (en) * 2014-02-21 2015-08-27 Medimmune, Llc Anti-pcsk9-glp-1 fusions and methods for use
JP6712230B2 (ja) 2014-03-11 2020-06-17 ノバルティス アーゲー リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法
US10519240B2 (en) 2014-03-25 2019-12-31 Regeneron Pharmaceuticals, Inc. Anti-FGFR1c antibody-FGF21 fusion proteins
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
US10456449B2 (en) 2014-06-16 2019-10-29 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
WO2016039339A1 (ja) * 2014-09-08 2016-03-17 国立大学法人大阪大学 脱髄疾患の予防又は治療剤
RU2729161C2 (ru) 2014-10-23 2020-08-04 ЭнДжиЭм БАЙОФАРМАСЬЮТИКАЛЗ, ИНК. Фармацевтические композиции, содержащие варианты пептидов, и способы их применения
HUE055311T2 (hu) 2014-10-24 2021-11-29 Bristol Myers Squibb Co Módosított FGF-21 polipeptidek és azok felhasználása
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KR20160088656A (ko) 2015-01-16 2016-07-26 주식회사유한양행 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
US11638745B2 (en) 2015-05-20 2023-05-02 University of Pittsburgh—Of the Commonwealth Cvctom of Hierher Education Method to improve neurologic outcomes in temperature managed patients
WO2017019957A2 (en) 2015-07-29 2017-02-02 Ngm Biopharmaceuticals, Inc. Binding proteins and methods of use thereof
KR102668200B1 (ko) * 2015-10-28 2024-05-23 주식회사유한양행 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
KR102670157B1 (ko) 2015-10-28 2024-05-29 주식회사유한양행 이중 작용 단백질 및 이를 포함하는 약학적 조성물
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CN105348380B (zh) * 2015-12-28 2019-03-01 江苏康缘瑞翱生物医药科技有限公司 犬成纤维细胞生长因子21及其在治疗犬内分泌疾病中的用途
CN106279437B (zh) 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
CN107759697B (zh) 2016-08-19 2023-03-24 安源医药科技（上海）有限公司 制备融合蛋白的方法
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CN107385020A (zh) * 2017-06-23 2017-11-24 西安医学院 瘦素在人重组fgf21蛋白活性检测中的应用
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CN102143758A (zh) * 2008-06-04 2011-08-03 安姆根有限公司 Fgf21突变体及其用途

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CN102143758A (zh) * 2008-06-04 2011-08-03 安姆根有限公司 Fgf21突变体及其用途

Also Published As

Publication number Publication date
TWI513705B (zh) 2015-12-21
BR112014029966A2 (pt) 2017-09-12
TW201408693A (zh) 2014-03-01
EA201492053A1 (ru) 2015-02-27
US8927492B2 (en) 2015-01-06
WO2013188181A1 (en) 2013-12-19
US20140228282A1 (en) 2014-08-14
IN2014MN02132A (enExample) 2015-09-11
JP6182600B2 (ja) 2017-08-16
KR20150006060A (ko) 2015-01-15
US20130330336A1 (en) 2013-12-12
ECSP14030742A (es) 2015-09-30
JP2015527974A (ja) 2015-09-24
TN2014000439A1 (en) 2016-03-30
EP2858662B1 (en) 2017-08-09
IL235832A0 (en) 2015-01-29
CL2014003078A1 (es) 2015-02-27
PH12014502766A1 (en) 2015-02-09
US8741841B2 (en) 2014-06-03
PE20150201A1 (es) 2015-02-19
CN104394882A (zh) 2015-03-04
MX2014015257A (es) 2015-03-05
CO7151525A2 (es) 2014-12-29
SG11201408095XA (en) 2015-01-29
ES2644787T3 (es) 2017-11-30
AU2013274638A1 (en) 2014-11-06
HK1203357A1 (en) 2015-10-30
AR091216A1 (es) 2015-01-21
EP2858662A1 (en) 2015-04-15
CA2871145A1 (en) 2013-12-19

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