JP6162662B2 - 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法 - Google Patents

加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法 Download PDF

Info

Publication number
JP6162662B2
JP6162662B2 JP2014162437A JP2014162437A JP6162662B2 JP 6162662 B2 JP6162662 B2 JP 6162662B2 JP 2014162437 A JP2014162437 A JP 2014162437A JP 2014162437 A JP2014162437 A JP 2014162437A JP 6162662 B2 JP6162662 B2 JP 6162662B2
Authority
JP
Japan
Prior art keywords
hpmcas
heat
drug
melt extrusion
acetate succinate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2014162437A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015057380A (ja
Inventor
直亮 丸山
直亮 丸山
彰吾 藁品
彰吾 藁品
史枝 草木
史枝 草木
栄 尾原
栄 尾原
一輝 菊池
一輝 菊池
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shin Etsu Chemical Co Ltd
Original Assignee
Shin Etsu Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51225402&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6162662(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shin Etsu Chemical Co Ltd filed Critical Shin Etsu Chemical Co Ltd
Priority to JP2014162437A priority Critical patent/JP6162662B2/ja
Publication of JP2015057380A publication Critical patent/JP2015057380A/ja
Application granted granted Critical
Publication of JP6162662B2 publication Critical patent/JP6162662B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2014162437A 2013-08-12 2014-08-08 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法 Active JP6162662B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2014162437A JP6162662B2 (ja) 2013-08-12 2014-08-08 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013167572 2013-08-12
JP2013167572 2013-08-12
JP2014162437A JP6162662B2 (ja) 2013-08-12 2014-08-08 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法

Publications (2)

Publication Number Publication Date
JP2015057380A JP2015057380A (ja) 2015-03-26
JP6162662B2 true JP6162662B2 (ja) 2017-07-12

Family

ID=51225402

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014162437A Active JP6162662B2 (ja) 2013-08-12 2014-08-08 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法

Country Status (6)

Country Link
US (1) US11090295B2 (enExample)
EP (1) EP2837391B1 (enExample)
JP (1) JP6162662B2 (enExample)
KR (1) KR102089112B1 (enExample)
CN (1) CN104371030B (enExample)
IN (1) IN2014DE02197A (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12285486B2 (en) 2017-08-07 2025-04-29 SE Tylose USA, Inc Pharmaceutical composition in solid extruded form

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6203702B2 (ja) * 2014-11-18 2017-09-27 信越化学工業株式会社 ヒプロメロース酢酸エステルコハク酸エステルを用いたスプレードライ用溶液及び固体分散体の製造方法
US10604588B2 (en) 2016-04-05 2020-03-31 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate powder excellent in dissolved state and production method thereof, and production methods for composition for solid dispersion, coating composition, drug-containing particle, and solid preparation
WO2017032908A1 (en) * 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
JP6683561B2 (ja) * 2016-07-12 2020-04-22 信越化学工業株式会社 腸溶性硬カプセル用組成物及び腸溶性硬カプセルの製造方法
JP6644656B2 (ja) 2016-08-29 2020-02-12 信越化学工業株式会社 ヒプロメロース酢酸エステルコハク酸エステルの製造方法
JP6742197B2 (ja) * 2016-08-29 2020-08-19 信越化学工業株式会社 ヒプロメロースフタル酸エステルの製造方法
TR201722852A2 (tr) * 2017-12-29 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Mesalazi̇ni̇n oral farmasöti̇k kompozi̇syonlari
JP6905035B2 (ja) * 2019-11-29 2021-07-21 Ｎｉｓｓｈａ株式会社 可食性フィルムの製造方法、フィルム製剤及び可食性フィルム
JP7399061B2 (ja) * 2020-10-01 2023-12-15 信越化学工業株式会社 ヒドロキシプロピルメチルセルロースフタレートの製造方法
JP2025019010A (ja) * 2023-07-26 2025-02-06 信越化学工業株式会社 ヒドロキシプロピルメチルセルロースアセテートサクシネート粉末及びその製造方法
CN120938940A (zh) * 2025-10-15 2025-11-14 成都药宜立康医药科技有限公司 一种苯磺酸美洛加巴林药物组合物及其制备方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226981A (en) 1977-09-28 1980-10-07 Shin-Etsu Chemical Co., Ltd. Ether-ester derivatives of cellulose and their applications
JPS5951562B2 (ja) 1977-10-25 1984-12-14 信越化学工業株式会社 セルロ−スエ−テルの酸性サクシニルおよび脂肪族モノアシル混成エステルの製造方法
JPS5535031A (en) * 1978-09-04 1980-03-11 Shin Etsu Chem Co Ltd Enteric coating composition
JP2528706B2 (ja) 1988-05-30 1996-08-28 ゼリア新薬工業株式会社 ジヒドロピリジン化合物の製剤組成物
JP2925346B2 (ja) 1991-03-18 1999-07-28 田辺製薬株式会社 腸溶性製剤およびその製法
JP2527107B2 (ja) 1991-04-16 1996-08-21 日本新薬株式会社 固体分散体の製造方法
JPH0920663A (ja) * 1995-07-07 1997-01-21 Teikoku Seiyaku Co Ltd イブジラストを含有する徐放性細粒剤およびその製法
JP4290817B2 (ja) 1999-07-29 2009-07-08 株式会社金門製作所 ガスメータ
PT1207866E (pt) * 1999-08-31 2005-02-28 Gruenenthal Gmbh Forma de administracao retardada contendo sacarinato de tramadol
PT1239831E (pt) 1999-12-23 2013-01-23 Mayne Pharma International Pty Ltd Composições farmacêuticas melhoradas para fármacos fracamente solúveis
JP3552160B2 (ja) * 2000-01-14 2004-08-11 信越化学工業株式会社 低置換度ヒドロキシプロピルセルロース粒子の形成方法
JPWO2003077827A1 (ja) 2002-03-19 2005-07-14 日本新薬株式会社 医薬固体分散体の製造方法
KR100454394B1 (ko) 2002-03-27 2004-10-26 이원희 맥파검출장치
GB0418791D0 (en) 2004-08-23 2004-09-22 Glaxo Group Ltd Novel process
JP5576922B2 (ja) * 2006-04-20 2014-08-20 信越化学工業株式会社 腸溶性固体分散体を含んでなる固形製剤
JP2007308480A (ja) * 2006-04-20 2007-11-29 Shin Etsu Chem Co Ltd 腸溶性固体分散体を含んでなる固形製剤
CN101125204A (zh) * 2006-08-08 2008-02-20 信越化学工业株式会社 含有固体分散体的固体制剂及其制备方法
WO2008138755A2 (en) * 2007-05-11 2008-11-20 F. Hoffmann-La Roche Ag Pharmaceutical compositions for poorly soluble drugs
JP2009089982A (ja) * 2007-10-11 2009-04-30 Ohara Yakuhin Kogyo Kk 打錠用造粒物の造粒方法
WO2009129301A2 (en) 2008-04-15 2009-10-22 Schering Corporation Oral pharmaceutical compositions in a molecular solid dispersion
TWI388324B (zh) * 2008-04-15 2013-03-11 Schering Corp 含有泊沙康唑（ｐｏｓａｃｏｎａｚｏｌｅ）之高密度組合物及包含該組合物之調配物
WO2009132208A1 (en) 2008-04-24 2009-10-29 Evestra, Inc. Oral contraceptive dosage forms comprising a progestogen dispersed in an enteric polymer and further comprising an estrogen
CN102988318A (zh) 2008-11-25 2013-03-27 田边三菱制药株式会社 口腔速崩片及其制备方法
MX2011008303A (es) * 2009-04-03 2011-11-29 Plexxikon Inc Composiciones del acido propano-1-sulfonico {3-[5-(4-cloro-fenil)- 1h-pirrolo [2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil}-amida y el uso de las mismas.
JP5324302B2 (ja) * 2009-04-22 2013-10-23 信越化学工業株式会社 高成型性、高流動性低置換度ヒドロキシプロピルセルロースおよびそれを含む固形製剤
FR2945947B1 (fr) * 2009-05-29 2011-07-29 Flamel Tech Sa Compositions pharmaceutiques flottantes a liberation controlee
EP2647648B1 (en) 2010-12-03 2017-08-09 Nippon Soda Co., Ltd. Solid dosage form containing a low viscosity HYDROXYALKYL CELLULOSE
US8591944B2 (en) 2011-03-08 2013-11-26 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
KR101916010B1 (ko) 2011-04-06 2018-11-08 다우 글로벌 테크놀로지스 엘엘씨 신규한 폴리사카라이드 유도체 및 제형
EP2524688B1 (en) 2011-05-11 2013-05-01 ratiopharm GmbH Composition for modified release comprising ranolazine
CN103083240B (zh) * 2011-10-28 2015-12-09 沈阳药科大学 紫杉醇及其同系物的固体分散体及其口服制剂的制备

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12285486B2 (en) 2017-08-07 2025-04-29 SE Tylose USA, Inc Pharmaceutical composition in solid extruded form

Also Published As

Publication number Publication date
JP2015057380A (ja) 2015-03-26
CN104371030A (zh) 2015-02-25
IN2014DE02197A (enExample) 2015-06-19
EP2837391A1 (en) 2015-02-18
US11090295B2 (en) 2021-08-17
US20150044289A1 (en) 2015-02-12
CN104371030B (zh) 2017-08-08
EP2837391B1 (en) 2017-05-10
KR102089112B1 (ko) 2020-03-13
KR20150020073A (ko) 2015-02-25

Similar Documents

Publication Publication Date Title
JP6162662B2 (ja) 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法
JP6126555B2 (ja) 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法
JP6203702B2 (ja) ヒプロメロース酢酸エステルコハク酸エステルを用いたスプレードライ用溶液及び固体分散体の製造方法
JP2017186331A (ja) 溶状に優れたヒプロメロース酢酸エステルコハク酸エステル粉末及びその製造方法、並びに固体分散体用組成物、コーティング用組成物、薬物含有粒子及び固形製剤の各製造方法
WO2017134418A1 (en) Oral dosage products and processes
JP7600350B2 (ja) ヒドロキシプロピルメチルセルロースアセテートサクシネート及び加熱溶融押出用組成物
JP2020169142A (ja) 腸溶性コーティング用組成物、固形製剤及び固形製剤の製造方法
JP2016084469A (ja) 打錠用アルキルセルロース及びこれを含む固形製剤
KR102333973B1 (ko) 저치환도 히드록시프로필셀룰로오스 및 고형 제제
JP7600351B2 (ja) ヒドロキシプロピルメチルセルロースフタレート及び加熱溶融押出用組成物
JP2024091760A (ja) 非晶質固体分散体を含む複合物
US20150250776A1 (en) Compositions and methods for oral delivery of encapsulated 3-aminopyridine-2-carboxaldehyde particles
BR112016017999B1 (pt) Comprimido, e, formulação adequada para prensar em um comprimido

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160728

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20170414

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170613

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170615

R150 Certificate of patent or registration of utility model

Ref document number: 6162662

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

RD07 Notification of extinguishment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7427

Effective date: 20170628