KR102089112B1 - 가열 용융 압출 담체용 히프로멜로오스 아세트산 에스테르 숙신산 에스테르, 가열 용융 압출용 조성물 및 가열 용융 압출 성형물의 제조 방법 - Google Patents

가열 용융 압출 담체용 히프로멜로오스 아세트산 에스테르 숙신산 에스테르, 가열 용융 압출용 조성물 및 가열 용융 압출 성형물의 제조 방법 Download PDF

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KR102089112B1
KR102089112B1 KR1020140101712A KR20140101712A KR102089112B1 KR 102089112 B1 KR102089112 B1 KR 102089112B1 KR 1020140101712 A KR1020140101712 A KR 1020140101712A KR 20140101712 A KR20140101712 A KR 20140101712A KR 102089112 B1 KR102089112 B1 KR 102089112B1
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hpmcas
melt extrusion
drug
hot melt
acid ester
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KR20150020073A (ko
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나오스케 마루야마
쇼고 와라시나
후미에 구사키
사카에 오바라
가즈키 기쿠치
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신에쓰 가가꾸 고교 가부시끼가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1020140101712A 2013-08-12 2014-08-07 가열 용융 압출 담체용 히프로멜로오스 아세트산 에스테르 숙신산 에스테르, 가열 용융 압출용 조성물 및 가열 용융 압출 성형물의 제조 방법 Active KR102089112B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013167572 2013-08-12
JPJP-P-2013-167572 2013-08-12

Publications (2)

Publication Number Publication Date
KR20150020073A KR20150020073A (ko) 2015-02-25
KR102089112B1 true KR102089112B1 (ko) 2020-03-13

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ID=51225402

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KR1020140101712A Active KR102089112B1 (ko) 2013-08-12 2014-08-07 가열 용융 압출 담체용 히프로멜로오스 아세트산 에스테르 숙신산 에스테르, 가열 용융 압출용 조성물 및 가열 용융 압출 성형물의 제조 방법

Country Status (6)

Country Link
US (1) US11090295B2 (enExample)
EP (1) EP2837391B1 (enExample)
JP (1) JP6162662B2 (enExample)
KR (1) KR102089112B1 (enExample)
CN (1) CN104371030B (enExample)
IN (1) IN2014DE02197A (enExample)

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JP6203702B2 (ja) * 2014-11-18 2017-09-27 信越化学工業株式会社 ヒプロメロース酢酸エステルコハク酸エステルを用いたスプレードライ用溶液及び固体分散体の製造方法
US10604588B2 (en) 2016-04-05 2020-03-31 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate powder excellent in dissolved state and production method thereof, and production methods for composition for solid dispersion, coating composition, drug-containing particle, and solid preparation
WO2017032908A1 (en) * 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
JP6683561B2 (ja) * 2016-07-12 2020-04-22 信越化学工業株式会社 腸溶性硬カプセル用組成物及び腸溶性硬カプセルの製造方法
JP6644656B2 (ja) 2016-08-29 2020-02-12 信越化学工業株式会社 ヒプロメロース酢酸エステルコハク酸エステルの製造方法
JP6742197B2 (ja) * 2016-08-29 2020-08-19 信越化学工業株式会社 ヒプロメロースフタル酸エステルの製造方法
US20190038754A1 (en) 2017-08-07 2019-02-07 SE Tylose, USA, Inc. Pharmaceutical composition in solid extruded form
TR201722852A2 (tr) * 2017-12-29 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Mesalazi̇ni̇n oral farmasöti̇k kompozi̇syonlari
JP6905035B2 (ja) * 2019-11-29 2021-07-21 Ｎｉｓｓｈａ株式会社 可食性フィルムの製造方法、フィルム製剤及び可食性フィルム
JP7399061B2 (ja) * 2020-10-01 2023-12-15 信越化学工業株式会社 ヒドロキシプロピルメチルセルロースフタレートの製造方法
JP2025019010A (ja) * 2023-07-26 2025-02-06 信越化学工業株式会社 ヒドロキシプロピルメチルセルロースアセテートサクシネート粉末及びその製造方法
CN120938940A (zh) * 2025-10-15 2025-11-14 成都药宜立康医药科技有限公司 一种苯磺酸美洛加巴林药物组合物及其制备方法

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WO2010114928A2 (en) * 2009-04-03 2010-10-07 F.Hoffmann-La Roche Ag Compositions and uses thereof

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US20090269403A1 (en) 2008-04-24 2009-10-29 Shaked Ze Ev Oral contraceptive dosage forms and methods of making such dosage forms
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Publication number Publication date
JP2015057380A (ja) 2015-03-26
CN104371030A (zh) 2015-02-25
IN2014DE02197A (enExample) 2015-06-19
EP2837391A1 (en) 2015-02-18
US11090295B2 (en) 2021-08-17
JP6162662B2 (ja) 2017-07-12
US20150044289A1 (en) 2015-02-12
CN104371030B (zh) 2017-08-08
EP2837391B1 (en) 2017-05-10
KR20150020073A (ko) 2015-02-25

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