JP6106085B2 - 内部非核酸スペーサーを含む一本鎖RNAi剤 - Google Patents
内部非核酸スペーサーを含む一本鎖RNAi剤 Download PDFInfo
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- JP6106085B2 JP6106085B2 JP2013526032A JP2013526032A JP6106085B2 JP 6106085 B2 JP6106085 B2 JP 6106085B2 JP 2013526032 A JP2013526032 A JP 2013526032A JP 2013526032 A JP2013526032 A JP 2013526032A JP 6106085 B2 JP6106085 B2 JP 6106085B2
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N2310/141—MicroRNAs, miRNAs
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- C12N2310/30—Chemical structure
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
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- C12N2310/351—Conjugate
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- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
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- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
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- Bioinformatics & Cheminformatics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37647110P | 2010-08-24 | 2010-08-24 | |
| US61/376,471 | 2010-08-24 | ||
| PCT/US2011/048338 WO2012027206A1 (en) | 2010-08-24 | 2011-08-19 | SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016249699A Division JP2017079776A (ja) | 2010-08-24 | 2016-12-22 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013535982A JP2013535982A (ja) | 2013-09-19 |
| JP6106085B2 true JP6106085B2 (ja) | 2017-03-29 |
Family
ID=45723747
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526032A Active JP6106085B2 (ja) | 2010-08-24 | 2011-08-19 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2016249699A Pending JP2017079776A (ja) | 2010-08-24 | 2016-12-22 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2020009687A Withdrawn JP2020074788A (ja) | 2010-08-24 | 2020-01-24 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2021199768A Pending JP2022037070A (ja) | 2010-08-24 | 2021-12-09 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2023076252A Active JP7527437B2 (ja) | 2010-08-24 | 2023-05-02 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016249699A Pending JP2017079776A (ja) | 2010-08-24 | 2016-12-22 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2020009687A Withdrawn JP2020074788A (ja) | 2010-08-24 | 2020-01-24 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2021199768A Pending JP2022037070A (ja) | 2010-08-24 | 2021-12-09 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2023076252A Active JP7527437B2 (ja) | 2010-08-24 | 2023-05-02 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9243246B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2609198B8 (cg-RX-API-DMAC7.html) |
| JP (5) | JP6106085B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20130137160A (cg-RX-API-DMAC7.html) |
| CN (1) | CN103140582A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012027206A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (40)
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| US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US8748405B2 (en) * | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| WO2011028550A1 (en) | 2009-08-24 | 2011-03-10 | Merck Sharp & Dohme Corp. | Segmented micro rna mimetics |
| EP2609198B8 (en) * | 2010-08-24 | 2018-03-28 | Sirna Therapeutics, Inc. | SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER |
| EP2632472B1 (en) | 2010-10-29 | 2017-12-13 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina) |
| WO2012083005A2 (en) | 2010-12-15 | 2012-06-21 | Miragen Therapeutics | Microrna inhibitors comprising locked nucleotides |
| AU2013201303C1 (en) | 2011-10-06 | 2016-06-23 | MiRagen Therapeutics, Inc. | Control of whole body energy homeostasis by microRNA regulation |
| EP3453762B1 (en) * | 2012-05-02 | 2021-04-21 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
| WO2013170146A1 (en) | 2012-05-10 | 2013-11-14 | Uab Research Foundation | Methods and compositions for modulating mir-204 activity |
| US20140378526A1 (en) * | 2012-05-11 | 2014-12-25 | City Of Hope | Design of nucleic acid binding molecules with non-watson crick and non-canonical pairing based on artificial mutation consensus sequences to counter escape mutations |
| CN110156844A (zh) * | 2012-05-21 | 2019-08-23 | 安捷伦科技有限公司 | 组合物和缀合寡核苷酸的方法 |
| WO2013182553A2 (en) | 2012-06-06 | 2013-12-12 | Boehringer Ingelheim International Gmbh | CELL ENGINEERING USING RNAs |
| CN107236735B (zh) | 2012-06-21 | 2019-11-08 | 米拉根医疗股份有限公司 | 包含锁核酸基序的基于寡核苷酸的抑制剂 |
| EP3052464B1 (en) | 2013-10-04 | 2020-04-15 | Novartis AG | 3'end caps for rna-interferring agents for use in rna interference |
| EP3052107B1 (en) | 2013-10-04 | 2018-05-02 | Novartis AG | Organic compounds to treat hepatitis b virus |
| CN104560992B (zh) * | 2013-10-10 | 2018-01-02 | 复旦大学附属妇产科医院 | 一种用于预防和治疗人乳头瘤病毒感染和宫颈癌的微小rna |
| KR101696704B1 (ko) * | 2013-12-17 | 2017-01-16 | 주식회사 인코드젠 | 오프-타겟을 막기 위해 변형된 rna 간섭 유도 핵산 및 그 용도 |
| WO2015106255A1 (en) | 2014-01-13 | 2015-07-16 | City Of Hope | Multivalent oligonucleotide assemblies |
| CN103924002B (zh) * | 2014-05-04 | 2016-01-20 | 山东大学 | 血清中的microRNA作为肝癌诊断标志物的应用 |
| KR102669353B1 (ko) * | 2014-06-12 | 2024-05-28 | 국립연구개발법인 고쿠리츠간켄큐센터 | 전립선암 검출 키트 또는 디바이스 및 검출 방법 |
| BR112017015618A2 (pt) | 2015-01-20 | 2018-04-10 | Miragen Therapeutics Inc | inibidores de mir-92 e usos destes. |
| ES2876930T3 (es) | 2015-08-20 | 2021-11-15 | Asociacion Centro De Investig Cooperativa En Biociencias Cic Biogune | Métodos y composiciones para tratar enfermedades y afecciones hepáticas |
| TWI685500B (zh) * | 2015-10-13 | 2020-02-21 | 長庚大學 | 以微核酸-520b(miR-520b)序列作爲抑制頭頸癌腫瘤生長、侵犯與轉移及其醫藥組成物之用途 |
| WO2017100461A1 (en) * | 2015-12-08 | 2017-06-15 | Solstice Biologics, Ltd. | Polynucleotide constructs having an auxiliary moiety non-bioreversibly linked to an internucleoside phosphate or phosphorothioate |
| WO2017181088A1 (en) * | 2016-04-14 | 2017-10-19 | University Of Florida Research Foundation, Incorporated | Use of mir-223-3p as a cancer therapeutic and method for treating cancer using the same |
| CN105861728B (zh) * | 2016-06-12 | 2024-11-19 | 上海市第十人民医院 | 循环miRNA作为年龄相关黄斑变性诊断标志物中的应用 |
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| EP3548005A4 (en) | 2016-11-29 | 2020-06-17 | Puretech Health LLC | Exosomes for delivery of therapeutic agents |
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| EP2609198B8 (en) | 2018-03-28 |
| WO2012027206A1 (en) | 2012-03-01 |
| JP2022037070A (ja) | 2022-03-08 |
| US20180080024A1 (en) | 2018-03-22 |
| US20160222381A1 (en) | 2016-08-04 |
| EP3372684A1 (en) | 2018-09-12 |
| US9845466B2 (en) | 2017-12-19 |
| JP2023100832A (ja) | 2023-07-19 |
| US10584335B2 (en) | 2020-03-10 |
| US20130171242A1 (en) | 2013-07-04 |
| EP2609198A1 (en) | 2013-07-03 |
| US9243246B2 (en) | 2016-01-26 |
| KR20130137160A (ko) | 2013-12-16 |
| EP2609198A4 (en) | 2014-11-19 |
| JP2020074788A (ja) | 2020-05-21 |
| JP7527437B2 (ja) | 2024-08-02 |
| CN103140582A (zh) | 2013-06-05 |
| EP2609198B1 (en) | 2018-02-21 |
| JP2017079776A (ja) | 2017-05-18 |
| JP2013535982A (ja) | 2013-09-19 |
| EP3372684B1 (en) | 2020-10-07 |
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