JP6063877B2 - ペプチド薬物の非経口注射用の安定な製剤 - Google Patents

ペプチド薬物の非経口注射用の安定な製剤 Download PDF

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JP6063877B2
JP6063877B2 JP2013557930A JP2013557930A JP6063877B2 JP 6063877 B2 JP6063877 B2 JP 6063877B2 JP 2013557930 A JP2013557930 A JP 2013557930A JP 2013557930 A JP2013557930 A JP 2013557930A JP 6063877 B2 JP6063877 B2 JP 6063877B2
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peptide
formulation
glucagon
buffer
dried
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JP2014507484A (ja
JP2014507484A5 (enExample
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スティーブン プレストレルスキ
スティーブン プレストレルスキ
ジョン キンツェル
ジョン キンツェル
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ゼリス ファーマシューティカルズ インコーポレイテッド
ゼリス ファーマシューティカルズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
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    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/22—Hormones
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2013557930A 2011-03-10 2012-03-09 ペプチド薬物の非経口注射用の安定な製剤 Active JP6063877B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161451568P 2011-03-10 2011-03-10
US61/451,568 2011-03-10
US201161478692P 2011-04-25 2011-04-25
US61/478,692 2011-04-25
US201161553388P 2011-10-31 2011-10-31
US61/553,388 2011-10-31
US201261609123P 2012-03-09 2012-03-09
PCT/US2012/028621 WO2012122535A2 (en) 2011-03-10 2012-03-09 Stable formulations for parenteral injection of peptide drugs
US61/609,123 2012-03-09

Publications (3)

Publication Number Publication Date
JP2014507484A JP2014507484A (ja) 2014-03-27
JP2014507484A5 JP2014507484A5 (enExample) 2014-05-08
JP6063877B2 true JP6063877B2 (ja) 2017-01-18

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US (6) US8697644B2 (enExample)
EP (1) EP2683364B1 (enExample)
JP (1) JP6063877B2 (enExample)
KR (1) KR101978527B1 (enExample)
CN (2) CN105853348B (enExample)
AU (2) AU2012225268B2 (enExample)
BR (1) BR112013023062B1 (enExample)
CA (1) CA2829400C (enExample)
DK (1) DK2683364T3 (enExample)
EA (1) EA028572B1 (enExample)
ES (1) ES2621304T3 (enExample)
IL (1) IL228348A0 (enExample)
MX (1) MX342675B (enExample)
SG (1) SG193389A1 (enExample)
WO (1) WO2012122535A2 (enExample)
ZA (1) ZA201306836B (enExample)

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US9125805B2 (en) 2012-06-27 2015-09-08 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of small molecule drugs
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
PT2934568T (pt) 2012-12-21 2018-01-04 Sanofi Sa Agonistas duplos de glp1/gip ou trigonais de glp1/gip/glucagina
US9956287B2 (en) 2013-02-06 2018-05-01 Perosphere Inc. Stable glucagon formulations
US9018162B2 (en) * 2013-02-06 2015-04-28 Xeris Pharmaceuticals, Inc. Methods for rapidly treating severe hypoglycemia
US8871713B2 (en) 2013-03-01 2014-10-28 Theratechnologies Inc. Formulations of growth hormone releasing factor (GRF) molecules with improved stability
US12239822B2 (en) 2013-03-15 2025-03-04 Windgap Medical, Inc. Portable drug mixing and delivery device and associated methods
KR20140123782A (ko) * 2013-04-15 2014-10-23 에스케이케미칼주식회사 카스포펀진 및 완충제를 포함하는 안정성이 개선된 약학적 조성물
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／ｇｉｐ受體促效劑
TW201609797A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／升糖素受體促效劑
TW201609796A (zh) 2013-12-13 2016-03-16 賽諾菲公司 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
TW201609795A (zh) 2013-12-13 2016-03-16 賽諾菲公司 作為雙重ｇｌｐ－１／ｇｉｐ受體促效劑的艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
CN106061253A (zh) 2013-12-18 2016-10-26 温德加普医疗股份有限公司 药物混合和递送系统及方法
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
EP3102184B1 (en) * 2014-02-06 2019-01-30 Xeris Pharmaceuticals, Inc. Stable peptide formulations and methods for preparation
WO2015153728A1 (en) 2014-04-02 2015-10-08 Xeris Pharmaceuticals, Inc. Polar aprotic solvent-compatible infusion sets, components, and methods
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SG193389A1 (en) 2013-10-30
MX2013010376A (es) 2014-04-14
AU2012225268B2 (en) 2016-10-20

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