JP6050226B2 - Ldh及びpdhk発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加 - Google Patents

Ldh及びpdhk発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加 Download PDF

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JP6050226B2
JP6050226B2 JP2013512251A JP2013512251A JP6050226B2 JP 6050226 B2 JP6050226 B2 JP 6050226B2 JP 2013512251 A JP2013512251 A JP 2013512251A JP 2013512251 A JP2013512251 A JP 2013512251A JP 6050226 B2 JP6050226 B2 JP 6050226B2
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pdhk
nucleic acid
acid sequence
cell
heterologous nucleic
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JP2013531978A (ja
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メイシア チョウ,
メイシア チョウ,
ブラッドリー リチャード スネデカー,
ブラッドリー リチャード スネデカー,
チー ギン ドミンゴス ング,
チー ギン ドミンゴス ング,
エイミー シェン,
エイミー シェン,
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Genentech Inc
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JP2013512251A 2010-05-28 2011-05-26 Ldh及びpdhk発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加 Active JP6050226B2 (ja)

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US34972710P 2010-05-28 2010-05-28
US61/349,727 2010-05-28
PCT/US2011/038191 WO2011150241A2 (en) 2010-05-28 2011-05-26 Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase

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JP2013531978A JP2013531978A (ja) 2013-08-15
JP2013531978A5 JP2013531978A5 (https=) 2014-07-10
JP6050226B2 true JP6050226B2 (ja) 2016-12-21

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JP2016227876A Active JP6325060B2 (ja) 2010-05-28 2016-11-24 Ldh及びpdhk発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加
JP2018076234A Active JP6706642B2 (ja) 2010-05-28 2018-04-11 Ldh及びpdhk発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加

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JP2018076234A Active JP6706642B2 (ja) 2010-05-28 2018-04-11 Ldh及びpdhk発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加

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US (4) US9487809B2 (https=)
EP (1) EP2576580B1 (https=)
JP (3) JP6050226B2 (https=)
KR (3) KR101989762B1 (https=)
CN (1) CN102985437B (https=)
BR (1) BR112012030197A2 (https=)
CA (1) CA2800728C (https=)
DK (1) DK2576580T3 (https=)
ES (1) ES2599412T3 (https=)
HU (1) HUE030820T2 (https=)
MX (3) MX374851B (https=)
PL (1) PL2576580T3 (https=)
RU (1) RU2614125C2 (https=)
SI (1) SI2576580T1 (https=)
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