CA2800728C - Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase - Google Patents

Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase Download PDF

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CA2800728C
CA2800728C CA2800728A CA2800728A CA2800728C CA 2800728 C CA2800728 C CA 2800728C CA 2800728 A CA2800728 A CA 2800728A CA 2800728 A CA2800728 A CA 2800728A CA 2800728 C CA2800728 C CA 2800728C
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pdhk
promoter
nucleic acid
cells
acid sequence
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CA2800728A1 (en
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Meixia Zhou
Bradley Richard Snedecor
Chi Kin Domingos Ng
Amy Shen
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Genentech Inc
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)
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    • C12Y102/04001—Pyruvate dehydrogenase (acetyl-transferring) (1.2.4.1)
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CA2800728A 2010-05-28 2011-05-26 Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase Active CA2800728C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34972710P 2010-05-28 2010-05-28
US61/349,727 2010-05-28
PCT/US2011/038191 WO2011150241A2 (en) 2010-05-28 2011-05-26 Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase

Publications (2)

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CA2800728A1 CA2800728A1 (en) 2011-12-01
CA2800728C true CA2800728C (en) 2020-10-27

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CA2800728A Active CA2800728C (en) 2010-05-28 2011-05-26 Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase

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US (4) US9487809B2 (https=)
EP (1) EP2576580B1 (https=)
JP (3) JP6050226B2 (https=)
KR (3) KR101869987B1 (https=)
CN (1) CN102985437B (https=)
BR (1) BR112012030197A2 (https=)
CA (1) CA2800728C (https=)
DK (1) DK2576580T3 (https=)
ES (1) ES2599412T3 (https=)
HU (1) HUE030820T2 (https=)
MX (3) MX343604B (https=)
PL (1) PL2576580T3 (https=)
RU (1) RU2614125C2 (https=)
SI (1) SI2576580T1 (https=)
WO (1) WO2011150241A2 (https=)

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