MX2020009460A - Disminuir nivel de lactato e incrementar produccion de polipeptidos por regulacion a la baja de la expresion de lactato dehidrogenasa y piruvato dehidrogenasa quinasa. - Google Patents

Disminuir nivel de lactato e incrementar produccion de polipeptidos por regulacion a la baja de la expresion de lactato dehidrogenasa y piruvato dehidrogenasa quinasa.

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Publication number
MX2020009460A
MX2020009460A MX2020009460A MX2020009460A MX2020009460A MX 2020009460 A MX2020009460 A MX 2020009460A MX 2020009460 A MX2020009460 A MX 2020009460A MX 2020009460 A MX2020009460 A MX 2020009460A MX 2020009460 A MX2020009460 A MX 2020009460A
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Mexico
Prior art keywords
lactate
production
dehydrogenase
polypeptides
expression
Prior art date
Application number
MX2020009460A
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English (en)
Inventor
Meixia Zhou
Amy Shen
Bradley Richard Snedecor
Ng Chi Kin Domingos
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Genentech Inc
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2020009460A publication Critical patent/MX2020009460A/es

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Abstract

La presente invención proporciona métodos y composiciones para reducir producción de lactato e incrementar producción de polipéptido en células cultivadas. En un aspecto, la invención proporciona un método que comprende cultivar células que expresan a) un RNA pequeño interferente (siRNA) específico para una lactato dehidrogenasa (LDH) y b) un siRNA específico para una piruvato dehidrogenasa quinasa (PDHK). En otro aspecto, la invención proporciona células cultivadas o vectores que comprenden un siRNA específico para un LDH y un siRNA específico para un PDHK.
MX2020009460A 2010-05-28 2012-11-22 Disminuir nivel de lactato e incrementar produccion de polipeptidos por regulacion a la baja de la expresion de lactato dehidrogenasa y piruvato dehidrogenasa quinasa. MX2020009460A (es)

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US34972710P 2010-05-28 2010-05-28

Publications (1)

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MX2020009460A true MX2020009460A (es) 2020-11-06

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ID=45004831

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MX2012013579A MX343604B (es) 2010-05-28 2011-05-26 Disminuir nivel de lactato e incrementar producción de polipéptidos por regulación a la baja de la expresión de lactato dehidrogenasa y piruvato dehidrogenasa quinasa.
MX2020009460A MX2020009460A (es) 2010-05-28 2012-11-22 Disminuir nivel de lactato e incrementar produccion de polipeptidos por regulacion a la baja de la expresion de lactato dehidrogenasa y piruvato dehidrogenasa quinasa.

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MX2012013579A MX343604B (es) 2010-05-28 2011-05-26 Disminuir nivel de lactato e incrementar producción de polipéptidos por regulación a la baja de la expresión de lactato dehidrogenasa y piruvato dehidrogenasa quinasa.

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US (4) US9487809B2 (es)
EP (1) EP2576580B1 (es)
JP (3) JP6050226B2 (es)
KR (3) KR20190067277A (es)
CN (1) CN102985437B (es)
BR (1) BR112012030197A2 (es)
CA (1) CA2800728C (es)
DK (1) DK2576580T3 (es)
ES (1) ES2599412T3 (es)
HU (1) HUE030820T2 (es)
MX (2) MX343604B (es)
PL (1) PL2576580T3 (es)
RU (1) RU2614125C2 (es)
SI (1) SI2576580T1 (es)
WO (1) WO2011150241A2 (es)

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