JP6032470B2 - Ｐｉｖｋａ−ｉｉ測定方法、測定試薬及び測定キット - Google Patents

Ｐｉｖｋａ−ｉｉ測定方法、測定試薬及び測定キット Download PDF

Info

Publication number
JP6032470B2
JP6032470B2 JP2012176761A JP2012176761A JP6032470B2 JP 6032470 B2 JP6032470 B2 JP 6032470B2 JP 2012176761 A JP2012176761 A JP 2012176761A JP 2012176761 A JP2012176761 A JP 2012176761A JP 6032470 B2 JP6032470 B2 JP 6032470B2
Authority
JP
Japan
Prior art keywords
antibody
pivka
prothrombin
fragment
plasma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2012176761A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014035278A5 (enExample
JP2014035278A (ja
Inventor
建太郎 山口
建太郎 山口
克己 青柳
克己 青柳
梓 寺尾
梓 寺尾
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujirebio Inc
Eidia Co Ltd
Original Assignee
Fujirebio Inc
Eidia Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2012176761A priority Critical patent/JP6032470B2/ja
Application filed by Fujirebio Inc, Eidia Co Ltd filed Critical Fujirebio Inc
Priority to PCT/JP2013/071188 priority patent/WO2014024853A1/ja
Priority to CN201380042250.5A priority patent/CN104520710B/zh
Priority to EP13828411.2A priority patent/EP2884277B1/en
Priority to KR1020157001025A priority patent/KR102100152B1/ko
Priority to US14/420,122 priority patent/US10539559B2/en
Priority to RU2015107740A priority patent/RU2015107740A/ru
Priority to TW102128608A priority patent/TWI589876B/zh
Publication of JP2014035278A publication Critical patent/JP2014035278A/ja
Publication of JP2014035278A5 publication Critical patent/JP2014035278A5/ja
Application granted granted Critical
Publication of JP6032470B2 publication Critical patent/JP6032470B2/ja
Priority to US16/696,803 priority patent/US20200088722A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2012176761A 2012-08-09 2012-08-09 Ｐｉｖｋａ−ｉｉ測定方法、測定試薬及び測定キット Active JP6032470B2 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2012176761A JP6032470B2 (ja) 2012-08-09 2012-08-09 Ｐｉｖｋａ−ｉｉ測定方法、測定試薬及び測定キット
CN201380042250.5A CN104520710B (zh) 2012-08-09 2013-08-06 Pivka-ii测定方法、测定试剂和测定试剂盒
EP13828411.2A EP2884277B1 (en) 2012-08-09 2013-08-06 Method and immunoassay reagent for measuring PIVKA-II
KR1020157001025A KR102100152B1 (ko) 2012-08-09 2013-08-06 Pivka-ⅱ 측정 방법, 측정 시약 및 측정 키트
US14/420,122 US10539559B2 (en) 2012-08-09 2013-08-06 PIVKA-II measurement method, measurement reagent, and measurement kit
RU2015107740A RU2015107740A (ru) 2012-08-09 2013-08-06 Способ измерения, реагент для измерения и набор для измерения pivka-ii
PCT/JP2013/071188 WO2014024853A1 (ja) 2012-08-09 2013-08-06 Pivka-ii測定方法、測定試薬及び測定キット
TW102128608A TWI589876B (zh) 2012-08-09 2013-08-09 Ｐｉｖｋａ－ii測定方法、測定試藥及測定套組
US16/696,803 US20200088722A1 (en) 2012-08-09 2019-11-26 Pivka-ii measurement method, measurement reagent, and measurement kit

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012176761A JP6032470B2 (ja) 2012-08-09 2012-08-09 Ｐｉｖｋａ−ｉｉ測定方法、測定試薬及び測定キット

Publications (3)

Publication Number Publication Date
JP2014035278A JP2014035278A (ja) 2014-02-24
JP2014035278A5 JP2014035278A5 (enExample) 2015-07-16
JP6032470B2 true JP6032470B2 (ja) 2016-11-30

Family

ID=50068077

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012176761A Active JP6032470B2 (ja) 2012-08-09 2012-08-09 Ｐｉｖｋａ−ｉｉ測定方法、測定試薬及び測定キット

Country Status (8)

Country Link
US (2) US10539559B2 (enExample)
EP (1) EP2884277B1 (enExample)
JP (1) JP6032470B2 (enExample)
KR (1) KR102100152B1 (enExample)
CN (1) CN104520710B (enExample)
RU (1) RU2015107740A (enExample)
TW (1) TWI589876B (enExample)
WO (1) WO2014024853A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104698174B (zh) * 2015-02-28 2017-10-31 江苏宜偌维盛生物技术有限公司 一种胃蛋白酶原ⅰ和ⅱ联合检测试剂盒
US10830771B2 (en) 2015-10-07 2020-11-10 Fujirebio Inc. PIVKA-II assay method and method for manufacturing reagent or kit for PIVKA-II immunoassay
KR102696526B1 (ko) * 2017-07-13 2024-08-19 에프. 호프만-라 로슈 아게 Pivka에 대한 신규 결합제 및 어세이
CN109207462B (zh) * 2018-08-01 2021-05-11 深圳市新产业生物医学工程股份有限公司 异常凝血酶原及其制备方法和包含其的检测剂、试剂盒及应用
CN112816694A (zh) * 2020-12-31 2021-05-18 泰州泽成生物技术有限公司 一种异常凝血酶原检测试剂盒及制备方法
CN115097122B (zh) * 2022-06-15 2025-08-26 安徽惠邦生物工程有限公司 抗缪勒氏管激素抗体-酶标记物及其制备方法和应用
CN120137043A (zh) * 2023-12-13 2025-06-13 菲鹏生物股份有限公司 抗pivka-ii抗体及其用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6060557A (ja) 1983-09-13 1985-04-08 Eisai Co Ltd Ｐｉｖｋａ−２の測定方法および試薬
US5811310A (en) * 1986-09-30 1998-09-22 Albert Einstein College Of Medicine Of Yeshiva Univ. The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease
JP2702616B2 (ja) 1991-03-12 1998-01-21 エーザイ株式会社 Ｐｉｖｋａ−ｉｉの測定試薬
JP3307422B2 (ja) * 1992-04-10 2002-07-24 株式会社ヤトロン ヒトｐｉｖｋａ−ｉｉの免疫学的測定方法
JPH0720127A (ja) * 1993-05-07 1995-01-24 Eisai Co Ltd 各種ｐｉｖｋａの測定方法および測定試薬
JP2867325B2 (ja) 1995-08-03 1999-03-08 株式会社エスアールエル 抗ｐｉｖｋａ−ｉｉ抗体産生ハイブリドーマ及び免疫学的測定方法
JPH09249699A (ja) 1996-03-11 1997-09-22 Fujirebio Inc 抗ヒトｐｉｖｋａ−ｉｉモノクローナル抗体、該抗体を産生するハイブリドーマ、該抗体を用いた測定試薬及び測定方法
JP3316199B2 (ja) * 1998-12-14 2002-08-19 三光純薬株式会社 Ｐｉｖｋａ−ｉｉの免疫学的測定法
JP2000346841A (ja) 1999-06-09 2000-12-15 Daiichi Radioisotope Labs Ltd Ｐｉｖｋａ−ｉｉの測定方法
DE60026023T2 (de) * 1999-12-14 2006-07-27 Sanko Junyaku Co., Ltd. Verfahren zum immunologischen bestimmen von pivka-ii
US6448086B1 (en) * 2000-01-18 2002-09-10 Diagnostic Systems Laboratories, Inc. Insulin-like growth factor system and cancer
DE10354403A1 (de) * 2003-11-20 2005-06-23 Dade Behring Marburg Gmbh Gegen das Prothrombin-Fragment F 1+2 gerichtete Antikörper, ihre Herstellung und Verwendung
JP2007192557A (ja) * 2006-01-17 2007-08-02 Perseus Proteomics Inc Ｃ型肝炎患者の肝疾患の重篤化をモニターする方法および肝癌の診断方法
CN101377505A (zh) * 2008-04-16 2009-03-04 北京科美东雅生物技术有限公司 脱γ羧基凝血酶原微孔板化学发光免疫分析测定试剂盒及其制备方法
DE102008049601A1 (de) * 2008-09-30 2010-04-01 Siemens Healthcare Diagnostics Products Gmbh Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay

Also Published As

Publication number Publication date
WO2014024853A1 (ja) 2014-02-13
EP2884277A1 (en) 2015-06-17
US10539559B2 (en) 2020-01-21
KR102100152B1 (ko) 2020-04-13
KR20150041620A (ko) 2015-04-16
JP2014035278A (ja) 2014-02-24
CN104520710B (zh) 2016-10-12
TW201411128A (zh) 2014-03-16
US20200088722A1 (en) 2020-03-19
EP2884277B1 (en) 2018-10-10
EP2884277A4 (en) 2016-04-27
TWI589876B (zh) 2017-07-01
US20150219638A1 (en) 2015-08-06
CN104520710A (zh) 2015-04-15
RU2015107740A (ru) 2016-09-27

Similar Documents

Publication Publication Date Title
US10830771B2 (en) PIVKA-II assay method and method for manufacturing reagent or kit for PIVKA-II immunoassay
JP6032470B2 (ja) Ｐｉｖｋａ−ｉｉ測定方法、測定試薬及び測定キット
JPWO2009107170A1 (ja) 抗ｃｒｐ抗体及びその利用
US10634676B2 (en) Method and kit for simultaneously detecting human parvovirus B19 antigen and antibody
JP5856956B2 (ja) 血液検査方法
WO1996028569A1 (en) Monoclonal antibody and antigen relating to human pulmonary adenocarcinoma and immunoassay method with the use of the same
JPH10226700A (ja) Ｍｉａの検出のためのイムノアッセイ
JPH07238099A (ja) モノクローナル抗体及びこれを用いる免疫学的測定法
JPH0572207A (ja) 非交差反応性ｃｅａ遺伝子系統群員抗体を用いる免疫検定方法
JP3888695B2 (ja) ヒトｌｅｃｔ２に対する抗体、それを産生する細胞、その測定法及び測定用キット
JP2518602B2 (ja) ヒトプロテインｓに対するモノクロ―ナル抗体を用いた免疫学的測定試薬及びキット
US20190369095A1 (en) Novel antibody for determination of adamts-13 activity
JP2000069963A (ja) アポリポプロテインｅ４特異モノクローナル抗体
CN110622002B (zh) 抗雌马酚抗体组合物及其利用
JP2025024795A (ja) 抗体又は抗原結合性断片－基材複合体
JP2003004748A (ja) 膵臓癌診断用試薬
JPH07117534B2 (ja) ヒトプロテインｓに対するモノクローナル抗体を用いた免疫学的測定試薬及びキット
JP2003180345A (ja) 遊離型肝細胞増殖因子受容体の測定方法
JP2005298521A (ja) モノクローナル抗体及びこれを用いる免疫学的測定法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150528

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150528

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160517

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160628

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160927

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20161012

R150 Certificate of patent or registration of utility model

Ref document number: 6032470

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313115

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250