JP2014035278A5 - - Google Patents
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- Publication number
- JP2014035278A5 JP2014035278A5 JP2012176761A JP2012176761A JP2014035278A5 JP 2014035278 A5 JP2014035278 A5 JP 2014035278A5 JP 2012176761 A JP2012176761 A JP 2012176761A JP 2012176761 A JP2012176761 A JP 2012176761A JP 2014035278 A5 JP2014035278 A5 JP 2014035278A5
- Authority
- JP
- Japan
- Prior art keywords
- plasma
- antibody
- serum
- alp
- labeled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002966 serum Anatomy 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 229940039716 prothrombin Drugs 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012176761A JP6032470B2 (ja) | 2012-08-09 | 2012-08-09 | Ｐｉｖｋａ−ｉｉ測定方法、測定試薬及び測定キット |
| CN201380042250.5A CN104520710B (zh) | 2012-08-09 | 2013-08-06 | Pivka-ii测定方法、测定试剂和测定试剂盒 |
| EP13828411.2A EP2884277B1 (en) | 2012-08-09 | 2013-08-06 | Method and immunoassay reagent for measuring PIVKA-II |
| KR1020157001025A KR102100152B1 (ko) | 2012-08-09 | 2013-08-06 | Pivka-ⅱ 측정 방법, 측정 시약 및 측정 키트 |
| US14/420,122 US10539559B2 (en) | 2012-08-09 | 2013-08-06 | PIVKA-II measurement method, measurement reagent, and measurement kit |
| RU2015107740A RU2015107740A (ru) | 2012-08-09 | 2013-08-06 | Способ измерения, реагент для измерения и набор для измерения pivka-ii |
| PCT/JP2013/071188 WO2014024853A1 (ja) | 2012-08-09 | 2013-08-06 | Pivka-ii測定方法、測定試薬及び測定キット |
| TW102128608A TWI589876B (zh) | 2012-08-09 | 2013-08-09 | Ｐｉｖｋａ－ii測定方法、測定試藥及測定套組 |
| US16/696,803 US20200088722A1 (en) | 2012-08-09 | 2019-11-26 | Pivka-ii measurement method, measurement reagent, and measurement kit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012176761A JP6032470B2 (ja) | 2012-08-09 | 2012-08-09 | Ｐｉｖｋａ−ｉｉ測定方法、測定試薬及び測定キット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014035278A JP2014035278A (ja) | 2014-02-24 |
| JP2014035278A5 true JP2014035278A5 (enExample) | 2015-07-16 |
| JP6032470B2 JP6032470B2 (ja) | 2016-11-30 |
Family
ID=50068077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012176761A Active JP6032470B2 (ja) | 2012-08-09 | 2012-08-09 | Ｐｉｖｋａ−ｉｉ測定方法、測定試薬及び測定キット |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10539559B2 (enExample) |
| EP (1) | EP2884277B1 (enExample) |
| JP (1) | JP6032470B2 (enExample) |
| KR (1) | KR102100152B1 (enExample) |
| CN (1) | CN104520710B (enExample) |
| RU (1) | RU2015107740A (enExample) |
| TW (1) | TWI589876B (enExample) |
| WO (1) | WO2014024853A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104698174B (zh) * | 2015-02-28 | 2017-10-31 | 江苏宜偌维盛生物技术有限公司 | 一种胃蛋白酶原ⅰ和ⅱ联合检测试剂盒 |
| US10830771B2 (en) | 2015-10-07 | 2020-11-10 | Fujirebio Inc. | PIVKA-II assay method and method for manufacturing reagent or kit for PIVKA-II immunoassay |
| KR102696526B1 (ko) * | 2017-07-13 | 2024-08-19 | 에프. 호프만-라 로슈 아게 | Pivka에 대한 신규 결합제 및 어세이 |
| CN109207462B (zh) * | 2018-08-01 | 2021-05-11 | 深圳市新产业生物医学工程股份有限公司 | 异常凝血酶原及其制备方法和包含其的检测剂、试剂盒及应用 |
| CN112816694A (zh) * | 2020-12-31 | 2021-05-18 | 泰州泽成生物技术有限公司 | 一种异常凝血酶原检测试剂盒及制备方法 |
| CN115097122B (zh) * | 2022-06-15 | 2025-08-26 | 安徽惠邦生物工程有限公司 | 抗缪勒氏管激素抗体-酶标记物及其制备方法和应用 |
| CN120137043A (zh) * | 2023-12-13 | 2025-06-13 | 菲鹏生物股份有限公司 | 抗pivka-ii抗体及其用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6060557A (ja) | 1983-09-13 | 1985-04-08 | Eisai Co Ltd | Ｐｉｖｋａ−２の測定方法および試薬 |
| US5811310A (en) * | 1986-09-30 | 1998-09-22 | Albert Einstein College Of Medicine Of Yeshiva Univ. | The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease |
| JP2702616B2 (ja) | 1991-03-12 | 1998-01-21 | エーザイ株式会社 | Ｐｉｖｋａ−ｉｉの測定試薬 |
| JP3307422B2 (ja) * | 1992-04-10 | 2002-07-24 | 株式会社ヤトロン | ヒトｐｉｖｋａ−ｉｉの免疫学的測定方法 |
| JPH0720127A (ja) * | 1993-05-07 | 1995-01-24 | Eisai Co Ltd | 各種ｐｉｖｋａの測定方法および測定試薬 |
| JP2867325B2 (ja) | 1995-08-03 | 1999-03-08 | 株式会社エスアールエル | 抗ｐｉｖｋａ−ｉｉ抗体産生ハイブリドーマ及び免疫学的測定方法 |
| JPH09249699A (ja) | 1996-03-11 | 1997-09-22 | Fujirebio Inc | 抗ヒトｐｉｖｋａ−ｉｉモノクローナル抗体、該抗体を産生するハイブリドーマ、該抗体を用いた測定試薬及び測定方法 |
| JP3316199B2 (ja) * | 1998-12-14 | 2002-08-19 | 三光純薬株式会社 | Ｐｉｖｋａ−ｉｉの免疫学的測定法 |
| JP2000346841A (ja) | 1999-06-09 | 2000-12-15 | Daiichi Radioisotope Labs Ltd | Ｐｉｖｋａ−ｉｉの測定方法 |
| DE60026023T2 (de) * | 1999-12-14 | 2006-07-27 | Sanko Junyaku Co., Ltd. | Verfahren zum immunologischen bestimmen von pivka-ii |
| US6448086B1 (en) * | 2000-01-18 | 2002-09-10 | Diagnostic Systems Laboratories, Inc. | Insulin-like growth factor system and cancer |
| DE10354403A1 (de) * | 2003-11-20 | 2005-06-23 | Dade Behring Marburg Gmbh | Gegen das Prothrombin-Fragment F 1+2 gerichtete Antikörper, ihre Herstellung und Verwendung |
| JP2007192557A (ja) * | 2006-01-17 | 2007-08-02 | Perseus Proteomics Inc | Ｃ型肝炎患者の肝疾患の重篤化をモニターする方法および肝癌の診断方法 |
| CN101377505A (zh) * | 2008-04-16 | 2009-03-04 | 北京科美东雅生物技术有限公司 | 脱γ羧基凝血酶原微孔板化学发光免疫分析测定试剂盒及其制备方法 |
| DE102008049601A1 (de) * | 2008-09-30 | 2010-04-01 | Siemens Healthcare Diagnostics Products Gmbh | Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay |
-
2012
- 2012-08-09 JP JP2012176761A patent/JP6032470B2/ja active Active
-
2013
- 2013-08-06 KR KR1020157001025A patent/KR102100152B1/ko active Active
- 2013-08-06 US US14/420,122 patent/US10539559B2/en active Active
- 2013-08-06 WO PCT/JP2013/071188 patent/WO2014024853A1/ja not_active Ceased
- 2013-08-06 EP EP13828411.2A patent/EP2884277B1/en active Active
- 2013-08-06 CN CN201380042250.5A patent/CN104520710B/zh active Active
- 2013-08-06 RU RU2015107740A patent/RU2015107740A/ru not_active Application Discontinuation
- 2013-08-09 TW TW102128608A patent/TWI589876B/zh active
-
2019
- 2019-11-26 US US16/696,803 patent/US20200088722A1/en not_active Abandoned
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