TWI589876B - Ｐｉｖｋａ－ii測定方法、測定試藥及測定套組 - Google Patents

Ｐｉｖｋａ－ii測定方法、測定試藥及測定套組 Download PDF

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Publication number
TWI589876B
TWI589876B TW102128608A TW102128608A TWI589876B TW I589876 B TWI589876 B TW I589876B TW 102128608 A TW102128608 A TW 102128608A TW 102128608 A TW102128608 A TW 102128608A TW I589876 B TWI589876 B TW I589876B
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TW
Taiwan
Prior art keywords
antibody
pivka
prothrombin
fragment
serum
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TW102128608A
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English (en)
Chinese (zh)
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TW201411128A (zh
Inventor
山口建太郎
青柳克己
寺尾梓
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富士麗比歐股份有限公司
積水醫療股份有限公司
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Publication of TW201411128A publication Critical patent/TW201411128A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • G01N33/57525—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW102128608A 2012-08-09 2013-08-09 Ｐｉｖｋａ－ii測定方法、測定試藥及測定套組 TWI589876B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012176761A JP6032470B2 (ja) 2012-08-09 2012-08-09 Ｐｉｖｋａ−ｉｉ測定方法、測定試薬及び測定キット

Publications (2)

Publication Number Publication Date
TW201411128A TW201411128A (zh) 2014-03-16
TWI589876B true TWI589876B (zh) 2017-07-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW102128608A TWI589876B (zh) 2012-08-09 2013-08-09 Ｐｉｖｋａ－ii測定方法、測定試藥及測定套組

Country Status (8)

Country Link
US (2) US10539559B2 (enExample)
EP (1) EP2884277B1 (enExample)
JP (1) JP6032470B2 (enExample)
KR (1) KR102100152B1 (enExample)
CN (1) CN104520710B (enExample)
RU (1) RU2015107740A (enExample)
TW (1) TWI589876B (enExample)
WO (1) WO2014024853A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104698174B (zh) * 2015-02-28 2017-10-31 江苏宜偌维盛生物技术有限公司 一种胃蛋白酶原ⅰ和ⅱ联合检测试剂盒
WO2017061546A1 (ja) * 2015-10-07 2017-04-13 富士レビオ株式会社 Ｐｉｖｋａ－ｉｉの測定方法、及びｐｉｖｋａ－ｉｉ免疫測定試薬又はキットの製造方法
JP7267253B2 (ja) * 2017-07-13 2023-05-01 エフ． ホフマン－ラ ロシュ アーゲー Ｐｉｖｋａに対する新規結合剤およびアッセイ
CN109207462B (zh) * 2018-08-01 2021-05-11 深圳市新产业生物医学工程股份有限公司 异常凝血酶原及其制备方法和包含其的检测剂、试剂盒及应用
CN112816694A (zh) * 2020-12-31 2021-05-18 泰州泽成生物技术有限公司 一种异常凝血酶原检测试剂盒及制备方法
CN115097122B (zh) * 2022-06-15 2025-08-26 安徽惠邦生物工程有限公司 抗缪勒氏管激素抗体-酶标记物及其制备方法和应用
CN120137043A (zh) * 2023-12-13 2025-06-13 菲鹏生物股份有限公司 抗pivka-ii抗体及其用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6060557A (ja) 1983-09-13 1985-04-08 Eisai Co Ltd Ｐｉｖｋａ−２の測定方法および試薬
US5811310A (en) * 1986-09-30 1998-09-22 Albert Einstein College Of Medicine Of Yeshiva Univ. The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease
JP2702616B2 (ja) 1991-03-12 1998-01-21 エーザイ株式会社 Ｐｉｖｋａ−ｉｉの測定試薬
JP3307422B2 (ja) * 1992-04-10 2002-07-24 株式会社ヤトロン ヒトｐｉｖｋａ−ｉｉの免疫学的測定方法
JPH0720127A (ja) 1993-05-07 1995-01-24 Eisai Co Ltd 各種ｐｉｖｋａの測定方法および測定試薬
JP2867325B2 (ja) 1995-08-03 1999-03-08 株式会社エスアールエル 抗ｐｉｖｋａ−ｉｉ抗体産生ハイブリドーマ及び免疫学的測定方法
JPH09249699A (ja) 1996-03-11 1997-09-22 Fujirebio Inc 抗ヒトｐｉｖｋａ−ｉｉモノクローナル抗体、該抗体を産生するハイブリドーマ、該抗体を用いた測定試薬及び測定方法
JP3316199B2 (ja) * 1998-12-14 2002-08-19 三光純薬株式会社 Ｐｉｖｋａ−ｉｉの免疫学的測定法
JP2000346841A (ja) 1999-06-09 2000-12-15 Daiichi Radioisotope Labs Ltd Ｐｉｖｋａ−ｉｉの測定方法
US6893831B1 (en) * 1999-12-14 2005-05-17 Sanko Junyaku Co., Ltd. Immunoassay of PIVKA-II
US6448086B1 (en) * 2000-01-18 2002-09-10 Diagnostic Systems Laboratories, Inc. Insulin-like growth factor system and cancer
DE10354403A1 (de) * 2003-11-20 2005-06-23 Dade Behring Marburg Gmbh Gegen das Prothrombin-Fragment F 1+2 gerichtete Antikörper, ihre Herstellung und Verwendung
JP2007192557A (ja) * 2006-01-17 2007-08-02 Perseus Proteomics Inc Ｃ型肝炎患者の肝疾患の重篤化をモニターする方法および肝癌の診断方法
CN101377505A (zh) * 2008-04-16 2009-03-04 北京科美东雅生物技术有限公司 脱γ羧基凝血酶原微孔板化学发光免疫分析测定试剂盒及其制备方法
DE102008049601A1 (de) * 2008-09-30 2010-04-01 Siemens Healthcare Diagnostics Products Gmbh Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay

Also Published As

Publication number Publication date
TW201411128A (zh) 2014-03-16
CN104520710A (zh) 2015-04-15
WO2014024853A1 (ja) 2014-02-13
EP2884277A1 (en) 2015-06-17
EP2884277A4 (en) 2016-04-27
US10539559B2 (en) 2020-01-21
JP6032470B2 (ja) 2016-11-30
JP2014035278A (ja) 2014-02-24
CN104520710B (zh) 2016-10-12
RU2015107740A (ru) 2016-09-27
KR20150041620A (ko) 2015-04-16
KR102100152B1 (ko) 2020-04-13
US20200088722A1 (en) 2020-03-19
US20150219638A1 (en) 2015-08-06
EP2884277B1 (en) 2018-10-10

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