JP6007189B2 - Ｉｒａｋ阻害剤としてのインダゾリルトリアゾール誘導体 - Google Patents

Ｉｒａｋ阻害剤としてのインダゾリルトリアゾール誘導体 Download PDF

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JP6007189B2
JP6007189B2 JP2013545217A JP2013545217A JP6007189B2 JP 6007189 B2 JP6007189 B2 JP 6007189B2 JP 2013545217 A JP2013545217 A JP 2013545217A JP 2013545217 A JP2013545217 A JP 2013545217A JP 6007189 B2 JP6007189 B2 JP 6007189B2
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alkyl
mmol
het
triazol
hal
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JP2014500286A (ja
JP2014500286A5 (https=
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ジョラン−ルブラン，カトリーヌ
クロジニャーニ，ステファノ
ドルベ，ジェローム
グリッピ−バロットン，タニア
プルートル，アドゥリーヌ
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メルク セローノ ソシエテ アノニム
メルク セローノ ソシエテ アノニム
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Hematology (AREA)
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  • Rheumatology (AREA)
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  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
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  • Psychology (AREA)
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JP2013545217A 2010-12-20 2011-12-16 Ｉｒａｋ阻害剤としてのインダゾリルトリアゾール誘導体 Expired - Fee Related JP6007189B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061424890P 2010-12-20 2010-12-20
US61/424,890 2010-12-20
EP10195867 2010-12-20
EP10195867.6 2010-12-20
PCT/EP2011/073015 WO2012084704A1 (en) 2010-12-20 2011-12-16 Indazolyl triazole derivatives as irak inhibitors

Publications (3)

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JP2014500286A JP2014500286A (ja) 2014-01-09
JP2014500286A5 JP2014500286A5 (https=) 2016-04-28
JP6007189B2 true JP6007189B2 (ja) 2016-10-12

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Country Link
US (1) US9073892B2 (https=)
EP (1) EP2655357B1 (https=)
JP (1) JP6007189B2 (https=)
KR (1) KR101842098B1 (https=)
CN (1) CN103429585B (https=)
AR (1) AR084507A1 (https=)
AU (1) AU2011347711B2 (https=)
BR (2) BR112013015460B1 (https=)
CA (1) CA2822166C (https=)
EA (1) EA023544B1 (https=)
ES (1) ES2592713T3 (https=)
HR (1) HRP20161127T1 (https=)
HU (1) HUE029617T2 (https=)
IL (1) IL226912A (https=)
LT (1) LT2655357T (https=)
MX (1) MX2013007149A (https=)
PL (1) PL2655357T3 (https=)
PT (1) PT2655357T (https=)
RS (1) RS55165B1 (https=)
SG (1) SG191205A1 (https=)
SI (1) SI2655357T1 (https=)
WO (1) WO2012084704A1 (https=)
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US9718883B2 (en) 2003-09-10 2017-08-01 Amgen Fremont Inc. Antibodies to M-CSF

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EP2654748B1 (en) * 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
ES2704744T3 (es) 2012-06-13 2019-03-19 Incyte Holdings Corp Compuestos tricíclicos sustituidos como inhibidores de FGFR
EP2934516A4 (en) * 2012-12-20 2016-07-20 Merck Sharp & Dohme 3 ESTER 4 SUBSTITUTED OREXINE RECEPTOR ANTAGONISTS
US9643955B2 (en) 2012-12-20 2017-05-09 Merck Sharp & Dohme Corp. 2-pyridyloxy-3-nitrile-4-substituted orexin receptor antagonists
EP2953944B1 (en) * 2013-02-07 2017-04-26 Merck Patent GmbH Pyridazinone-amides derivatives
LT2953952T (lt) * 2013-02-07 2017-08-25 Merck Patent Gmbh Makrocikliniai piridazinono dariniai
EA035095B1 (ru) 2013-04-19 2020-04-27 Инсайт Холдингс Корпорейшн Бициклические гетероциклы в качестве ингибиторов fgfr
TWI667233B (zh) * 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
SG11201605408RA (en) * 2014-01-10 2016-07-28 Aurigene Discovery Tech Ltd Indazole compounds as irak4 inhibitors
FI3805233T3 (fi) 2014-01-13 2024-04-17 Aurigene Oncology Ltd N-(5-(3-hydroksipyrrolidin-1-yyli)-2-morfolinooksatsolo[4,5-b]pyridin-6-yyli)-2-(2-metylipyridin-4-yyli)okatsoli-karboksamidin (r)- (s)-enantiomeerit irak4-estäjänä syövän hoitoon
US9932350B2 (en) 2014-09-30 2018-04-03 Merck Sharp & Dohme Corp. Inhibitors of IRAK4 activity
US9969749B2 (en) 2014-09-30 2018-05-15 Merck Sharp & Dohme Corp. Inhibitors of IRAK4 activity
US9926330B2 (en) 2014-09-30 2018-03-27 Merck Sharp & Dohme Corp. Inhibitors of IRAK4 activity
EP3200790B1 (en) 2014-09-30 2020-08-26 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
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