JP5907866B2 - ダウン症候群遺伝子に対する天然アンチセンス転写物の抑制によるダウン症候群遺伝子関連疾患の治療 - Google Patents
ダウン症候群遺伝子に対する天然アンチセンス転写物の抑制によるダウン症候群遺伝子関連疾患の治療 Download PDFInfo
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- JP5907866B2 JP5907866B2 JP2012517732A JP2012517732A JP5907866B2 JP 5907866 B2 JP5907866 B2 JP 5907866B2 JP 2012517732 A JP2012517732 A JP 2012517732A JP 2012517732 A JP2012517732 A JP 2012517732A JP 5907866 B2 JP5907866 B2 JP 5907866B2
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/14—Type of nucleic acid interfering N.A.
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22074709P | 2009-06-26 | 2009-06-26 | |
US61/220,747 | 2009-06-26 | ||
US23575209P | 2009-08-21 | 2009-08-21 | |
US61/235,752 | 2009-08-21 | ||
PCT/US2010/039827 WO2010151674A2 (en) | 2009-06-26 | 2010-06-24 | Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012531427A JP2012531427A (ja) | 2012-12-10 |
JP5907866B2 true JP5907866B2 (ja) | 2016-04-26 |
Family
ID=43387128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012517732A Active JP5907866B2 (ja) | 2009-06-26 | 2010-06-24 | ダウン症候群遺伝子に対する天然アンチセンス転写物の抑制によるダウン症候群遺伝子関連疾患の治療 |
Country Status (8)
Country | Link |
---|---|
US (4) | US8921330B2 (ko) |
EP (1) | EP2446037B1 (ko) |
JP (1) | JP5907866B2 (ko) |
KR (1) | KR101807324B1 (ko) |
CN (1) | CN102482672B (ko) |
CA (1) | CA2765815A1 (ko) |
ES (1) | ES2583691T3 (ko) |
WO (1) | WO2010151674A2 (ko) |
Families Citing this family (15)
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WO2010014857A2 (en) | 2008-07-30 | 2010-02-04 | University Of Massachusetts | Chromosome therapy |
WO2012065143A1 (en) | 2010-11-12 | 2012-05-18 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
WO2013173608A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics, Inc. | Compositions and methods for modulating mecp2 expression |
CN104583401A (zh) | 2012-05-16 | 2015-04-29 | Rana医疗有限公司 | 用于调节atp2a2表达的组合物和方法 |
EP2850189B8 (en) | 2012-05-16 | 2019-01-23 | Translate Bio MA, Inc. | Compositions and methods for modulating gene expression |
EA201492122A1 (ru) | 2012-05-16 | 2015-10-30 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии utrn |
AP2014008100A0 (en) | 2012-05-16 | 2014-12-31 | Gen Hospital Corp | Compositions and methods for modulating hemoglobingene family expression |
DK2850186T3 (en) | 2012-05-16 | 2019-04-08 | Translate Bio Ma Inc | COMPOSITIONS AND PROCEDURES FOR MODULATING SMN GENFAMILY EXPRESSION |
US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
WO2014152607A2 (en) * | 2013-03-14 | 2014-09-25 | University Of Massachusetts | Dosage compensating transgenes and cells |
US9681646B2 (en) | 2013-03-15 | 2017-06-20 | University Of Massachusetts | Dosage compensating transgenes and cells |
WO2016070060A1 (en) | 2014-10-30 | 2016-05-06 | The General Hospital Corporation | Methods for modulating atrx-dependent gene repression |
US10900036B2 (en) | 2015-03-17 | 2021-01-26 | The General Hospital Corporation | RNA interactome of polycomb repressive complex 1 (PRC1) |
CN108384787B (zh) * | 2018-03-09 | 2020-05-19 | 山东大学深圳研究院 | 一种RCAN1适配子RCAN1-s14 |
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CA2765815A1 (en) | 2010-12-29 |
KR20120086282A (ko) | 2012-08-02 |
WO2010151674A2 (en) | 2010-12-29 |
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US10876117B2 (en) | 2020-12-29 |
JP2012531427A (ja) | 2012-12-10 |
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US20180305693A1 (en) | 2018-10-25 |
KR101807324B1 (ko) | 2017-12-08 |
WO2010151674A3 (en) | 2011-07-21 |
ES2583691T3 (es) | 2016-09-21 |
US10036014B2 (en) | 2018-07-31 |
US8921330B2 (en) | 2014-12-30 |
US10450567B2 (en) | 2019-10-22 |
CN102482672A (zh) | 2012-05-30 |
EP2446037B1 (en) | 2016-04-20 |
EP2446037A2 (en) | 2012-05-02 |
US20120142758A1 (en) | 2012-06-07 |
CN102482672B (zh) | 2016-11-09 |
EP2446037A4 (en) | 2013-11-06 |
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